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Asynchronous GABA release at output synapses of fast-spiking interneurons shortens the duration of network activity

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Asynchronous GABA release at output synapses of fast-spiking...

Treatment of Pulsatile Tinnitus Associated with Multiple Factors

中国神经科学学会第十二届全国学术会议

作者： Quan-sheng He Da-Hui Wang You-sheng shu School of Brain and Cognitive Sciences Beijing Normal University Institute of Systems Science Beijing Normal University

The release of neurotransmitter is normally synchronized to the presynaptic action potential（AP）, however at certain types of synapses neurotransmitter release is not tightly coupled to APs, showing delayed, prolonged and thus asynchronous release（AR）. Output synapses of cortical fast-spiking（FS） interneurons show both synchronous release（SR） and AR, and the strength of AR is substantially enhanced in epileptic tissue. The underlying mechanism of AR and its role in regulating network activity remains unclear. We performed whole-cell recording from FS cells and their neighboring pyramidal cells（PC） in rodent and human cortical slices. High frequency stimulation in FS cells could cause AR at FS autapses and FS-to-PC synapses. During the stimulation, the number of AR progressively built up, and the SR gradually decreased, while the total amount of release kept relatively constant. Immediately after the stimulation, the number of AR showed an abrupt increase and then decayed exponentially. These data suggest that AR competes with SR for the same pool of vesicles, but uses different release machinery. To address the functional role of AR in regulating network activity, we built a computational network model where excitatory PCs and FS cells showed recurrent synaptic connections and FS cells possessed autaptic connections. This model captured our experimental observations and could generate network activity. Enhancing the AR strength shortened the duration of network activity but had no effect on the propagation velocity. Together, our results support the vesicle-completing mechanism of AR and suggest an important role of AR in shaping network activity, which might alleviate epileptiform activities in human patients.

关键词： Asynchronous release vesicle competing GABA epilepsy cerebral cortex

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Chinese Medical Journal 2015年第3期128卷 413-414页

作者： Xiao-Bo Ma Guo-Peng Wang Rong Zeng shu-sheng Gong Department of Otolaryngology Head and Neck Surgery Beijing Tongren Hospital Capital Medical University Beijing 100730 China

Numerous factors may lead to pulsatile tinnitus （PT）, including atherosclerosis, benign intracranial hypertension, glomus tympanicum tumor, dural arteriovenous fistulas （dAVFs）, abnormalities of the sigmoid sinus （dehiscence and diverticulum）, and jugular bulb anomalies （glomus jugular tumor, diverticulum, high-riding or dehiscent jugular bulb）. However, exact causes often cannot be found in many patients even after a detailed physical examination and extensive auxiliary examinations. Moreover, no effective treatment is available for these patients. Patients with PT associated with multiple factors are seldom reported, and the condition is essentially intractable. Here, we reported three cases with PT involving multiple factors.

关键词： Dural Arteriovenous Fistulas Jugular Bulb Mastoid Emissary Vein Pulsatile Tinnitus Sigmoid Sinus

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参数摄动机械臂鲁棒控制器的演化设计

机器人 2006年第2期28卷 160-163页

作者：杨书生钟宜生清华大学自动化系北京100084

对于存在参数区间摄动的机械臂,提出了一种利用遗传算法进行鲁棒控制器演化设计的方法.将具有给定结构的控制器的参数编码后作为控制器种群,将机械臂的摄动参数编码后作为受控对象种群;对两个种群进行双向演化操作,得到对区间摄动系统... 详细信息

对于存在参数区间摄动的机械臂,提出了一种利用遗传算法进行鲁棒控制器演化设计的方法.将具有给定结构的控制器的参数编码后作为控制器种群,将机械臂的摄动参数编码后作为受控对象种群;对两个种群进行双向演化操作,得到对区间摄动系统具有足够鲁棒性的控制器和最差控制性能所对应的受控对象模型.对存在参数摄动的二自由度机械臂进行鲁棒控制器设计的结果表明,所提出的方法是有效的.

