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Enhancing photoresponsiveness of metal-organic polyhedra by modifying microenvironment

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Nano Research 2024年第6期17卷 5712-5717页

作者： Long Zheng Peng Tan Qian Song sheng-tao Wang Min Li Xiao-Qin Liu Lin-Bing Sun State Key Laboratory of Materials-Oriented Chemical Engineering Jiangsu National Synergetic Innovation Center for Advanced Materials(SICAM)College of Chemical EngineeringNanjing Tech UniversityNanjing 211816China

Photoresponsiveness of materials is critical to their tunability and efficiency in terminal *** metal-organic polyhedra(PMOPs)feature intrinsic pores and remote controllability,but aggregation of PMOPs in solid state hampers their photoresponsiveness ***,we report the construction of a new PMOP(Cu_(24)(C_(16)H_(12)N_(2)O_(4))_(12)(C_(18)H_(22)O_(5))12,denoted as MOP-PR-LA),where long alkyl(LA)chains act as the intermolecular poles,propping against adjacent PMOP molecules to create individual microenvironment benefiting the isomerization of photoresponsive(PR)*** ultraviolet(UV)-and visible-light irradiation,MOP-PR-LA is much easier to isomerize than the counterpart MOP-PR without *** propylene adsorption,MOP-PR has a low change of adsorption capacity(9.9%),while that of MOP-PR-LA reaches 58.6%.Density functional theory calculations revealed that PR in the cis state has a negative effect on adsorption,while the trans state of PR favors *** work might open an avenue for the construction of photoresponsive materials with high responsiveness and controllability.

关键词： photoresponsive adsorption metal-organic polyhedra azobenzene long alkyl chains propylene capture

Xuebijing improves intestinal microcirculation dysfunction in septic rats by regulating the VEGF-A/PI3K/Akt signaling pathway

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World Journal of Emergency Medicine 2024年第3期15卷 206-213页

作者： A-ling Tang Yan Li Li-chao Sun Xiao-yu Liu Nan Gao sheng-tao Yan Guo-qiang Zhang Department of Emergency China-Japan Friendship HospitalBeijing 100029China Graduate School Beijing University of Chinese MedicineBeijing 100105China

BACKGROUND:This study aims to explore whether Xuebijing(XBJ) can improve intestinal microcirculation dysfunction in sepsis and its ***:A rat model of sepsis was established by cecal ligation and puncture(CLP).A total of 30 male SD rats were divided into four groups:sham group,CLP group,XBJ + axitinib group,and XBJ *** was intraperitoneally injected 2 h before *** data(blood pressure and heart rate) were *** intestinal microcirculation data of the rats were analyzed via microcirculation ***-linked immunosorbent assay(ELISA) kits were used to detect the serum levels of interleukin-6(IL-6),C-reactive protein(CRP),and tumor necrosis factor-α(TNF-α) in the *** analysis and transmission electron microscopy were used to analyze the injury of small intestinal microvascular endothelial cells and small intestinal mucosa in *** expression of vascular endothelial growth factor A(VEGF-A),phosphoinositide 3-kinase(PI3K),phosphorylated PI3K(p-PI3K),protein kinase B(Akt),and phosphorylated Akt(p-Akt) in the small intestine was analyzed via Western ***:XBJ improved intestinal microcirculation dysfunction in septic rats,alleviated the injury of small intestinal microvascular endothelial cells and small intestinal mucosa,and reduced the systemic inflammatory ***,XBJ upregulated the expression of VEGF-A,p-PI3K/total PI3K,and p-Akt/total Akt in the rat small ***:XBJ may improve intestinal microcirculation dysfunction in septic rats possibly through the VEGF-A/PI3K/Akt signaling pathway.

