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High multiple mutations of Plasmodium falciparum-resistant genotypes to sulphadoxine-pyrimethamine in Lagos, Nigeria

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Infectious Diseases of Poverty 2020年第4期9卷 152-153页

作者： Hong Quan Uche Igbasi Wellington Oyibo Sunday Omilabu shen-bo chen Hai-Mo shen Chukwuma Okolie Jun-Hu chen Xiao-Nong Zhou National Institute of Parasitic Diseases Chinese Center for Disease Control and PreventionChinese Center for Tropical Diseases ResearchWHO Collaborating Center for Tropical DiseasesNational Centre for International Research on Tropical DiseasesMinistry of Science and TechnologyKey Laboratory of Parasite and Vector BiologyMinistry of HealthShanghai200025People’s Republic of China National Institute of Parasitic Diseases Chinese Center for Disease Control and Prevention-Shenzhen Center for Disease Control and Prevention Joint Laboratory for Imported Tropical Disease ControlShanghai200025People’s Republic of China Center for Infectious Diseases Research Microbiology DepartmentNigerian Institute of Medical Research6 Edmund CrescentYabaLagosNigeria ANDI Center of Excellence for Malaria Diagnosis Department of Medical Microbiology and ParasitologyCollege of MedicineUniversity of LagosLagosNigeria Department of Medical Microbiology and Parasitology College of MedicineUniversity of LagosLagosNigeria Department of Surveying and Geoinformatics Faculty of EngineeringUniversity of LagosLagosNigeria

Background Plasmodium falciparum-resistance to sulphadoxine-pyrimethamine(SP)has been largely reported among pregnant ***,the profile of resistance markers to SP dihydrofolate reductase(dhfr)and dihydropteroate synthase(dhps)in the general population are varied and not frequently ***,SP is used as partner drug for artemisinin combination therapy(SP-artesunate)in some sub-Saharan African countries or as a prophylactic drug in intermittent preventive treatment of malaria during pregnancy and infants and in seasonal malaria chemoprevention(SMC).Profiling of ***-resistant genotypes to SP is dynamic and critical in providing data that would be useful for malaria control *** study assessed the profile of dhfr and dhps genes genotypes among individuals with malaria in Lagos,*** Molecular markers of SP resistance were identified by nested PCR and sequenced among malaria positive dried blood spots(DBS)that were collected from individuals attending health facilities from January 2013 to February 2014 and during community surveys from October 2010 to September 2011 across different Local Government Areas of Lagos State,*** A total of 242 and 167 samples were sequenced for dhfr and dhps,*** analysis of dhfr showed that 95.5%(231/242),96.3%(233/242)and 96.7%(234/242)of the samples had N51I,C59R and S108N mutant alleles,*** prevalence of dhps mutation at codons A437G,A613S,S436A,A581G,I431V and K540E were 95.8%(160/167),41.9%(70/167),41.3%(69/167),31.1%(52/167),25.1%(42/167),and 1.2%(2/167)*** prevalence of triple mutations(CIRNI)in dhfr was 93.8%and 44.3%for the single dhps haplotype mutation(SGKAA).Partial SP-resistance due to quadruple dhfr-dhps haplotype mutations(CIRNI-SGKAA)and octuple haplotype mutations(CIRNI-VAGKGS)with rate of 42.6%and 22.0%,respectively has been *** There was increased prevalence in dhfr triple haplotype mutations when com

关键词： Plasmodium falciparum Antimalarial drug resistance Sulphadoxine-pyrimethamine Dihydrofolate reductase Dihydropteroate synthase

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Novel Adaptive Memory Event-Triggered-Based Fuzzy Robust Control for Nonlinear Networked Systems via the Differential Evolution Algorithm

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IEEE/CAA Journal of Automatica Sinica 2024年第8期11卷 1836-1848页

作者： Wei Qian Yanmin Wu bo shen School of Electrical Engineering and Automation Henan Polytechnic UniversityJiaozuo 454000China College of Information Science and Technology Donghua UniversityShanghai 201620China

This article mainly investigates the fuzzy optimization robust control issue for nonlinear networked systems characterized by the interval type-2(IT2)fuzzy technique under a differential evolution *** provide a more reasonable utilization of the constrained communication channel,a novel adaptive memory event-triggered(AMET)mechanism is developed,where two event-triggered thresholds can be dynamically adjusted in the light of the current system information and the transmitted historical *** conditions with less conservative design of the fuzzy imperfect premise matching(IPM)controller are presented by introducing the Wirtinger-based integral inequality,the information of membership functions(MFs)and slack ***,under the IPM policy,a new MFs intelligent optimization technique that takes advantage of the differential evolution algorithm is first provided for IT2 TakagiSugeno(T-S)fuzzy systems to update the fuzzy controller MFs in real-time and achieve a better system control ***,simulation results demonstrate that the proposed control scheme can obtain better system performance in the case of using fewer communication resources.

