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Effect of WFDC 2 silencing on the proliferation,motility and invasion of human serous ovarian cancer cells in vitro

Asian Pacific Journal of Tropical Medicine 2013年第4期6卷 265-272页

作者： Ya-Fei Zhu Guo-Lan Gao sheng-bo tang Zhen-Dong Zhang Qing-Shui Huang Department of Gynaecology and Obstetrics First Affiliated Hospital of Nanchang University Department of Clinical Laboratory First Affiliated Hospital of Nanchang University Department of Oncology First Affiliated Hospital of Nanchang University Department of Pathology First Affiliated Hospital of Nanchang University Department of Obstetrics and Gynecology Aviation General Hospital

Objective:To investigate effect and possible mechanisms of silencing human WFDC2（HE4） gene on biological behavior changes as cell proliferation,apoplosis,movement and invasion of human serous ovarian cancer cell line ***:Lentiviral WFDC2 gene sequence of small interfering siRNA was stablely transfected into SKOV3 identified by Q-PCR and western-blot. Obtained SKOV3 stable strains with silenced HE4 were measured by proliferation,apoplosis, migration,and ***:Gene sequencing showed that the oligonucleotides were successfully inserted into the expected *** silencing HE4 in the SKOV3,proliferation was significandy inhibited（P0/G1 phase was arrested by the cell cycle（P<0.01） and capacity of the migration and invasion decreased significandy（P<0.01）.Slight early apoptosis ratio and no change of late apoplosis were found without change of Caspase-3 or Bcl-2 *** involed in ERK pathway as phosphorylated protein as p-EGFR,p- ERK decreased and protease protein involved in tissue remoding as matrix metalloproteinases MMP-9,MMP-2 and cathepsin B decreased compared with control ***:HE4 gene plays an important role in regulating proliferation,apoptosis,migration,invasion of serous ovarian cancer cells by ERK pathway and protease *** role in apoptosis needs to be further explored,and it may be a potential target for serous ovarian cancer.

关键词： WFDC2 protein Human epididymal secretory protein 4 Ovarian neoplasms Cell proliferation Cell movement Invasion

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Dispatchable Capability of Aggregated Electric Vehicle Charging in Distribution Systems

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Energy Engineering 2025年第1期122卷 129-152页

作者： ShiqianWang bo Liu Yuanpeng Hua Qiuyan Li Binhua tang Jianshu Zhou Yue Xiang Economic and Technology Research Institute State Grid Henan Electric Power CompanyZhengzhou450052China College of Electrical Engineering Sichuan UniversityChengdu610065China

This paper introduces a method for modeling the entire aggregated electric vehicle(EV)charging process and analyzing its dispatchable *** methodology involves developing a model for aggregated EV charging at the charging station level,estimating its physical dispatchable capability,determining its economic dispatchable capability under economic incentives,modeling its participation in the grid,and investigating the effects of different scenarios and EV penetration on the aggregated load dispatch and dispatchable *** results indicate that using economic dispatchable capability reduces charging prices by 9.7%compared to physical dispatchable capability and 9.3%compared to disorderly ***,the peak-to-valley difference is reduced by 64.6%when applying economic dispatchable capability with 20%EV penetration and residential base load,compared to disorderly charging.

关键词： Aggregated charging dispatchable capability peak shaving and valley filling the economics of charging demand response

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Relationship Between Developmental Intensity of Landslide and Malan Loess Cohesion at a Regional Horizontal Space Scale

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Journal of Earth Science 2025年

作者： Yongheng Zhou Yaming tang bo Hong Fan Feng Longhui Wang Institute of Geological Survey， China University of Geosciences (Wuhan) Institute of Earth Environment， Chinese Academy of Sciences Xi'an Geological Survey Center China Geological Survey Chinese Academy of Geological Sciences

Malan loess is highly water-sensitive， with its shear strength， particularly cohesive strength， significantly decreasing under the influence of water. The Western Shanxi Loess Plateau （WSLP） is especially prone to loess landslides， which are closely linked to rainfall infiltration. Understanding the regional variation of Malan loess cohesion (cm) and its distribution in relation to the developmental intensity of landslides in this area can provide essential scientific evidence for effective landslide prevention. Loess landslides and Malan loess were selected as the objects of study for the current research. The regional variation and distribution pattern of the cmwere revealed through undisturbed loess direct shear tests and Inverse Distance Weighting （IDW） interpolation. The relationship between the developmental intensity of landslide and the regional variation of the cmwas explored using the Cumulative Sum Variable Dimension Fractal （CSVDF）， Frequency Ratio （FR） model， and Certainty Factor （CF） model. The following conclusions were drawn: Results from the direct shear tests and IDW method indicate that the cmtends to decrease from south to north and exhibits a positively skewed spatial distribution pattern. The CSVDF results indicates a similarity between the regional variation of the cmand the development intensity of loess landslides. The FR and CF results reveal that loess landslides are more likely to occur when the cmis between 0 and 16.14 kPa.

