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Silk Fibroin‑Based Wearable All‑Fiber Multifunctional Sensor for Smart Clothing

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Advanced Fiber Materials 2022年第4期4卷 873-884页

作者： Dan‑Liang Wen Yu‑Xing Pang Peng Huang Yi‑Lin Wang Xin‑Ran Zhang Hai‑Tao Deng xiao‑sheng Zhang School of Electronic Science and Engineering University of Electronic Science and Technology of ChinaChengdu 611731China

Wearable sensing technology enables the interaction between the physical world and the digital world,as takes an irreplaceable role in development of the Internet of Things(IoT),and artificial intelligence(AI).However,increasing requirements posed by rapid development of wearable electronic information technology bring about many for wearable sensing technology,such as the demands for ultrahigh flexibility,air permeability,excellent biocompatibility,and multifunctional integration.Herein,we propose a wearable all-fiber multifunctional sensor(AFMS)based on a biocompatible material,i.e.,silk fibroin.A simple two-layer configuration of a silk fiber film and an interdigital Ag nanowires(AgNWs)electrode was designed to construct the AFMS,in which silk fibroin simultaneously serves as a fundamental supporting component and a functional sensing component.Electrospinning and spray coating technologies were introduced to process the silk fiber film and the AgNWs electrode.The all-fiber configuration allows AFMS to possess ultrahigh flexibility and good air permeability,and silk fibroin enables the AFMS to have excellent biocompatibility.More importantly,benefiting from the all-fiber structure and the environmentally sensitive dielectric property of silk fibroin,the AFMS presented multiple sensing characteristics,including pressure sensing,temperature sensing,and humidity sensing.Among them,the pressure sensing function reached a high sensitivity of 2.27 pF/kPa(7.5%/kPa)and a remarkable resolution of~26 Pa in the low pressure range.Additionally,the outstanding mechanical reliability and sensing stability of AFMS were proven by a systematic experiment.In addition,the AFMS was successfully applied for smart mask for breathing monitoring and a smart glove for bending angle recognition of finger joints.Multiple sensing characteristics combined with prominent fundamental features enable the AFMS tremendous potential in the smart sensing field,e.g.,smart clothing.

关键词： Wearable electronics Silk fibroin Multifunctional sensing Smart clothing

Increased risk of colorectal neoplasia in inflammatory bowel disease patients with post-inflammatory polyps:A systematic review and meta-analysis

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World Journal of Gastrointestinal Oncology 2022年第1期14卷 348-361页

作者： De-Gao He Xi-Jie Chen Juan-Ni Huang Jun-Guo Chen Min-Yi Lv Tian-Ze Huang Ping Lan xiao-sheng He Department of Colorectal Surgery The Sixth Affiliated HospitalSun Yat-sen UniversityGuangdong Institute of GastroenterologyGuangdong Provincial Key Laboratory of Colorectal and Pelvic Floor DiseasesGuangzhou 510655Guangdong ProvinceChina Department of Geriatrics the first Affiliated HospitalGuangzhou Medical UniversityGuangzhou 510120Guangdong ProvinceChina

