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基于自适应填充准则的昂贵约束优化算法

太原科技大学学报 2024年第4期45卷 329-335页

作者：谭瑛常圣方孙超利李晓波太原科技大学计算机科学与技术学院太原030024

近年来,代理模型辅助的优化算法用于求解昂贵约束问题逐渐受到关注。这类算法中,选择个体进行真实昂贵约束和目标函数计算的策略将直接影响算法的求解结果。但目前的算法对模型更新操作不够严谨,为了解决在昂贵评价次数有限的情况下获... 详细信息

近年来,代理模型辅助的优化算法用于求解昂贵约束问题逐渐受到关注。这类算法中,选择个体进行真实昂贵约束和目标函数计算的策略将直接影响算法的求解结果。但目前的算法对模型更新操作不够严谨,为了解决在昂贵评价次数有限的情况下获得较好的可行解。该算法提出了利用可行规则法进行环境选择,并根据到目前为止是否找到可行解提出一种自适应的填充准则。该方法填充准则思路是:当样本库没有找到可行解时,利用可行性概率选择概率最大的个体进行真实评价。否则若至少找到一个可行解时,选择约束期望提高值最大的个体进行真实的昂贵目标函数和约束函数评价。该方法提高了高斯过程模型的准确度和进化种群的收敛能力。在实验对比上,10个测试函数和工字梁设计优化问题上的运行结果表明,该算法相比于已有针对昂贵约束优化问题的求解算法具有更好的寻优能力。

关键词：代理模型约束优化可行性概率约束期望提高

基于应变测量的桩基础轴力和横向变形同步监测方法

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广州建筑 2024年第4期52卷 43-47页

作者：乔升访曾繁良陈航侯景强广州市建筑科学研究院集团有限公司广州510440 广州建筑股份有限公司广州510000 中国建筑第二工程局有限公司北京100160

深厚软土层地区超长桩基础的轴向受力、水平变形对工程结构正常使用与安全性起着重要影响,而实现二者同步监测尚无可用方法。本文提出基于应变测量的桩基础轴向压力和水平位移同步监测方法,以应变片感知应变变化来反映桩基础轴向压力和... 详细信息

深厚软土层地区超长桩基础的轴向受力、水平变形对工程结构正常使用与安全性起着重要影响,而实现二者同步监测尚无可用方法。本文提出基于应变测量的桩基础轴向压力和水平位移同步监测方法,以应变片感知应变变化来反映桩基础轴向压力和水平位移情况,通过振弦式钢筋计进行验证。依托某立交桥工程,建立深厚软土层超长桩基础无线智能监测系统,采用无线智能采集仪采集传感器数据,借助于Lora模块形成局域网并汇总各传感器的监测数据,再通过4G模块将汇总数据上传至云平台。通过无线监测数据与传统采集器数据进行对比,发现二者数据误差在微小(0.3 Hz)以内,表明无线智能监测系统可靠性好、精度高;传统振弦式钢筋计所测应变与智能测斜管的误差在-11.32%~6.03%之间,表明智能测斜管具有较高的准确度和稳定性,采用智能测斜管进行桩基础受力性能监测是可行的。研究可为桩基础轴向压力和水平位移监测提供新的思路。

关键词：深厚软土层超长桩基础智能测斜管无线智能监测系统云平台

Expression level of augmenter of liver regeneration in patients with hepatic failure and hepatocellular carcinoma

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Hepatobiliary & Pancreatic Diseases International 2010年第5期9卷 492-498页

作者： Yu, Hai-Ying Xiang, Dai-Rong Huang, Hai-Jun Li, Jun sheng, Ji-fang Zhejiang Univ Sch Med Affiliated Hosp 1 Dept Infect Dis Hangzhou 310003 Zhejiang Peoples R China Zhejiang Univ Sch Med Affiliated Hosp 1 Key Lab Infect Dis Hangzhou 310003 Zhejiang Peoples R China

