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Curve Classification Based onMean-Variance Feature Weighting and Its Application

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Computers, Materials & Continua 2024年第5期79卷 2465-2480页

作者： Zewen Zhang sheng zhou Chunzheng Cao School of Mathematics and Statistics Nanjing University of Information Science and TechnologyNanjing210044China Center for Applied Mathematics of Jiangsu Province Nanjing University of Information Science and TechnologyNanjing210044China

The classification of functional data has drawn much attention in recent *** main challenge is representing infinite-dimensional functional data by finite-dimensional features while utilizing those features to achieve better classification *** this paper,we propose a mean-variance-based(MV)feature weighting method for classifying functional data or functional *** the feature extraction stage,each sample curve is approximated by B-splines to transfer features to the coefficients of the spline *** that,a feature weighting approach based on statistical principles is introduced by comprehensively considering the between-class differences and within-class variations of the *** also introduce a scaling parameter to adjust the gap between the weights of *** new feature weighting approach can adaptively enhance noteworthy local features while mitigating the impact of confusing *** algorithms for feature weighted K-nearest neighbor and support vector machine classifiers are both ***,the new approach can be well integrated into existing functional data classifiers,such as the generalized functional linear model and functional linear discriminant analysis,resulting in a more accurate *** performance of the mean-variance-based classifiers is evaluated by simulation studies and real *** results show that the newfeatureweighting approach significantly improves the classification accuracy for complex functional data.

关键词： Functional data analysis classification feature weighting B-splines

Biopsy forceps are useful for measuring esophageal varices in vitro

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World Journal of Gastrointestinal Surgery 2024年第2期16卷 539-545页

作者： Zhi-Hui Duan sheng-Yun zhou Endoscopy Center Xingtai People’s HospitalXingtai 054000Hebei ProvinceChina

BACKGROUND To avoid acute variceal bleeding in cirrhosis,current guidelines recommend screening for high-risk esophageal varices(EVs)by determining variceal size and identifying red wale ***,visual measurements of EV during routine endoscopy are often *** To determine whether biopsy forceps(BF)could be used as a reference to improve the accuracy of binary classification of variceal *** An in vitro self-made EV model with sizes ranging from 2 to 12 mm in diameter was *** online image-based survey comprising 11 endoscopic images of simulated EV without BF and 11 endoscopic images of EV with BF was assembled and sent to 84 *** endoscopists were blinded to the actual EV size and evaluated the 22 images in random *** The respondents included 48 academic and four private *** accuracy of EV size estimation was low in both the visual(13.81%)and BF-based(20.28%)*** use of open forceps improved the ability of the endoscopists to correctly classify the varices by size(small≤5 mm,large>5 mm)from 71.85%to 82.17%(P<0.001).CONCLUSION BF may improve the accuracy of EV size assessment,and its use in clinical practice should be investigated.

关键词： Accuracy Liver cirrhosis Esophageal varices Endoscopy Measurement

Microstructure,wear and friction behavior of CoCrAITaY-xCNTs composite coatings deposited by laser-induction hybrid cladding

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Rare Metals 2024年第4期43卷 1815-1827页

作者： sheng-Feng zhou Yu Long Yan-Liang Yi Cheng Deng Lian-Xi Hu Institute of Advanced Wear&Corrosion Resistant and Functional Materials Jinan UniversityGuangzhou510632China Wuhan National Laboratory for Optoelectronics(WNLO) Huazhong University of Science and TechnologyWuhan430074China MOE Key Laboratory of New Processing Technology for Non-Ferrous Metals and Materials Guangxi Key Laboratory of Processing for Non-Ferrous Metals and Featured MaterialsGuangxi UniversityNanning530004China School of Mechatronics Engineering Guangdong Polytechnic Normal UniversityGuangzhou510635China School of Materials Science and Engineering Harbin Institute of TechnologyHarbin150001China

