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Aluminum exposure impairs oocyte quality via subcellular structure disruption and DNA damage-related apoptosis in mice

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Journal of Environmental Sciences 2024年第5期139卷 308-319页

作者： Hongge Li Jingcai Liu Weihua Nong Mengying Shen sheng dou Shaochen Sun Junli Wang The Affiliated Hospital of Youjiang Medical University for Nationalities Guangxi 533000China College of Animal Science and Technology Nanjing Agricultural UniversityNanjing 210095China School of Medical Laboratory Youjiang Medical University for NationalitiesGuangxi 533000China Industrial College of Biomedicine and Health Industry Youjiang Medical University for NationalitiesGuangxi 533000China Reproductive Medicine Guangxi Medical and Health Key Discipline Construction ProjectThe Affiliated Hospital of Youjiang Medical University for NationalitiesGuangxi 533000China

Aluminum(Al)can lead to an exposure of creature in varieties ways for its universality,and it could disturb normal physiological metabolism,with the damage to multisystem including *** the oocyte quality is critical for female reproduction,we inspected the toxicity of Al on mouse oocyte *** constructed in vitro exposure mouse model,and we found that 5 mmol/L Al had adverse effects on oocyte maturation by impairing organelle and *** spindle and misaligned chromosomes which might be considered to be caused by elevated levels of acetylation,as well as abnormal distribution of actin dynamics could hinder normal meiosis of *** dysfunction indicated that Al affected proteins synthesis,transport and digestion,which would further damage oocyte *** order to explore the mechanism of Al toxicity,our further investigation demonstrated that Al caused mitochondrial dysfunction and imbalance calcium homeostasis,resulting in limited energy ***,high level of reactive oxygen species,DNA damage and apoptosis caused by oxidative stress were also the manifestation of Al toxicity on *** conclusion,our study provided the evidence that Al exposure affected oocyte quality through its effects on spindle organization,actin dynamics,organelle function and the induction of DNA damage-related apoptosis with mouse model.

关键词： Aluminum Oocyte Cytoskeleton Organelle DNA damage

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Single-cell RNA sequencing in cornea research:Insights into limbal stem cells and their niche regulation

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World Journal of Stem Cells 2023年第5期15卷 466-475页

作者： Di Sun Wei-Yun Shi sheng-Qian dou State Key Laboratory Cultivation Base Shandong Provincial Key Laboratory of OphthalmologyEye Institute of Shandong First Medical UniversityQingdao 266000Shandong ProvinceChina Qingdao Eye Hospital of Shandong First Medical University Qingdao 266000Shandong ProvinceChina Eye Hospital of Shandong First Medical University Jinan 250000Shandong ProvinceChina School of Ophthalmology Shandong First Medical UniversityQingdao 266000Shandong ProvinceChina

The corneal epithelium is composed of stratified squamous epithelial cells on the outer surface of the eye,which acts as a protective barrier and is critical for clear and stable *** continuous renewal or wound healing depends on the proliferation and differentiation of limbal stem cells(LSCs),a cell population that resides at the limbus in a highly regulated *** of LSCs or their niche can cause limbal stem cell deficiency,a disease that is manifested by failed epithelial wound healing or even ***,compared to stem cells in other tissues,little is known about the LSCs and their *** the advent of single-cell RNA sequencing,our understanding of LSC characteristics and their microenvironment has grown *** this review,we summarized the current findings from single-cell studies in the field of cornea research and focused on important advancements driven by this technology,including the heterogeneity of the LSC population,novel LSC markers and regulation of the LSC niche,which will provide a reference for clinical issues such as corneal epithelial wound healing,ocular surface reconstruction and interventions for related diseases.

关键词： Cornea Limbal stem cells Single cell RNA sequencing Heterogeneity Novel markers Niche regulation

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Radiofrequency ablation is an inferior option to liver resection for solitary hepatocellular carcinoma≤5 cm without cirrhosis:A population-based study with stratification by tumor size

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Hepatobiliary & Pancreatic Diseases International 2023年第6期22卷 605-614页

作者： Song-Chen Dong dou-sheng Bai Fu-An Wang sheng-Jie Jin Chi Zhang Bao-Huan Zhou Guo-Qing Jiang Department of Hepatobiliary Surgery Clinical Medical CollegeYangzhou UniversityYangzhou 225001China Department of Hepatobiliary Surgery The First Clinical CollegeDalian Medical UniversityDalian 116000China Department of Interventional Radiology Clinical Medical CollegeYangzhou UniversityYangzhou 225001China