BACKGROUND: Augmenter of liver regeneration (ALR) is an important polypeptide in the process of liver regeneration. This study aimed to determine the expression level of ALR in different liver diseases and its significance. METHODS: We prepared murine polyclonal antibody against ALR protein from Balb/C mice and purified the IgG fraction, which specifically combined to ALR protein as shown by Western blotting. Serum ALR levels in patients with hepatocellular carcinoma (HCC), hepatic failure (HF), chronic hepatitis B, and healthy persons were compared by ELISA. ALR mRNA expression levels in liver tissues in some of these patients were also compared by real-time RT-PCR. Immunohistochemical analysis was carried out on HF and HCC liver tissues. RESULTS: Different serum ALR levels foreshowed completely different prognoses in 18 HF patients. Higher ALR levels were noted in 6 improved patients (1613.5+/-369.6 pmol/ml) than in 12 deteriorating patients (462.3+/-235.8 pmol/m1). Similar levels were found in 20 HCC patients (917.9+/-332. 7 pmol/m1), 24 chronic hepatitis B patients (969.2+/-332.5 pmol/ml) and 10 healthy persons (806.9+/-240.8 pmol/ml). ALR mRNA levels in HCC liver tissues [10E6.24 (1.74x10(6)) copies/mu l] were much higher than in those of HF patients receiving orthotopic liver transplantation [10E3.45 (2.82x10(3)) copies/mu l] or in healthy liver tissues [10E4.31 (2.04x10(4)) copies/mu l]. In immunohistochemical analysis, positive immunostaining in HCC liver tissue was more intense than that in HF liver tissue. CONCLUSION: Serum ALR level is helpful in estimating the survival time of patients with HF, and ALR may play an important role in hepatocarcinogenesis.

关键词： liver regeneration expression level hepatic failure hepatocellular carcinoma chronic hepatitis B

Primary acinic cell carcinoma of the breast: A case report and review of literature

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World Journal of Clinical Cases 2024年第1期12卷 196-203页

作者： Jia-sheng Ding Min Zhang fang-fang Zhou Department of Intensive Care Unit Lishui Central HospitalThe Fifth Affiliated Hospital of Wenzhou Medical UniversityLishui 323000Zhejiang ProvinceChina Department of Pathology Lishui Central HospitalThe Fifth Affiliated Hospital of Wenzhou Medical UniversityLishui 323000Zhejiang ProvinceChina Department of Ultrasound Lishui Central HospitalThe Fifth Affiliated Hospital of Wenzhou Medical UniversityLishui 323000Zhejiang ProvinceChina

BACKGROUND In the current World Health Organization classification,acinic cell carcinoma(AcCC)of the breast is considered a rare histological subtype of triple-negative breast *** of the few reports in the literature,data concerning clinical outcomes are ***,we report a case of AcCC of the breast in a 48-year-old woman.A 48-year-old woman with a mass in her right breast came to our hospital for further *** and an ultrasound(US)scan showed a mass in the upper inner side of the right *** then underwent surgery to resect the mass in her right *** pathological examination revealed that the tumor had abundant acinar-like structures formed by tumor cells with prominent eosinophilic granules in the cytoplasm,consistent with acinar cell *** results of immunohistochemical analysis supported the diagnosis of breast acinar cell *** months later,she underwent breast-conserving surgery and sentinel lymph node *** pTNM stage was *** surgery,the patient received 30 radiotherapy *** patient was followed up for a period of one year,and no recurrence was *** of the breast is a rare type of malignant *** it is usually asym-ptomatic and can be detected by imaging studies,routine breast US or mamm-ograms are ***,there are no characteristic diagnostic imaging findings or clinical manifestations,so immunohistochemical examination is critical for an accurate diagnosis of AcCC of the breast.

关键词： Acinic cell carcinoma Breast Malignant tumor Immunohistochemical Surgery Case report

A CONSERVATIVE UNSTRUCTURED STAGGERED GRID SCHEME FOR INCOMPRESSIBLE NAVIER-STOKES EQUATIONS

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Journal of Hydrodynamics 2010年第2期22卷 173-184页

作者： LV Biao JIN sheng AI Cong-fang State Key Laboratory of Coastal and Offshore Engineering Dalian University of Technology Dalian 116024China Key Laboratory of Engineering Sediment of Ministry of Communications Tianjin Research Institute for WaterTransport Engineering Tianjin 300456 China

A finite-volume formulation is proposed to solve the three-dimensional,non-hydrostatic Navier-Stokes equations on an unstructured,staggered,z-lever grid,with the goal of simulating non-hydrostatic processes in the free-surface *** advection and diffusion terms in the momentum equation are discretized explicitly with the Eulerian scheme,which has the attractive property of being *** integral method of the top-layer pressure is applied to account for the full effects of non-hydrostatic pressure at the free-surface *** is shown that the results obtained with a small number of vertical layers（e.g.,2-3 layers） are in good agreements with experimental data or analytical solutions,demonstrating the efficiency and accuracy of the model in simulating a range of free-surface flow problems including wave motion and tide-induced motion.

