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Hemoglobin integrated red blood cell membrane-coated metalorganic framework nano-platform for improving the self-adaptive blood glucose management

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Nano Research 2025年第1期18卷 618-627页

作者： Shuai Wu Li Zhu sheng ni Xiong Zhao Meng Yan Yuan Zhong Karissa Kusuma Yi Liang Kaiwen Bao Kai Qu Xian Qin Kun Zhang Wuquan Deng Da Sun Wei Wu Key Laboratory of Biorheological Science and Technology Ministry of EducationCollege of BioengineeringChongqing UniversityChongqing 400044China Chongqing University Three Gorges Hospital Chongqing Municipality Clinical Research Center for Endocrinology and Metabolic DiseasesChongqing 404000China Institute of Life Sciences&Biomedical Collaborative Innovation Center of Zhejiang Province Wenzhou UniversityWenzhou 325035China Department of Endocrinology School of MedicineChongqing Emergency Medical CenterChongqing University Central HospitalChongqing 400014China

Diabetes,a prevalent chronic metabolic disorder,often leads to severe ***,existing treatment methods may pose life-threatening risks due to poor patient compliance and inaccurate dosing of subcutaneous insulin ***,a biomimetic red blood cell(RBC)membrane-coated glucose-responsive nanoplatform is developed for controlling insulin *** nanoplatforms with RBC membrane can prolong the half-life of nano-formulation in vivo mediated by the biomimetic immune ***,the cascade catalytic effect of glucose oxidase(GOx)encapsulated in metal-organic frameworks(MOFs)and hemoglobin(Hb)in the RBC membrane are able to not only facilitate glucose-responsive insulin release,but also eliminate the detrimental by-product hydrogen peroxide(H_(2)O_(2))resulting from the Hb mediated H_(2)O_(2)*** in vitro and in vivo studies have demonstrated the favorable glucose-responsive performances of this advanced nano-platform with a single intravenous injection maintaining blood glucose balance in Type 1 Diabetes(T1D)mice for an extended duration without the hypoglycemia ***,this biomimetic insulin delivery system is poised to function as a strategy for the intravenous insulin administration,offering a promising drug candidate for the self-adaptive long-term T1D treatment.

关键词： glucose-responsive metal-organic frameworks red blood cell membrane insulin delivery glucose oxidase hemoglobin

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A building-based data capture and data mining technique for air quality assessment

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Frontiers of Environmental Science & Engineering 2011年第4期5卷 543-551页

作者： ni sheng U Wa TANG Faculty of Management and Administration Macao University of Science and TechnologyMacaoChina Department of Civil and Environmental Engineering University of MacaoMacaoChina Dirccao dos Servicos de Proteccao Ambiental MacaoChina

Recently,a building-based air quality model system which can predict air quality in front of individual buildings along both sides of a road has been *** the Macao Peninsula as a case study,this paper shows the advantages of building-based model system in data capture and data *** with the traditional grid-based model systems with input/output spatial resolutions of 1-2 km,the building-based approach can extract the street configuration and traffic data building by building and therefore,can capture the complex spatial variation of traffic emission,urban geometry,and air *** non-homogeneous distribution of air pollution in the Macao Peninsula was modeled in a highspatial resolution of 319 receptors·km^(-2).The spatial relationship among air quality,traffic flow,and urban geometry in the historic urban area is *** study shows that the building-based approach may open an innovative methodology in data mining of urban spatial data for environmental *** results are particularly useful to urban planners when they need to consider the influences of urban form on street environment.

关键词： traffic air pollution spatial distribution high resolution geographic information system

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Effects of post-heading high temperature on some quality traits of malt barley

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Journal of Integrative Agriculture 2020年第11期19卷 2674-2679页

作者： ni sheng-jing ZHAO Hui-fang ZHANG Guo-ping Department of Agronomy College of Agriculture and BiotechnologyZhejiang UniversityHangzhou 310029P.R.China

Global change is bringing barley with more frequency of suffering from high ***,little has been known about the influence of high temperature on malt quality *** this study,we investigated the impact of 1-wk heat stress(32°C/26°C,day/night,12 h/12 h)initiating from the 7th(HT7)and 14th(HT14)days after heading on some grain and malt quality traits of two barley *** comparison with normal temperature(24°C/18°C,day/night,12 h/12 h),heat stress significantly reduced kernel weight,seed setting rate and grains per spike:HT7 having a larger effect than ***,total protein andβ-glucan contents,andβ-amylase and limit dextrinase activities were significantly increased under high temperature,with HT7-treated plants showing larger ***,the different changes of four protein fractions under heat stress were found in the two barley cultivars,indicating the possibility of breaking positive association between protein content and enzyme activity.

