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Transition-Metal-Free Allylic Defluorination Cross-Electrophile Coupling Employing Rongalite

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Chinese Journal of Chemistry 2024年第12期42卷 1360-1366页

作者： Xiang-Long Chen Chun-Yan Wu Dong-sheng yang Bo-Cheng Tang Huai-Yu Wang Zhi-Cheng Yu Anling Li Yan-Dong Wu An-Xin Wu National Key Laboratory of Green Pesticide International Joint Research Center for Intelligent Biosensor Technology and HealthCollege of ChemistryCentral China Normal UniversityWuhanHubei 430079China state Key Laboratory of Chemical Biology and Drug Discovery Department of Applied Biology and Chemical Technology The HongKong Polytechnic UniversityKowloonHong Kong SARChina Department of Clinical Laboratory Center for Gene Diagnosisand Program of Clinical Laboratory MedicineZhongnan Hospital of Wuhan UniversityWuhanHubei 430062China

Comprehensive Summary The conversion of CF3-alkenes to gem-difluoroalkenes using reductive cross-coupling strategy has received much attention in recent years,however,the use of green and readily available reducing salt to mediate these reactions remains to be *** this work,a concise construction of gem-difluoroalkenes,which requires neither a catalyst nor a metal reducing agent,was ***,a safe and inexpensive industrial product,was employed as both a radical initiator and *** procedure was compatible with both linear and cyclic diaryliodonium salts,enabling a wide variety of substrates(>70 examples).The utility of this approach was demonstrated through gram-scale synthesis and efficient late-stage functionalizations of anti-inflammatory drugs.

关键词： Defluoroarylation Transition metal free gem-Difluoroalkenes Rongalite Single electron transfer C-C coupling Redox reactions Cross-coupling

Genetically modified pigs with CD163 point mutation are resistant to HP-PRRSV infection

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Zoological Research 2024年第4期45卷 833-844页

作者： Ying Liu Lin yang Hong-Yong Xiang Ming Niu Jia-Cheng Deng Xue-Yuan Li Wen-Jie Hao Hong-sheng Ou-yang Tong-Yu Liu Xiao-Chun Tang Da-Xin Pang Hong-Ming Yuan State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases Animal Genome Editing Technology Innovation CenterCollege of Animal SciencesJilin UniversityChangchunJilin 130062China Chifeng Best Genetics Technology Co. Ltd.ChifengNei Mongol 024000China Chongqing Jitang Biotechnology Research Institute Co. Ltd.Chongqing 400015China

Porcine reproductive and respiratory syndrome(PRRS)is a globally prevalent contagious disease caused by the positive-strand RNA PRRS virus(PRRSV),resulting in substantial economic losses in the swine *** the CD163 SRCR5 domain,either through deletion or substitution,can eff1ectively confer resistance to PRRSV infection in ***,large fragment modifications in pigs inevitably raise concerns about potential adverse effects on growth *** the impact of genetic modifications on normal physiological functions is a promising direction for developing PRRSV-resistant *** the current study,we identified a specific functional amino acid in CD163 that influences PRRSV *** infection experiments conducted on Marc145 and PK-15CD163 cells illustrated that the mE535G or corresponding pE529G mutations markedly inhibited highly pathogenic PRRSV(HP-PRRSV)proliferation by preventing viral binding and ***,individual viral challenge tests revealed that pigs with the E529G mutation had viral loads two orders of magnitude lower than wild-type(WT)pigs,confirming effective resistance to *** of the physiological indicators and scavenger function of CD163 verified no significant differences between the WT and E529G *** findings suggest that E529G pigs can be used for breeding PRRSV-resistant pigs,providing novel insights into controlling future PRRSV outbreaks.

