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Assessing myocardial indices and inflammatory factors to determine anxiety and depression severity in patients with chronic heart failure

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World Journal of Psychiatry 2024年第1期14卷 53-62页

作者： Li Zhang Qiang Wang Hong-sheng cui Yuan-Yuan Luo Department of Cardiology Jingzhou HospitalYangtze UniversityJingzhou 434020Hubei ProvinceChina Department of Intensive Care Unit The First Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510000Guangdong ProvinceChina

BACKGROUND Patients with chronic heart failure(CHF)have a progressive disease that is associated with poor quality of life and high *** patients experience anxiety and depression(A&D)symptoms,which can further accelerate disease *** hypothesized that indicators of myocardial function and inflammatory stress may reflect the severity of A&D symptoms in patients with *** in these biomarkers could potentially predict whether A&D symptoms will deteriorate further in these *** To measure changes in cardiac and inflammatory markers in patients with CHF to determine A&D severity and predict *** We retrospectively analyzed 233 patients with CHF treated at the Jingzhou Hospital,Yangtze University between 2018-2022 and grouped them according to Self-Rating Anxiety Scale(SAS)and Self-Rating Depression Scale(SDS)*** compared clinical data in the no-A&D,mild-A&D,moderate-A&D,and severe-A&D groups,the SAS and SDS scores with the New York Heart Association(NYHA)functional classification,and cardiac markers and inflammatory factors between the no/mild-A&D and moderate/severe-A&D *** analysis was performed on the markers with P0.05).In addition,we found that higher NYHA classes were associated with higher the SAS and SDS scores(P<0.05).Regression analysis showed that LVEF,NTproBNP,and IL-6 were independent risk factors for A&D severity(P<0.05).Among them,NT-pr

关键词： Chronic heart failure Anxiety Depression Cardiac markers Inflammatory factors Prediction

A novel Ce_(0.485)Zr_(0.485)Y_(0.03)O_(2) composite oxide with surface doping of Y and its application in Pd-only three-way catalyst

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Rare Metals 2024年第2期43卷 749-757页

作者： Zheng Zhao Wei-Xin Zhao Yong-Qi Zhang Mei-sheng cui Yong-Ke Hou Dong-Ming Chen Juan-Yu Yang Zong-Yu Feng Xiao-Wei Huang National Engineering Research Center for Rare Earth Grirem Advanced Materials Co.Ltd.GRINM Group Corporation LimitedBeijing100088China Griem Hi-Tech Co.Ltd. Langfang065000China Rare Earth Functional Materials(Xiong’an)Innovation Venter Co.Ltd. Baoding071700China

The ceria-zirconia compound oxide-supported noble metal Pd(Pd@CZ)is widely used in three-way ***,the surface structure of CZ plays an important role in catalytic activity of ***,how to regulate the surface structure of CZ and clarify the structure–activity relationship is still a *** this paper,a strategy is proposed to develop high activity Pd@CZ nanocatalysts by tuning Y doping sites in *** precipitate-deposition method is developed to prepare the novel Ce_(0.485)Zr_(0.485)Y_(0.03)O_(2) composite with surface doping of Y(CZ-Y-S).In addition,the Pd@CZ-Y-S(Pd supported on CZ-Y-S)exhibits superior catalytic activity for HC,CO,and NO oxide,wherein,for CO and C_(3)H_(6) oxidation,the low-temperature activity of Pd@CZ-Y-S is still 20%higher than that of Pd@CZ-Y-B(Y bulk doping)and commercial Pd@CZ after 1000℃/4 h *** effect mechanism is further studied by density functional theory(DFT)*** with Pd@CZ-Y-B,Pd@CZ-Y-S shows the lower CO oxide reaction energy barriers due to the weaker adsorption strength of *** Y surface doping strategy could provide valuable insights for the development of highly efficient Pd@CZ catalyst with extensive applications.