关键词： barley β-glucan β-amylase heat stress limited dextrinase protein

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Effect of Carbon Particles with Different Topological Shape on the Rheological Behavior of PVA Aqueous Dispersion

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Chinese Journal of Polymer Science 2022年第11期40卷 1402-1410页

作者： Qing-sheng ni Miao Du Guo-Rong Shan Yi-Hu Song Qiang Zheng State Key Laboratory of Chemical Engineering College of Chemical and Biological EngineeringZhejiang UniversityHangzhou310027China Institute of Zhejiang University-Quzhou Quzhou324000China Ministry of Education Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou310027China

Poly(vinyl alcohol)(PVA)is usually processed and used in a form of aqueous dispersion.A large number of inter-and intramolecular hydrogen bonds make it very difficult to obtain suitable rheological behavior for *** this study,carbon particles with different topological shapes were added into PVA aqueous dispersion to tune the steady and dynamic rheological *** results show that the zero-dimensional particles(carbon black,CB)increase monotonically the zero-shear viscosity of PVA dispersion,while the one-dimensional particles(carbon nanotubes,CNTs)make it first increase,and then decrease and rise again,like an N-shape,and the two-dimensional particles(graphene oxide,GO)can make it first decrease and then increase,exhibiting a *** is believed that the topological shape of the carbon particles brought about these *** zero-dimensional particles mainly act as physical crosslinking points due to their small *** at a certain content,both CNTs and GO can destroy the intermolecular hydrogen bonds between PVA chains because the PVA chains can twine around the slim CNTs and the large planar size of GO prevents the adsorbed PVA from forming hydrogen bond with other *** high hydroxyl value of carbon particle surface could strengthen this *** is expected that the viscosity of polymer dispersion can be regulated by particles with different topological shape and the surface characteristic,so as to widen the operable concentration range during preparing composite functional materials.

关键词： Topological shape Hydrogen bond Rheological behavior PVA aqueous dispersion

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Giant complex hepatic cyst causing pseudocystitis:A case report

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World Journal of Clinical Cases 2023年第33期11卷 8030-8037页

作者： Song Li Jie Tang De-sheng ni A-Dong Xia Guo-Liang Chen Department of Hepatobilary Pancreatic Gastrointestinal Surgery Jinhua People's HospitalJinhua 321000Zhejiang ProvinceChina Department of General Surgery The Second Affiliated Hospital of Bengbu Medical CollegeBengbu 233000Anhui ProvinceChina Anhui Key Laboratory of Tissue Transplantation Bengbu Medical CollegeBengbu 233000Anhui ProvinceChina

BACKGROUND Hepatic cysts are common benign liver tumors that are typically ***,larger cysts,particularly giant liver cysts,can potentially induce *** the diameter of the cyst exceeds 10 cm,it can exert pressure on adjacent organs,leading to manifestations of corresponding ***,we report the case of a complex giant hepatic cyst that caused *** SUMMARY A 16-year-old girl was admitted to our hospital with frequent and urgent *** revealed no obvious uterine adnexal abnormalities but showed a hypoechoic,cystic mass(173 mm×84 mm×138 mm)with clear boundaries,and an unclear blood flow signal in the abdominal cavity(extending from the lower edge of the left lobe of liver to the upper edge of the bladder).Abdominal contrast-enhanced computed tomography revealed a giant cystic mass in the abdominal and pelvic cavities,possibly originating from the liver,and a small amount of free fluid in the pelvic cavity,which subsequent magnetic resonance imaging *** imaging characteristics were consistent with a benign *** patient underwent laparoscopic resection of the giant liver cyst with partial liver ***-surgery her symptoms urinary symptoms were relieved completely and she was discharged on the sixth postoperative *** Our patient presented with symptoms suggestive of pseudocystitis,stressing the need for considering possibilities of other etiologies and differential diagnoses.