BACKGROUND Inflammatory bowel disease(IBD)patients with post-inflammatory polyps(PIPs)may carry an increased risk of colorectal neoplasia(CRN)including dysplasia and cancer.Current guidelines recommend active colonoscopy follow-up for these patients.However,the evidence for guidelines is still poor.In addition,some recent high-quality reports present a different view,which challenges the current guidelines.We hypothesize that IBD patients with PIPs are at increased risk of CRN.AIM To evaluate the risk of CRN in IBD patients with and without PIPs.METHODS A systematic search of PubMed,Embase,Cochrane Library,and Web of Science was performed to identify studies that compared the risk of CRN in IBD patients with and without PIPs.In addition,we screened the reference lists and citation indices of the included studies.Quality assessment was performed using the Newcastle–Ottawa Scale.Pooled odds ratio(OR)was calculated using the random-effects model to explore the final pooled effect size of the included studies and determine whether PIPs increase the risk of CRN.Sensitivity analysis,subgroup analysis,and assessment of publication bias were performed to examine the sources of heterogeneity.RESULTS Twelve studies with 5819 IBD patients,including 1281(22.01%)with PIPs,were considered eligible for this meta-analysis.We found that IBD patients with PIPs were at an increased risk of CRN as compared to those without PIPs[OR 2.01;95%confidence interval(CI):1.43–2.83].The results were similar when colorectal cancer was used as the study endpoint(OR 2.57;95%CI:1.69–3.91).Furthermore,the risk of CRN was still increased(OR 1.80;95%CI:1.12–2.91)when restricted to ulcerative colitis patients.Heterogeneity was high among the included studies(I^(2)=75%).Subgroup analysis revealed that the high heterogeneity was due to the study design.Sensitivity analysis showed that the main statistical outcomes did not essentially change after excluding any one of the included studies.No significant publication bias was found in the funnel plots.CON

关键词： Colorectal neoplasia Inflammatory bowel disease Ulcerative colitis Postinflammatory polyps Pseudopolyps Meta-analysis

Limits of Riemann Solutions for Isentropic MHD in a Variable Cross-Section Duct as Magnetic Field Vanishes

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Chinese Annals of Mathematics,Series B 2024年第4期 637-660页

作者： Wancheng sheng Tao xiao Department of Mathematics Shanghai University Shanghai Aircraft Design and Research Institute

The stability for magnetic field to the solution of the Riemann problem for the polytropic fluid in a variable cross-section duct is discussed. By the vanishing magnetic field method, the stable solutions are determined by comparing the limit solutions with the solutions of the Riemann problem for the polytropic fluid in a duct obtained by the entropy rate admissibility criterion.

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A micro-crosslinked amphoteric hydrophobic association copolymer as high temperature-and salt-resistance fluid loss reducer for water-based drilling fluids

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Petroleum Science 2024年第3期21卷 1980-1991页

作者： Jian Li Yu-Xi Ji xiao-xiao Ni Kai-He Lv Xian-Bin Huang Jin-sheng Sun School of Petroleum Engineering China University of Petroleum(East China) Key Laboratory of Unconventional Oil & Gas Development China University of Petroleum(East China) Inspection and Testing Center of Huabei Oil Field Company PetroChina Drilling Fluid Research Institute CNPC Engineering Technology R&D Company Limited

During ultradeep oil and gas drilling, fluid loss reducers are highly important for water-based drilling fluids, while preparing high temperature-and salt-resistance fluid loss reducers with excellent rheology and filtration performance remains a challenge. Herein, a micro-crosslinked amphoteric hydrophobic association copolymer(i.e., DADC) was synthesized using N,N-dimethyl acrylamide, diallyl dimethyl ammonium chloride, 2-acrylamido-2-methylpropane sulfonic acid, hydrophobic monomer, and pentaerythritol triallyl ether crosslinker. Due to the synergistic effects of hydrogen bonds, electrostatic interaction, hydrophobic association, and micro-crosslinking, the DADC copolymer exhibited outstanding temperature-and salt-resistance. The rheological experiments have shown that the DADC copolymer had excellent shear dilution performance and a certain degree of salt-responsive viscosity-increasing performance. The DADC copolymer could effectively adsorb on the surface of bentonite particles through electrostatic interaction and hydrogen bonds, which bring more negative charge to the bentonite, thus improving the hydration and dispersion of bentonite particles as well as the colloidal stability of the drilling fluids. Moreover, the drilling fluids constructed based on the DADC copolymer exhibited satisfactory rheological and filtration properties(FLHTHP= 12 m L) after aging at high temperatures(up to200°C) and high salinity(saturated salt) environments. Therefore, this work provided new insights into designing and fabricating high-performance drilling fluid treatment agents, demonstrating good potential applications in deep and ultradeep drilling engineering.

