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Gradient-induced long-range optical pulling force based on photonic band gap

Light(Science & Applications) 2024年第5期13卷 865-874页

作者： Wenlong Lu Alexey V.Krasavin sheng lan Anatoly V.Zayats Qiaofeng Dai Guangdong Basic Research Center of Excellence for Structure and Fundamental Interactions of Matter Guangdong Provincial Key Laboratory of Nanophotonic Functional Materials and DevicesSchool of Information and Optoelectronic Science and EngineeringSouth China Normal UniversityGuangzhou 510006China Department of Physics and London Centre for Nanotechnology King’s College LondonLondon WC2R 2LSUK

Optical pulling provides a new degree of freedom in optical *** is generally believed that long-range optical pulling forces cannot be generated by the gradient of the incident ***,we theoretically propose and numerically demonstrate the realization of a long-range optical pulling force stemming from a self-induced gradient field in the manipulated *** analogy to potential barriers in quantum tunnelling,we use a photonic band gap design in order to obtain the intensity gradients inside a manipulated object placed in a photonic crystal waveguide,thereby achieving a pulling *** the usual scattering-type optical pulling forces,the proposed gradient-field approach does not require precise elimination of the reflection from the manipulated *** particular,the Einstein-Laub formalism is applied to design this unconventional gradient *** magnitude of the force can be enhanced by a factor of up to 50 at the optical resonance of the manipulated object in the waveguide,making it insensitive to *** developed approach helps to break the limitation of scattering forces to obtain longrange optical pulling for manipulation and sorting of nanoparticles and other *** developed principle of using the band gap to obtain a pulling force may also be applied to other types of waves,such as acoustic or water waves,which are important for numerous applications.

关键词： optical waveguide scattering

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Highly Transparent Fire-resistant Coatings with Intumescent Three-source Integration

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Chinese Journal of Polymer Science 2024年第7期42卷 907-915,I0005页

作者： Xiao-Liang Zeng Xin-sheng lan Yan Wang Lin Zhang De-Ming Guo Hai-Bo Zhao State Grid Sichuan Electric Power Research Institute Chengdu610041China The Collaborative Innovation Center for Eco-Friendly and Fire-Safety Polymeric Materials(Ministry of Education) National Engineering Laboratory of Eco-Friendly Polymeric Materials(Sichuan)State Key Laboratory of Polymer Materials EngineeringCollege of ChemistrySichuan UniversityChengdu610064China

Wood,a readily available and sustainable natural resource,has found widespread use in construction and ***,its inherent flammability poses a potential fire *** intumescent fire-retardant coatings effectively mitigate this risk,achieving high transparency in such coatings presents a significant *** our approach,we employed a cross-linked network of phytic acid anion and N-[3-(trimethoxysilyl)propyl]-N,N,N-trimethylammonium cation to create a transparent"three-in-one"intumescent *** collaborative P/N/Si flame-retardant effect markedly improved the intumescent char-forming capability,preventing the wood from rapid *** resulted in a substantial reduction in heat release(13.9%decrease in THR)and an increased limiting oxygen index(LOI)value of 35.5%.Crucially,the high transparency of the coating ensured minimal impact on the wood's appearance,allowing the natural wood grains to remain clearly *** innovative approach provides a straightforward method for developing transparent intumescent flame-retardant coatings suitable for wooden *** potential applications extend to preserving ancient buildings and heritage conservation efforts.

关键词： Fire-resistant coating Flame retardancy Wood Transparency

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Controllable shaping of high-index dielectric nanoparticles by exploiting the giant optical force of femtosecond laser pulses

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Photonics Research 2024年第2期12卷 282-291页

作者： YUHENG MAO SHUWEN BAI MINGCHENG PANMAI LIDAN ZHOU SHIMEI LIU SHULEI LI HAIYING LIU HAIHUA FAN JUN DAI sheng lan Guangdong Provincial Key Laboratory of Nanophotonic Functional Materials and Devices School of Information and Optoelectronic Science and EngineeringSouth China Normal UniversityGuangzhou 510006China Shenzhen Institute of Terahertz Technology and Innovation Shenzhen 518102China State Key Laboratory of Optoelectronic Materials and Technologies School of Electronics and Information TechnologySun Yat-sen UniversityGuangzhou 510006China School of Optoelectronic Engineering Guangdong Polytechnic Normal UniversityGuangzhou 510665China

