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Enhanced subacute ischemic stroke treatment via multistage drug delivery system design for combination therapy

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Science China Chemistry 2025年

作者： Xihan Xu Juan-Juan li Jiamin li Hui-yan Zhang Yilin qi Bing-Sen Shi Tianqi li Shan-Shan Su Weitao Zhao Chang Chen Zhongying Gong Huiyu liu Ke-Rang wang dong-sheng Guo Xue Xue State Key Laboratory of Medicinal Chemical Biology College of Pharmacy Nankai University College of Chemistry State Key Laboratory of Elemento-Organic Chemistry Key Laboratory of Functional Polymer Materials (Ministry of Education) Frontiers Science Center for New Organic Matter Collaborative Innovation Center of Chemical Science and EngineeringNankai University College of Chemistry and Materials Science State Key Laboratory of New Pharmaceutical Preparations and Excipients Key Laboratory of Medicinal Chemistry and Molecular Diagnosis (Ministry of Education) Key Laboratory of Chemical Biology of Hebei Province Hebei Research Center of the Basic Discipline of Synthetic Chemistry Hebei University Department of Neurology Tianjin First Central Hospital School of Medicine Nankai University Beijing Advanced Innovation Center for Soft Matter Science and Engineering State Key Laboratory of Organic-Inorganic Composites Beijing Laboratory of Biomedical Materials Bionanomaterials & Translational Engineering Laboratory Beijing Key Laboratory of BioprocessBeijing University of Chemical Technology

The management of acute ischemic stroke remains challenging due to its abrupt onset and the narrow treatment window,resulting in high rates of disability and *** therapy for neuroprotection and neurorepair strategies provided new hopes for subacute stroke *** we designed a multistage nanodelivery system that matches the unique microenvironment of the subacute phase of stroke,which utilizes calixarene as a building block to effectively load the neuroprotective drug *** calixarene is designed with glycosidic linkages targeting the glucose transporter 1 (GLUT1)on the blood-brain barrier (BBB) and azo bonds that are responsive to hypoxic ***,the decomposed calixarene molecules themselves possess intrinsic bio-activation to modulate inflammatory responses,achieving a multistage therapeutic approach that transitions from targeting to release and finally to *** approach combines anti-inflammation and neuroprotection,providing a multi-level treatment *** system was validated in a rat model of permanent middle cerebral artery occlusion (pMCAO),demonstrating that intravenous administration of the nanodelivery system repairs brain damage and improves motor function 24 h post-pMCAO *** work offers a precise and integrative strategy for stroke patients missing the acute therapy window to improve functional recovery and enhance the effect of comprehensive treatment.

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20(S)-20-O-Camptothecin β-Aminopropionate: Novel Synthesis and Antitumor Activity in vitro

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Chemical Research in Chinese Universities 2006年第6期22卷 727-731页

作者： li yu-yan you qi-dong wang Lei CHEN sheng CHEN Xiao-guang li yan li Hong-yan Department of Medicinal Chemistry School of Pharmacy China Pharmaceutical University Nanjing 210009 P. R. China Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College eijing 100050 P.R. China

To improve the biological anticancer activity of 20 （S）-camptothecin, a novel class of 20 （S）-20-O-camptotheein β-aminopropionates were designed and synthesized with eamptothecins as the starting materials, through acylation with acryloyl chloride followed by Michael＇s addition. Twelve esters, 1a-1d, 4a-4d and 5a-5d, were synthesized and evaluated by using MTT assay method. The results demonstrate that all these compounds show a potential eytotoxicity on KB, HT-29, HCT-8, and Bel7402 tumor cell lines. Some compounds, 1d, 4c, 5b, 5c and 5d, show a higher cytoto-xicity on KB and HCT-8 compared with eamptotheein.