关键词： Rare earth Ceria-zirconia-supported Pd Surface doping Experiment and theory Catalytic application

SARS-CoV-2 ORF10 hijacking ubiquitination machinery reveals potential unique drug targeting sites

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Acta Pharmaceutica Sinica B 2024年第9期14卷 4164-4173页

作者： Kaixiang Zhu Lili Song Linyue Wang Lei Hua Ziyu Luo Tongyun Wang Bo Qin Shuofeng Yuan Xiaopan Gao Wenyi Mi sheng cui NHC Key Laboratory of Systems Biology of Pathogens National Institute of Pathogen BiologyChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Key Laboratory of Pathogen Infection Prevention and Control(Peking Union Medical College) Ministry of EducationBeijing 100730China The Province and Ministry Co-Sponsored Collaborative Innovation Center for Medical Epigenetics Key Laboratory of Immune Microenvironment and Disease(Ministry of Education)Tianjin Medical University General HospitalDepartment of ImmunologyTianjin Medical UniversityTianjin 300070China Medical School Yan’an UniversityShaanxi ProvinceYan’an 716000China State Key Laboratory of Emerging Infectious Diseases Li Ka Shing Faculty of Medicinethe University of Hong KongPokfulamHong Kong SARChina Department of Microbiology Li Ka ShingFaculty of Medicinethe University of Hong KongPokfulamHong Kong SARChina

Viruses often manipulate ubiquitination pathways to facilitate their replication and ***2ZYG11B known as the substrate receptor of cullin-2 RING E3 ligase,is bound by SARS-CoV-2 ORF10 to increase its E3 ligase activity,leading to degradation of IFT46,a protein component of the intraflagellar transport(IFT)complex *** results in dysfunctional cilia,which explains certain symptoms that are specific to ***,the precise molecular mechanism of how ORF10 recognizes CUL2ZYG11B remains ***,we determined the crystal structure of CUL2ZYG11B complexed with the N-terminal extension(NTE)of SARS-CoV-2 ORF10(2.9 A°).The structure reveals that the ORF10 N-terminal heptapeptide(NTH)mimics the Gly/N-degron to bind *** studies identified key residues within ORF10 that are key players in its interaction with CUL2ZYG11B both in ITC assay and in vivo *** addition,we prove that enhancement of CUL2ZYG11B activity for IFT46 degradation by which ORF10-mediated correlates with the binding affinity between ORF10 and ***,we used a Global Protein Stability system to show that the NTH of ORF10 mimics the Gly/N-degron motif,thereby binding competitively to CUL2ZYG11B and inhibiting the degradation of target substrates bearing the Gly/N-degron ***,this study sheds light on how SARS-CoV-2 ORF10 exploits the ubiquitination machinery for proteasomal degradation,and offers valuable insights for optimizing PROTAC-based drug design based on NTH CUL2ZYG11B interaction,while pinpointing a promising target for the development of treatments for COVID-19.

关键词： SARS-CoV-2 ORF10 Crystal structure cullin-2 RING E3 ligase Drug design

B meson rare decays in the TNMSSM

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Chinese Physics C 2024年第5期48卷 72-91页

作者：陈海翔高生恺朱宁宇张兆阳胡怀聪 School of Physical Science and Technology Guangxi UniversityNanning 530004China

We investigate the two loop electroweak corrections to B meson rare decays B¯→Xsγand B0s→μ+μ−in the minimal supersymmetry standard model(MSSM)extension with two triplets and one singlet(TNMSSM).The new particle contents and interactions in the TNMSSM can affect the theoretical predictions of the branching ratios Br(B¯→Xsγ)and Br(B0s→μ+μ−),and the corrections from two loop diagrams to the process B¯→Xsγcan reach around 4%.Considering the latest experimental measurements,the numerical results of Br(B¯→Xsγ)and Br(B0s→μ+μ−)in the TNMSSM are presented and *** findings indicate that the results in the TNMSSM can fit the updated experimental data well,and the new parameters Tλ,κ,λ,clearly affect the theoretical predictions of Br(B¯→Xsγ)and Br(B0s→μ+μ−).

