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Mitochondrial dysfunction affects hepatic immune and metabolic remodeling in patients with hepatitis B virus-related acute-onchronic liver failure

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World Journal of Gastroenterology 2024年第8期30卷 881-900页

作者： Yu Zhang Xiao-Ling Tian Jie-Qun Li dong-sheng wu Qiang Li Bin Chen Department of Hepatology Institute of HepatologyThe First Affiliated Hospital of Hunan University of Chinese MedicineChangsha 410021Hunan ProvinceChina Department of Liver Transplant Transplant Medical Research CenterThe Second Xiangya Hospital of Central South UniversityChangsha 410011Hunan ProvinceChina Department of Surgery The First Affiliated Hospital of Hunan University of Chinese MedicineChangsha 410021Hunan ProvinceChina

BACKGROUND Immune dysregulation and metabolic derangement have been recognized as key factors that contribute to the progression of hepatitis B virus(HBV)-related acute-on-chronic liver failure(ACLF).However,the mechanisms underlying immune and metabolic derangement in patients with advanced HBV-ACLF are *** To identify the bioenergetic alterations in the liver of patients with HBV-ACLF causing hepatic immune dysregulation and metabolic *** Liver samples were collected from 16 healthy donors(HDs)and 17 advanced HBV-ACLF patients who were eligible for liver *** mitochondrial ultrastructure,metabolic characteristics,and immune microenvironment of the liver were *** focus was given to organic acid metabolism as well as the function and subpopulations of macrophages in patients with *** Compared with HDs,there was extensive hepatocyte necrosis,immune cell infiltration,and ductular reaction in patients with *** patients,the liver suffered severe hypoxia,as evidenced by increased expression of hypoxia-inducible factor-1α.Swollen mitochondria and cristae were observed in the liver of *** number,length,width,and area of mitochondria were adaptively increased in *** metabolomics analysis revealed that mitochondrial oxidative phosphorylation decreased,while anaerobic glycolysis was enhanced in patients with *** findings suggested that,to a greater extent,hepa-tocytes used the extra-mitochondrial glycolytic pathway as an energy *** with HBV-ACLF had elevated levels of chemokine C-C motif ligand 2 in the liver homogenate,which stimulates peripheral monocyte infiltration into the *** and functional analysis of macrophage subsets revealed that patients with ACLF had a high abundance of CD68^(+)HLA-DR^(+)macrophages and elevated levels of both interleukin-1βand transforming growth factor-β1 in their *** abundance of CD206^(+)CD163^(+)macrophag

关键词： Acute-on-chronic liver failure Hypoxia-inducible factor-1α Mitochondria Metabolic phenotype Immune cells

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Adaptive vertical handoff algorithm in heterogeneous networks

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The Journal of China Universities of Posts and Telecommunications 2007年第1期14卷 22-25,44页

作者： XIE sheng-dong wu Meng Communication and Information Engineering Institute Nanjing University of Posts and Telecommunications Nanjing 210003 China

The integration of cellular network （CN） and wireless local area network （WLAN） is the trend of the next generation mobile communication systems, and nodes will handoff between the two kinds of networks. The received signal strength （RSS） is the dominant factor considered when handoff occurs. In order to improve the handoff efficiency, this study proposes an adaptive decision algorithm for vertical handoff on the basis of fast Fourier transform （FFT）. The algorithm makes handoff decision after analyzing the signal strength fluctuation which is caused by slow fading through FFT. Simulations show that the algorithm reduces the number of handoff by 35%, shortens the areas influenced by slow fading, and enables the nodes to make full use of WLAN in communication compared with traditional algorithms.

关键词： vertical handoff signal strength slow fading fast Fourier transform

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Dimensional Properties of Fractional Brownian Motion

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Acta Mathematica Sinica,English Series 2007年第4期23卷 613-622页

作者： dong sheng wu Yi Min XIAO Department of Statistics and Probability A-413 Wells Hall Michigan State University East Lansing MI 48824 USA

Let B^α = {B^α（t）,t E R^N} be an （N,d）-fractional Brownian motion with Hurst index α∈ （0, 1）. By applying the strong local nondeterminism of B^α, we prove certain forms of uniform Hausdorff dimension result... 详细信息

关键词： fractional Brownian motion Hausdorff dimension uniform dimension results strong local nondeterminism

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Packing Dimension of Space-time Anisotropic Gaussian Random Fields

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Acta Mathematica Sinica,English Series 2021年第12期37卷 1826-1840页

作者： hen Long CHEN Jun WANG dong sheng wu School of Statistics and Mathematics Zhejiang Gongshang UniversityHangzhou 310018P.R.China School of Mathematics and Finance Chuzhou UniversityChuzhou 239000P.R.China Department of Mathematical Sciences University of Alabama in HuntsvilleHuntsvilleAlabama 35899USA

Let X={X(t)∈R^(d),t∈R^(N)}be a centered space-time anisotropic Gaussian random field whose components are independent and satisfy some mild *** study the packing dimension of range X(E)under the anisotropic(time variable)metric space(R^(N),ρ)and(space variable)metric space(R^(d),τ),where E⊂R^(N) is a Borel *** results generalize the corresponding results of Estrade,wu and Xiao(***.,5,41-64(2011))for time-anisotropic Gaussian random fields to space-time anisotropic Gaussian fields.

