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Nomogram based on clinical characteristics for predicting overall survival in gastric cancer patients with preoperative anemia

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World Journal of Gastrointestinal Surgery 2023年第7期15卷 1375-1387页

作者： Yan Long Xiao-Lu Zhou Cheng-Long Zhang Ya-Nan Wang Wen-sheng pan Department of Gastroenterology Zhejiang Provincial People’s HospitalAffiliated People’s HospitalHangzhou Medical CollegeHangzhou 310014Zhejiang ProvinceChina Department of Traumatology the Affiliated Hospital of Qingdao UniversityQingdao 266003Shandong ProvinceChina College of Biotechnology and Bioengineering Zhejiang University of TechnologyHangzhou 310014Zhejiang ProvinceChina

BACKGROUND Preoperative anemia is associated with increased postoperative morbidity and mortality and increased perioperative transfusion *** surgical patients,this affects physical and cognitive ability and quality of life,but it is an important and modifiable risk *** To determine the effect of preoperative anemia on the prognosis of gastric cancer(GC)patients and generate a prognostic nomogram to predict the postoperative overall survival(OS)of GC patients with preoperative *** Clinicopathological and follow-up data of GC patients treated at Zhejiang Provincial People's Hospital(China)from 2010 to 2015 were *** prognostic factors were screened by univariate and multivariate Cox regression ***,these factors were used to construct a nomogram to predict 1-,3-,and 5-year postoperative OS in preoperative anemic GC *** nomogram was assessed by calibration curves,receiver operating characteristic(ROC)curves,and decision curve analysis(DCA).RESULTS Nine hundred and sixty GC patients were divided into two groups(preoper atively anemic and nonanemic),and postoperative survival analysis was performed on both groups,yielding a shorter postoperative survival for preoperatively anemic patients than for nonanemic patients.A total of 347 GC patients with preoperative anemia were ***,preoperative alpha-fetoprotein level,monocyte count,lymphocyte count,clinicopathological stage,liver metastasis,and GC type were identified as independent prognostic factors for *** area under the ROC curve(AUC)of the nomogram for predicting 1-,3-,and 5-year OS was 0.831,0.845,and 0.840,respectively,for the training cohort,and the corresponding AUC values in the validation cohort were 0.827,0.829,and 0.812,*** curves and DCA indicated good performance of the *** In all,we have successfully produced and verified a useful nomogram for predicting OS in GC patients with preoperative *** no

关键词： Anemia Gastric cancer Nomogram Overall survival

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Improved Corrosion Resistance in AZ61 Magnesium Alloys Induced by Impurity Reduction

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Acta Metallurgica Sinica(English Letters) 2020年第2期33卷 225-232页

作者： Yan Dai Xian-Hua Chen Tao Yan Ai-Tao Tang Di Zhao Zhu Luo Chun-Quan Liu Ren-Ju Cheng Fu-sheng pan College of Materials Science and Engineering Chongqing UniversityChongqing 400045China Chongqing Academy of Science and Technology Chongqing 401123China

The effect of impurity element Fe on corrosion behavior of AZ61 magnesium alloys in various states has been investigated by immersion test and hydrogen evolution measurements in 3.5% sodium chloride *** corrosion rate is found to relay on the impurity Fe concentration in the alloys and decreases with decreasing Fe *** Fe content drops from 150 ppm to 10 ppm,the corresponding corrosion rates under as-cast and solution treatment conditions are reduced from 8.54 mm/a and 8.61 mm/a to 2.54 mm/a and 0.21 mm/a,*** corrosion pattern of the AZ61 alloys is the localized corrosion,and the galvanic couples are formed among the impurity particles,second-phase particles and the *** Fe impurity particles tend to act as main cathodic to form micro-galvanic cell with the α-Mg matrix,which is harmful for corrosion resistance of AZ61 alloy.