关键词： Sepsis Xuebijing Vascular endothelial growth factor A Microcirculation Rat Phosphoinositide 3-kinase Protein kinase B

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Research advances in smart responsive-hydrogel dressings with potential clinical diabetic wound healing properties

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Military Medical Research 2024年第4期11卷 543-566页

作者： Ying Chen Xing Wang sheng tao Qi Wang Pan-Qin Ma Zi-Biao Li Yun-Long Wu Da-Wei Li Fujian Provincial Key Laboratory of Innovative Drug Target Research and State Key Laboratory of Cellular Stress Biology School of Pharmaceutical SciencesXiamen UniversityXiamen 361102FujianChina Beijing National Laboratory for Molecular Sciences Institute of ChemistryChinese Academy of SciencesBeijing 100090China University of Chinese Academy of Sciences Beijing 100049China Senior Department of Orthopedics the Fourth Medical Center of Chinese PLA General HospitalBeijing 100091China Institute of Materials Research and Engineering A*STAR(Agency for ScienceTechnology and Research)Singapore 138634Singapore

The treatment of chronic and non-healing wounds in diabetic patients remains a major medical *** reports have shown that hydrogel wound dressings might be an effective strategy for treating diabetic wounds due to their excellent hydrophilicity,good drug-loading ability and sustained drug release *** a typical example,hyaluronic acid dressing(Healoderm)has been demonstrated in clinical trials to improve wound-healing efficiency and healing rates for diabetic foot ***,the drug release and degradation behavior of clinically-used hydrogel wound dressings cannot be adjusted according to the wound *** to the intricacy of diabetic wounds,antibiotics and other medications are frequently combined with hydrogel dressings in clinical practice,although these medications are easily hindered by the hostile *** this case,scientists have created responsive-hydrogel dressings based on the microenvironment features of diabetic wounds(such as high glucose and low pH)or combined with external stimuli(such as light or magnetic field)to achieve controllable drug release,gel degradation,and microenvironment improvements in order to overcome these clinical *** responsive-hydrogel dressings are anticipated to play a significant role in diabetic therapeutic wound ***,we review recent advances on responsive-hydrogel dressings towards diabetic wound healing,with focus on hydrogel structure design,the principle of responsiveness,and the behavior of *** but not least,the advantages and limitations of these responsive-hydrogels in clinical applications will also be *** hope that this review will contribute to furthering progress on hydrogels as an improved dressing for diabetic wound healing and practical clinical application.

关键词： Responsive-hydrogel Diabetic wound Anti-inflammation Tissue remodeling

Expression levels of K_(ATP)channel subunits and morphological changes in the mouse liver after exposure to radiation

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World Journal of Experimental Medicine 2024年第2期14卷 103-113页

作者： Ming Zhou tao-sheng Li Hiroshi Abe Hideo Akashi Ryoji Suzuki Yoshio Bando Department of Anatomy Akita University Graduate School of MedicineAkita 010-8543Japan Department of Stem Cell Biology Atomic Bomb Disease InstituteNagasaki UniversityNagasaki 852-8523Japan Sendai Old Age Refresh Station A Long-term Care Health FacilitySendai 981-1105Japan

BACKGROUND ATP sensitive K+(K_(ATP))channels are ubiquitously distributed in various of cells and tissues,including the *** play a role in the pathogenesis of myocardial and liver *** To evaluate the radiation-induced changes in the expression of K_(ATP)channel subunits in the mouse liver to understand the potential role of K_(ATP)channels in radiation *** Adult C57BL/6 mice were randomly exposed toγ-rays at 0 Gy(control,n=2),0.2 Gy(n=6),1 Gy(n=6),or 5 Gy(n=6).The livers were removed 3 and 24 h after radiation *** and eosin staining was used for morphological observation;immunohistochemical staining was applied to determine the expression of K_(ATP)channel subunits in the liver *** Compared with the control group,the livers exposed to 0.2 Gyγ-ray showed an initial increase in the expression of Kir6.1 at 3 h,followed by recovery at 24 h after *** to a high dose of 5.0 Gy resulted in decreased expression of Kir6.1 and increased expression of SUR2B at 24 ***,the expression of Kir6.2,SUR1,or SUR2A had no remarkable changes at 3 and 24 h after exposure to any of these *** The expression levels of Kir6.1 and SUR2B in mouse liver changed differently in response to different radiation doses,suggesting a potential role for them in radiation-induced liver injury.