关键词： Camptothecin β-Aminopropionate Anticancer Synthesis

I_(2)-DMSO-Mediated Multicomponent [2+1+1+1] Annulation Reaction via Ethyl Nitroacetate C-NO_(2), Bond Cleavage as a C1 Synthon: A Route to Multisubstituted β-Pyrrolidinones Derivatives with a Quaternary Center

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Chinese Journal of Chemistry 2024年第17期42卷 2029-2034页

作者： Zhi-Cheng yu Xi Shen you Zhou Xiang-Long Chen li-sheng wang yan-dong Wu An-Xin Wu National Key Laboratory of Green Pesticide International Joint Research Centerfor Intelligent BiosensorTechnologyand HealthCollegeof ChemistryCentral ChinaNormal UniversityWuhanHubei 430079China

A[2+1+1+1]cyclization reaction has been developed for the synthesis of multisubstituted 6-pyrrolidinones from commercially available aryl methyl ketones,primary amines,and ethyl *** this I_(2)-DMSO-meditated process,the C-NO_(2) bond of ethyl nitroacetate is cleaved,affording a C1 synthon,and the formation of two C-C and two C-N bonds and a quaternary carbon center are constructed in one *** method has good substrate compatibility and permits the late-stage modification of pharmaceutical compounds.

关键词： Cyclization Multisubstitutedβ-pyrrolidinones I_(2)-DMSO C1 building blocks Quaternary carbon center Late-stage modification Cracking

Porphyromonas gingivalis Induces Chronic Kidney Disease through Crosstalk between the NF-κB/NLRP3 Pathway and Ferroptosis in GMCs

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Current Medical Science 2024年第5期44卷 932-946页

作者： Xue li Chao YAO dong-mei LAN yan wang sheng-cai qi Medical College Anhui University of Science and TechnologyHuainan232007China Department of Oral Prosthodontics Shanghai Stomatological HospitalFudan UniversityShanghai200001China Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases Shanghai Stomatological Hospital&School of Stomatology Fudan UniversityShanghai200002China Department of Orthodontics Shanghai Stomatological Hospital&School of StomatologyFudan UniversityShanghai200433China

Objective Porphyromonas gingivalis(***)is a gram-negative bacterium found in the human oral cavity and is a recognized pathogenic bacterium associated with chronic periodontitis and systemic diseases,including chronic kidney disease(CKD),but the roles and molecular mechanism of *** in CKD pathogenesis are *** In this study,an animal model of oral *** administration and glomerular mesangial cells(GMCs)cocultured with M1-polarized macrophages and *** supernatant were *** seven weeks of *** gavaged,peripheral blood was collected to detect the changes in renal *** collecting the teeth and kidneys of mice,H&E staining and IHC were used to analyze the expression of periodontal inflammatory factors in mice,PAS staining was used to analyze glomerular *** supernatant of macrophages was treated with 5%*** supernatant.H&E staining,IHC,Western blot and RT-PCR were applied to analyze renal inflammatory factors,macrophage M1 polarization,NF-κB,NLRP3 and ferroptosis changes in *** We found that oral *** administration induced CKD in *** supernatant induced macrophage polarization and inflammatory factor upregulation,which triggered the activation of the NF-κB/NLRP3 pathway and ferroptosis in *** inhibiting the NF-κB/NLRP3 pathway and ferroptosis in GMCs,cell viability and the inflammatory response were partially alleviated in *** We demonstrated that *** induced CKD in mice by triggering crosstalk between the NFκB/NLRP3 pathway and ferroptosis in ***,our study suggested that periodontitis can promote the pathogenesis of CKD in mice,which provides evidence of the importance of periodontitis therapy in the prevention and treatment of CKD.