关键词： AZ61 magnesium alloy Impurity Fe Corrosion rate

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Recent advances in bioinspired vision systems with curved imaging structures

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Rare Metals 2024年第4期43卷 1407-1434页

作者： Ze-Ping He Xun Han Wen-Qiang Wu Zhang-sheng Xu Cao-Feng pan CAS Center for Excellence in Nanoscience Beijing Key Laboratory of Micro-Nano Energy and SensorBeijing Institute of Nanoenergy and NanosystemsChinese Academy of SciencesBeijing100083China School of Nanoscience and Technology University of Chinese Academy of SciencesBeijing100049China ZJU-Hangzhou Global Scientific and Technological Innovation Center School of Micro-Nano ElectronicsZhejiang UniversityHangzhou311200China Institute of Microscale Optoelectronics Shenzhen UniversityShenzhen518060China

Limited by the planar imaging structure,the commercial camera needs to introduce additional optical elements to compensate for the curved focal plane to match the planar image *** results in a complex and bulky *** contrast,biological eyes possess a simple and compact structure due to their curved imaging structure that can directly match with the curved focal *** by the structures and functions of biological eyes,curved vision systems not only improve the image quality,but also offer a variety of advanced ***,we review the recent advances in bioinspired vision systems with curved imaging ***,we focus on their applications in implementing different functions of biological eyes,as well as the emerging curved neuromorphic imaging systems that incorporate bioinspired optical and neuromorphic processing *** addition,the challenges and opportunities of bioinspired curved imaging systems are also discussed.

关键词： Bioinspired Curved vision system Compound eye Chambered eye Neuromorphic

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Phosphine/Benzocyclone-based Neutral Nickel Catalysts for Ethylene Polymerization and Copolymerization with Polar Monomers

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Chinese Journal of Polymer Science 2024年第2期42卷 202-212,I0007页

作者： Fei Wang Li pan Vladislav A.Tuskaev Svetlana Ch.Gagieva Yue-sheng Li Tianjin Key Lab of Composite&Functional Materials School of Material Science and EngineeringTianjin UniversityTianjin300072China Department of Chemistry Lomonosov Moscow State UniversityRussian Federation InstitutionLeninskie Gory 1Moscow119991Russian Federation A N Nesmeyanov Institute of Organoelement Compounds Russian Academy of SciencesVavilova st.28Moscow119991Russian Federation

The efficient copolymerization of olefin with polar monomers using nickel-based catalysts presents a longstanding challenge. In this contribution, three phosphine-benzocyclone ligands and corresponding neutral nickel catalysts(Ni1: Ar = Ph;Ni2: Ar = 2-(C_(6)H_(5))C_(6)H_(4);Ni3: Ar = 2-[2',6'-(Me O)_(2)-C_(6)H3]C_(6)H_(4)) were prepared and applied for the ethylene polymerization and copolymerization with polar monomers without any cocatalyst. The bulky substituent groups in complexes Ni2 and Ni3 contributed to high catalytic activities(up to 7.24×10^(6) and 9.04×10^(6)g·mol Ni^(-1)·h^(-1), respectively), and produced high-molecular-weight polyethylene(Mw up to 545.7 k Da). Complex Ni3 exhibited high activities for ethylene polymerization at the level of 10^(6) g·mol Ni^(-1)·h^(-1) across a wide range from 30 ℃ to 120 ℃, exhibiting excellent high temperature tolerance. These nickel complexes were also effectively employed in the copolymerization of ethylene with methyl acrylate, ethyl acrylate, butyl acrylate and lauryl acrylate, producing copolymers with high molecular weights(Mw up to 80.5 k Da) and high polar monomer incorporation(up to 8.2 mol%). Microstructure analyses revealed that the introduction of large sterically hindered substituents facilitated the incorporation of polar functional units into the polymer backbone. This study demonstrates the potential of these nickel-based catalysts for efficient copolymerization of olefin with polar monomers.