Background:About 10%-20%of all individuals who develop hepatocellular carcinoma(HCC)do not have *** are rarely reported regarding the effectiveness of radiofrequency ablation(RFA)and liver resection(LR)in survival of HCC without cirrhosis and stratification by tumor size≤5 ***:We used the Surveillance,Epidemiology,and End Results(SEER)database and identified 1505 patients with a solitary HCC tumor≤5 cm who underwent RFA or LR during *** were classified into non-cirrhosis and cirrhosis groups and each group was categorized into three subgroups,according to tumor size(≤30 mm,31-40 mm,41-50 mm).Results:In patients without cirrhosis,LR showed better 5-year HCC cancer-specific survival than RFA in all tumor size subgroups(≤30 mm:82.51%vs.56.42%;31-40 mm:71.31%vs.46.83%;41-50 mm:74.7%vs.37.5%;all P0.05).However,in those with tumor size 41-50 mm,LR showed significantly better 5-year HCC cancer-specific survival than RFA in both univariate(54.72%vs.23.06%;P<0.001)and multivariate analyses(HR=0.297;95%CI:0.136-0.648;P=0.002).Conclusions:RFA is an inferior treatment option to LR for patients without cirrhosis who have a solitary HCC tumor≤5 cm.

关键词： Cirrhosis Liver resection Radiofrequency ablation Hepatocellular carcinoma Tumor size

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Semiannual oscillation,annual oscillation,quasibiennial oscillation,and solar cycle variation of the OH airglow emission in the mesopause region

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Earth and Planetary Physics 2024年第3期8卷 479-496页

作者： sheng-Yang Gu Dong Wang YuSong Qin Liang Tang YaFei Wei XianKang dou Electronic Information School Wuhan UniversityWuhan 430072China School of Optoelectronic Engineering Chongqing University of Posts and TelecommunicationsChongqing 400065China

The vertically integrated emission rate,centroid altitude,peak emission rate,and peak height of the hydroxyl(OH)airglow were calculated from Thermosphere Ionosphere Mesosphere Energetics and Dynamics(TIMED)/Sounding of the Atmosphere using Broadband Emission Radiometry(SABER)observations to study the seasonal and interannual variations in the intensity and location of the OH *** emission rate is inversely proportional to the height of the emission,with the semiannual oscillation dominating at low latitudes and the annual oscillation dominating at higher *** OH emission is modulated by the quasibiennial oscillation at the equator,and the quasibiennial oscillation signal is weak at other *** represented the vertical transport of atomic oxygen by using atomic oxygen concentrations obtained from a global atmospheric model,the Specified Dynamics Whole Atmosphere Community Climate Model with thermosphere and ionosphere eXtension *** with the amplitudes of the migrating diurnal tide(DW1)calculated from temperature data observed by TIMED/SABER,we found that both the vertical transport of atomic oxygen and DW1 amplitudes in the equatorial region exhibit semiannual oscillation and quasibiennial oscillation,which have a strong correlation with the variations in the amplitude and phase of semiannual oscillation and quasibiennial oscillation in OH *** is likely that the DW1 affects the vertical transport of atomic oxygen that is involved in the reaction to produce O3,thus affecting the OH *** analyzed the relationship between OH emission and solar activity by using the solar radio flux at 10.7 cm as a proxy for solar *** results showed that the OH emission is well correlated with solar activity,and the modulation of OH emission by solar activity has a significant latitudinal *** small correlation between emission height and solar activity indicates that solar activity modulates OH emission mainly thr

关键词： OH airglow semiannual oscillation quasibiennial oscillation solar activity diurnal tide

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Limit Theorems for Critical Galton-Watson Processes with Immigration Stopped at Zero

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Acta Mathematica Sinica,English Series 2024年第2期40卷 435-450页

作者： dou dou LI Mei ZHANG Xian Yu ZHANG College of Statistics and Data Science Faculty of ScienceBeijing University of TechnologyBeijing 100124P.R.China Laboratory of Mathematics and Complex Systems(Ministry of Education) School of Mathematical SciencesBeijing Normal UniversityBeijing 100875P.R.China

In this paper,we consider a critical Galton-Watson branching process with immigration stopped at zero *** precise estimation on the probability generating function of the n-th population are obtained,and the tail prob... 详细信息

关键词： Branching immigration critical life period limit theorems

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Luminescent metal-halide perovskites:fundamentals,synthesis,and light-emitting devices

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Science China Chemistry 2024年第6期67卷 1776-1838页