关键词： Giant hepatic cyst Pseudocystitis Symptoms Case report

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A Novel Biferrocene Trinuclear Complex with Cis-Configuration

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Chinese Chemical Letters 1999年第3期10卷 251-254页

作者： Jie Ying WU Yu Peng TIAN Fu Xin XIE Shi sheng ni(Department of Chemistry, Anhui University, Hefei 230039) Department of Chemistry Anhui University Hefei 230039 China

A novel biferocene trinuclear complex for Schiff base ligand S-methyl-N- (ferrocenyl-1-methyl -methylidene) dithiocarbazate thereafter abbreviated as HL) is described. X-ray diffraction studies established the structure of the palladium complex, PdL2. The geometry of Pd (II) in the complex is close to square planar and in novel cis-configuration with two ferrocene moieties on the same side. Degenerate four-wave mixing (DFWM) measurements show that the complex exhibit obvious nonlinear optical response.

关键词： palladium complex cis-configuration biferrocene third-order nonlinear optical property

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Design, Synthesis and Characterization of a Novel Schiff Base Bis(iminoantipyrine) and Its Modified Electrode

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Chinese Chemical Letters 1998年第3期9卷 245-248页

作者： Jin Gang Liu Fu Xin Xie sheng Yi Zhang Yu Peng Tian Shi sheng ni(Department of Chemistry, Anhui University,Hefei 230039)(Coordination Chemistry State Key Laboratory of Nanjing University, Nanjing 210093) Department of Chemistry Anhui University Hefei 230039 China

A novel Schiff base, N,N-bis[2-(2-iminoantipyrinephenoxy)ethyl]-p-toluenesulfonamide (BIAET), was synthesized and characterized, and a carbon paste electrode modified with BIAET was prepared and employed for quantitat... 详细信息

关键词： synthesis lead(II)complex modified electrode

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Relaxant Effect of Bioactive Component Compatibility of San-ao Decoction on In vitro Guinea Pig Airway Smooth Muscle:A Dose-Response Relationship Study

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World Journal of Traditional Chinese Medicine 2022年第2期8卷 262-272页

作者： Wen-Jie Song Yan-Ling Fu sheng-Lou ni Jia-Jia Fan Qian Du Hao Zheng Chinese Medical College School of Traditional Chinese MedicineTianjin University of Traditional Chinese MedicineJing Hai DistrictTianjinChina Chinese Medical College School of Traditional Chinese MedicineBeijing University of Chinese MedicineChaoyang DistrictBeijingChina Periodicals Publishing Center Beijing University of Chinese MedicineChaoyang DistrictBeijingChina Wenzhou Traditional Chinese Medicine Hospital WenzhouChina

Background:Component compatibility is important to the modernization of traditional Chinese *** have shown that San-ao decoction(SAD)can treat respiratory diseases by relaxing airway smooth muscle(ASM)and reducing airway ***,whether its bioactive components and compatibility also present with similar relaxant effects remains *** study aims to explore the potential relaxant property,dose-response relationship,and underlying mechanisms of the bioactive component compatibility in ***:Network pharmacology was primarily used to identify the bioactive components of SAD and uncover its underlying *** tension force measuring technique was utilized to verify the relaxant and dose-response effects on in vitro guinea pig ***:We postulated pseudoephedrine hydrochloride(PH),amygdalin(AM),and diammonium glycyrrhizate(DG)to be the bioactive components of SAD,which could effectively relax ASM in a dose-dependent manner on both acetylcholine-induced and spontaneous *** PH and AM could lead to DG dose–response curve *** regression equation of these three bioactive components was Y=-2.048×X_(1)+0.411×X_(2)+14.052×X_(3)(X_(1),X_(2),X_(3)representing PH,AM,and DG,respectively).The underlying mechanisms of these components might be associated with the regulation of smooth muscle ***:PH,AM,and DG are the bioactive components of SAD,which can relax ASM in a dose–response manner and exert a synergistic ***,compatibility of these three bioactive components may serve as a new complementary and alternative treatment for respiratory diseases.