关键词：不确定机械臂鲁棒控制器遗传算法演化设计

Diagnosis and surgical treatment of esophageal gastrointestinal stromal tumors

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World Journal of Gastroenterology 2015年第18期21卷 5630-5634页

作者： Fang-Biao Zhang Hong-Can Shi Yu-sheng shu Wei-Ping Shi Shi-Chun Lu Xiang-Yan Zhang Shao-Song Tu Department of Cardiothoracic Surgery Lishui Center Hospital Department of Cardiothoracic Surgery Clinical College Yangzhou University

AIM: To retrospectively evaluate our experience with the diagnosis and surgical resection of esophageal gastrointestinal stromal tumors(GISTs).METHODS: Between January 2003 and August 2014, five esophageal GIST cases were admitted to our hospital. In this study, the hospital records, surgery outcomes, tumor recurrence and survival of these patients were retrospectively ***: The median age of the patients was 45.6 years(range: 12-62 years). Three patients presented with dysphagia, and one patient presented with chest discomfort. The remaining patient was asymptomatic. Four patients were diagnosed with esophageal GISTs by a preoperative endoscopic biopsy. Three patients underwent esophagectomy, and two patients underwent video-assisted thoracoscopic surgery. The mean operating time was 116 min(range: 95-148 min), and the mean blood loss was 176 m L(range: 30-300 m L). All tumors were completely resected. The mean length of postoperative hospital stay was 8.4 d(range: 6-12 d). All patients recovered and were discharged successfully. The median postoperative follow-up duration was 48 mo(range: 29-72 mo). One patient was diagnosed with recurrence, one patient was lost to follow-up, and three patients were asymptomatic and are currently being managed with close radiologic and clinical ***:Surgery is the standard,effective and successful treatment for esophageal *** follow-up is required to monitor recurrence and metastasis.

关键词： Esophagus Gastrointestinal stromal tumors Recurrence

Acute respiratory distress syndrome following multiple wasp stings treated with extracorporeal membrane oxygenation:A case report

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World Journal of Clinical Cases 2022年第30期10卷 11122-11127页

作者： Zheng-Yin Cai Bao-Ping Xu Wei-Hao Zhang Huai-Wen Peng Qing Xu Huai-Bin Yu Quan-Gen Chu shu-sheng Zhou Department of Critical Care Medicine Traditional Chinese Hospital of Lu'an Affiliated to Anhui University of Traditional Chinese MedicineLu'an 237000Anhui ProvinceChina Department of Chinese Medicine Anhui University of Traditional Chinese MedicineHefei 230031Anhui ProvinceChina Department of Intensive Care Unit The First Affiliated Hospital of University of Science and Technology of ChinaHefei 230001Anhui ProvinceChina

BACKGROUND It is necessary for clinicians to be aware of a rare but possible acute respiratory distress syndrome(ARDS)complication caused by multiple wasp *** ARDS has a high mortality rate but no specific pharmacotherapies have been identified to *** case study presents the first case of severe ARDS caused by multiple wasp stings,treated successfully with extracorporeal membrane oxygenation(ECMO).It also emphasizes the effectiveness of early ECMO treatment for severe ARDS with persistent *** SUMMARY A 24-year-old woman was admitted to the emergency department after being stung by more than 10 wasps within a 30-min period,with clinical symptoms of multiple rashes,dizziness,chest tightness,nausea,and *** the 2nd day of admission,the patient developed progressive *** patient was diagnosed with ARDS based on clinical manifestations and lung computed tomography(CT)*** of the progressive dyspnea,the intensive care unit physician performed endotracheal intubation and continued to provide ventilator support,but the patient’s respiratory distress worsened,as indicated by the ratio of arterial partial pressure of oxygen to fraction of inspired ***-venous ECMO was initiated for 6 *** day 7 of admission,ECMO was *** the 11th day of admission,CT scan of the lungs revealed significant reduction of ground-glass opacities and *** about 2 wk,the patient recovered completely from ARDS and was discharged to *** the 2-mo follow-up,the patient was in good health with no recurrence of dyspnea nor chest *** ARDS complication caused by multiple wasp stings may be fatal when mechanical ventilation becomes dangerous due to persistent hypoxemia and despite optimization of ARDS *** propose that the early implementation of ECMO is a relatively effective treatment,although the evidence is relatively limited.

关键词： Wasp Bites and stings Respiratory distress syndrome Persistent hypoxemia Extracorporeal membrane oxygenation Case report

Factors associated with the clinical outcomes of adult cardiac and non-cardiac origin cardiac arrest in emergency departments: a nationwide retrospective cohort study from China

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World Journal of Emergency Medicine 2023年第3期14卷 238-240页

作者： Yue-guo Wang Cudjoe Obed Yu-lan Wang Feng-feng Deng shu-sheng Zhou Yang-yang Fu Jian Sun Wenwen Wang Jun Xu Kui Jin Department of Emergency Medicine the First Affi liated Hospital of USTCDivision of Life Science and MedicineUniversity of Science and Technology of ChinaHefei 230001China Department of Microbiology&Immunology School of Medical SciencesUniversity of Cape CoastCape Coast 00233Ghana Department of Cardiovascular Medicine Huangshan City People's HospitalHuangshan 245000China Department of Emergency Medicine Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Graduate School of Bengbu Medical College Bengbu 233000China