Nanoparticles made of different materials usually support optical resonances in the visible to near infrared spectral range,such as the localized surface plasmons observed in metallic nanoparticles and the Mie resonances observed in dielectric *** optical resonances,which are important for practical applications,depend strongly on the morphologies of *** irradiation is a simple but effective way to modify such optical resonances through the change in the morphology of a *** laser-induced shaping of metallic nanoparticles has been successfully demonstrated,it remains a big challenge for dielectric nanoparticles due to their larger Young’s modulus and smaller thermal ***,we proposed and demonstrated a strategy for realizing controllable shaping of high-index dielectric nanoparticles by exploiting the giant optical force induced by femtosecond laser *** was found that both Si and Ge nanoparticles can be lit up by resonantly exciting the optical resonances with femtosecond laser pulses,leading to the luminescence burst when the laser power exceeds a *** addition,the morphologies of Si and Ge nanoparticles can be modified by utilizing the giant absorption force exerted on them and the reduced Young’s modulus at high *** shape transformation from sphere to ellipsoid can be realized by laser irradiation,leading to the blueshifts of the optical *** was found that Si and Ge nanoparticles were generally elongated along the direction parallel to the polarization of the laser *** shaping of Si and Ge can be achieved by deliberately adjusting the excitation wavelength and the laser *** findings are helpful for understanding the giant absorption force of femtosecond laser light and are useful for designing nanoscale photonic devices based on shaped highindex nanoparticles.

关键词： optical polarization dielectric

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Plasma metabolites and risk of myocardial infarction:a bidirectional Mendelian randomization study

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Journal of Geriatric Cardiology 2024年第2期21卷 219-231页

作者： Dong-Hua LI Qiang WU Jing-sheng lan Shuo CHEN You-Yi HUANG lan-Jin WU Zhi-Qing QIN Ying HUANG Wan-Zhong HUANG Ting ZENG Xin HAO Hua-Bin SU Qiang SU Department of Cardiovascular Medicine Minzu Hospital of Guangxi Zhuang Autonomous RegionGuangxiChina Senior Department of Cardiology the Sixth Medical CenterChinese PLA General HospitalBeijingChina Library of Graduate School Chinese PLA General HospitalBeijingChina Department of Cardiology Jiangbin Hospital of Guangxi Zhuang Autonomous RegionGuangxiChina Health Management Institute the Second Medical CenterChinese PLA General HospitalBeijingChina

BACKGROUND Myocardial infarction(MI)is a critical cardiovascular event with multifaceted etiology,involving several genetic and environmental *** is essential to understand the function of plasma metabolites in the development of MI and unravel its complex *** This study employed a bidirectional Mendelian randomization(MR)approach to investigate the causal relationships between plasma metabolites and MI *** used genetic instruments as proxies for plasma metabolites and MI and conducted MR analyses in both directions to assess the impact of metabolites on MI risk and vice *** addition,the large-scale genome-wide association studies datasets was used to identify genetic variants associated with plasma metabolite(1400 metabolites)and MI(20,917 individuals with MI and 440,906 individuals without MI)*** variance weighted was the primary method for estimating causal *** estimates are expressed as beta coefficients or odds ratio(OR)with 95%*** We identified 14 plasma metabolites associated with the occurrence of MI(P<0.05),among which 8 plasma metabolites[propionylglycine levels(OR=0.922,95%CI:0.881–0.965,P<0.001),gamma-glutamylglycine levels(OR=0.903,95%CI:0.861–0.948,P<0.001),hexadecanedioate(C16-DC)levels(OR=0.941,95%CI:0.911–0.973,P<0.001),pentose acid levels(OR=0.923,95%CI:0.877–0.972,P=0.002),X-24546 levels(OR=0.936,95%CI:0.902–0.971,P<0.001),glycine levels(OR=0.936,95%CI:0.909–0.964,P<0.001),glycine to serine ratio(OR=0.930,95%CI:0.888–0.974,P=0.002),and mannose to trans-4-hydroxyproline ratio(OR=0.912,95%CI:0.869–0.958,P<0.001)]were correlated with a decreased risk of MI,whereas the remaining 6 plasma metabolites[1-palmitoyl-2-arachidonoyl-GPE(16:0/20:4)levels(OR=1.051,95%CI:1.018–1.084,P=0.002),behenoyl dihydrosphingomyelin(d18:0/22:0)levels(OR=1.076,95%CI:1.027–1.128,P=0.002),1-stearoyl-2-docosahexaenoyl-GPE(18:0/22:6)levels(OR=1.067,95%CI:1.027–1.109,P=0.001),alpha-ketobutyrate levels(OR=1.108,95%

关键词： infarction alterations diagnosis

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Histological Features of Uterine Myometrial Dysfunction:Possible Involvement of Localized Inflammation

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Current Medical Science 2024年第3期44卷 633-641页

作者： sheng-lan ZHU Hui-ting ZHANG Yuan-yuan DU Yi JIANG Shao-shuai WANG Wen-cheng DING Ling FENG National Clinical Research Center for Obstetrics and Gynecology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Department of Obstetrics and Gynecology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