关键词： PRRSV CD163 Point mutation E529G Pigs

Dawn of CAR-T cell therapy in autoimmune diseases

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Chinese Medical Journal 2024年第10期137卷 1140-1150页

作者： Yuxin Liu Minghao Dong Yunhui Chu Luoqi Zhou Yunfan You Xiaowei Pang sheng yang Luyang Zhang Lian Chen Lifang Zhu Jun Xiao Wei Wang Chuan Qin Daishi Tian Department of Neurology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030China Hubei Key Laboratory of Neural Injury and Functional Reconstruction Huazhong University of Science and TechnologyWuhanHubei 430030China

Chimeric antigen receptor(CAR)-T cell therapy has achieved remarkable success in the treatment of hematological *** on the immunomodulatory capability of CAR-T cells,efforts have turned toward exploring their potential in treating autoimmune *** analysis of 210 records from 128 academic journals published by 372 institutions in 40 countries/regions indicates a growing number of publications on CAR-T therapy for autoimmune diseases,covering a range of subtypes such as systemic lupus erythematosus,multiple sclerosis,among ***-T therapy holds promise in mitigating several shortcomings,including the indiscriminate suppression of the immune system by traditional immunosuppressants,and non-sustaining therapeutic levels of monoclonal antibodies due to inherent pharmacokinetic *** persisting and proliferating in vivo,CAR-T cells can offer a tailored and precise *** paper reviewed preclinical experiments and clinical trials involving CAR-T and CAR-related therapies in various autoimmune diseases,incorporating innovations well-studied in the field of hematological tumors,aiming to explore a safe and effective therapeutic option for relapsed/refractory autoimmune diseases.

关键词： CAR-T cell therapy Autoimmune disease Immunotherapy Multiple sclerosis Neuromyelitis optica spectrum disorder Systemic lupus erythematosus

In vivo study of the effect of anlotinib on the stemness of the lenvatinib-resistant hepatocellular carcinoma cells and the underlying mechanisms

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Oncology and Translational Medicine 2024年第1期10卷 4-12页

作者： Jing Zhan Shu Huang Bai Wei Zao-Zao Huang sheng-Li yang Division of Oncology Tianyou Hospital Affiliated to Wuhan University of Science and TechnologyWuhanChina Department of Hepatology of Integrated Traditional Chinese and Western Medicine The Third People's Hospital of Hubei Province Affiliated to Jianghan UniversityWuhanChina Division of Oncology Liyuan HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina yangchunhu Community Hospital Liyuan HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Cancer Center Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Hubei Key Laboratory of Precision Radiation Oncology WuhanChina Institute of Radiation Oncology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina

Background:In vivo experiments were conducted to examine the effects of the targeted drug anlotinib on the stemness of hepatocellular carcinoma(HCC)cells and lenvatinib-resistant liver cancer cells and to explore the underlying molecular ***:A subcutaneous xenograft model of Hep3B-derived HCC was established in nude mice,which were randomly divided into 2 groups(n=5 males per group):(1)intragastric administration of anlotinib(0.4 mg/kg)and(2)intragastric administration of normal *** constructed lenvatinib-resistant cell lines and randomly divided the mice into 3 groups(n=5 males per group):(1)intragastric administration of anlotinib,(2)intragastric administration of lenvatinib,and(3)intragastric administration of normal *** 2 weeks of treatment,tumor tissues were harvested,and mRNA and proteins were isolated from the *** in the expression of cancer stemness markers(epithelial cell adhesion molecule[EpCAM],CD13,CD90,aldehyde dehydrogenase 1[ALDH1],CD44,and CD45),totipotency factors(sex-determining region Y-box 2[Sox2],Nanog,octamer-binding transcription factor 4[Oct4]),and genes related to the Notch signaling pathway were ***:Compared with that in the control group,tumor size and weight were reduced in nude mice treated with *** differences were statistically significant in both the types of nude *** affected stemness markers and totipotency factors by downregulating the expression of CD133,CD90,and G-protein–coupled receptor 5(LGR5)and upregulating the expression of intercellular adhesion molecule 1(ICAM-1)and *** addition,lenvatinib-resistant cell lines increased Notch signaling pathway,whereas anlotinib inhibited Notch signaling ***:The antitumor effect of anlotinib on HCC and lenvatinib-resistant HCC cellsmay occur through inhibition of the Notch signaling *** may be the drug of choice for sequential therapy in lenvatinib-resistant liver cancer.