关键词： Adaptive memory event-triggered(AMET) differential evolution algorithm fuzzy optimization robust control interval type-2(IT2)fuzzy technique.

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Evolution of anomalous Hall effect in ferromagnetic Weyl semimetal Nb_(x)Zr_(1-x)Co_(2)Sn

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Chinese Physics B 2024年第8期33卷 491-496页

作者：陈博文沈冰 Center for Neutron Science and Technology Guangdong Provincial Key Laboratory of Magnetoelectric Physics and DevicesSchool of PhysicsSun Yat-Sen UniversityGuangzhou 510275China State Key Laboratory of Optoelectronic Materials and Technologies Sun Yat-Sen UniversityGuangzhou 510275China

Magnetic topological semimetal can host various topological non-trivial states leading to exotic novel transport *** we report the systematic magneto-transport studies on the Heusler alloy Nb_(x)Zr_(1-x)Co_(2)Sn considered as a ferromagnetic(FM)Weyl *** cusp anomaly of temperature-dependent resistivity and large isotropic negative magneto-resistivity(MR)emerge around the FM transition consistent with the theoretical half-metallic *** prominent anomalous Hall effect(AHE)has the same behavior with the applied field along various crystal *** Nb doping introduces more disorder resulting in the enhancement of the upturn for the temperature-dependent resistivity in low *** Nb doping,the AHE exhibits systemic evolution with the Fermi level *** the doping level of x=0.25,the AHE mainly originates from the intrinsic contribution related to non-trivial topological Weyl states.

关键词： anomalous Hall effect magnetic Weyl semimetal ferromagnetism

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Recursive Filtering for Stochastic Systems With Filter-and-Forward Successive Relays

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IEEE/CAA Journal of Automatica Sinica 2024年第5期11卷 1202-1212页

作者： Hailong Tan bo shen Qi Li Hongjian Liu School of Mathematics-Physics and Finance Anhui Polytechnic UniversityWuhu 241000China Anhui Future Technology Research Institute Anhui Polytechnic UniversityWuhu 241000China College of Information Science and Technology Donghua UniversityShanghai 201620China Engineering Research Center of Digitalized Textile and Fashion Technology Ministry of EducationShanghai 201620China School of Information Science and Engineering Hangzhou Normal UniversityHangzhou 311121China

In this paper,the recursive filtering problem is considered for stochastic systems over filter-and-forward successive relay(FFSR)*** FFSR is located between the sensor and the remote filter to forward the *** the successive relay,two cooperative relay nodes are adopted to forward the signals alternatively,thereby existing switching characteristics and inter-relay interferences(IRI).Since the filter-and-forward scheme is employed,the signal received by the relay is retransmitted after it passes through a linear *** objective of the paper is to concurrently design optimal recursive filters for FFSR and stochastic systems against switching characteristics and IRI of ***,a uniform measurement model is proposed by analyzing the transmission mechanism of ***,novel filter structures with switching parameters are constructed for both FFSR and stochastic *** the help of the inductive method,filtering error covariances are presented in the form of coupled difference ***,the desired filter gain matrices are further obtained by minimizing the trace of filtering error ***,the stability performance of the filtering algorithm is analyzed where the uniform bound is guaranteed on the filtering error ***,the effectiveness of the proposed filtering method over FFSR is verified by a three-order resistance-inductance-capacitance circuit system.

关键词： filtering successive stochastic

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Co-infections with Babesia microti and Plasmodium parasites along the China-Myanmar border

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Infectious Diseases of Poverty 2013年第1期2卷 188-194页

作者： Xia Zhou sheng-Guo Li shen-bo chen Jia-Zhi Wang Bin Xu He-Jun Zhou Hong-Xiang Zhu Ge Jun-Hu chen Wei Hu National Institute of Parasitic Diseases Chinese Center for Disease Control and PreventionWHO Collaborating Centre for MalariaSchistosomiasis and FilariasisKey Laboratory of Parasite&Vector Biology Ministry of HealthShanghai 200025China Department of Parasitology Medical College of Soochow UniversityNo.199 Renai RoadSuzhou 215123China Tengchong Center for Disease Control and prevention Yunnan province 679100China Department of Microbiology and Microbial Engineering School of Life ScienceFudan UniversityShanghai 200433China

