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Indigenous Purple Vegetable Extracts Protect against Hydrogen Peroxide-Induced DNA Damage in human Lymphocytes

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Food and Nutrition Sciences 2013年第8期4卷 62-70页

作者： Pi-Yu Chao Wei-Yu huang shene-pin hu Hsiao-Feng Lo Kuan-hung Lin Meng-Yuan huang Tsan-Ru Chang Chi-Ming Yang Department of Food Health and Nutrition Science Chinese Culture University Taipei Taiwan Department of Horticulture and Landscape Architecture National Taiwan University Taipei Taiwan Graduate Institute of Bio- technology Chinese Culture University Taipei Taiwan Institute of Applied Life Science Chinese Culture University Taipei Taiwan Research Center for Biodiversity Academia Sinica Taipei Taiwan School of Nutrition and Health Sciences Taipei Medical University Taipei Taiwan Taoyuan District Agricultural Research and Extension Station Council of Agriculture Executive Yuan Taoyuan Taiwan

The objectives of this study were to identify the antioxidants in acid hydrolysates of six of Taiwan’s indigenous purple-leaved vegetables (IPLV), including purple-leaved sweet potato (Ipomoea batatas L. Lamark), purple-leaved gynura line 1 (Gynura bicolor D.C.), purple-leaved gynura line 2 (Gynura bicolor D.C.), purple-leaved perilla line 1 (Perilla frutescents L. Britton), bicolored-leaved perilla line 2 (Perilla frutescens L. Britton), and heartleaf houttuynia (Houttuynia cordata Thumb.). Their antioxidant activity and ability to protect DNA from oxidative damage was also evaluated. The antioxidants identified included flavonoids, anthocyanidins and flavonols. Both purple-leaved perilla line 1 and bicolored-leaved perilla line 2 were found to be abundant in cynidin, malvidin, and myricetin. Moreover, purple-leaved sweet potato and heartleaf houttuynia were found to be abundant in quercetin. Purple-leaved sweet potato and purple-leaved perilla line 1 contained significantly higher inhibition percentages of conjugated diene formation than other vegetables. Purple-leaved sweet potato, heartleaf houttuynia, purple-leaved perilla line 1, and bicolored-leaved perilla line 2 had better inhibition percentages of tail DNA% and tail moment in the study. In conclusion, the abovementioned four indigenous purple-leaved vegetables abounded in antioxidants had strong antioxidant activity for protecting DNA in lymphocytes from oxidative damages.

关键词： Antioxidant Indigenous Purple-Leaved Vegetables Comet Assay Flavonols Cynidin

Light-Mediated Spatiotemporally Dynamic Assembly of DNA Nanostructures in Living Cells Regulates Autophagy

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CCS Chemistry 2024年第6期6卷 1557-1570页

作者： Rui Zhang pin hu Yuwei Xu Ziqing Wang Dayong Yang Chi Yao Frontiers Science Center for Synthetic Biology Key Laboratory of Systems Bioengineering(MOE)School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300350 Department of Chemistry State Key Laboratory of Molecular Engineering of PolymersShanghai Key Laboratory of Molecular Catalysis and Innovative MaterialsCollege of Chemistry and MaterialsFudan UniversityShanghai 200438

The assembly of exogenous artificial architectures inside cells can regulate a series of biological events,which heavily relies on the development of spatiotemporally controlled molecular assembly *** herein report a designer deoxyribonucleic acid(DNA)nanostructure that enables light-mediated spatiotemporally dynamic assembly in living cells and consequently achieves efficient regulation of cell *** DNA nanostructure was constructed from i-motif moiety-containing branched DNA,photocleavable bond-containing linker,and tumor cell-targeting *** cellular uptake mediated by aptamers,under the spatiotemporal control of both UV light and late endosomal/lysosomal acidic environments,disassembly/reassembly of DNA nanostructure occurred via two rationally designed routes,generating microsized DNA *** a result,autophagy was significantly enhanced with the increase of DNA assembly *** enhanced autophagy showed an impact on related biological *** system is expected to be a powerful tool for the regulation of intracellular events and cellular behaviors.

关键词： DNA nanotechnology DNA hydrogel self-assembly autophagy i-motif

General anesthetic agents induce neurotoxicity through astrocytes

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Neural Regeneration Research 2024年第6期19卷 1299-1307页

作者： Yanchang Yang Tiantian Liu Jun Li Dandan Yan Yuhan hu pin Wu Fuquan Fang Patrick M.McQuillan Wenxin Hang Jianhang Leng Zhiyong hu Department of Anesthesiology The First Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina Department of Anesthesiology Ningbo Women and Children’s HospitalNingboZhejiang ProvinceChina Department of Anesthesiology Shulan(Hangzhou)Hospital Affiliated to Zhejiang Shuren University Shulan International Medical CollegeHangzhouZhejiang ProvinceChina Cell Biology Department Yale UniversityNew HavenCTUSA Department of Anesthesiology Penn State Hershey Medical CentrePenn State College of MedicineHersheyPAUSA Department of Central Laboratory Affiliated Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina

Neuroscientists have recognized the importance of astrocytes in regulating neurological function and their influence on the release of glial *** studies,however,have focused on the effects of general anesthetic agents on neuroglia or *** can also be an important target of general anesthetic agents as they exert not only sedative,analgesic,and amnesic effects but also mediate general anesthetic-induced neurotoxicity and postoperative cognitive ***,we analyzed recent advances in understanding the mechanism of general anesthetic agents on astrocytes,and found that exposure to general anesthetic agents will destroy the morphology and proliferation of astrocytes,in addition to acting on the receptors on their surface,which not only affect Ca^(2+)signaling,inhibit the release of brain-derived neurotrophic factor and lactate from astrocytes,but are even involved in the regulation of the pro-and anti-inflammatory processes of *** would obviously affect the communication between astrocytes as well as between astrocytes and neighboring neurons,other neuroglia,and vascular *** this review,we summarize how general anesthetic agents act on neurons via astrocytes,and explore potential mechanisms of action of general anesthetic agents on the nervous *** hope that this review will provide a new direction for mitigating the neurotoxicity of general anesthetic agents.

关键词： astrocytes brain-derived neurotrophic factor general anesthetic agents neuron neurotoxicity N-methyl-D-aspartate receptor perioperative neurocognition Toll-like receptor γ-aminobutyric acid receptor

Therapeutic effects of Buzhong Yiqi decoction in patients with spleen and stomach qi deficiency after routine surgery and chemotherapy for colorectal cancer

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World Journal of Gastrointestinal Surgery 2024年第7期16卷 2183-2193页

作者： Qi hu Xiao-pin Chen Zhi-Jun Tang Xue-Yuan Zhu Chun Liu College of Integrated Traditional Chinese and Western Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Department of Anorectal Surgery The Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210023Jiangsu ProvinceChina Department of Anorectal Surgery The First Traditional Chinese Medicine Hospital of ChangdeChangde 415000Hunan ProvinceChina Intensive Care Unit The First Traditional Chinese Medicine Hospital of ChangdeChangde 415000Hunan ProvinceChina

BACKGROUND According to the theory of traditional Chinese medicine(TCM),the spleen and stomach are the basis of acquired nature and the source of qi and blood *** surgery and chemotherapy,patients with colorectal cancer often develop spleen and stomach qi deficiency syndrome,leading to decreased immune *** Yiqi decoction,a classic TCM prescription,has the effect of tonifying middle-jiao and invigorating qi,boosting Yang,and suppressing immune-related ***,it is widely used in the treatment of spleen and stomach qi deficiency *** To investigate the effect of Buzhong Yiqi decoction on spleen and stomach qi deficiency in patients with colorectal *** One hundred patients with colorectal cancer who underwent preoperative chemotherapy and laparoscopy at The First TCM Hospital of Changde from January 2022 to October 2023 were retrospectively *** patients were divided equally into control and observation *** groups underwent conventional rehabilitation surgery,and the observation group was supplemented with Buzhong Yiqi *** 26.0 was used for statistical ***χ2 test was used for univariate analysis;independent sample t-tests were used in all *** No significant differences were observed preoperatively in the general characteristics of the two *** days post-surgery,the abdominal distension,emaciation,loose stool,loss of appetite,and vomiting scores were significantly lower in the observation group than in the control group(P<0.05).Immune function and interleukin(IL)-10 levels in the observation group were significantly higher than those of the control group,whereas IL-6,tumor necrosis factor-α,and C-reactive protein levels,tumor biological indexes,and adverse reactions in the observation group were significantly lower than those of the control group(P<0.05).One month after surgery,the patients’quality of life in the observation group was significantly high

关键词： Buzhong Yiqi decoction Colorectal cancer Laparoscopic radical surgery Immune function Inflammatory mediators Spleen

Pentacoordinate Phosphoranes as Versatile Reagents in Fluoroalkylation Reactions

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CCS Chemistry 2024年第1期6卷 165-176页

作者： huanhuan Song Weihao Li Xiaoying Wang Kaiteng Wang Jingwen Li Shuai Liu pin Gao Xin-hua Duan Jinbo hu Mingyou hu School of Chemistry Engineering Research Center of Energy Storage Materials and DevicesMinistry of EducationXi’an Key Laboratory of Sustainable Energy Material ChemistryXi’an Jiaotong UniversityXi’an 710049 Key Laboratory of Organofluorine Chemistry Center for Excellence in Molecular SynthesisShanghai Institute of Organic ChemistryUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200032

A general method for the synthesis of bench-stable bis(difluoromethyl)pentacoordinate phosphoranes has been *** reaction is rapid,operationally simple,and easily *** pentacoordinate phosphoranes can generate both difluoromethyl radical(·CF_(2)H)and difluorocarbene(:CF_(2))***,a variety of fluoroalkylation transformations havebeen achieved by·CF_(2)H,such asoxidativedifluoromethylation of electron-deficient heterocycles,nickel/photoredox dual-catalyzed difluoromethylation of aryl bromides,and photoredox difluoromethylation of alkenes,or by:CF_(2),such as gem-difluorocyclopropanation of alkenes,base-promoted difluoromethylation of heteroatom nucleophiles,Pd-catalyzed difluoromethylation of arylboronic acids,and Cu-mediated trifluoromethylation of aryl iodides(via:CF_(2) and recombined CF_(3)-).These fluoroalkylation methods have been successfully applied to late-stage fluoroalkylation of drugs and drug-like molecules.