关键词： Porphyromonas gingivalis chronic kidney disease glomerular mesangial cells macrophages NF-κB/NLRP3 pathway ferroptosis

La-enhanced Ni nanoparticles highly dispersed on SiC for low-temperature CO methanation performance

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Rare Metals 2021年第7期40卷 1753-1761页

作者： Jiang-Wei li qi Song Jiang-Bing li sheng-Chao yang yan-Shan Gao qiang wang Feng yu Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan School of Chemistry and Chemical EngineeringShihezi UniversityShihezi 832003China Environmental Functional Nanomaterials(EFN)Laboratory College of Environmental Science and EngineeringBeijing Forestry UniversityBeijing 100083China

For better performances of Ni-based catalysts at low temperatures,Ni/SiC catalyst doped with a little amount of additive La was successfully *** catalytic CO methanation activity tests showed that 3%La-Ni/SiC catalyst was excellent at a low reaction temperature(95.9%CO conversion and 85.1%CH4 selectivity at250℃)with a superior stability compared with Ni/SiC(3.4%CO conversion and 0%CH4 selectivity at 250℃).This can be attributed to that the addition of La can markedly improve the dispersibility of active metal Ni and reduce the particle sizes of Ni nanoparticles or clusters,and can also regulate the interaction between active components and ***,the high thermal conductivity and thermal stability could avoid the generation of hot spots in the catalyst *** results will promote the development of highly active Ni-based catalysts for the low-temperature methanation reaction.

关键词： Silicon carbide Rare-earth promoter Synthetic natural gas Hydrogen energy Carbon monoxide methanation

A N-CoSe/CoSe_(2)-C@Cu hierarchical architecture as a current collector-integrated anode for potassium-ion batteries

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Rare Metals 2024年第8期43卷 3702-3712页

作者： Zi-Jie Mu yan-Jun Gao Wen-Shuai dong Zong-you li qing-Yi Song Han-Jiao Huang li-dong Xing Jian-Guo Zhang Wei wang qi-Yao yu State Key Laboratory of Explosion Science and Technology School of Mechatronical EngineeringBeijing Institute of TechnologyBeijing 100081China School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China

The highly reversible insertion/extraction of large-radius K^+into electrode materials remains a tough goal,especially for con version-type ***,we design a current collector-integrated electrode(N-CoSe/CoSe_(2)-C@Cu) as an advanced anode for potassium-ion battery(PIBs).The conductive CoSe/CoSe_(2) heterojunction with rich Se vacancy defects,conductive sp^2 N-doped carbon layer,and the elastic copper foil matrix can greatly accelerate the electron transfer and enhance the structural ***,the well-designed N-CoSe/CoSe_(2)-C@Cu current collector-integrated electrode displays enhanced potassium storage performance with regard to a high capacity(325.1 mAh·g^(-1) at 0.1 A·g^(-1) after 200cycles),an exceptional rate capability(223.5 mAh·g^(-1) at2000 mA·g^(-1)),and an extraordinary long-term cycle stability(a capacity fading of only 0.019% per cycle over1200 cycles at 2000 mA·g^(-1)).Impressively,ex situ scanning electron microscopy(SEM) characterizations prove that the elastic structure of copper foil is merged into the cleverly designed N-CoSe/CoSe_(2)-C@Cu heterostructure,which buffers the deformation of structure and volume and greatly promotes the cycle life during the potassium/depotassium process.

关键词： Potassium-ion battery Integrated collector electrode CoSe CoSe_2 Heterojunction Copper foil matrix N-doped carbon

Fabrication and characterization of mussel-inspired layer-by-layer assembled CL-20-based energetic films via micro-jet printing

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Defence Technology（防务技术） 2022年第10期18卷 1748-1759页

作者： Chun-yan li sheng Kong dong-jie liao Chong-wei An Bao-yun Ye Jing-yu wang School of Environment and Safety Engineering North University of ChinaTaiyuan030051ShanxiChina Shanxi Engineering Technology Research Center for Ultrafine Powder North University of ChinaTaiyuan030051ShanxiChina Taiyuan Institute of Technology Taiyuan030008ShanxiChina