To improve the wear performance of CoCrAlYTa coating,part of the carbon nanotubes(CNTs)chemically reacted with Ta to form reinforcement phase(TaC),while the other CNTs were retained as lubrication ***,the CoCrAlYTa-xCNTs(x=0,1,2,and 4;wt%)composite coatings were prepared by laserinduction hybrid cladding(LIHC),and the microstructure and wear resistance of coatings were systematically *** show that the coatings are mainly composed of TaC,y-(Co,Cr)andβ-(Co,Cr)*** the CNTs content increases from 0 wt%to 4 wt%,the volume fraction of TaC increases from 13.11 vol%to 16.12 vol%.Meanwhile,the nano-hardness ofγ-(Co,Cr)andβ-(Co,Cr)Al are improved from 7.49 and 9.72 to 9.36 and 11.19 GPa,*** a result,the microhardness of coating increases from HV536.25 to HV 738.16,the wear rate decreases from32.4×10^(-3)to 6.1×10^(-3)mg·m^(-1),and the average friction coefficient decreases from 0.55 to *** good wear performance of the coating is attributed to the formation of TaC and the existence of remained CNTs lubricant film.

关键词： Carbon nanotube MCrAlY coating Friction and wear performance Laser-induction hybrid cladding

Better use of experience from other reservoirs for accurate production forecasting by learn-to-learn method

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Petroleum Science 2024年第1期21卷 716-728页

作者： Hao-Chen Wang Kai Zhang Nancy Chen Wen-sheng zhou Chen Liu Ji-Fu Wang Li-Ming Zhang Zhi-Gang Yu Shi-Ti Cui Mei-Chun Yang China University of Petroleum(East China) 66 Changjiang West RoadQingdao West Coast New AreaQingdao266580ShandongChina University of Calgary 2500 University Dr NWCalgaryT2N 1N4AlbertaCanada Qingdao University of Technology Qingdao266071ShandongChina State Key Laboratory of Offshore Oil Exploitation Beijing100028China CNOOC Research Institute Ltd. Beijing100028China CNPC Tarim Oilfield Branch Company Korla841000XinjiangChina National Engineering Laboratory for Exploration and Development of Low-Permeability Oil and Gas Fields Xi'an710000ShaanxiChina Sinopec Matrix Co. LTDQingdao266000ShandongChina

To assess whether a development strategy will be profitable enough,production forecasting is a crucial and difficult step in the *** development history of other reservoirs in the same class tends to be studied to make predictions ***,the permeability field,well patterns,and development regime must all be similar for two reservoirs to be considered in the same *** results in very few available experiences from other reservoirs even though there is a lot of historical information on numerous reservoirs because it is difficult to find such similar *** paper proposes a learn-to-learn method,which can better utilize a vast amount of historical data from various ***,the proposed method first learns how to learn samples before directly learning rules in ***,by utilizing gradients from networks with independent parameters and copied structure in each class of reservoirs,the proposed network obtains the optimal shared initial parameters which are regarded as transferable information across different *** on that,the network is able to predict future production indices for the target reservoir by only training with very limited samples collected from reservoirs in the same *** cases further demonstrate its superiority in accuracy to other widely-used network methods.

关键词： Production forecasting Multiple patterns Few-shot learning Transfer learning

Evaluation of retinal and choroidal thickness changes in overweight and obese adults without ocular symptoms by swept-source optical coherence tomography

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International Journal of Ophthalmology(English edition) 2024年第4期17卷 707-712页

作者： Qing-Jian Li sheng-Mei zhou Ling-Yu Zhang An-Ni Lin Yang Zhang Jing Jiang Xin Che Yi-Wen Qian Yan Liu Zhi-Liang Wang Department of Ophthalmology Huashan HospitalFudan UniversityShanghai 200040China Eye Institute of Xiamen University Xiamen University School of MedicineXiamen 361005Fujian ProvinceChina Department of Gastroenterology Huashan HospitalFudan UniversityShanghai 200040China