关键词： Fluid loss reducer Temperature- and salt-resistance Hydrophobic association Amphoteric Micro-crosslinking

Clinical efficacy and mechanism study of mid-frequency anti-snoring device in treating moderate obstructive sleep apnea-hypopnea syndrome

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World Journal of Clinical Cases 2024年第5期12卷 942-950页

作者： Bao Qian Zhan-Jun Chen Yong-sheng Wang xiao-Yan Hu xiao-Biao Hu Yong-Hua Zheng Pulmonary Medicine Shanghai Jinshan Tinglin HospitalShanghai 201505China Radiology Medicine Shanghai Jinshan Tinglin HospitalShanghai 201505China

BACKGROUND Obstructive sleep apnea-hypopnea syndrome(OSAHS)is primarily caused by airway obstruction due to narrowing and blockage in the nasal and nasopha-ryngeal,oropharyngeal,soft palate,and tongue base areas.The mid-frequency anti-snoring device is a new technology based on sublingual nerve stimulation.Its principle is to improve the degree of oropharyngeal airway stenosis in OSAHS patients under mid-frequency wave stimulation.Nevertheless,there is a lack of clinical application and imaging evidence.METHODS We selected 50 patients diagnosed with moderate OSAHS in our hospital between July 2022 and August 2023.They underwent a 4-wk treatment regimen involving the mid-frequency anti-snoring device during nighttime sleep.Following the treatment,we monitored and assessed the sleep apnea quality of life index and Epworth Sleepiness Scale scores.Additionally,we performed computed tomo-graphy scans of the oropharynx in the awake state,during snoring,and while using the mid-frequency anti-snoring device.Cross-sectional area measurements in different states were taken at the narrowest airway point in the soft palate posterior and retrolingual areas.RESULTS Compared to pretreatment measurements,patients exhibited a significant reduction in the apnea-hypopnea index,the percentage of time with oxygen saturation below 90%,snoring frequency,and the duration of the most prolonged apnea event.The lowest oxygen saturation showed a notable increase,and both sleep apnea quality of life index and Epworth Sleepiness Scale scores improved.Oropharyngeal computed tomography scans revealed that in OSAHS patients cross-sectional areas of the oropharyngeal airway in the soft palate posterior area and retrolingual area decreased during snoring compared to the awake state.Conversely,during mid-frequency anti-snoring device treatment,these areas increased compared to snoring.CONCLUSION The mid-frequency anti-snoring device demonstrates the potential to enhance various sleep parameters in patients with moderate OSAHS,thereby improving thei

关键词： Mid-frequency anti-snoring device Obstructive sleep apnea-hypopnea syndrome Sleep monitoring Oropharyngeal computed tomography Curative effect

Customization of FeNi alloy nanosheet arrays inserted with biomass-derived carbon templates for boosted electromagnetic wave absorption

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International Journal of Minerals,Metallurgy and Materials 2024年第4期31卷 812-824页

作者： Xuanqi Yang Honghan Wang Jing Chen Qingda An Zuoyi xiao Jingai Hao Shangru Zhai Junye sheng Liaoning Key Lab of Lignocellulose Chemistry and BioMaterials Liaoning Collaborative Innovation Center for Lignocellulosic BiorefineryCollege of Light Industry and Chemical EngineeringDalian Polytechnic UniversityDalian 116034China Qingdao Medical College Qingdao UniversityQingdao 266071China

Electromagnetic wave(EMW)-absorbing materials have considerable capacity in the military field and the prevention of EMW radiation from harming human health.However,obtaining lightweight,high-performance,and broadband EMW-absorbing material remains an overwhelming challenge.Creating dielectric/magnetic composites with customized structures is a strategy with great promise for the development of high-performance EMW-absorbing materials.Using layered double hydroxides as the precursors of bimetallic alloys and combining them with porous biomass-derived carbon materials is a potential way for constructing multi-interface heterostructures as efficient EMW-absorbing materials because they have synergistic losses,low costs,abundant resources,and light weights.Here,FeNi alloy nanosheet array/Lycopodium spore-derived carbon(FeNi/LSC)was prepared through a simple hydrothermal and carbonization method.FeNi/LSC presents ideal EMW-absorbing performance by benefiting from the FeNi alloy nanosheet array,sponge-like structure,capability for impedance matching,and improved dielectric/magnetic losses.As expected,FeNi/LSC exhibited the minimum reflection loss of-58.3 dB at 1.5 mm with 20wt%filler content and a widely effective absorption bandwidth of 4.92 GHz.FeNi/LSC composites with effective EMW-absorbing performance provide new insights into the customization of biomass-derived composites as high-performance and lightweight broadband EMW-absorbing materials.