关键词： Radiation exposure ATP-sensitive K^(+)channel Mouse Liver

Lymph node-biomimetic scaffold boosts CAR-T therapy against solid tumor

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National Science Review 2024年第4期11卷 206-215页

作者： Ziyan Liao Jie Jiang Wei Wu Jiaqi Shi Yanfang Wang Yuejun Yao tao sheng Feng Liu Wei Liu Peng Zhao Feifei Lv Jie Sun Hongjun Li Zhen Gu National Key Laboratory of Advanced Drug Delivery and Release Systems College of Pharmaceutical Sciences Zhejiang University Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang University Liangzhu Laboratory Zhejiang University Bone Marrow Transplantation Center of the First Affiliated Hospital and Department of Cell Biology Zhejiang University School of Medicine Department of Medical Oncology The First Affiliated Hospital School of Medicine Zhejiang University Department of Laboratory Medicine The First Affiliated Hospital Zhejiang University School of Medicine Department of Hepatobiliary and Pancreatic Surgery The Second Affiliated HospitalSchool of MedicineZhejiang University Jinhua Institute of Zhejiang University MOE Key Laboratory of Macromolecular Synthesis and Functionalization of Ministry of Education Department of Polymer Science and EngineeringZhejiang University Department of General Surgery Sir Run Run Shaw Hospital School of Medicine Zhejiang University

The limited infiltration and persistence of chimeric antigen receptor(CAR)-T cells is primarily responsible for their treatment deficits in solid tumors. Here, we present a three-dimensional scaffold, inspired by the physiological process of T-cell proliferation in lymph nodes. This scaffold gathers the function of loading,delivery, activation and expansion for CAR-T cells to enhance their therapeutic effects on solid tumors. This porous device is made from poly(lactic-co-glycolic acid) by a microfluidic technique with the modification of T-cell stimulatory signals, including anti-CD3, anti-CD28 antibodies, as well as cytokines. This scaffold fosters a 50-fold CAR-T cell expansion in vitro and a 15-fold cell expansion in vivo. Particularly, it maintains long-lasting expansion of CAR-T cells for up to 30 days in a cervical tumor model and significantly inhibits the tumor growth. This biomimetic delivery strategy provides a versatile platform of cell delivery and activation for CAR-T cells in treating solid tumors.

关键词： drug delivery cell therapy bioinspired biomaterials cancer immunotherapy

Research advances in smart responsive-hydrogel dressings with potential clinical diabetic wound healing properties

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Military Medical Research 2024年第04期 543-566页

作者： Ying Chen Xing Wang sheng tao Qi Wang Pan-Qin Ma Zi-Biao Li Yun-Long Wu Da-Wei Li Fujian Provincial Key Laboratory of Innovative Drug Target Research and State Key Laboratory of Cellular Stress Biology School of Pharmaceutical SciencesXiamen University Beijing National Laboratory for Molecular Sciences Institute of ChemistryChinese Academy of Sciences University of Chinese Academy of Sciences Senior Department of Orthopedics the Fourth Medical Center of Chinese PLA General Hospital Institute of Materials Research and Engineering A*STAR (Agency for ScienceTechnology and Research)

The treatment of chronic and non-healing wounds in diabetic patients remains a major medical *** reports have shown that hydrogel wound dressings might be an effective strategy for treating diabetic wounds due to their excellent hydrophilicity,good drug-loading ability and sustained drug release *** a typical example,hyaluronic acid dressing (Healoderm) has been demonstrated in clinical trials to improve wound-healing efficiency and healing rates for diabetic foot ***,the drug release and degradation behavior of clinicallyused hydrogel wound dressings cannot be adjusted according to the wound *** to the intricacy of diabetic wounds,antibiotics and other medications are frequently combined with hydrogel dressings in clinical practice,although these medications are easily hindered by the hostile *** this case,scientists have created responsive-hydrogel dressings based on the microenvironment features of diabetic wounds (such as high glucose and low pH) or combined with external stimuli (such as light or magnetic field) to achieve controllable drug release,gel degradation,and microenvironment improvements in order to overcome these clinical *** responsive-hydrogel dressings are anticipated to play a significant role in diabetic therapeutic wound ***,we review recent advances on responsive-hydrogel dressings towards diabetic wound healing,with focus on hydrogel structure design,the principle of responsiveness,and the behavior of *** but not least,the advantages and limitations of these responsive-hydrogels in clinical applications will also be *** hope that this review will contribute to furthering progress on hydrogels as an improved dressing for diabetic wound healing and practical clinical application.