关键词： Neutral nickel catalyst Ethylene polymerization Copolymerization Polar acrylate monomers

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Immunotherapy in combination with chemotherapy for Peutz-Jeghers syndrome with advanced cervical cancer:A case report

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World Journal of Gastrointestinal Surgery 2023年第3期15卷 480-487页

作者： Xiang-Cheng Hu Chen-Xiao Gan Hui-Min Zheng Xue-Ping Wu Wen-sheng pan Department of Gastroenterology Bengbu Medical CollegeBengbu 233000Anhui ProvinceChina Department of Gastroenterology Zhejiang Provincial People’s hospitalHangzhou 310014Zhejiang ProvinceChina

BACKGROUND Peutz-Jeghers syndrome(PJS)is a rare autosomal dominant disorder,and female patients may develop gynecologic *** prognosis for such patients is poor and the specific pathogenesis remains ***,there are currently no uniform treatment *** SUMMARY Herein,we introduce the case of a 45-year-old female who was diagnosed with PJS for 45 years and cervical cancer for 3 *** pathological examination showed metastases in the right external iliac lymph *** patient was initially treated with a combination of doxorubicin and carboplatin chemotherapy and pelvic magnetic resonance showed that the metastases had ***,we performed whole exome sequencing in this patient and identified the relevant causative *** addition to the chemotherapy regimen,sindilizumab was administered and the patient was followed *** 4 cycles of treatment,the metastases were substantially reduced and were not enlarged after six months of *** case report suggests that patients with PJS combined with cervical cancer may have a sustained response to immunecombination chemotherapy *** Clinicians should be aware of the importance of immunotherapy in patients with PJS combined with advanced cervical cancer.

关键词： Peutz-Jeghers syndrome Cervical cancer Programmed cell death protein 1 Chemotherapy Case report

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A feasibility study of using biodegradable magnesium alloy in glaucoma drainage device

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International Journal of Ophthalmology(English edition) 2018年第1期11卷 135-142页

作者： Xiang-Ji Li Lin Xie Fu-sheng pan Yong Wang Hong Liu Yu-Rong Tang Cindy-ML Hutnik Department of Ophthalmology University of Western Ontario Ivey Eye Institute St.Joseph's Hospital Department of Ophthalmology Institute of Surgery ResearchDaping Hospital Third Military Medical University Collage of Material Science & Engineering ChongqingUniversity National Engineering Research Center for Magnesium Alloys Chongqing University Department of Ophthalmology People's Hospital Zhongshan Branch

Technological advances in glaucoma have challenged the traditional treatment paradigm. Historically incisional surgery has been used in cases of advanced disease and/or uncontrolled intraocular pressures resistant to medical or laser interventions. More recently, perhaps due to advancements in imaging, surgery has been suggested to be beneficial earlier in the treatment paradigm. Despite these trends, surgical manipulation of the tissues and unpredictability of wound healing continue to result in surgical failure. Magnesium is an essential element for human body and plays a critically important role in maintaining the functional and structural integrity of several tissues, including the eye. Due to several of its advantageous properties such as non-toxicity, biodegradability, and high biological compatibility, magnesium alloy has attracted great attention as a novel biomaterial. Biodegradable cardiovascular stents made of magnesium alloy have already been introduced into clinical practice. The purpose of this review is to determine if bioabsorbable magnesium alloys can be utilized as a promising candidate for the development of a new generation of glaucoma surgical assistive devices.