关键词： pentacoordinate phosphorane difluoromethyl radical difluorocarbene difluoromethylation fluoroalkylation

High-efficiency gene editing in Anopheles sinensis using ReMOT control

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Insect Science 2024年第1期31卷 307-312页

作者： Xiao-lin Yang Xia Ling Quan Sun pin-pin Qiu Kai Xiang Jun-feng Hong Shu-lin He Jie Chen Xin Ding Hai hu Zheng-bo He Cao Zhou Bin Chen Liang Qiao Chongqing Key Laboratory of Vector Insects Institute of Entomology and Molecular BiologyCollege of Life SciencesChongqing Normal UniversityChongqingChina Xunjian Life Science&Technology Co.Ltd. ChongqingChina State Key Laboratory of Resource Insects Southwest UniversityChongqingChina

Dear editor,Functional genomics studies of mosquito vectors are crucial for understanding their physiological behavior,pathogen transmission,and evolution,and for providing essential molecular targets for genetic control(Severson&Behura,201l;Alphey,2014;Ruzzante et al.,2019;Hong et al.,2022).The main methods involve clustered regularly interspaced palindromic repeats(CRISPR)/CRISPR-associated protein 9(Cas9)gene editing via embryo microinjection(Criscione et al.,2015;Kistler et al.,2015).

关键词： editor editing injection

Predicting the strut forces of the steel supporting structure of deep excavation considering various factors by machine learning methods

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Underground Space 2024年第5期18卷 114-129页

作者： Haibo hu Xunjian hu Xiaonan Gong Research Center of Coastal and Urban Geotechnical Engineering Zhejiang UniversityHangzhou 310058China

The application of steel strut force servo systems in deep excavation engineering is not widespread,and there is a notable scarcity of in-situ measured *** presents a significant research gap in the *** this,our study introduces a valuable dataset and application scenarios,serving as a reference point for future *** main objective of this study is to use machine learning(ML)methods for accurately predicting strut forces in steel supporting structures,a crucial aspect for the safety and stability of deep excavation *** employed five different ML methods:radial basis function neural network(RBFNN),back propagation neural network(BPNN),K-Nearest Neighbor(KNN),support vector machine(SVM),and random forest(RF),utilizing a dataset of 2208 measured *** points included one output parameter(strut forces)and seven input parameters(vertical position of strut,plane position of strut,time,temperature,unit weight,cohesion,and internal frictional angle).The effectiveness of these methods was assessed using root mean square error(RMSE),correlation coefficient(R),and mean absolute error(MAE).Our findings indicate that the BPNN method outperforms others,with RMSE,R,and MAE values of 72.1 kN,0.9931,and 57.4 kN,respectively,on the testing *** study underscores the potential of ML methods in precisely predicting strut forces in deep excavation engineering,contributing to enhanced safety measures and project planning.

关键词： Deep excavation Steel supporting structure Strut forces Machine learning Time Temperature

The super-cycle of the global land-monsoon system

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National Science Review 2024年第5期11卷 107-109页

作者： Yongyun hu Laboratory for Climate and Ocean-Atmosphere Studies Department of Atmospheric and Oceanic Sciences School of Physics Peking University

The modern monsoon system consists of six regional monsoons [1]. These regional monsoons demonstrate coherently annual variations of precipitation and atmospheric circulation patterns, although they have different characteristics. Therefore, these regional monsoons are unified in the context of the global monsoon [1,2], which reflects the dominant mode of coherent annual variations of precipitation and atmospheric circulations in the tropics and subtropics.

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R-matrix for the 8-Dimensional Spin Representation of Uq(so7)

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Acta Mathematica Sinica,English Series 2024年第2期40卷 485-497页

作者： Hong Mei hu Nai Hong hu School of Mathematical Sciences Suzhou University of Science and TechnologySuzhou 215009P.R.China School of Mathematical Sciences MOE Key Laboratory of Mathematics and Engineering Applications&Shanghai Key Laboratory of PMMPEast China Normal UniversityShanghai 200241P.R.China

The purpose of the paper is to describe the solution to the quantum Yang-Baxter equation associated with the 8-dimensional spin representation Tsp of Uq(so7).The self-duality of Tsp and the symmetry of the corresponding braiding matrix are ***,the minimal polynomial of the braiding R-matrix of Tsp is presented explicitly in an ingenious method by taking advantage of nice features of the spin representation Tsp.

关键词： Braiding R-matrix spin module minimal polynomial