关键词： unstructured staggered grid finite-volume formulation non-hydrostatic free surface flows

Synthesis and Crystal Structure of a Novel Manganese Coordination Polymer: 2,5-Bis(4-pyridyl)-3,4-diaza-2,4-hexadiene

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Chinese Journal of Structural Chemistry 2007年第2期26卷 219-223页

作者： CHEN Man-sheng DENG Yi-fang ZHANG Chun-Hua KUANG Dai-Zhi FENG Yong-Lan PENG Yun-Lin Department of Chemistry and Materials Science Hen gyan g Normal University Hen gyan g 421008 China

A new manganese coordination polymer 1, [Mn（H2O）4（L）]n（ClO4）2n.2nH2O.3nL （L = 2,5-bis（4-pyridyl）-3,4-diaza-2,4-hexadiene）, has been synthesized and structurally characterized. The crystal structure was determined by single-crystal X-ray diffraction. The crystal is of monoclinic, space group Pn with a = 13.9176（8）, b = 15.4754（9）, c = 15.9670（9） A, β = 99.5010（10）°, V = 3391.8（3） ]k3, Z = 2, C56H68C12MnN16O14, Mr= 1315.10, Dc = 1.288 g/cm^3,μ = 0.344 mm^-1, F（000） = 1374, R = 0.0733 and wR = 0.2035. In the crystal the manganese atom is six-coordinated by two nitrogen atoms from 2,5-bis（4-pyridyl）-3,4-diaza-2,4-hexadiene and four oxygen atoms from water molecules, completing an octahedral geometry. The title complex exhibits a novel supramolecular layer architecture sustained by the concurrence of coordination bonds, hydrogen bonds, and π-π stacking interactions.

关键词： manganese complex Schiff bases crystal structure

Spatial and Seasonal Variations of Heavy Metals in Wetland Soils of the Tidal Flats in the Yangtze Estuary, China: Environmental Implications

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Pedosphere 2013年第4期23卷 511-522页

作者： HU Xue-Feng DU Yan FENG Jian-Wei fang sheng-Qiong GAO Xiao-Jiang XU Shi-Yuan Department of Environmental Science and Engineering School of Environmental and Chemical EngineeringShanghai University Department of Environmental Science and Engineering Fuzhou University Department of Environmental Science and Engineering Fudan University Department of Geography East China Normal University

The environment of estuarine wetlands has been attracting worldwide attention. To study the spatial distribution of pollutants in the tidal flats of the Yangtze Estuary, Southeast China, the Eastern Tidal Flat of Chongming Island (EC) and the Jiuduansha Shoal (JS) of the estuary were selected as the study sites. At each of the two sites, a cross-transect from land to sea was established and topsoil and soil core samples in the cross-transect were collected spatially and seasonally to determine their contents of heavy metals (Cu, Zn, Pb, Cd, Cr, Ni, Mn, and Fe) and grain-size characteristics. The results showed that the heavy metal loads were commonly higher in the soils of nearshore high tidal flats and had a tendency of decreasing from land to sea at both of the study sites. The contents of heavy metals in the soils of the high and medial tidal flats were mostly higher in April and November but lower in July. Corresponding spatial and seasonal variations in grain size of the intertidal soils were also observed at the two study sites. The soils in the nearshore high tidal flats were finer and gradually got coarser seawards; they were relatively finer in April and November but coarser in July. Furthermore, the contents of heavy metals in the intertidal soils of both the sites EC and JS were significantly positively correlated with the clay (63 μm) and 20-63 μm fractions, which suggested that the heavy metals in the intertidal soils were primarily combined with the fine particulate fraction (<20 μm), especially clay, and hence the spatial and seasonal variations in heavy metals were actually caused by the change of the grain-size characteristics of the intertidal soils due to the different sedimentary environments in the estuary. The results of this study may also contribute to a better understanding of the soil formation and classification in the tidal flats of the Yangtze Estuary.

关键词： clay fraction grain-size characteristics intertidal soils pollutants sedimentary environments

红芪多糖调控FXR-SHP通路改善糖尿病大鼠肝组织糖脂代谢的研究

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中国临床药理学杂志 2024年第17期40卷 2538-2542页

作者：张磊万生芳李亚玲梁乾坤田一虹马欣欣郭倩甘肃中医药大学基础医学院甘肃兰州730000 甘肃中医药大学公共卫生学院甘肃兰州730000 福建中医药大学中医证研究基地福建福州350122

目的探究红芪多糖(HPS)对糖尿病大鼠肝组织法尼醇X受体(FXR)-小分子异源二聚体伴侣受体(SHP)信号通路及糖脂代谢关键蛋白的影响。方法Wistar雄性大鼠随机选取12只作为空白组,其余60只采用一次性腹腔注射链脲佐菌素(STZ,50 mg·kg^(-1))... 详细信息