关键词： supersymmetry B physics rare decays

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玄武岩纤维棒聚合物混凝土的弯曲韧性

建筑材料学报 2024年第2期27卷 99-105页

作者：崔圣爱徐李麟饶家锐曹卓颖西南交通大学土木工程学院四川成都610031

研究了玄武岩纤维棒(BFB)的纤维增强指数I_(R)对玄武岩纤维棒聚合物混凝土(BFB-PC)韧性指标T_((2(n-1)))(n)的影响,通过分形理论探究了T_((2(n-1)))(n)与裂缝形貌的关系,并建立了弯曲韧性计算模型.结果表明:当IR=90.0时,BFB对BFB-PC的... 详细信息

研究了玄武岩纤维棒(BFB)的纤维增强指数I_(R)对玄武岩纤维棒聚合物混凝土(BFB-PC)韧性指标T_((2(n-1)))(n)的影响,通过分形理论探究了T_((2(n-1)))(n)与裂缝形貌的关系,并建立了弯曲韧性计算模型.结果表明:当IR=90.0时,BFB对BFB-PC的增韧效果最优,此时BFB-PC的弯曲韧性比未掺BFB时提升了8.39倍;BFB的增韧阈值为IR=37.5和IR=90.0;当IR相同时,与未掺聚合物的混凝土相比,聚灰比为0.06的BFB-PC T_((2(n-1)))(n)更高;IR越大裂缝形貌越复杂,T(2(n-1))(n)与裂缝分形维数呈二次函数关系;本文提出的弯曲韧性计算模型准确描述了BFB对PC梁的增韧作用,其试验值与理论值的相对误差小于15.00%.

关键词：聚合物混凝土玄武岩纤维棒纤维增强指数韧性指标分形维数

隧道衬砌背后小尺寸空洞用聚氨酯注浆材料探究

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建筑材料学报 2024年第7期27卷 645-652页

作者：曹卓颖侯勇杜鹏雷杨崔圣爱西南交通大学土木工程学院四川成都610031 四川川交路桥有限责任公司四川广汉618300

为探索适用于隧道衬砌背后小尺寸空洞的高性能注浆材料,制备了11组聚氨酯注浆材料,研究了其力学性能,提出了改进本构方程,并采用灰色关联进行综合评价.结果表明:1.16%~1.94%催化剂、3.80%~5.60%扩链剂可有效提高聚氨酯的力学性能;高相... 详细信息

为探索适用于隧道衬砌背后小尺寸空洞的高性能注浆材料,制备了11组聚氨酯注浆材料,研究了其力学性能,提出了改进本构方程,并采用灰色关联进行综合评价.结果表明:1.16%~1.94%催化剂、3.80%~5.60%扩链剂可有效提高聚氨酯的力学性能;高相对分子质量多元醇的引入降低了聚氨酯的压缩强度和拉伸强度,却显著改善了其黏结强度;基于唯象模型提出的本构模型可准确表征聚氨酯的压缩变形;基于灰色关联得到聚氨酯的最佳配合比为异氰酸酯、相对分子质量为8000的多元醇及500的多元醇质量比25∶2∶23,催化剂掺量1.16%,扩链剂掺量1.94%,此配合比下聚氨酯综合性能最佳.

关键词：隧道衬砌空洞聚氨酯注浆材料力学性能本构模型灰色关联

反向累加生成绝对灰度性质及其在灾害事件预测中的应用

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辽宁工程技术大学学报（自然科学版） 2024年第3期43卷 288-295页

作者：陈紫维赵守江刘军崔盛三峡大学理学院湖北宜昌443002 三峡大学三峡数学研究中心湖北宜昌443002

为研究反向累加生成序列绝对灰度的变化规律,基于原始序列与其一次反向累加生成序列的级比关系,推导了整数阶反向累加生成序列绝对灰度的一般表达式及其相关性质。结合实际问题背景,讨论了融合绝对灰度的反向累加灰色模型在突发灾害事... 详细信息

为研究反向累加生成序列绝对灰度的变化规律,基于原始序列与其一次反向累加生成序列的级比关系,推导了整数阶反向累加生成序列绝对灰度的一般表达式及其相关性质。结合实际问题背景,讨论了融合绝对灰度的反向累加灰色模型在突发灾害事件预测中的应用效果。研究结果表明:当原始序列的绝对灰度大于0.6时,进行反向累加生成变换能够有效降低序列的绝对灰度,当原始序列的绝对灰度小于0.25时,对序列进行反向累加生成变换会增大序列的绝对灰度。研究结论为灰建模的模型选择及序列预处理方式的选择提供参考。