Objective The latest perspective suggests that elevated levels of inflammation and cytokines are implicated in atonic postpartum ***(LPS)has been widely used to induce inflammation in animal ***,this study aimed to induce uterine inflammation using LPS to investigate whether local inflammation triggers dysfunction and atrophy in the myometrium,as well as the potential underlying molecular mechanisms *** In vivo,an animal model was established by intraperitoneal injection of 300μg/kg LPS in rats on gestational day ***-eosin(H&E)staining and Masson staining were employed to determine morphological changes in the rat uterine smooth ***-linked immunosorbent assay(ELISA)was used to detect inflammatory ***,tissue fluorescence,and Western blotting were conducted to assess the expression levels of the uterine contraction-related proteins Toll-like receptor 4(TLR4)and the nuclear factor kappa-B(NF-κB)signaling *** vitro,human uterine smooth muscle cells(HUtSMCs)were exposed to 2μg/mL LPS to further elucidate the involvement of the TLR4/NF-κB signaling pathway in LPS-mediated *** In this study,LPS induced uterine myometrial dysfunction in rats,leading to a disorganized arrangement,a significant increase in collagen fiber deposition,and widespread infiltration of inflammatory *** both in vivo animal models and in vitro HUtSMCs,LPS elevated IL-6,IL-1β,and TNF-αlevels while concurrently suppressing the expression of connexin 43(Cx43)and oxytocin receptor(OXTR).Mechanistically,the LPS-treated group exhibited TLR4 activation,and the phosphorylation levels of p65 and IκBαwere notably *** LPS triggered the TLR4/NF-κB signaling pathway,inducing an inflammatory response in the myometrium and leading to uterine myometrial dysfunction and uterine atony.

关键词： lipopolysaccharide inflammatory response TLR4 NF-κB myometrium

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Small extracellular vesicles derived from human induced pluripotent stem cell-differentiated neural progenitor cells mitigate retinal ganglion cell degeneration in a mouse model of optic nerve injury

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Neural Regeneration Research 2025年第2期20卷 587-597页

作者： Tong Li Hui-Min Xing Hai-Dong Qian Qiao Gao sheng-lan Xu Hua Ma Zai-Long Chi State Key Laboratory of Ophthalmology Optometry and Visual ScienceEye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina

Several studies have found that transplantation of neural progenitor cells(NPCs)promotes the survival of injured ***,a poor integration rate and high risk of tumorigenicity after cell transplantation limits their clinical *** extracellular vesicles(sEVs)contain bioactive molecules for neuronal protection and *** studies have shown that stem/progenitor cell-derived sEVs can promote neuronal survival and recovery of neurological function in neurodegenerative eye diseases and other eye *** this study,we intravitreally transplanted sEVs derived from human induced pluripotent stem cells(hiPSCs)and hiPSCs-differentiated NPCs(hiPSC-NPC)in a mouse model of optic nerve *** results show that these intravitreally injected sEVs were ingested by retinal cells,especially those localized in the ganglion cell *** with hiPSC-NPC-derived sEVs mitigated optic nerve crush-induced retinal ganglion cell degeneration,and regulated the retinal microenvironment by inhibiting excessive activation of *** analysis further revealed that hiPSC-NPC derived sEVs transported neuroprotective and anti-inflammatory miRNA cargos to target cells,which had protective effects on RGCs after optic nerve *** findings suggest that sEVs derived from hiPSC-NPC are a promising cell-free therapeutic strategy for optic neuropathy.

关键词： exosome miRNA neural progenitor cell neurodegeneration neuroinflammation neuroprotection optic nerve crush optic neuropathy retinal ganglion cell small extracellular vesicles

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“在地国际化”视域下高等职业教育中外合作办学质量认证体系研究

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黑龙江高教研究 2024年第4期42卷 137-143页

作者：陶宇陆胜蓝浙江机电职业技术学院浙江杭州310053 福建师范大学福建福州350007 浙江交通职业技术学院浙江杭州310023

“在地国际化”是突破高校师生跨境流动的传统观念,在本土创设国际化学习环境、教学资源和育人机制的教育模式。中外合作办学是高等职业教育“在地国际化”的载体与表现形式。在“在地国际化”视域下,中外合作办学存在理念更迭滞缓、认... 详细信息

“在地国际化”是突破高校师生跨境流动的传统观念,在本土创设国际化学习环境、教学资源和育人机制的教育模式。中外合作办学是高等职业教育“在地国际化”的载体与表现形式。在“在地国际化”视域下,中外合作办学存在理念更迭滞缓、认证系统与评价体系未协同、缺乏国际通行认证指标体系等问题,高等职业教育中外合作办学质量认证体系的建构将满足面向全球,培养国际化人才质量保障需求。依据“输入-环境-输出”理论模型,高等职业教育中外合作办学“在地”发展质量认证体系的构建与应用旨在凸显夯实高等职业教育国际化人才培养质量观、实现国际化高技能人才在地培养的实质等效和增强“在地”培养国际化技术技能型人才实力的应用价值。