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The potential mechanism and clinical application value of remote ischemic conditioning in stroke

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Neural Regeneration Research 2025年第6期20卷 1613-1627页

作者： Yajun Zhu Xiaoguo Li Xingwei Lei Liuyang tang Daochen Wen bo Zeng Xiaofeng Zhang Zichao Huang Zongduo Guo The First Affiliated Hospital of Chongqing Medical University ChongqingChina

Some studies have confirmed the neuroprotective effect of remote ischemic conditioning against stroke. Although numerous animal researches have shown that the neuroprotective effect of remote ischemic conditioning may be related to neuroinflammation, cellular immunity, apoptosis, and autophagy, the exact underlying molecular mechanisms are unclear. This review summarizes the current status of different types of remote ischemic conditioning methods in animal and clinical studies and analyzes their commonalities and differences in neuroprotective mechanisms and signaling pathways. Remote ischemic conditioning has emerged as a potential therapeutic approach for improving stroke-induced brain injury owing to its simplicity, non-invasiveness, safety, and patient tolerability. Different forms of remote ischemic conditioning exhibit distinct intervention patterns, timing, and application range. Mechanistically, remote ischemic conditioning can exert neuroprotective effects by activating the Notch1/phosphatidylinositol 3-kinase/Akt signaling pathway, improving cerebral perfusion, suppressing neuroinflammation, inhibiting cell apoptosis, activating autophagy, and promoting neural regeneration. While remote ischemic conditioning has shown potential in improving stroke outcomes, its full clinical translation has not yet been achieved.

关键词： Akt apoptosis autophagy cerebral perfusion cerebral vascular stenosis clinical transformation hemorrhagic stroke ischemic stroke neuroinflammation neuroprotection Notch1 PI3K remote ischemic conditioning stroke

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Deciphering fungal metabolon coupling tandem inverse-electrondemand Diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids

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Science China Chemistry 2025年第1期68卷 288-296页

作者： Shuai Liu Wen-Qiang Xu Ying-Tong Di Man-Cheng tang Ding-Kang Chen Ming-Ming Cao Yao-Wen Chang Hong-Yu tang Chun-Mao Yuan Jun-bo Yang Zhi-Li Zuo Han Guo Zi-Fei Xu Ying Zeng Yun-Dong Wu Xiao-Jiang Hao Key Laboratory of Phytochemistry and Natural Medicines (Chinese Academy of Sciences) Kunming Institute of Botany Chinese Academy of Sciences University of Chinese Academy of Sciences Lab of Computational Chemistry and Drug Design State Key Laboratory of Chemical Oncogenomics Peking University Shenzhen Graduate School Shenzhen Bay Laboratory State Key Laboratory of Microbial Metabolism School of Life Sciences & Biotechnology Shanghai Jiao Tong University State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University Molecular Biology Experimental Center Germplasm Bank of Wild Species in Southwest China Kunming Institute of Botany Chinese Academy of Sciences Yunnan Key Laboratory for Wild Plant Resources Kunming Institute of Botany Chinese Academy of Sciences Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical Sciences

In the intricate process of natural product biosynthesis, a metabolon can enhance metabolic flux by associating sequential enzymes. A fungal metabolon, comprising of flavin-dependent monooxygenase Spe F and P450 monooxygenase Spe G, is identified in the biosynthesis of spiro polycyclic alkaloids(+)-notoamide B and its diastereomer(+)-versicolamide B. Using notoamide E as a substance, Spe F/Spe G metabolon can control the stereoselectivity of its 2,3-epoxidation, followed by hydrogen atom ion at C-17 to generate reactive epoxide tau-m A with dienyl iminium unit. Subsequently,(+)-notoamide B and(+)-versicolamide B are produced via tandem nonenzymatic inverse-electron-demand Diels-Alder reaction and semipinacol rearrangement. This provides the first example of metabolon in the biosynthesis of spiro-prenylated indole alkaloids.

关键词： metabolon Diels-Alder reaction semipinacol rearrangement biosynthesis notoamides spiro polycyclic alkaloids

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A coordinated planning strategy of energy storage allocation and line upgrading to increase photovoltaic consumption with lowest planning cost

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Science China Technological Sciences 2025年

作者： bo ZHANG Yuqi JI Lu ZHANG Wei tang Xiaohui ZHANG Liang WANG Haoran DING Hanchen MAO College of Information and Electrical Engineering China Agricultural University State Grid Heilongjiang Electric Power Research Institute State Grid Heilongjiang Electric Power Company Limited School of Electrical and Information Engineering Zhengzhou University of Light Industry

Random integration of massive distributed photovoltaic (PV) generation poses serious challenges to distribution networks. Voltage violations, line overloads, increased peak–valley differences, and power-flow reversals can occur at different locations, times, and severities. Traditional planning methods such as energy storage (ES) allocation and upgrading of lines may result in poor economics and low equipment utilization. This study proposes a distribution-network planning strategy that coordinates three planning mechanisms:ES allocation to substations and to feeders, and line upgrading. The proposed strategy achieved the lowest annual cost, considering the distribution network problems at different locations, times, and severities. A net load curve description method was first proposed considering economic planning and the uncertain distribution of loads and PVs. Second, a multistage optimization model for ES allocation and line upgrading was established based on the net load curves. Finally, an improved IEEE33 node system was used in the case study. The planning results show that the proposed coordinated planning strategy can address the problems caused by the random integration of massive distributed PVs, improve equipment utilization, and obtain the lowest total annual planning cost.