关键词： Anlotinib HCC Lenvatinib-resistant Notch signaling pathway

三区视角下长江中游城市群国土空间格局演化及驱动力分析

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长江流域资源与环境 2024年第7期33卷 1489-1503页

作者：魏超吴洲叶圣魏馨月杨剩富湖北大学公共管理学院湖北武汉430062 中国地质大学(武汉)公共管理学院湖北武汉430074 中国地质大学(武汉)经济管理学院湖北武汉430074 湖北大学湖北县域治理研究院湖北武汉430062

长江中游城市群是中国高质量发展的重要增长极,识别该区域不同经济发展梯度下国土空间格局演变的时空特征及驱动力,对于优化国土空间格局、推动区域协调发展具有重要意义。借助国土空间转移矩阵、标准差椭圆、核密度分析、空间计量模型... 详细信息

长江中游城市群是中国高质量发展的重要增长极,识别该区域不同经济发展梯度下国土空间格局演变的时空特征及驱动力,对于优化国土空间格局、推动区域协调发展具有重要意义。借助国土空间转移矩阵、标准差椭圆、核密度分析、空间计量模型等方法,揭示1990~2020年长江中游城市群不同经济发展阶段下国土空间格局演变特征及驱动机制。主要结论如下:(1)长江中游城市群国土空间类型主要占比从高到低依次为生态空间、农业空间、城镇空间;不同发展阶段下国土空间格局变化特征存在显著差异。(2)城镇-农业-生态空间互竞形成了“一增双减”的国土空间格局,且随着经济发展阶段的提升,不同国土空间类型间呈现出更加繁杂多样的转换模式,耕地、绿地也越容易流失。(3)城镇空间由主核数量较少且集聚特征不明显转变为多核扩散且高值区增加,重心变化较为剧烈;农业空间次核数量增加,高值区域明显减少,空间破碎化程度较高,重心变动较为稳定;生态空间的核密度由空间集中转变为空间破碎,西北地区变化较为明显。(4)国土空间格局形成受到自然、人口、经济等多重因素驱动,各因素对不同空间的影响程度及方向存在差异。应充分考虑长江中游城市群未来发展定位,加强国土空间分类管理,协调国土空间格局各驱动因素,以期为新时代长江中游城市群“三区”空间协调健康可持续发展提供理论依据和决策参考。

关键词：国土空间城镇-农业-生态空间格局演变驱动力长江中游城市群

The energy response of LaBr_(3)(Ce),LaBr_(3)(Ce,Sr),and NaI(Tl)crystals for GECAM

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Nuclear Science and Techniques 2024年第2期35卷 110-122页

作者： Pei-Yi Feng Xi-Lei Sun Zheng-Hua An Yong Deng Cheng-Er Wang Huang Jiang Jun-Jie Li Da-Li Zhang Xin-Qiao Li Shao-Lin Xiong Chao Zheng Ke Gong sheng yang Xiao-Jing Liu Min Gao Xiang-yang Wen Ya-Qing liu Yan-Bing Xu Xiao-Yun Zhao Jia-Cong Liu Fan Zhang Hong Lu Particle and Astrophysics Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China Experimental Physics Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China School of Nuclear Science and Technology University of South ChinaHengyang 421001China National Engineering Research Center for Rare Earth Grirem Advanced Materials Co.Ltd.and General Research Institute for Nonferrous MetalsBeijing 100088China