关键词： Airway smooth muscle bioactive component compatibility dose–response manner relaxant effect San-ao decoction

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Crystal Structure and Third-order Nonlinear Optical Property Studies on Copper(Ⅱ) Complex Containing NS Donor Ligand

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Chinese Chemical Letters 1998年第7期9卷 691-693页

作者： Fu Xin XIE Yu Peng TIAN Shi sheng ni (Department of Chemistry, Anhui University, Hefei 230039)(State Key Laboratory of Coordination Chemistry, Nanjing University, Naning 210093) Anhui Univ Dept Chem Hefei 230039 Peoples R China Nanjing Univ State Key Lab Coordinat Chem Nanjing 210093 Peoples R China

A novel Schiff base ligand (HL) derived from S-methyldithiocabazate and pmethoxylbenzaldehyde was prepared and characterized. The Schiff base ligand acts as a single negatively charged bidentate ligand fondng D-M-D type comPlex (D=donor, M=metal). Single crystal X-ray diffraction analysis of the copper(Ⅱ) complex established that the geometry around Cu (Ⅱ) is square-planar with two equivalent M-N and M-S bonds. The two phenyl rings and the coordinated plane are almost in one plane fotheng an electronic delocalization system. Their thirdorder response was also studied.

关键词： copper (Ⅱ) complex third-order nonlinear optical property NS donor ligand

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An integrated microfluidic platform for nucleic acid testing

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Microsystems & Nanoengineering 2024年第3期10卷 181-194页

作者： Antao Sun Petra Vopařilová Xiaocheng Liu Bingqian Kou TomášŘezníček TomášLednický sheng ni JiříKudr Ondřej Zítka Zdenka Fohlerová Petr Pajer Haoqing Zhang Pavel Neužil Ministry of Education Key Laboratory of Micro and Nano Systems for Aerospace School of Mechanical EngineeringNorthwestern Polytechnical University127 West Youyi RoadXi’anShaanxi 710072P.R.China Department of Chemistry and Biochemistry Mendel University in BrnoZemědělská161300 BrnoCzech Republic ITD Tech s.r.o Osvoboditelů100573581 BohumínCzech Republic Central European Institute of Technology Brno University of TechnologyPurkyňova 123Brno 61200Czech Republic Department of Electronic and Computer Engineering The Hong Kong University of Science and TechnologyClear Water BayKowloonHong Kong SARChina Department of Microelectronics Faculty of Electrical Engineering and CommunicationBrno University of TechnologyTechnická3058/10Brno 61600Czech Republic Military Health Institute U Vojenskénemocnice 120016200 Praha 6Czech Republic The Key Laboratory of Biomedical Information Engineering of Ministry of Education School of Life Science and TechnologyXi’an Jiaotong UniversityXi’anShaanxi 710049P.R.China Bioinspired Engineering and Biomechanics Center(BEBC) Xi’an Jiaotong UniversityXi’an 710049P.R.China

This study presents a rapid and versatile low-cost sample-to-answer system for SARS-CoV-2 *** system integrates the extraction and purification of nucleic acids,followed by amplification via either reverse transcriptionquantitative polymerase chain reaction(RT–qPCR)or reverse transcription loop-mediated isothermal amplification(RT–LAMP).By meeting diverse diagnostic and reagent needs,the platform yields testing results that closely align with those of commercial RT-LAMP and RT‒qPCR *** advantages of our system include its speed and *** assay is completed within 28 min,including sample loading(5 min),ribonucleic acid(RNA)extraction(3 min),and RT-LAMP(20 min).The cost of each assay is≈$9.5,and this pricing is competitive against that of Food and Drug Administration(FDA)-approved commercial *** some RNA loss during on-chip extraction is observed,the platform maintains a potential limit of detection lower than 297 *** makes the system particularly useful in environments where centralized laboratories are either unavailable or inconveniently *** key feature is the platform’s versatility,allowing users to choose between RT‒qPCR or RT‒LAMP tests based on specific requirements.

关键词： testing maintain versatile

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