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Feature extraction for latent fault detection and failure modes classification of board-level package under vibration loadings.

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Science China(Technological Sciences) 2015年第11期58卷 1905-1914页

作者： tang Wei JING bo HUANG YiFeng sheng ZengJin Aeronautics and Astronautics Engineering College Air Force Engineering University

A feature extraction for latent fault detection and failure modes classification method of board-level package subjected to vibration loadings is presented for prognostics and health management(PHM) of electronics using adaptive spectrum kurtosis and kernel probability distance clustering. First, strain response data of electronic components is filtered by empirical mode decomposition(EMD) method based on maximum spectrum kurtosis(SK), and fault symptom vector is developed by computing and reconstructing the envelope spectrum. Second, nonlinear fault symptom data is mapped and clustered in sparse Hilbert space using Gaussian radial basis kernel probabilistic distance clustering method. Finally, the current state of board level package is estimated by computing the membership probability of its envelope spectrum. The experimental results demonstrated that the method can detect and classify the latent failure mode of board level package effectively before it happened.

关键词： board-level package vibration loading spectrum kurtosis kernel probabilistic distance clustering

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Unraveling the mechanism of action of Shangxia Liangji formula for treating insomnia:a metabolomics and network pharmacology approach

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Traditional Medicine Research 2025年第2期10卷 16-29页

作者： Xia-Jie Quan Hao Liang Yong-Hong tang Li Jiang Xiong-Ying Ji Feng-Ying Zhang Ping Zhang bo Ouyang Department of Information The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Neurology The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Gastroscopy The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Traditional Chinese Medicine The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China

Background:Insomnia is a prevalent clinical condition and Shangxia Liangji formula(SXLJF)is a well-established method of ***,the specific mechanism of action of SXLJF remains ***:The mouse model of insomnia was established by intraperitoneal injection of ***-two mice were randomly divided into a negative control group,model group,SXLJF group(18.72 g/kg/day),and positive control group(diazepam,2 mg/kg)and treated with the corresponding drugs for 7 consecutive *** open field test and pentobarbital-induced sleeping test were ***-MS-based untargeted metabolomics and network pharmacology were applied to explore the potential targets of SXLJF for treating ***,key targets were validated using ***:Behavioral tests demonstrated that SXLJF reduced the total distance,average velocity,central distance,and sleep latency,and prolonged sleep *** and network pharmacology revealed potential targets,signaling pathways,metabolic pathways,and metabolites associated with the anti-insomnia effects of ***,tyrosine hydroxylase(TH)and tyrosine metabolism emerged as crucial metabolic pathways and targets,***-qPCR results supported the role of TH in the mechanism of SXLJF in treating ***:In conclusion,TH and tyrosine metabolism may represent significant targets and pathways for SXLJF in treating insomnia.

关键词： Shangxia Liangji formula insomnia metabolomics network pharmacology tyrosine hydroxylase tyrosine metabolism

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Multistate Degradation Model for Prognostics of Solder Joints Under Vibration Conditions

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Chinese Journal of Electronics 2016年第4期25卷 779-785页

作者： tang Wei JING bo HUANG Yifeng sheng Zengjin JIAO Xiaoxuan Aeronautics and Astronautics Engineering College Air Force Engineering University

This paper develops a multistate degradation structure of the solder joints which can be used under various vibration conditions based on nonhomogeneous continuous-time hidden semi-Markov *** parameters of the structure were estimated to illustrate the stochastic relationship between the degradation process and the monitoring indicator by using unsupervised learning *** vibration tests on solder joints with different levels of power spectral density and fixed forms were conducted with a real time monitoring electrical resistance to examine the suitability of the *** was experimentally verified that the multistate degradation structure matches the experimental process reasonably and *** on this multistate degradation model,the online prognostics of solder joint were analyzed and the results indicated that faults or failures can be detected timely,leading to appreciate maintenance actions scheduled to avoid catastrophic failures of electronics.

关键词： Multistate degradation Prognostics Solder joint Vibration loading

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Robust Variable Selection and Estimation in Threshold Regression Model

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Acta Mathematicae Applicatae Sinica 2020年第2期36卷 332-346页

作者： bo-wen LI Yun-qi ZHANG Nian-sheng tang School of Management University of Science and Technology of ChinaHefei 230026China Key Lab of Statistical Modeling and Data Analysis of Yunnan Province Yunnan UniversityKunming 650091China

We combine the robust criterion with the lasso penalty together for the high-dimensional threshold *** estimates regression coefficients as well as the threshold parameter robustly that can be resistant to outliers or heavy-tailed noises and perform variable selection *** illustrate our approach with the absolute loss,the Huber’s loss,and the Tukey’s loss,it can also be extended to any other robust *** studies are conducted to demonstrate the usefulness of our robust ***,we use our estimators to investigate the presence of a shift in the effect of debt on future GDP growth.

关键词： Threshold regression Robust estimation Lasso

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