关键词： “在地国际化” 高等职业教育中外合作办学质量认证体系应用价值

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法治化营商环境建设与商业银行风险——基于专业破产审判庭的视角

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金融论坛 2024年第5期 38-48页

作者：陈胜蓝侯明月浙江工业大学经济学院、现代化产业体系研究院杭州310023 浙江工业大学经济学院杭州310023

本文利用专业破产审判庭对地区司法效率产生的外生变化,考察法治化营商环境建设对商业银行风险的影响。研究表明,法治化营商环境建设能够使银行风险降低约12.19%,降低银行管理成本是司法效率提升进而降低商业银行风险的重要机制。当银... 详细信息

本文利用专业破产审判庭对地区司法效率产生的外生变化,考察法治化营商环境建设对商业银行风险的影响。研究表明,法治化营商环境建设能够使银行风险降低约12.19%,降低银行管理成本是司法效率提升进而降低商业银行风险的重要机制。当银行所在地区法治环境差、司法透明度低、地方政府干预力度大时,法治化营商环境建设对商业银行风险的抑制效应更明显。司法效率的提升能够促使商业银行优化其贷款结构,增加对企业的贷款发放。

关键词：法治化营商环境专业破产审判庭商业银行风险银行管理成本

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Highly efficient discovery of the covalent Minhibitors from crude Pu-erh tea by integrating biochemical and chemoproteomic approaches

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Food Science and Human Wellness 2024年

作者： Guang-Hao Zhu Ya-Ni Zhang sheng-lan Qi Jian-Rong Xu Yuan Xiong Zhao-Qin Zhang Xi-Xiang Chen Yuan-Yuan Xie Xiao-Qing Guan Wei-Dong Zhang Wei Liu Guang-Bo Ge Shanghai Frontiers Science Center of TCM Chemical Biology Institute of Interdisciplinary Integrative Medicine Research Shanghai University of Traditional Chinese Medicine Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine

The main proteases (Mpros) are hydrolases playing essential roles in the replication of β-coronaviruses including SARS-CoV-2. Herein， a highly efficient strategy was developed for discovering the Mproinactivators from crude plant extract integrating target-based biochemical assay and chemoproteomic approaches. Firstly， Pu-erh tea was found to potently suppress SARS-CoV-2 Mproin a time-dependent manner. Next， global chemical analysis coupling with peptide-modification profiling were used to identify the cysteine-modified constituents in Pu-erh tea. The results suggested that seven constituents in Pu-erh tea could modify SARS-CoV-2 Mpro， which turned out that epigallocatechin， gallocatechin and gallic acid were the most efficacious Mproinactivators. Further investigations demonstrated that epigallocatechin and gallocatechin could inactivate SARS-CoV-2 Mprovia blocking the formation of the homodimers. Collectively， this work proposed a novel and practical strategy for highly efficient discovery of time-dependent inhibitors of SARS-CoV-2 Mprofrom plant extracts， while three constituents in Pu-erh tea have emerged as robust SARS-CoV-2 Mproinactivators.

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基于源导向的农用地土壤重金属健康风险评估及优先控制因子分析

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环境科学 2024年第1期45卷 396-406页

作者：马杰葛淼王胜蓝邓力孙静蒋月周林重庆市生态环境监测中心重庆401147 有机污染物环境化学行为与生态毒理重庆市重点试验室重庆401147

以重庆市农产品主产区为研究对象,运用正定矩阵因子分解(PMF)受体模型对土壤重金属进行源解析,运用蒙特卡罗模拟的健康风险评估(HRA)模型,探析土壤重金属对人体的健康风险,并将PMF受体模型和HRA模型结合,探讨不同污染源影响下的土壤健... 详细信息

以重庆市农产品主产区为研究对象,运用正定矩阵因子分解(PMF)受体模型对土壤重金属进行源解析,运用蒙特卡罗模拟的健康风险评估(HRA)模型,探析土壤重金属对人体的健康风险,并将PMF受体模型和HRA模型结合,探讨不同污染源影响下的土壤健康风险,确定优先管控要素.结果表明,研究区土壤Cd均值含量远高于背景值,Cr均值含量低于背景值,As、Pb、Cu、Ni和Zn均值含量与背景值基本持平.PMF受体模型源解析结果表明,研究区土壤受自然源、工业源和农业源影响,贡献率分别为35%、24%和41%.HRA模型评估结果表明,研究区土壤重金属对儿童和成人存在可耐受致癌健康风险(1.00E-6

关键词：土壤重金属正定矩阵因子分解(PMF)模型蒙特卡罗健康风险评估重庆

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