关键词： spore-derived carbon FeNi alloy nanosheet array multi-interface heterostructures synergistic effect efficient electromagnet-ic wave absorption

Inhibition of EGFR attenuates EGF-induced activation of retinal pigment epithelium cell via EGFR/AKT signaling pathway

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International Journal of Ophthalmology(English edition) 2024年第6期17卷 1018-1027页

作者： Yu-sheng Zhu Si-Rui Zhou Hui-Hui Zhang Tong Wang xiao-Dong Chen Faculty of Life Sciences and Medicine Northwest UniversityXi’an 710069Shaanxi ProvinceChina First Affiliated Hospital of Northwest University Northwest UniversityXi’an 710069Shaanxi ProvinceChina Department of Ophthalmology Xi’an No.1 HospitalXi’an 710002Shaanxi ProvinceChina Shaanxi Institute of Ophthalmology Shaanxi Provincial Key Lab of OphthalmologyClinical Research Center for Ophthalmology Diseases of Shaanxi ProvinceXi’an 710002Shaanxi ProvinceChina

AIM:To explore the effect of epidermal growth factor receptor(EGFR)inhibition by erlotinib and EGFR siRNA on epidermal growth factor(EGF)-induced activation of retinal pigment epithelium(RPE)cells.METHODS:Human RPE cell line(ARPE-19 cells)was activated by 100 ng/mL EGF.Erlotinib and EGFR siRNA were used to intervene EGF treatment.Cellular viability,proliferation,and migration were detected by methyl thiazolyl tetrazolium(MTT)assay,bromodeoxyuridine(BrdU)staining assay and wound healing assay,respectively.EGFR/protein kinase B(AKT)pathway proteins and N-cadherin,α-smooth muscle actin(α-SMA),and vimentin were tested by Western blot assay.EGFR was also determined by immunofluorescence staining.RESULTS:EGF treatment for 24h induced a significant increase of ARPE-19 cells’viability,proliferation and migration,phosphorylation of EGFR/AKT proteins,and decreased total EGFR expression.Erlotinib suppressed ARPE-19 cells’viability,proliferation and migration through down regulating total EGFR and AKT protein expressions.Erlotinib also inhibited EGF-induced an increase of proliferative and migrative ability in ARPE-19 cells and clearly suppressed EGF-induced EGFR/AKT proteins phosphorylation and decreased expression of N-cadherin,α-SMA,and vimentin proteins.Similarly,EGFR inhibition by EGFR siRNA significantly affected EGF-induced an increase of cell proliferation,viability,and migration,phosphorylation of EGFR/AKT proteins,and up-regulation of N-cadherin,α-SMA,and vimentin proteins.CONCLUSION:Erlotinib and EGFR-knockdown suppress EGF-induced cell viability,proliferation,and migration via EGFR/AKT pathway in RPE cells.EGFR inhibition may be a possible therapeutic approach for proliferative vitreoretinopathy(PVR).