AIM:To evaluate the relationship of overweight and obesity with retinal and choroidal thickness in adults without ocular symptoms by swept-source optical coherence tomography(SS-OCT).METHODS:According to the body mass index(BMI)results,the adults enrolled in the cross-sectional study were divided into the normal group(18.50≤BMI<25.00 kg/m^(2)),the overweight group(25.00≤BMI<30.00 kg/m^(2)),and the obesity group(BMI≥30.00 kg/m^(2)).The one-way ANOVA and the Chi-square test were used for ***’s correlation analysis was used to evaluate the relationships between the measured ***:This research covered the left eyes of 3 groups of 434 age-and sex-matched subjects each:normal,overweight,and *** mean BMI was 22.20±1.67,26.82±1.38,and 32.21±2.35 kg/m^(2) in normal,overweight and obesity groups,*** choroid was significantly thinner in both the overweight and obesity groups compared to the normal group(P<0.05 for all),while the retinal thickness of the three groups did not differ ***’s correlation analysis showed that BMI was significantly negatively correlated with choroidal thickness,but no significant correlation was observed between BMI and retinal ***:Choroidal thickness is decreased in people with overweight or *** on changes in choroidal thickness contributes to the understanding of the mechanisms of certain ocular disorders in overweight and obese adults.

关键词： overweight obesity body mass index choroidal thickness retinal thickness swept-source optical coherence tomography

Rapid development of double-hit mRNA antibody cocktail against orthopoxviruses

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1768-1776页

作者： Hang Chi Suo-Qun Zhao Ru-Yi Chen Xing-Xing Suo Rong-Rong Zhang Wen-Hui Yang Dong-sheng zhou Min Fang Bo Ying Yong-Qiang Deng Cheng-Feng Qin State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyAMMS100071BeijingChina College of Life Sciences Inner Mongolia Agricultural UniversityHohhot010018Inner MongoliaChina School of Life Sciences Henan UniversityKaifeng475004HenanChina Suzhou Abogen Biosciences Co. LtdSuzhou215123JiangsuChina Research Unit of Discovery and Tracing of Natural Focus Diseases Chinese Academy of Medical Sciences100071BeijingChina

The Orthopoxvirus genus,especially variola virus(VARV),monkeypox virus(MPXV),remains a significant public health threat *** development of therapeutic antibodies against orthopoxviruses is largely hampered by the high cost of antibody engineering and manufacturing ***-encoded antibodies have emerged as a powerful and universal platform for rapid antibody ***,by using the established lipid nanoparticle(LNP)-encapsulated mRNA platform,we constructed four mRNA combinations that encode monoclonal antibodies with broad neutralization activities against *** vivo characterization demonstrated that a single intravenous injection of each LNP-encapsulated mRNA antibody in mice resulted in the rapid production of neutralizing *** importantly,mRNA antibody treatments showed significant protection from weight loss and mortality in the vaccinia virus(VACV)lethal challenge mouse model,and a unique mRNA antibody cocktail,Mix2a,exhibited superior in vivo protection by targeting both intracellular mature virus(IMV)-form and extracellular enveloped virus(EEV)-form *** summary,our results demonstrate the proof-of-concept production of orthopoxvirus antibodies via the LNP-mRNA platform,highlighting the great potential of tailored mRNA antibody combinations as a universal strategy to combat orthopoxvirus as well as otheremerging viruses.

关键词： proof universal neutral

可靠性标准YY/T1837—2022在有源植入式医疗器械研制中的应用探讨

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中国医疗器械杂志 2024年第2期48卷 221-227页

作者：盛宙微创投资控股有限公司上海市201203

在医疗器械领域,长期缺乏高风险有源植入式医疗器械研制中可应用的可靠性通用技术要求框架,该研究结合YY/T 1837—2022的要求,全面阐释探讨了有源植入式医疗器械产品在研制各阶段可进行的可靠性工作的要求,为行业内产品可靠性工作提供... 详细信息

在医疗器械领域,长期缺乏高风险有源植入式医疗器械研制中可应用的可靠性通用技术要求框架,该研究结合YY/T 1837—2022的要求,全面阐释探讨了有源植入式医疗器械产品在研制各阶段可进行的可靠性工作的要求,为行业内产品可靠性工作提供参考。

关键词：有源植入式医疗器械可靠性标准应用

Cinobufotalin prevents bone loss induced by ovariectomy in mice through the BMPs/SMAD and Wnt/β-catenin signaling pathways

