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Causal relationship between feelings and cognitive decline:An univariable and multivariable Mendelian randomization study

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World Journal of Psychiatry 2024年第3期14卷 421-433页

作者： Juan liu Lin liu Yi-Xin Hu Jian-Hua Li Xiao Zou Hao-yun Zhang Li Fan Department of Cardiology The Second Medical Center&National Clinical Research Center for Geriatric DiseasesChinese PLA General HospitalBeijing 100853China Department of Pulmonary and Critical Care Medicine The Second Medical Center&National Clinical Research Center for Geriatric DiseasesChinese PLA General HospitalBeijing 100853China The Fourth Department of Geriatric Health Care The Second Medical Center&National Clinical Research Center for Geriatric DiseasesChinese PLA General HospitalBeijing 100853China Department of Anesthesiology First Medical Center of Chinese PLA General HospitalBeijing 100853China

BACKGROUND While the impact of depression on cognition is well-documented,the relationship between feelings and cognition has received limited *** To explore the potential association between feelings and cognition with a twosample Mendelian randomization(MR)*** Our analysis utilized genome-wide association data on various feelings(fed-up feelings,n=453071;worrier/anxious feelings,n=450765;guilty feelings,n=45-0704;nervous feelings,n=450700;sensitivity/hurt feelings,n=449419;miserableness,n=454982;loneliness/isolation,n=455364;happiness,n=152348)in the European population and their impact on cognitive functions(intelligence,n=269867).Conducting a univariable MR(UVMR)analysis to assess the relationship between feelings and *** this analysis,we applied the inverse variance weighting(IVW),weighted median,and MR Egger ***,we performed sensitivity analysis(leave-one-out analysis),assessed heterogeneity(using MR-PRESSO and Cochran’s Q test),and conducted multiple validity test(employing MR-Egger regression).Subsequently,a multivariable MR(MVMR)analysis was employed to examine the impact of feelings on *** served as the primary method in the multivariable analysis,complemented by median-based and MR-Egger *** In this study,UVMR indicated that sensitivity/hurt feelings may have a negative causal effect on cognition(OR=0.63,95%CI:0.43-0.92,P=0.017).After adjustment of other feelings using MVMR,a direct adverse causal effect on cognition was observed(OR_(MVMR)=0.39,95%CI:0.17-0.90,P_(MVMR)=0.027).While a potential increased risk of cognitive decline was observed for fed-up feelings in the UVMR analysis(ORUVMR=0.64,95%CI:0.42-0.97,PUVMR=0.037),this effect disappeared after adjusting for other feelings(OR_(MVMR)=1.42,95%CI:0.43-4.74,P_(MVMR)=0.569).These findings were generally consistent across MV-IVW,median-based,and MR-Egger ***-Egger regression revealed pleiotropy in the impact of worrier/anxious

关键词： Mendelian randomization analysis Feelings Cognition Intelligence

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Bioactive citrate-based polyurethane tissue adhesive for fast sealing and promoted wound healing

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Regenerative Biomaterials 2024年第1期3卷 69-81页

作者： Yan Li Jiawei liu Chenxi Lian He Yang Mingjiang Zhang Youfa Wang Honglian Dai State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Biomedical Materials and Engineering Research Center of Hubei ProvinceWuhan University of TechnologyWuhan 430070China Chaozhou Branch of Chemistry and Chemical Engineering Guangdong Laboratory Chaozhou 521000China Shenzhen Research Institute of Wuhan University of Technology Shenzhen 518000China

As a superior alternative to sutures,tissue adhesives have been developed significantly in recent ***,existing tissue adhesives struggle to form fast and stable adhesion between tissue interfaces,bond weakly in wet environments and lack *** this study,a degradable and bioactive citrate-based polyurethane adhesive is constructed to achieve rapid and strong tissue *** hydrophobic layer was created with polycaprolactone to overcome the bonding failure between tissue and adhesion layer in wet environments,which can effectively improve the wet bonding *** citrate-based polyurethane adhesive provides rapid,non-invasive,liquid-tight and seamless closure of skin incisions,overcoming the limitations of sutures and commercial tissue *** addition,it exhibits biocompatibility,biodegradability and hemostatic *** degradation product citrate could promote the process of angiogenesis and accelerate wound *** study provides a novel approach to the development of a fast-adhering wet tissue adhesive and provides a valuable contribution to the development of polyurethane-based tissue adhesives.