Cardiac arrest(CA)is one of the most common causes of death.[1-3]Despite extensive studies on the management of CA,the global survival rate in adults is only approximately 7%,and 30-day survival is even less than 2%in China.[4]Some studies have shown that CA patients of cardiac and non-cardiac origin may differ in underlying diseases,clinical manifestations,and prognosis,which leads to diff erences in terms of the pathophysiological mechanism and treatment measure.[5,6]However,little is known about the risk factors in relation to the prognosis of CA across arrest etiologies.

关键词： cardiac clinical prognosis

Cassiterite U-Pb age in the Bawapin tin deposit, Tanintharyi Region, southern Myanmar

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China Geology 2023年第2期6卷 358-360,I0046页

作者： Song-yang Wu shu-sheng Liu Yong-fei Yang Bin Zhang Hui-min Liang Hong Zhang Xiang-ting Zeng Fei Nie Chengdu Center China Geological SurveyChengdu 610081China Applied Geological Survey Center China Geological SurveyChengdu 610036China

*** Southeast Asia has a 3500 km tin metallogenic belt in the world,extending from southern Yunnan Province to Bangka,*** region is also the world’s largest one regarding tin production,which accounts for 85%of historical tin production globally(Lehmann B,2021).Myanmar is one of the main tin producers within this region(33000 t in 2020)and has become the key supplier after China and *** on tin mineralization in Myanmar mostly focused on ore-related granites,for zircon geochronology,magma evolution,and tectonic settings(Mao W et al.,2020).

关键词： Myanmar mostly globally

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改革开放三十年中国的教育学话语与教育变革

教育学报 2008年第5期4卷 3-19页

作者：于述胜北京师范大学教育学院北京100875

改革开放30年,是中国教育学百年历程中发展最快、成果最多的时期。从学术话语的变迁来看,它经历了1980年代的"反政治化的政治化"阶段,1990年代的"知识化和专业化"阶段,以及2000年代"超越知识的文化追求"阶段。这个过程,也是学术、政治... 详细信息

改革开放30年,是中国教育学百年历程中发展最快、成果最多的时期。从学术话语的变迁来看,它经历了1980年代的"反政治化的政治化"阶段,1990年代的"知识化和专业化"阶段,以及2000年代"超越知识的文化追求"阶段。这个过程,也是学术、政治和大众三大文化系统从浑沌一体,到分化独立,再到沟通对话并呈现出融合趋势的过程。为了把"超越知识的文化追求"落到实处,全面、准确把握"理论与实践统一"的现实内涵及其实践方式,把严谨学理、宽厚知识与人文情怀、人文化探究和表达方式统一起来,以充分展现教育学的人文学特性,当是我们的可能选择之一。

关键词：改革开放中国教育学学术话语政治话语大众话语

切近中国历史文化语境的教育史研究——以孔子之“学”的阐释为例

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教育学报 2012年第5期8卷 98-106页

作者：于述胜北京师范大学教育历史与文化研究院北京100875

教育史既是社会科学,也是人文学科。作为人文学科,教育史研究应该切近中国历史文化语境,在"入境"、"构境"和"引人入境"上多下功夫。例如,在对孔子之"学"的阐释上,如果超越"规律—原则—方法"这一技术化进路,在同情与体贴中切近之,我们... 详细信息

教育史既是社会科学,也是人文学科。作为人文学科,教育史研究应该切近中国历史文化语境,在"入境"、"构境"和"引人入境"上多下功夫。例如,在对孔子之"学"的阐释上,如果超越"规律—原则—方法"这一技术化进路,在同情与体贴中切近之,我们将会发现:对于孔子来说具有根本意义的"学",并非服于任何外在目的、对象化、工具性的知识活动,而是一个人不断自我超越的生命和生活历程,其间充满了精神张力和乐感韵律。学与不学的根本区别,就在于是否进入此境;而教,不过是通过在境中言并引人入境,有效介入学者的精神世界,让学者进入居间引发、欲罢不能的状态。"入境"意味着进入时间(历史的时间而非物理的时间),感受并顺应"生命—生活"的节拍,在自我兴发中不断超越既成状态。这其实也是"学习"和"教育"的本义。

关键词：孔子历史文化语境孔子之“学”