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Animal Models and Experimental Medicine 2024年第3期7卷 208-221页

作者： Da-zhuang Lu Li-jun Zeng Yang Li Ran-li Gu Meng-long Hu Ping Zhang Peng Yu Xiao Zhang Zheng-wei Xie Hao Liu Yong-sheng zhou Department of Prosthodontics Peking University School and Hospital of StomatologyBeijingChina National Center of Stomatology BeijingChina National Clinical Research Center for Oral Diseases BeijingChina Beijing Key Laboratory of Digital Stomatology BeijingChina Department of Cariology and Endodontology Peking University School and Hospital of StomatologyBeijingChina Peking University International Cancer Institute Peking University Health Science CenterPeking UniversityBeijingChina Central Laboratory Peking University School and Hospital of StomatologyBeijingChina National Engineering Research Center of Oral Biomaterials and Digital Medical Devices BeijingChina

Background:Osteoporosis is a chronic bone disease characterized by bone loss and decreased bone ***,current anti-resorptive drugs carry a risk of various *** deep learning-based efficacy prediction system(DLEPS)is a forecasting tool that can effectively compete in drug screening and prediction based on gene expression *** study aimed to explore the protective effect and potential mechanisms of cinobufotalin(CB),a traditional Chinese medicine(TCM),on bone ***:DLEPS was employed for screening anti-osteoporotic agents according to gene profile changes in primary ***-CT,histological and morphological analysis were applied for the bone protective detection of CB,and the osteogenic differentiation/function in human bone marrow mesenchymal stem cells(hBMMSCs)were also *** underlying mechanism was verified using qRT-PCR,Western blot(WB),immunofluorescence(IF),***:A safe concentration(0.25mg/kg in vivo,0.05μM in vitro)of CB could effectively preserve bone mass in estrogen deficiency-induced bone loss and promote osteogenic differentiation/function of *** BMPs/SMAD and Wnt/β-catenin signaling pathways participated in CB-induced osteogenic differentiation,further regulating the expression of osteogenesis-associated factors,and ultimately promoting ***:Our study demonstrated that CB could significantly reverse estrogen deficiency-induced bone loss,further promoting osteogenic differentiation/function of hBMMSCs,with BMPs/SMAD and Wnt/β-catenin signaling pathways involved.

关键词： BMPs/SMAD bone loss cinobufotalin hBMMSCs osteogenesis osteoporosis Wnt/β-catenin signaling pathways

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活性横向增强弹靶后横向效应实验与数值模拟

兵工学报 2024年第7期45卷 2270-2281页

作者：张甲浩郭萌萌周晟余庆波北京理工大学爆炸科学与技术国家重点实验室北京100081

为揭示活性横向增强弹(Penetrator with Enhanced Lateral Effect,PELE)的靶后横向增强机理,开展活性PELE冲击钢靶毁伤效应实验,在钢靶后设置效应铝靶,得到不同前置钢靶厚度条件下的穿孔毁伤情况。基于点火增长模型建立活性PELE冲击爆... 详细信息

为揭示活性横向增强弹(Penetrator with Enhanced Lateral Effect,PELE)的靶后横向增强机理,开展活性PELE冲击钢靶毁伤效应实验,在钢靶后设置效应铝靶,得到不同前置钢靶厚度条件下的穿孔毁伤情况。基于点火增长模型建立活性PELE冲击爆燃反应过程的两步仿真分析模型。综合实验和仿真对活性PELE在780 m/s速度条件下冲击6~20 mm厚度范围内钢靶的靶后横向增强效应进行讨论,从效应靶毁伤、芯体反应、波相互作用及壳体破片飞散4个方面进行深入分析。分析结果表明:仿真分析模型有效模拟了活性PELE冲击靶板的爆燃反应过程;靶板厚度对活性PELE在效应靶上的穿孔散布尺寸影响显著,随着靶板厚度的增加,活性PELE的靶后横向增强效应先增大后减小;活性芯体的爆燃反应释能使壳体最大径向速度提高了40%以上。

关键词：活性横向增强弹活性材料冲击爆燃点火增长

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