关键词： tissue adhesive polyurethane citrate wet adhesion

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A model for predicting the segregation directions of binary Geldart B particle mixtures in bubbling fluidized beds

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Particuology 2024年第7期90卷 340-349页

作者： Chenmin liu yuemin Zhao Yanjiao Li yuqing Feng Chenlong Duan Chenyang Zhou Liang Dong Key Laboratory of Coal Processing and Efficient Utilization Ministry of EducationChina University of Mining and TechnologyXuzhou221116China School of Chemical Engineering and Technology China University of Mining and TechnologyXuzhou221116China Mineral Resources Business Unit CSIROClaytonVIC 3169Australia

In gas fluidization processes involving different types of particles,the mixing or segregation behavior of the solid mixture is crucial to the overall outcome of the *** study develops a model to predict the segregation directions of binary mixtures of Geldart B particles with density and size differences in bubbling fluidized *** proposed model was established by combining the particle segregation model,a previous particle segregation model,with a derived bed voidage equation of the bubbling fluidization based on the two-phase *** model was then analyzed with different function graphs of the model equations under various *** results indicated that an increase in gas velocity or volume fraction of larger particles would strengthen size segregation,causing the larger and less dense components to *** validate the model,42 sets of data collected from 6 independent literature sources were compared with the predictions of the *** the gas velocities were below 3.2 times the minimum gas velocity,the predictions were consistent with experimental *** study has shed new light on the mechanisms of particle segregation in binary fluidized systems and provides a theoretical foundation for designing and manipulating gas-solid fluidized reactors.

关键词： Particle segregation Binary mixture Bubbling fluidization Geldart B particles Two-phase theory

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A method to determine the bonded-particle model parameters for simulation of ores

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Particuology 2024年第3期86卷 24-38页

作者： Shuwei Wu Guoqiang Wang Longfei Fan Wei Guan Jianbo Guo Zhengbin liu yukuan Wang School of Mechanical and Aerospace Engineering Jilin UniversityChangchun130025China

The bonded-particle model(BPM)is commonly used in the numerical analysis of ore *** improve the accuracy of simulating the mechanical process of ore process of ore crushing in a crusher,the parameters of the BPM for the ore must be *** this study,a calibration method was proposed for the scientific determination of the parameters of the BPM for ore undergoing uniaxial ***,physical tests and simulations were conducted to determine the mechanical response(uniaxial compressive strength and macroscopic stiffness)of ore during uniaxial ***,the sensitivity of the mechanical response to the values of microscopic parameters was tested using a Plackett-Burman ***,the microscopic parameters with the greatest impact on the response were identified,and the range of parameters that met the target response was determined using a steepest ascent design;Second,a second-order model of the mechanical response was established using the sensitive parameters by combining a Box-Behnken design with response surface methodology to obtain the optimal BPM *** tests showed that the normal stiffness per unit area,critical shear stress,and bonded disk radius had significant effects on the uniaxial compressive strength(UCS)and macroscopic stiffness(MS).To verify the validity of the proposed calibration method,laboratory tests were *** consistency of the simulation results with experimental results indicated that response surface methodology with the Plackett-Burman design,steepest ascent design,and Box-Behnken design can be an effective method for calibrating the BPM of ores.

关键词： Bonded-particle model Discrete element method Calibration method Design of experiment Uniaxial compression test

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Conventional and micro scale finite element modeling for metal cutting process:A review

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Chinese Journal of Aeronautics 2024年第2期37卷 199-232页

作者： Le WANG Caixu yuE Xianli liu Ming LI Yongshi XU Steven Y.LIANG Key Laboratory of Advanced Manufacturing and Intelligent Technology Ministry of EducationHarbin University of Science and TechnologyHarbin 150080China George W.Woodruff School of Mechanical Engineering Georgia Institute of TechnologyAtlanta 30332USA

The metal cutting process is accompanied by complex stress field,strain field,temperature *** comprehensive effects of process parameters on chip morphology,cutting force,tool wear and residual stress are complex and *** element method(FEM)is considered as an effective method to predict process variables and reveal microscopic physical phenomena in the cutting ***,the finite element(FE)simulation is used to research the conventional and micro scale cutting process,and the differences in the establishment of process variable FE simulation models are distinguished,thereby improving the accuracy of FE *** reliability and effectiveness of FE simulation model largely depend on the accuracy of the simulation method,constitutive model,friction model,damage model in describing mesh element,the dynamic mechanical behavior of materials,the tool-chip-workpiece contact process and the chip formation *** this paper,the FE models of conventional and micro process variables are comprehensively and up-to-date reviewed for different materials and machining *** purpose is to establish a FE model that is more in line with the real cutting conditions,and to provide the possibility for optimizing the cutting process *** development direction of FE simulation of metal cutting process is discussed,which provides guidance for future cutting process modeling.