作者： Kang Wang Jeong Hui Kim Jie Yang Xiaoke Liu Yixuan dou Yuxuan Li Weijian Tao Haiyun Dong Haiming Zhu Kaifeng Wu Li Na Quan Feng Gao Jianpu Wang Letian dou Yong sheng Zhao Beijing National Laboratory for Molecular Sciences(BNLMS) Key Laboratory of PhotochemistryInstitute of ChemistryChinese Academy of SciencesBeijing100190China Davidson School of Chemical Engineering Purdue UniversityWest LafayetteIN47907USA School of Chemical Sciences University of Chinese Academy of SciencesBeijing100049China Key Laboratory of Flexible Electronics(KLOFE) Institute of Advanced Materials(IAM)&School of Flexible Electronics(Future Technologies)Nanjing Tech University(NanjingTech)Nanjing211816China Department of Physics Linköping UniversityLinköping58183Sweden Department of Chemistry Virginia TechBlacksburgVA24060USA State Key Laboratory of Molecular Reaction Dynamics Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian116023China Department of Chemistry Zhejiang UniversityHangzhou310058China Changzhou University Changzhou213164China Department of Chemistry Purdue UniversityWest LafayetteIN47907USA

Metal-halide perovskites have garnered considerable research attention as highly efficient light emitters in recent years due to their outstanding optoelectronic properties with remarkable tunability and excellent solution *** advancements have been achieved in the development of novel halide perovskites,and the exploitations of these materials in lightemitting *** review comprehensively outlines recent breakthroughs in metal-halide perovskites,encompassing the rational design of perovskite materials with tunable light emission properties,the controllable growth of single crystal for a deeper understanding of their structure-property relationships,as well as the fundamental insights into the photophysics and carrier dynamics in perovskite ***,it provides an overview of recent applications of perovskite materials in high-performance light-emitting diodes(LEDs)and lasers.

关键词： metal-halide perovskites perovskite luminescent materials perovskite synthesis excited-state processes perovskite light-emitting diodes perovskite lasers

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Progress in neurorehabilitation research and the support by the National Natural Science Foundation of China from 2010 to 2022

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Neural Regeneration Research 2024年第1期19卷 226-232页

作者： Qian Tao Honglu Chao Dong Fang dou dou School of Medicine Jinan UniversityGuangzhouGuangdong ProvinceChina School of Health and Life Science University of Health and Rehabilitation SciencesQingdaoShandong ProvinceChina Department of Health Sciences National Natural Science Foundation of ChinaBeijingChina Department of Neurosurgery The First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu ProvinceChina

The National Natural Science Foundation of China is one of the major funding agencies for neuro rehabilitation research in *** study reviews the frontier directions and achievements in the field of neurorehabilitation in China and wo *** used data from the Web of Science Core Collection(WoSCC) database to analyze the publications and data provided by the National Natural Science Foundation of China to analyze funding *** addition,the prospects for neurorehabilitation research in China are *** 2010 to 2022,a total of 74,220 publications in neurorehabilitation were identified,with there being an overall upward *** this period,the National Natural Science Foundation of China has funded 476 research projects with a total funding of 192.38 million RMB to support neuro rehabilitation research in *** the support of the National Natural Science Foundation of China,China has made some achievements in neurorehabilitation *** related to neurorehabilitation is believed to be making steady and significant progress in China.

关键词： brain computer interface invasive neuromodulation National Natural Science Foundation of China(NSFC) neuroreha bilitation non-invasive brain stimulation publication rehabilitation robotics virtual reality

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The growth rate of hepatocellular carcinoma is different with different TNM stages at diagnosis

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Hepatobiliary & Pancreatic Diseases International 2021年第4期20卷 330-336页

作者： Tian-Ming Gao dou-sheng Bai Jian-Jun Qian Chi Zhang sheng-Jie Jin Guo-Qing Jiang Department of Hepatobiliary Surgery Clinical Medical CollegeYangzhou UniversityYangzhou 225001China Department of Hepatobiliary Surgery The Second Clinical CollegeDalian Medical UniversityDalian 116023China