关键词： Gaussian random fields anisotropic packing dimension packing dimension profile range

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Gallbladder neuroendocrine carcinoma diagnosis, treatment and prognosis based on the SEER database: A literature review

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World Journal of Clinical Cases 2022年第23期10卷 8212-8223页

作者： Xing-Chen Cai sheng-dong wu Department of Hepato-Pancreato-Billiary Surgery The affiliated Lihuili HospitalNingbo UniversityNingboZhejiangChina

BACKGROUND Gallbladder neuroendocrine carcinoma(GB-NEC)has a low incidence rate;therefore,its clinical characteristics,diagnosis,treatment and prognosis are not well *** To review recent research and analyze corresponding data in the Surveillance Epidemiology and End Results(SEER)*** Data of GB-NEC(n=287)and gallbladder adenocarcinoma(GB-ADC)(n=19484)patients from 1975 to 2016 were extracted from the SEER *** analysis was performed using Kaplan–Meier and Cox proportional hazards regression.P<0.05 was considered statistically *** also reviewed 108 studies retrieved from PubMed and Reference Citation Analysis(https://***/).The keywords used for the search were:"(Carcinoma,Neuroendocrine)AND(Gallbladder Neoplasms)".RESULTS The GB-NEC incidence rate was 1.6%(of all gallbladder carcinomas),male to female ratio was 1:2 and the median survival time was 7 *** 1-,2-,3-and 5-year overall survival(OS)was 36.6%,17.8%,13.2%and 7.3%*** chromogranin A levels may be a specific tumor marker for the diagnosis of *** carcinoembryonic antigen,carbohydrate antigen(CA)-19-9 and CA-125 levels were associated with poor ***[hazard ratio(HR)=1.027,95%confidence interval(CI):1.006–1.047,P=0.01]and liver metastasis(HR=3.055,95%CI:1.839–5.075,P<0.001)are independent prognostic risk factors for *** with advanced GB-NEC treated with surgical resection combined with radiotherapy and/or chemotherapy may have a better prognosis than those treated with surgical resection *** was no significant difference in OS between GB-NEC and *** The clinical manifestations and prognosis of GB-NEC are similar to GB-ADC,but the treatment is completely *** diagnosis and treatment are the top priorities.

关键词： Clinical features Diagnosis Gallbladder neuroendocrine tumor Pathology Treatment

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PROBABILISTIC NUMERICAL APPROACH FOR PDE AND ITS APPLICATION IN THE VALUATION OF EUROPEAN OPTIONS

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Journal of Computational Mathematics 2001年第6期19卷 591-600页

作者： dong-sheng wu (Institute of Systems Science, Academy of Mathematics and Systems Sciences, Chinese Academy of Sciences, Beijing 100080, China ) 中科院系统科学所北京 100080

Presents a probabilistic numerical approach for a class of probabilistic differential equation. Application of the Brownian motion and Monte-Carlo method; Application in the valuation of European Options.

关键词： Brownian motion probabilistic numerical solution European Options

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CONVERGENCE AND SUPERCONVERGENCE OF HERMITE BICUBIC ELEMENT FOR EIGENVALUE PROBLEM OF THE BIHARMONIC EQUATION

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Journal of Computational Mathematics 2001年第2期19卷 139-142页

作者： dong-sheng wu (Institute of Systems Science, Academy of Mathematics and Systems Sciences, Chinese Academy of Sciences, Beijing 100080, China ) 中科院系统科学所北京 100080

Provides information on a study which discussed the convergence and superconvergence for eigenvalue problem of the biharmonic equation using the Hermite bicubic element. Discussion on eigenvalue problem for biharmonic equation; Background on asymptotic error expansions and interpolation postprocessing; Superconvergence approximations to the eigenvalue and eigenfunction.

关键词： Hermite bicubic element biharmonic equation interpolation postprocessing eigenvalue problem

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Prognostic and clinicopathological value of Twist expression in esophageal cancer:A meta-analysis

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World Journal of Gastrointestinal Oncology 2022年第9期14卷 1874-1886页