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资产价格泡沫与金融稳定——基于QVAR-DY的实证研究

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金融论坛 2024年第5期 26-37页

作者：郭文伟罗胜涛广东财经大学金融学院广州510320

本文采用BSADF方法测度中国股市和房市的泡沫水平,并通过TVP-FAVAR模型构建中国的金融稳定状况指数,进而通过QVAR-DY模型分析股市泡沫和房市泡沫对金融稳定的异质性溢出效应。研究发现:第一,资产泡沫对金融稳定存在显著的溢出效应,且沪... 详细信息

本文采用BSADF方法测度中国股市和房市的泡沫水平,并通过TVP-FAVAR模型构建中国的金融稳定状况指数,进而通过QVAR-DY模型分析股市泡沫和房市泡沫对金融稳定的异质性溢出效应。研究发现:第一,资产泡沫对金融稳定存在显著的溢出效应,且沪市泡沫、深市泡沫和房市泡沫之间存在泡沫传染;第二,在低分位数下,股市泡沫对金融稳定的溢出效应要大于房市泡沫,其中沪市泡沫的负向冲击比深市泡沫更大;第三,在高分位数下,房市泡沫对金融稳定的溢出效应要大于股市泡沫。

关键词：资产泡沫金融稳定 BSADF TVP-FAVAR QVAR-DY

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一种干涉仪测向中圆锥效应的消除方法

信息记录材料 2024年第7期25卷 1-3,6页

作者：盛涛电子信息控制重点实验室四川成都610036

现有干涉仪测向体制在入射信号的俯仰角度较小时具备较高的测向精度,能够满足电子侦察设备的使用需求,但在入射信号的俯仰角度较大时或载机在机动期间,会引入圆锥效应,造成干涉仪测向精度急剧下降,严重影响电子侦察设备的作战效能的发... 详细信息

现有干涉仪测向体制在入射信号的俯仰角度较小时具备较高的测向精度,能够满足电子侦察设备的使用需求,但在入射信号的俯仰角度较大时或载机在机动期间,会引入圆锥效应,造成干涉仪测向精度急剧下降,严重影响电子侦察设备的作战效能的发挥。本文通过采用水平-俯仰二维测向基线设计,实现对入射信号的俯仰角的感知,并根据该信号的入射俯仰角计算出圆锥效应带来的误差,通过抵消圆锥效应误差的方式提升干涉仪在俯仰空域内的测向精度,提升电子侦察设备的作战效能。

关键词：干涉仪圆锥效应测向精度

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风浪与冲击载荷作用下海上火箭发射船运动响应研究

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船舶力学 2024年第9期28卷 1339-1346页

作者：韩彦青楚胜涛巩庆涛孙忠玉杜正发鲁东大学水利工程学院山东烟台264025 鲁东大学蔚山船舶与海洋学院山东烟台264025 山东省海上航天装备技术创新中心山东烟台264004 中集来福士海洋工程研究院有限公司山东烟台264670

海上火箭发射船在海洋环境载荷与发射冲击载荷作用下将发生复杂的非线性运动响应,对火箭发射的安全性有着至关重要的影响。本文基于三维势流理论研究不同海况风浪与冲击载荷作用下某海上火箭发射船的运动响应特性,并分析船舶有无动力定... 详细信息

海上火箭发射船在海洋环境载荷与发射冲击载荷作用下将发生复杂的非线性运动响应,对火箭发射的安全性有着至关重要的影响。本文基于三维势流理论研究不同海况风浪与冲击载荷作用下某海上火箭发射船的运动响应特性,并分析船舶有无动力定位系统、发射点火时间的选择等因素对发射船运动特性的影响。结果表明:发射冲击载荷对船舶的纵摇运动影响较大,尤其是在风浪方向和船舶方向平行时,纵摇角较大;动力定位系统的存在会增加发射船的横摇角度;发射点火时间选择在发射船纵摇运动即将达到极值并折返的时刻,可减小发射船纵摇运动对火箭起飞姿态的影响。

关键词：海上发射冲击运动响应风浪载荷动力定位系统

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