Background: Hepatocellular carcinoma(HCC) progresses fast and has a poor prognosis, but the growth rate in different TNM stages is not clear. The present study was to estimate the growth rate of HCC with different TNM stages at diagnosis. Methods: Baseline demographics and tumor characteristics were analyzed for 10145 patients in Surveillance, Epidemiology, and End Results(SEER) Program-registered HCC. Multiple linear regression models were used for age adjustment with patient race, sex, marital status, and HCC grade. Results: The age at diagnosis was younger in Caucasians and males. The adjusted average age of patients with stage I HCC was 65.26 years. The adjusted age of patients with stage II, IIIA, IIIB, and IIIC was-0.17,-0.25,-0.29, and-0.55 adjusted-year younger compared with patients with stage I HCC(all P < 0.001). The adjusted average age of patients with T1 was 65.26 years. The age adjustment was-0.17,-0.26, and-0.55 respectively(all P < 0.001) for T2, T3 or T4 tumors without distant metastases. Conclusions: These findings demonstrated that the more advanced the HCC stage at diagnosis, the younger the age at diagnosis and the faster the HCC growth from tumor occurrence.

关键词： Hepatocellular carcinoma Growth rate TNM stage SEER

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Development and validation of a model integrating clinical and coronary lesion-based functional assessment for longterm risk prediction in PCI patients

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Journal of Geriatric Cardiology 2024年第1期21卷 44-63页

作者： Shao-Yu WU Rui ZHANG sheng YUAN Zhong-Xing CAI Chang-Dong GUAN Tong-Qiang ZOU Li-Hua XIE Ke-Fei dou State Key Laboratory of Cardiovascular Disease BeijingChina Cardiometabolic Medicine Center Fu Wai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Catheterization Laboratories Fu Wai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Cardiology Fu Wai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

OBJECTIVES To establish a scoring system combining the ACEF score and the quantitative blood flow ratio(QFR) to improve the long-term risk prediction of patients undergoing percutaneous coronary intervention(PCI).METHODS In this population-based cohort study, a total of 46 features, including patient clinical and coronary lesion characteristics, were assessed for analysis through machine learning models. The ACEF-QFR scoring system was developed using 1263consecutive cases of CAD patients after PCI in PANDA Ⅲ trial database. The newly developed score was then validated on the other remaining 542 patients in the *** In both the Random Forest Model and the Deep Surv Model, age, renal function(creatinine), cardiac function(LVEF)and post-PCI coronary physiological index(QFR) were identified and confirmed to be significant predictive factors for 2-year adverse cardiac events. The ACEF-QFR score was constructed based on the developmental dataset and computed as age(years)/EF(%) + 1(if creatinine ≥ 2.0 mg/d L) + 1(if post-PCI QFR ≤ 0.92). The performance of the ACEF-QFR scoring system was preliminarily evaluated in the developmental dataset, and then further explored in the validation dataset. The ACEF-QFR score showed superior discrimination(C-statistic = 0.651;95% CI: 0.611-0.691, P < 0.05 versus post-PCI physiological index and other commonly used risk scores) and excellent calibration(Hosmer–Lemeshow χ^(2)= 7.070;P = 0.529) for predicting 2-year patient-oriented composite endpoint(POCE). The good prognostic value of the ACEF-QFR score was further validated by multivariable Cox regression and Kaplan–Meier analysis(adjusted HR = 1.89;95% CI: 1.18–3.04;log-rank P < 0.01) after stratified the patients into high-risk group and low-risk *** An improved scoring system combining clinical and coronary lesion-based functional variables(ACEF-QFR)was developed, and its ability for prognostic prediction in patients with PCI was further validated to be signi

关键词： patients coronary prediction

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Optimization-based mode selection scheme for OAM millimeter wave system in the off-axis misalignment case

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Digital Communications and Networks 2024年第1期10卷 101-108页

作者： Haie dou Lei Wang Bin Kang Baoyu Zheng Key Lab of Broadband Wireless Communication and Sensor Network Technology(Nanjing University of Posts and Telecommunications) Ministry of EducationNanjing210003China School of Internet of Things Nanjing University of Posts and TelecommunicationsNanjing210003China

Millimeter-wave transmission combined with Orbital Angular Momentum(OAM)has the advantage of reducing the loss of beam power and increasing the system ***,to fulfill this advantage,the antennas at the transmitter and receiver must be parallel and coaxial;otherwise,the accuracy of mode detection at the receiver can be seriously *** this paper,we design an OAM millimeter-wave communication system for overcoming the above ***,the first contribution is that the power distribution between different OAM modes and the capacity of the system with different mode sets are analytically derived for performance *** second contribution lies in that a novel mode selection scheme is proposed to reduce the total interference between different *** results show that system performance is less affected by the offset when the mode set with smaller modes or larger intervals is selected.

关键词： Orbital angular momentum Millimeter wave Off-axis misalignment Mode selection Capacity

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