关键词： glaucoma glaucoma drainage implant magnesium alloy anti-scarring

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专业心理求助态度在家庭教养方式与中学生非自杀性自伤间的中介作用

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现代预防医学 2024年第18期51卷 3398-3403页

作者：王群罗鹏张江萍陈思银徐孟群彭晓唯潘胜国李秀玲汪俊华贵州医科大学公共卫生与健康学院环境污染与疾病监控教育部重点实验室贵阳市云岩区卫生健康局贵阳市云岩区疾病预防控制中心

目的探究专业心理求助态度在家庭教养方式与中学生非自杀性自伤(NSSI)间的中介作用。方法采用多阶段分层整群抽样方法，于2023年10—12月选取贵州省贵阳市2个区的12所中学的4 393名中学生为研究对象，采用自编一般情况调查表、中文版... 详细信息

目的探究专业心理求助态度在家庭教养方式与中学生非自杀性自伤(NSSI)间的中介作用。方法采用多阶段分层整群抽样方法，于2023年10—12月选取贵州省贵阳市2个区的12所中学的4 393名中学生为研究对象，采用自编一般情况调查表、中文版简式父母教养方式问卷、专业心理支持求助态度简版量表、中国青少年NSSI评定问卷对中学生进行调查。使用SPSS 27.0对数据进行描述性分析、相关性分析，使用PROCESS 4.1程序进行中介效应分析，Bootstrap法进行验证。结果中学生NSSI检出率为34.9%。积极家庭教养方式与专业心理求助态度呈正相关、与NSSI呈负相关(r=0.308,-0.191,P<0.001);消极家庭教养方式与专业心理求助态度呈负相关、与NSSI呈正相关(r=-0.213,0.310,P<0.001);专业心理求助态度与NSSI呈负相关(r=-0.190,P<0.001)。专业心理求助态度在积极家庭教养方式、消极家庭教养方式与NSSI间均发挥部分中介作用，中介效应占总效应分别为28.76%、8.87%。结论专业心理求助态度在家庭教养方式与中学生NSSI间发挥中介作用。父母应采取积极的教养方式、提高中学生专业心理求助的积极性，可预防和减少NSSI的发生。

关键词：中学生家庭教养方式专业心理求助态度 NSSI 中介作用

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Intestinal natural killer/T-cell lymphoma presenting as a pancreatic head space-occupying lesion:A case report

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World Journal of Gastrointestinal Oncology 2023年第1期15卷 195-204页

作者： Ya-Nan Wang Yi-Miao Zhu Xiao-Ju Lei Yuan Chen Wan-Mao Ni Zheng-Wei Fu Wen-sheng pan College of Biotechnology and Bioengineering Zhejiang University of TechnologyHangzhou 310032Zhejiang ProvinceChina Department of Gastroenterology Zhejiang Provincial People’s HospitalPeople’s Hospital of Hangzhou Medical CollegeHangzhou 310014Zhejiang ProvinceChina Department of Endoscopy Center Zhejiang Provincial People’s HospitalPeople’s Hospital of Hangzhou Medical CollegeHangzhou 310014Zhejiang ProvinceChina Department of Pathology Zhejiang Provincial People’s HospitalPeople’s Hospital of Hangzhou Medical CollegeHangzhou 310014Zhejiang ProvinceChina Cancer Center Key Laboratory of Tumor Molecular Diagnosis and Individualized Medicine of Zhejiang ProvinceZhejiang Provincial People’s HospitalHangzhou Medical CollegeHangzhou 310014Zhejiang ProvinceChina Molecular Diagnosis Laboratory Zhejiang Provincial People's HospitalPeople's Hospital of Hangzhou Medical CollegeHangzhou 310014Zhejiang ProvinceChina