作者： Wen-Peng Song Su-Yan Wang Si-Cheng Zhou dong-sheng wu Jia-Yu Xie Tong-Tong Liu Xiu-Zhu wu Guo-Wei Che Lung Cancer Center West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Frontiers Science Center for Disease-related Molecular Network West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina West China School of Medicine Sichuan UniversityChengdu 610041Sichuan ProvinceChina Laboratory Experiments in Microbiology Shuang Liu Center for Disease Control and PreventionChengdu 610041Sichuan ProvinceChina West China School of Public Health&West China Fourth Hospital Sichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND Twist is a repressor of E-cadherin transcription that induces epithelial-mesenchymal transition and cancer ***,the prognostic value of Twist expression in patients with esophageal cancer remains *** To investigate the prognostic and clinicopathological value of Twist expression in esophageal *** Published literature in databases such as EMBASE,Web of Science,PubMed,China National Knowledge Infrastructure,Wanfang,and VIP databases was searched for eligible *** with esophageal cancer whose tumor tissues underwent immunohistochemistry to detect the expression of Twist were *** meta-analysis was conducted using Stata version *** hazard ratio(HR) and relative ratio(RR) with their 95 % CI were *** was estimated by I^(2) *** Eleven articles published between 2009 and 2021 fulfilled the selection *** pooled HR for overall survival was 1.88(95%CI:1.32-2.69,I^(2)=68.6%),and the pooled HR for disease-free survival/relapse-free survival/progression-free survival was 1.84(95 % CI:1.12-3.02,I^(2)=67.1%),suggesting that high Twist expression is associated with poor prognosis in esophageal cancer *** addition,overexpression of Twist was correlated with T stage(T3+T4 vs T1+T2,RR=1.38,95 % CI:1.14-1.67),lymph node metastasis(yes vs no,RR=1.34,95 % CI:1.11-1.60),distant metastasis(yes vs no,RR=1.18,95 % CI:1.02-1.35),tumor,node and metastasis(TNM) stage(Ⅲ+Ⅳ vs Ⅰ+Ⅱ,RR=1.35,95 % CI:1.14-1.60),and clinical stage(Ⅲ+Ⅳ vs Ⅰ+Ⅱ,RR=1.58,95 % CI:1.34-1.87).However,no correlation between Twist expression and age,gender,tumor location,differentiation,or venous invasion was *** High expression of Twist is associated with poor esophageal cancer ***,Twist overexpression is correlated with T stage,lymph node metastasis,distant metastasis,TNM stage,and clinical stage,which indicates that Twist might accelerate esophageal cancer progression

关键词： Twist Esophageal cancer Prognosis Epithelial-mesenchymal transition Metastasis Meta-analysis

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Transition-Metal-Free Allylic Defluorination Cross-Electrophile Coupling Employing Rongalite

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Chinese Journal of Chemistry 2024年第12期42卷 1360-1366页

作者： Xiang-Long Chen Chun-Yan wu dong-sheng Yang Bo-Cheng Tang Huai-Yu Wang Zhi-Cheng Yu Anling Li Yan-dong wu An-Xin wu National Key Laboratory of Green Pesticide International Joint Research Center for Intelligent Biosensor Technology and HealthCollege of ChemistryCentral China Normal UniversityWuhanHubei 430079China state Key Laboratory of Chemical Biology and Drug Discovery Department of Applied Biology and Chemical Technology The HongKong Polytechnic UniversityKowloonHong Kong SARChina Department of Clinical Laboratory Center for Gene Diagnosisand Program of Clinical Laboratory MedicineZhongnan Hospital of Wuhan UniversityWuhanHubei 430062China

Comprehensive Summary The conversion of CF3-alkenes to gem-difluoroalkenes using reductive cross-coupling strategy has received much attention in recent years,however,the use of green and readily available reducing salt to mediate these reactions remains to be *** this work,a concise construction of gem-difluoroalkenes,which requires neither a catalyst nor a metal reducing agent,was ***,a safe and inexpensive industrial product,was employed as both a radical initiator and *** procedure was compatible with both linear and cyclic diaryliodonium salts,enabling a wide variety of substrates(>70 examples).The utility of this approach was demonstrated through gram-scale synthesis and efficient late-stage functionalizations of anti-inflammatory drugs.

关键词： Defluoroarylation Transition metal free gem-Difluoroalkenes Rongalite Single electron transfer C-C coupling Redox reactions Cross-coupling

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State-Based Opacity Verification of Networked Discrete Event Systems Using Labeled Petri Nets

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IEEE/CAA Journal of Automatica Sinica 2024年第5期11卷 1274-1291页

作者： Yifan dong Naiqi wu Zhiwu Li The authors are with the Institute of Systems Engineering Macao University of Science and TechnologyTaipa 999078MacaoChina

The opaque property plays an important role in the operation of a security-critical system,implying that pre-defined secret information of the system is not able to be inferred through partially observing its *** paper addresses the verification of current-state,initial-state,infinite-step,and K-step opacity of networked discrete event systems modeled by labeled Petri nets,where communication losses and delays are *** on the symbolic technique for the representation of states in Petri nets,an observer and an estimator are designed for the verification of current-state and initial-state opacity,***,we propose a structure called an I-observer that is combined with secret states to verify whether a networked discrete event system is infinite-step opaque or K-step *** to the utilization of symbolic approaches for the state-based opacity verification,the computation of the reachability graphs of labeled Petri nets is avoided,which dramatically reduces the computational overheads stemming from networked discrete event systems.

关键词： infinite system symbolic

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