目的探究红芪多糖(HPS)对糖尿病大鼠肝组织法尼醇X受体(FXR)-小分子异源二聚体伴侣受体(SHP)信号通路及糖脂代谢关键蛋白的影响。方法Wistar雄性大鼠随机选取12只作为空白组,其余60只采用一次性腹腔注射链脲佐菌素(STZ,50 mg·kg^(-1))联合高糖高脂饮食饲养复制糖尿病大鼠模型。成模大鼠随机分为模型组,阳性对照组(灌胃给予双歧杆菌四联活菌片混悬液400 mg·kg^(-1)·d^(-1)),HPS高、中、低剂量实验组(分别灌胃给予HPS混悬液200、100、50 mg·kg^(-1)·d^(-1)剂量);空白组和模型组灌胃给予等体积纯净水,每日1次,连续8周。灌胃前后测血糖(Glu),用实时荧光聚合酶链反应(RT-PCR)法、蛋白质印迹(Western blot)法分别检测肝组织法尼醇X受体(FXR)、小分子异源二聚体伴侣受体(SHP)、抗过氧化物酶体增殖物激活受体α(PPARα)、抗磷酸烯醇丙酮酸羧化激酶(PEPCK)、甾醇调节原件结合蛋白-1c(SREBP-1c)、抗葡萄糖-6-磷酸酶(G6Pase)mRNA和蛋白相对表达水平。结果正常组、模型组、阳性对照组、HPS高剂量实验组治疗后Glu分别为(7.66±0.61)、(29.25±1.64)、(23.31±3.02)、(19.31±5.13)mmol·L^(-1),肝组织中FXR mRNA相对表达水平分别为1.00±0.04、0.44±0.03、0.61±0.06、0.87±0.03,SHP mRNA相对表达水平分别为1.00±0.04、0.40±0.01、0.67±0.01、0.67±0.02,肝组织中G6Pase mRNA相对表达水平分别为1.00±0.06、3.00±0.08、1.87±0.03、1.44±0.05,肝组织中PEPCK mRNA相对表达水平分别为1.00±0.04、1.88±0.03、1.31±0.02、1.23±0.04,肝组织中SREBP-1c mRNA相对表达水平分别为1.00±0.04、1.90±0.01、1.26±0.03、1.06±0.04,肝组织中PPARαmRNA相对表达水平分别为1.00±0.02、0.16±0.01、0.45±0.01、0.96±0.03;模型组的上述指标与空白组比较,阳性对照组及HPS高剂量组的上述指标与模型组比较,在统计学上差异均有统计学意义(均P<0.01)。FXR、SHP、G6Pase、PEPCK、SREBP-1c、PPARα蛋白表达结果的趋势与mRNA表达一致。结论HPS可能通过调控肝组织FXR-SHP信号通路,抑制糖尿病大鼠肝组织糖脂代谢关键蛋白表达,促进脂质氧化,从而改善血糖,保护肝组织。

关键词：红芪多糖糖尿病法尼醇X受体肝组织糖脂代谢

Experimental study on energy characteristics and ignition performance of recessed multichannel plasma igniter

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Chinese Physics B 2020年第6期29卷 339-348页

作者： Bang-Huang Cai Hui-Min Song Min Jia Yun Wu Wei Cui sheng-fang Huang Science and Technology on Plasma Dynamics Laboratory Air Force Engineering UniversityXi’an 710038China

In the extreme conditions of high altitude,low temperature,low pressure,and high speed,the aircraft engine is prone to flameout and difficult to start secondary ignition,which makes reliable ignition of combustion chamber at high altitude become a worldwide *** solve this problem,a kind of multichannel plasma igniter with round cavity is proposed in this paper,the three-channel and five-channel igniters are compared with the traditional *** discharge energy of the three igniters was compared based on the electric energy test and the thermal energy test,and ignition experiments was conducted in the simulated high-altitude environment of the component combustion *** results show that the recessed multichannel plasma igniter has higher discharge energy than the conventional spark igniter,which can increase the conversion efficiency of electric energy from 26%to 43%,and the conversion efficiency of thermal energy from 25%to 73%.The recessed multichannel plasma igniter can achieve greater spark penetration depth and excitation area,which both increase with the increase of *** the same height,the inlet flow helps to increase the penetration depth of the *** recessed multichannel plasma igniter can widen the lean ignition boundary,and the maximum enrichment percentage of lean ignition boundary can reach 31%.

关键词： high altitude extreme condition recessed multichannel plasma igniter discharge energy lean ignition boundary