BACKGROUND Intestinal natural killer/T-cell lymphoma(NKTCL)is a rare and aggressive non-Hodgkin’s lymphoma,and its occurrence is closely related to Epstein-Barr virus *** addition,the clinical symptoms of NKTCL are not obvious,and the specific pathogenesis is still *** NKTCL may occur in any segment of the intestinal tract,its distinct location in the periampullary region,which leads clinicians to consider mimics of a pancreatic head mass,should also be ***,there remain huge challenges in the diagnosis and treatment of intestinal *** SUMMARY In this case,we introduce a male who presented to the clinic with edema of both lower limbs,accompanied by diarrhea,and abdominal *** ultrasound(EUS)showed well-defined homogeneous hypoechoic lesions with abundant blood flow signals and compression signs in the head of the *** the guidance of EUS-fine needle biopsy(FNB)with 19 gauge or 22 gauge needles,combined with multicolor flow cytometry immunophenotyping(MFCI)helped us diagnose *** treatments,the patient was prescribed the steroid(dexamethasone),methotrexate,ifosfamide,L-asparaginase,and etoposide chemotherapy ***,he died of leukopenia and severe septic shock in a local *** Clinicians should enhance their understanding of *** key factors,including EUS characteristics,the right choice of FNB needle,and combination with MFCI,are crucial for improving the diagnostic rate and reducing the misdiagnosis rate.

关键词： Intestinal natural killer/T-cell lymphoma Endoscopic ultrasound-guided fine-needle biopsy Multicolor flow cytometry immunophenotyping Diagnosis Case report

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Strengthening Mechanism and Microstructure of Deformable Ti Particles Reinforced AZ91 Composite

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Acta Metallurgica Sinica(English Letters) 2022年第12期35卷 1935-1945页

作者： Biao Tang Jian-Bo Li Jun-Liu Ye Huan Luo Yi-Tao Wang Bo Guan Yang-Fan Lu Xian-Hua Chen Kai-Hong Zheng Fu-sheng pan School of Materials Science and Engineering Chongqing UniversityChongqing 400044China International Joint Laboratory for Light Alloys(MOE) School of Materials Science and EngineeringChongqing UniversityChongqing 400044China Institute of New Materials Guangdong Academy of SciencesGuangzhou 510650China

In this study,the deformable titanium(Ti)particles reinforced AZ91 composite was successfully prepared by powder metallurgy and subsequent *** mechanical properties and microstructural evolution of pure AZ91 and 5 Ti/AZ91 composite were *** yield strength,ultimate tensile strength,and elongation of 5 Ti/AZ91 composite are measured to be 212 MPa,323 MPa,and 10.1%,*** analysis revealed that Ti particles are elongated along the extrusion direction,forming a discontinuous strip Ti particles,fine precipitated Mg_(17)Al_(12) phase inhibits dynamic recrystallization(DRX)behavior through Zener pinning effect and hinders the growth of matrix grains,resulting in refiner grains of 5 Ti/AZ91 *** deformed Ti particles and magnesium(Mg)matrix to generate additional heterogeneous deformation-induced(HDI)*** deformation-induced strengthening mainly contributed to the increment of yield strength for 5 Ti/AZ91 composite.

关键词： Magnesium matrix composites Tiparticles Recrystallization Mechanical properties Heterogeneous deformation

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某输油管道杂散电流干扰检测及排流防护相关研究

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全面腐蚀控制 2024年第3期38卷 73-77页

作者：代爱印潘省江汪运宏闫然孙贺於涛中国化学工程第十三建设有限公司河北沧州061000 内蒙古科技大学内蒙古包头014017 青岛融合桥头堡开发有限公司山东青岛266041 青岛昆泉建设工程有限公司山东青岛266041 青岛海诚油气技术有限公司山东青岛266041

输油管道与地铁运行线路交叉、平行,管道电位出现漂移,断电电位正向偏移,受杂散电流干扰的管道会出现部分时段处于欠保护状态。干扰段管道采取排流防护措施后,通过监测管道电位发现,管道电位波动范围缩小、断电电位负向偏移。管道杂散... 详细信息

输油管道与地铁运行线路交叉、平行,管道电位出现漂移,断电电位正向偏移,受杂散电流干扰的管道会出现部分时段处于欠保护状态。干扰段管道采取排流防护措施后,通过监测管道电位发现,管道电位波动范围缩小、断电电位负向偏移。管道杂散电流干扰得到有效的消除和抑制,管道全时段处于阴极保护状态下运行。

关键词：电位波动监测杂散电流

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