关键词： Conventional and micro scale Finite element simulation Metal cutting process Micro cutting Modeling

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A 27 GHz,simple 2-bit 1×8 phased array

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Journal of Electronic Science and Technology 2024年第3期22卷 26-34页

作者： Jun-Xian liu yun-Ying Man Hao Yang Peng Yang School of Electronic Science and Engineering University of Electronic Science and Technology of ChinaChengdu611731China

This study demonstrates a simple 2-bit phased array operating at 27 GHz that supports one-dimensional beam scanning with left-handed circular polarization(LHCP).The antenna is constructed using a compact four-layer printed circuit board(PCB)structure,consisting of a 90°phase shifter layer with microstrip structures,a ground(GND)layer,a direct current(DC)control layer,and a circularly polarized annular radiation patch layer with 1-bit phase *** on the proposed unit structure,a 1×8 array with half-wavelength inter-element spacing was designed and *** results show that the array achieves a peak gain of 10.23 dBi and is capable of beam scanning within±50°.

关键词： 27 GHz 2-bit P-i-n diodes Phased array Reconfigurable antennas

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Neural Network State Learning Based Adaptive Terminal ILC for Tracking Iteration-varying Target Points

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International Journal of Automation and computing 2015年第3期12卷 266-272页

作者： yu liu Rong-Hu Chi Zhong-sheng Hou School of Automation and Electronic Engineering Qingdao University of Science and Technology Advanced Control Systems Lab School of Electronics and Information Engineering Beijing Jiaotong University

Terminal iterative learning control(TILC) is developed to reduce the error between system output and a fixed desired point at the terminal end of operation interval over iterations under strictly identical initial conditions. In this work, the initial states are not required to be identical further but can be varying from iteration to iteration. In addition, the desired terminal point is not fixed any more but is allowed to change run-to-run. Consequently, a new adaptive TILC is proposed with a neural network initial state learning mechanism to achieve the learning objective over iterations. The neural network is used to approximate the effect of iteration-varying initial states on the terminal output and the neural network weights are identified iteratively along the iteration axis.A dead-zone scheme is developed such that both learning and adaptation are performed only if the terminal tracking error is outside a designated error bound. It is shown that the proposed approach is able to track run-varying terminal desired points fast with a specified tracking accuracy beyond the initial state variance.

关键词： Adaptive terminal iterative learning control neural network initial state learning iteration-varying terminal desired points ini

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Effect of different gas releasing methods on anaerobic fermentative hydrogen production in batch cultures

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Frontiers of Environmental Science & Engineering 2012年第6期6卷 901-906页

作者： sheng CHANG Jianzheng LI Feng liu Ze yu State Key Laboratory of Urban Water Resource and Environment School of Municipal and Environmental EngineeringHarbin Institute of TechnologyHarbin 150090China

Decreasing hydrogen partial pressure can not only increase the activity of the hydrogen enzyme but also decrease the products inhibition, so it is an appropriate method to enhance the fermentative hydrogen production from anaerobic mixed culture. The effect ofbiogas release method on anaerobic fermentative hydrogen production in batch culture system was compared, i.e., Owen method with intermediately release, continuous releasing method, and continuous releasing ＋ CO2 absorbing. The experi- mental results showed that, at 35℃, initial pH 7.0 and glucose concentration of 10 g.L-1, the hydrogen produc- tion was only 28 mL when releasing gas by Owen method, while it increased two times when releasing the biogas continuously. The cumulative hydrogen production could reach 155 mL when carbon dioxide in the gas stream was continuously absorbed by 1 mol.L-1 NaOH. The results showed that acetate was dominated, accounting for 43% in the dissolved fermentation products in Owen method, whereas the butyrate predominated and reached 47%-53% of the total liquid end products when releasing gas continuously. It is concluded that the homoacetogenesis could be suppressed when absorbing CO2 in the gas phase in fermentative hydrogen production system.