The GECAM series of satellites utilizes LaBr_(3)(Ce),LaBr_(3)(Ce,Sr),and NaI(Tl)crystals as sensitive materials for gamma-ray detectors(GRDs).To investigate the nonlinearity in the detection of low-energy gamma rays and address the errors in the calibration of the E-C relationship,comprehensive tests and comparative studies of the three aforementioned crystals were conducted using Compton electrons,radioactive sources,and mono-energetic *** nonlinearity test results of the Compton electrons and X-rays demonstrated substantial differences,with all three crystals presenting a higher nonlinearity for X/-rays than for Compton *** the LaBr_(3)(Ce)and LaBr_(3)(Ce,Sr)crystals having higher absolute light yields,they exhibited a noticeable nonlinear decrease in the light yield,especially at energies below 400 *** NaI(Tl)crystal demonstrated an"excess"light output in the 6-200 keV range,reaching a maximum"excess"of 9.2%at 30 keV in the X-ray testing and up to 15.5%at 14 keV during Compton electron testing,indicating a significant advantage in the detection of low-energy gamma ***,we explored the underlying causes of the observed nonlinearity in these *** study not only elucidates the detector responses of GECAM,but also initiates a comprehensive investigation of the nonlinearity of domestically produced lanthanum bromide and sodium iodide crystals.

关键词： LaBr_(3)(Ce)detector LaBr_(3)(Ce,Sr)detector NaI(Tl)detector GECAM Energy response Light yield nonlinearity

Risk factors and clinical significance of posterior slip of the proximal vertebral body after lower lumbar fusion

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World Journal of Clinical Cases 2024年第26期12卷 5885-5892页

作者： Jia-Jun Zhu Yi Wang Jun Zheng sheng-yang Du Lei Cao Yu-Ming yang Qing-Xi Zhang Ding-Ding Xie Department of Spinal Surgery Xuzhou First People’s HospitalXuzhou 221112Jiangsu ProvinceChina Department of Spinal Surgery The Affiliated Xuzhou Municipal Hospital of Xuzhou Medical UniversityXuzhou 221112Jiangsu ProvinceChina Department of Spinal Surgery The Affiliated Hospital of China University of Mining and TechnologyXuzhou 221112Jiangsu ProvinceChina

BACKGROUND Adjacent segment disease(ASD)after fusion surgery is frequently manifests as a cranial segment instability,disc herniation,spinal canal stenosis,spondylolisthesis or *** risk factors and mechanisms of ASD have been widely discussed but never clearly *** To investigate the risk factors and clinical significance of retrograde movement of the proximal vertebral body after lower lumbar *** This was a retrospective analysis of the clinical data of patients who underwent transforaminal lumbar interbody fusion surgery between September 2015 and July 2021 and who were followed up for more than 2 ***-one patients with degenerative lumbar diseases were included(22 males and 69 females),with an average age of 52.3 years(40-73 years).According to whether there was retrograde movement of the adjacent vertebral body on postoperative X-rays,the patients were divided into retrograde and nonretrograde *** sagittal parameters of the spine and pelvis were evaluated before surgery,after surgery,and at the final *** the same time,the Oswestry Disability Index(ODI)and Visual Analogue Scale(VAS)were used to evaluate the patients’quality of *** Nineteen patients(20.9%)who experienced retrograde movement of proximal adjacent segments were included in this *** pelvic incidence(PI)of the patients in the retrograde group were significantly higher than those of the patients in the nonretrograde group before surgery,after surgery and at the final follow-up(P<0.05).There was no significant difference in lumbar lordosis(LL)between the two groups before the operation,but LL in the retrograde group was significantly greater than that in the nonretrograde group postoperatively and at the final *** significant differences were detected in terms of the|PI–LL|,and there was no significant difference in the preoperative lordosis distribution index(LDI)between the two *** LDIs of the retrograde group were

关键词： Adjacent segment disease Posterior vertebral slip Sagittal alignment of spine-pelvis Lower lumbar fusion Quality of life

二极管激光辅助治疗种植体周围疾病的Meta分析

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应用激光 2024年第2期44卷 144-153页

作者：杨侨李雨舟杨生重庆医科大学附属口腔医院重庆401147 口腔疾病与生物医学重庆市重点实验室重庆401147 重庆市高校市级口腔生物医学工程重点实验室重庆401147

为系统性评价二极管激光辅助治疗种植体周围疾病的临床疗效,检索中国知网、万方、维普和中国生物医学文献数据库、PubMed、Embase、Cochrane Library等数据库中关于二极管激光辅助治疗种植体周围疾病的文献,检索时间从建库至2022年6月。... 详细信息