Three-dimensional(3D)micro-jet printing is a droplet deposition technique based on liquid-phase *** improve the deposition density and performance of energetic films with micro/nanoscale on an energetic chip,polydopamine(PDA)was utilized as a linker bridge to induce the in-situ self-assembly of CL-20-based energetic film via 3D micro-jet *** self-assembly was extensively characterized by confocal laser scanning microscopy(CLSM),SEM,power-XRD,XPS,and *** performance of the self-assembled film was verified by the mechanical properties and detonation properties,and a possible self-assembly mechanism in the layer-by-layer micro-jet printing process was *** results indicated PDA-induced self-assembly enhanced the physical entanglement between the binders and energetic crystal,reduced the porosity from 15.87%to 11.28%,and improved the elastic modulus and the detonation performance of the CL-20-based energetic *** work proposes a novel and promising energetic film design and fabrication strategy to enhance the interaction between the energetic composite layers in the micro-jet printing process.

关键词： CL-20-Based energetic film Micro-jet printing Polydopamine Self-assembly

Effect of water loss during curing on hydration reaction and hydrates conversion in calcium aluminate cement-bonded castables

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Journal of Iron and Steel Research International 2024年第9期31卷 2133-2141页

作者： Zhong-zhuang Zhang Xiao-yu wang Song-zhu Chu Jin-yan Zeng yuan-dong Mu you-qi li Zhong-tao Luo Guo-tian Ye Henan Key Laboratory of High Temperature Functional Ceramics School of Materials Science and EngineeringZhengzhou UniversityZhengzhou450001HenanChina School of Materials Science and Engineering Key Laboratory of Materials Processing and Mold Ministry of EducationZhengzhou UniversityZhengzhou450000HenanChina Jiangsu Jingxin New Materials Co. Ltd.Yangzhou225000JiangsuChina

Free water available in calcium aluminate cement(CAC)-bonded castables is crucial for the hydration of CAC and the conversion of hydration products in the curing and drying processes,as both the hydration and conversion reactions are dissolution–precipitation *** elucidate the effect of different levels of free water loss upon the hydration of CAC,the conversion of hydration products and the mechanical strength of the CAC-bonded castables,the CAC-bonded castables were subjected to sealed and unsealed curing conditions at 50℃ and drying at 110℃.The results demonstrate that the fast removal of free water during unsealed curing would hinder the conversion from 2CaO·Al_(2)O_(3)·8H_(2)O to 3CaO·Al_(2)O_(3)·6H_(2)O and consequently prevent the deterioration of *** a comparison,although sealed-cured samples have less water loss and high degree of hydration of CAC,they still show lower strength than the unsealed samples after *** following drying process further accelerates the hydration of residual calcium aluminate clinkers for both the sealed and unsealed samples,but still does not favor the conversion from 2CaO·Al_(2)O_(3)·8H_(2)O to 3CaO·Al_(2)O_(3)·6H_(2)O in the unsealed-cured samples.

关键词： Water loss Hydration Conversion Mechanical strength Calcium aluminate cement

Evaluating the efficacy of immunotherapy in gastric cancer:Insights from immune checkpoint inhibitors

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World Journal of Gastroenterology 2024年第32期30卷 3726-3729页

作者： yu-Nuo yang li-sheng wang yan-qi Dang Guang Ji Institute of Digestive Diseases Longhua HospitalChina-Canada Center of Research for Digestive DiseasesShanghai University of Traditional Chinese MedicineShanghai 200032China Department of Biochemistry University of OttawaOttawa K1H 8M5ONCanada

The emergence of immunotherapy,particularly immune checkpoint inhibitors(ICIs),represents a groundbreaking approach to treating gastric cancer(GC).However,the prognosis of GC patients receiving ICI treatment is influenced by various *** manuscript identified sarcopenia and myosteatosis as independent prognostic factors impacting the outcomes of GC patients treated with ***,this study introduced a visual predictive model to estimate the prognosis of GC *** confirmed by further studies,this observation could provide valuable insights to propel the advancement of personalized clinical medicine and the integration of precision medicine practices.

关键词： Gastric cancer Immune checkpoint inhibitors Sarcopenia Myosteatosis Prediction model