关键词：反向累加生成绝对灰度灰色模型新信息优先突发灾害事件预测

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一株野生桑黄菌的分离鉴定及活性成分分析

北方园艺 2024年第12期 108-114页

作者：王华朱荣才崔胜潘茂华崔自学张芊河南省蚕业科学研究院河南郑州454000

以采自河南省南阳市西峡县的野生桑黄为试材,采用形态学鉴定、系统发育分析及单因素试验法,研究了该菌的分类地位和生物学特性。同时,对比了桑树桑黄、杨树桑黄及粗毛纤孔菌3种子实体中多糖、黄酮、多酚及皂苷4种活性成分含量,以期丰富... 详细信息

以采自河南省南阳市西峡县的野生桑黄为试材,采用形态学鉴定、系统发育分析及单因素试验法,研究了该菌的分类地位和生物学特性。同时,对比了桑树桑黄、杨树桑黄及粗毛纤孔菌3种子实体中多糖、黄酮、多酚及皂苷4种活性成分含量,以期丰富桑树桑黄种质资源。结果表明:该菌为桑黄孔菌属的桑树桑黄(Sanghuangporus sanghuang)。在纯培养条件下,该菌的最适温度为26~28℃,最适生长pH为6,最适碳源为麦芽糖和葡萄糖,最适氮源为酵母浸粉和胰蛋白胨。桑树桑黄、杨树桑黄及粗毛纤孔菌3种桑黄的活性成分含量差异显著,其中,桑树桑黄中黄酮和总酚含量最高,粗毛纤孔菌中多糖和皂苷含量最高。综上所述,采自河南省的野生桑黄为桑树桑黄,且该菌在桑黄类真菌中具备较高的药用价值。

关键词：桑树桑黄分子鉴定活性成分

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基于拉曼光谱鉴定书写/打印文件的朱墨时序

光谱学与光谱分析 2024年第9期44卷 2501-2505页

作者：万敬伟陈蕾柴威孔维刚崔胜峰郑州警察学院刑事科学技术系河南郑州450053 河南医学高等专科学校药学系河南郑州451191 中国刑事警察学院辽宁沈阳110854 郑州市公安局物证鉴定中心河南郑州450016

朱墨时序鉴定是司法鉴定文件检验研究与实践领域中的热点和难点问题。朱墨时序的鉴定可证明文件真伪,推断文件物证是否与案件事实相符,从而为司法机关的侦查破案和案件判定提供法律依据。常见的检验方法有显微镜法、荧光法、文检仪法、... 详细信息

朱墨时序鉴定是司法鉴定文件检验研究与实践领域中的热点和难点问题。朱墨时序的鉴定可证明文件真伪,推断文件物证是否与案件事实相符,从而为司法机关的侦查破案和案件判定提供法律依据。常见的检验方法有显微镜法、荧光法、文检仪法、计算机软件辅助法等,其鉴定结论易受检验人员主观意识的影响,因不够客观而备受质疑。研究在制备3类签字笔和9种印油组合54个书写样本、激光打印和9种印油组合18个打印样本的基础上,运用共焦显微拉曼光谱仪对其进行检验。以10#百乐签字笔和1#印之秀印油为样本测试得到最佳实验条件,将制备的72个样本放入储存箱内避光保存1年,依次测定样本中先字后印、先印后字、印油和字迹4个位点的拉曼光谱,每个样本测试3次。实验结果基本不受储存环境、纸张本底等因素的干扰,无论是书写样本还是打印样本,先字后印交叉点显示出了印油的部分特征,先印后字交叉点显示出了字迹的部分特征,交叉位点的拉曼光谱图显示大部分为上层相应的字迹或印油的拉曼位移,这与20倍物镜观察的μView图显示结果相互印证。通过比对印文交叉部位的拉曼位移,进而鉴定出样本的朱墨时序。结果表明:相比常规检验方法,此新颖方法简便快捷、无损、灵敏度和准确率高,对文件的朱墨时序鉴定具有指导意义。

关键词：拉曼光谱朱墨时序书写/打印文件无损检验