为系统性评价二极管激光辅助治疗种植体周围疾病的临床疗效,检索中国知网、万方、维普和中国生物医学文献数据库、PubMed、Embase、Cochrane Library等数据库中关于二极管激光辅助治疗种植体周围疾病的文献,检索时间从建库至2022年6月。由2位评价者独立鉴别、分析、评估相关文献后采用RevMan5.4进行Meta分析。最终筛选纳入文献8篇,Meta分析结果显示:相较于单纯机械清创治疗,二极管激光辅助治疗种植体周围疾病能显著减少治疗后3个月的牙周探诊深度(PD)[MD=-0.28,95%CI:(-0.46,-0.10),P=0.002],能有效减少3个月后的菌斑指数(PI)[MD=-0.13,95%CI:(-0.21,-0.05),P=0.002],能明显减少3个月后的出血指数(BI)[MD=-0.42,95%CI:(-0.83,-0.01),P=0.05],也能改善治疗3个月后的探诊出血指数(BOP)[MD=-1.81,95%CI:(-2.53,-1.08),P0.05)。现有证据表明,二极管激光辅助治疗种植体周围疾病仅在3个月的短期观察随访中有效。

关键词：二极管激光种植体周围炎种植体细菌感染种植体骨缺损 Meta分析

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基于非对称多项式拟合的光谱波纹系数算法

光谱学与光谱分析 2024年第5期44卷 1283-1290页

作者：孙胜琳徐宏杰杨晟旻方佳豪梁佳辉北京航空航天大学仪器科学与光电工程学院北京100191

在光纤陀螺中,常采用超辐射发光二极管(SLD)或放大自发辐射(ASE)光源,其较宽的光谱可有效抑制偏振噪声及背向反射、瑞利散射等影响。在SLD及ASE光源中,波纹系数是一项重要指标,其主要来自于宽带光源中未完全抑制掉的激射部分,会对光纤... 详细信息

在光纤陀螺中,常采用超辐射发光二极管(SLD)或放大自发辐射(ASE)光源,其较宽的光谱可有效抑制偏振噪声及背向反射、瑞利散射等影响。在SLD及ASE光源中,波纹系数是一项重要指标,其主要来自于宽带光源中未完全抑制掉的激射部分,会对光纤陀螺的精度产生影响。目前在国军标中对波纹系数的定义是:光谱曲线峰值波长附近的模式幅值的极差,单位为dB。目前对波纹系数还是采用人眼观察的方法,人眼观察具有一定的主观性和偶然性,不能排除人们主观因素以及外界干扰带来的测量误差,并且经过处理后得到的对数光谱不能准确反映原始光谱特性。针对宽带光源非对称光谱中的波纹系数进行分析,对比多峰高斯拟合和多项式拟合各自的优缺点,选择多项式拟合的方式;通过理论分析及实验验证,采用五次多项式拟合满足要求。基于三倍标准差原理提出了一种新的波纹系数计算方法,可以准确反映波纹系数大小。采用AQ6370D光谱仪和自制的“光谱波纹系数测试”软件对ASE光源和SLD光源进行实验,计算结果与人眼观察数据基本吻合。在此基础上进行重复性验证实验,采集同一光源的五次实验数据,分别计算其波纹系数,并与人眼观察结果比较,结果表明人眼观察只能估算到小数点后两位,而光谱波纹系数算法精度较高,分辨率可达0.0001。自制的“光谱波纹系数测试”软件可以在交互界面上得到测试光谱的平均波长、峰值波长、中心波长、谱宽、波纹系数、线性坐标和对数坐标下的光谱及其拟合曲线表达式,使实验分析更加方便快捷,大大提高了实验效率。提出的基于非对称多项式拟合的光谱波纹系数算法可以更有效地对光源波纹系数进行判断,提高了计算效率,消除了主观性和偶然性的影响,对国军标进行了补充,有较为广阔的应用前景。

关键词：波纹系数多项式拟合光谱拟合光源