关键词： erlotinib epidermal growth factor receptor protein kinase B epithelial-mesenchymal transition retinal pigment epithelium cell

P-and SV-wave dispersion and attenuation in saturated microcracked porous rock with aligned penny-shaped fractures

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Petroleum Science 2024年第1期21卷 143-161页

作者： sheng-Qing Li Wen-Hao Wang Yuan-Da Su Jun-Xin Guo xiao-Ming Tang School of Geosciences China University of Petroleum(East China)Qingdao 266580ShandongChina Laoshan National Laboratory Qingdao 266071ShangdongChina Guangdong Provincial Key Laboratory of Geophysical High-resolution Imaging Technology Southern University of Science and TechnologyShenzhen 518055GuangdongChina Department of Earth and Space Sciences Southern University of Science and TechnologyShenzhen 518055GuangdongChina

P-and SV-wave dispersion and attenuation have been extensively investigated in saturated poroelastic media with aligned fractures.However,there are few existing models that incorporate the multiple wave attenuation mechanisms from the microscopic scale to the macroscopic scale.Hence,in this work,we developed a unified model to incorporate the wave attenuation mechanisms at different scales,which includes the microscopic squirt flow between the microcracks and pores,the mesoscopic wave-induced fluid flow between fractures and background(FB-WIFF),and the macroscopic Biot's global flow and elastic scattering(ES)from the fractures.Using Tang's modified Biot's theory and the mixed-boundary conditions,we derived the exact frequency-dependent solutions of the scattering problem for a single penny-shaped fracture with oblique incident P-and SV-waves.We then developed theoretical models for a set of aligned fractures and randomly oriented fractures using the Foldy approximation.The results indicated that microcrack squirt flow considerably influences the dispersion and attenuation of P-and SV-wave velocities.The coupling effects of microcrack squirt flow with the FB-WIFF and ES of fractures cause much higher velocity dispersion and attenuation for P waves than for SV waves.Randomly oriented fractures substantially reduce the attenuation caused by the FB-WIFF and ES,particularly for the ES attenuation of SV waves.Through a comparison with existing models in the limiting cases and previous experimental measurements,we validated our model.

关键词： Aligned fractures P-and SV-wave Dispersion and attenuation Microcracked porous background FB-WIFF Elastic scattering Squirt flow

棉花AP2/ERF转录因子Gh TINY2负调控植株抗盐性的功能分析

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作物学报 2024年第1期50卷 126-137页

作者：肖胜华陆妍李安子覃耀斌廖铭静闭兆福卓柑锋朱永红朱龙付广西大学农学院/亚热带农业生物资源保护与利用国家重点实验室广西南宁530000 华中农业大学/作物遗传改良国家重点实验室湖北武汉430000

棉花属于相对耐盐作物,但高盐胁迫同样会造成棉花产量和纤维品质的大幅下降。深入挖掘抗盐基因并解析棉花响应盐胁迫的分子机理,对加快棉花抗盐遗传改良育种进程具有重要意义。本研究从棉花响应盐胁迫的转录组数据中鉴定到一个受盐诱导... 详细信息

棉花属于相对耐盐作物,但高盐胁迫同样会造成棉花产量和纤维品质的大幅下降。深入挖掘抗盐基因并解析棉花响应盐胁迫的分子机理,对加快棉花抗盐遗传改良育种进程具有重要意义。本研究从棉花响应盐胁迫的转录组数据中鉴定到一个受盐诱导极显著下调表达的AP2/ERF转录因子GhTINY2,并分析了GhTINY2超表达拟南芥的抗盐表型和各生理指标。结果显示,在盐胁迫下,GhTINY2超表达植株的种子萌发率显著下降;脯氨酸、可溶性糖、叶绿素含量等均显著减少;多个盐胁迫响应基因显著下调表达;因而表现出更为严重的叶片萎蔫枯黄表型。通过分析GhTINY2超表达拟南芥中的RNA-seq数据,发现差异表达基因(DEGs)富集到叶绿素代谢、刺激响应等生物过程中,且DEGs均呈下调表达趋势。此外,在棉花中通过病毒诱导的基因沉默(VIGS)试验沉默GhTINY2后,TRV:GhTINY2植株在盐胁迫下叶绿素和脯氨酸含量显著增加,从而增强了棉花的抗盐性。综上,GhTINY2是棉花中一个负调控盐胁迫抗性的重要基因,未来将有望通过现代基因工程技术利用GhTINY2创制耐盐棉花材料。

关键词：棉花 GhTINY2 盐胁迫转录因子转基因