关键词： batch fermentation hydrogen production,biogas releasing hydrogen pressure homoacetogenesis

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Eco-physiological characteristics of Tetracentron sinense *** in response to different light intensities

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Journal of Forestry Research 2024年第3期35卷 29-44页

作者： Rong Wang Xueheng Lu Hongyan Han Xuemei Zhang Yonghong Ma Qinsong liu Xiaohong Gan Key Laboratoryof Southwest Wildlife Resources Conservation Ministry of EducationChina West Normal UniversityNanchong 637009People's Republic of China Institute of Plant Adaptation and Utilization in Southwest Mountain China West Normal UniversityNanchong 637009People's Republic of China Office of the People's Government of yuexi County Yuexi County 616650Liangshan Yi Autonomous PrefecturePeople's Republic of China

The regeneration of Tetracentron sinense *** poor in the understory and in open areas due to the charac-teristics of natural regeneration of the species on forest edges and in *** is unclear whether different light intensities in various habitats affect eco-physiological characteristics of saplings and their natural *** this study,the light intensity in *** habitats was simulated by artificial shading(L1:100%NS(natural sunlight)in the open;L2:50%NS in a forest gap or edge;L3:10%NS in understory)to investigate differences in morphology,leaf structure,physiology,and photosynthesis of 2-year-old sap-lings,and to analyze the mechanism of light intensity on sapling *** differences were observed in morphology(including leaf area,and specific leaf area)under different light *** to L1 and L3,chloroplast structure in L2 was *** increasing time,superoxide dismutase(SOD)and catalase(CAT)activities in L2 became gradually higher than under the other light intensities,while malondialdehyde(MDA)content was *** decreased osmoregulation substance contents of leaves but increased *** results suggest that light intensities significantly affect the eco-physiological characteristics of *** saplings and they would respond most favorably at intermediate levels of light by optimizing eco-physiological ***,50%natural sunlight should be created to promote saplings establishment and population recovery of *** during in situ conservation,including sowing mature seeds in forest edges or gaps and providing appropriate shade protection for seedlings and saplings in the open.

关键词： Chloroplast ultrastructure Eco-physiological characteristics Light intensities Sapling establishment Tetracentron sinense Oliv

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Integration of advanced biotechnology for green carbon

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Green Carbon 2024年第2期2卷 164-175页

作者： Miao Wang Yixiang Wang Jingyuan liu Hua yu Peng liu yujing Yang Dan Sun Heng Kang Yanting Wang Jingfeng Tang Chunxiang Fu Liangcai Peng Key Laboratory of Fermentation Engineering(Ministry of Education) National"111"Center for Cellular Regulation&Molecular PharmaceuticsCooperative Innovation Center of Industrial Fermentation(Ministry of Education&Hubei Province)Hubei Key Laboratory of Industrial MicrobiologyBiomass&Bioenergy Research CenterHubei University of TechnologyWuhan 430068China College of Plant Science&Technology Huazhong Agricultural UniversityWuhan 430070China Shandong Provincial Key Laboratory of Energy Genetics CAS Key Laboratory of BiofuelsQingdao Institute of Bioenergy&Bioprocess TechnologyChinese Academy of SciencesQingdao 266101China Shandong Energy Institute Qingdao 266101China

Carbon neutralization has been introduced as a long-term policy to control global warming and climate *** plant photosynthesis produces the most abundant lignocellulosic biomass on Earth,its conversion to biofuels and bioproducts is considered a promising solution for reducing the net carbon ***,natural lignocellulose recalcitrance crucially results in a costly biomass process along with secondary waste *** updating recent advances in plant biotechnology,biomass engineering,and carbon nanotechnology,this study proposes a novel strategy that integrates the genetic engineering of bioenergy crops with green-like biomass processing for cost-effective biofuel conversion and high-value *** selecting key genes and appropriate genetic manipulation approaches for precise lignocellulose modification,this study highlights the desirable genetic site mutants and transgenic lines that are raised in amorphous regions and inner broken chains account for high-density/length-reduced cellulose nanofiber assembly in *** the amorphous regions and inner-broken chains of lignocellulose substrates are defined as the initial breakpoints for enhancing biochemical,chemical,and thermochemical conversions,desirable cellulose nanofibers can be employed to achieve nearcomplete biomass enzymatic saccharification for maximizing biofuels or high-quality biomaterials,even under cost-effective and green-like biomass processes in *** study emphasizes the optimal thermal conversion for generating high-performance nanocarbons by combining appropriate nanomaterials generated from diverse lignocellulose ***,this study provides a perspective on the potential of green carbon productivity as a part of the fourth industrial revolution.

关键词： Lignocellulose Biofuels Nanomaterials Nanocarbon Genetic engineering

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