Background:Babesiosis is an emerging health risk in several parts of the ***,little is known about the prevalence of Babesia in malaria-endemic *** area along the China-Myanmar border in Yunnan is a main endemic area of malaria in ***,however,human infection with Babesia microti(***)is not recognized in this region,and its profile of co-infection is not yet ***:To understand its profile of co-infections with ***,our investigation was undertaken in the malaria-endemic area along the China-Myanmar border in Yunnan between April 2012 and June *** parasite species,including ***,Plasmodium falciparum(***),***,and ***,were identified among 449 suspected febrile persons detected by nested polymerase chain reaction(PCR)assay based on small subunit ribosomal ribonucleic acid(RNA)genes of *** and Plasmodium ***:Of all the collected samples from febrile patients,mono-infection with ***,***,***,and *** accounted for 1.8%(8/449),9.8%(44/449),2.9%(13/449),and 0.2%(1/449),*** rate of mixed infections of *** with *** or *** are both 0.2%(1/449),and mixed infections of *** and *** accounted for 1.1%(5/449).Conclusions:This report supports the hypothesis that babesiosis caused by *** is emerging along the China-Myanmar border in the Yunnan province,***,but it was ignored because of low parasitemia or mixed infection with Plasmodium *** sensitive and specific diagnosis methods are needed to find the rapid response mechanism of emergency for babesiosis and malaria co-prevalence areas.

关键词： Babesia Plasmodium Co-infection China-Myanmar border

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Modeling solubility of oxaprozin and irbesartan in biorelevant complex solutions based on a combination of pH-dependent and micellar solubilization models

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Chinese Journal of Chemical Engineering 2024年第8期72卷 34-43页

作者： chen shen Yuanhui Ji Jiangsu Province Hi-Tech Key Laboratory for Biomedical Research School of Chemistry and Chemical EngineeringSoutheast UniversityNanjing 211189China

Biological solubility is one of the important basic parameters in the development process of poorly soluble drugs,but the current measurement methods are mainly based on a large number of experiments,which are time-consuming and *** is still a lack of effective theoretical models to accurately describe and predict the biological solubility of drugs to reduce ***,in this study,osaprazole and irbesartan were selected as model drugs,and their solubility in solutions containing surfactants and biorelevant media was measured *** calculating the parameters of each component using the perturbed-chain statistical associating fluid theory(PC-SAFT)model,combined with pH-dependent and micellar solubilization models,the thermodynamic phase behavior of the two drugs was successfully modeled,and the predicted results were in good agreement with the experimental *** results demonstrate that the model combination used provides important basic parameters and theoretical guidance for the development and screening of poorly soluble drugs and related formulations.

关键词： Biorelevant media pH-dependent solubility Micellar solubilization PC-SAFT Active pharmaceutical ingredients

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Osteology of Leptobrachella bijie(Anura,Megophryidae)

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Asian Herpetological Research 2024年第2期15卷 90-103页

作者： Wei LI Meihua ZHANG Zhonghao LUO Jing LIU Tuo shen bo chen Haijun SU Bin WANG College of Forestry Guizhou UniversityGuiyang 550025GuizhouChina chengdu Institute of Biology Chinese Academy of SciencesChengdu 610041SichuanChina

The Asian leaf litter toad genus Leptobrachella contains more than 100 species widely distributed in southwestern ***,the systematic profiles of this group remain *** morphology is important for taxonomic and phylogenetic ***,few studies have focused on the osteology of the ***,we comprehensively described the osteological features of a representative species *** based on micro-CT scanning and double-staining *** results show that the skull of adult *** is well-ossified,exhibiting sexual dimorphism and minimal intraspecific *** skull length is slightly greater than the width,with the maxilla slightly overlapping with the *** nasal connects with the sphenethmoid in males,but only part or not connects with the sphenethmoid in *** transverse processes of the sacrum are robust and symmetrically butterfly-shaped,and the presacral vertebrae are *** pectoral girdle is *** phalangeal formula is 2-2-3-3 for the hand,and 2-2-3-4-3 for the *** study provides the first detailed and comprehensive osteological accounts of the genus Leptobrachella.

关键词： sexual dimorphism skeleton taxonomy

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On the half-quantized Hall conductance of massive surface electrons in magnetic topological insulator films

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Science China(Physics,Mechanics & Astronomy) 2024年第6期67卷 127-136页

作者： Rui chen Shun-Qing shen Department of Physics The University of Hong KongHong Kong 999077China Department of Physics Hubei UniversityWuhan 430062China

In topological insulators,massive surface states resulting from local symmetry breaking were thought to exhibit a half-quantized Hall conductance,obtained from the low-energy effective model in an infinite Brillouin *** a lattice model,the surface band is composed of a combination of surface states and bulk *** massive surface states alone may not be enough to support an exact one-half quantized surface Hall conductance in a finite Brillouin zone and the whole surface band always gives an integer quantized Hall conductance as enforced by the TKNN *** explore this,we investigate the band structures of a lattice model describing the magnetic topological insulator film that supports the axion insulator,Chern insulator,and semi-magnetic topological insulator *** reveal that the gapped and gapless surface bands in the three phases are characterized by an integer-quantized Hall conductance and a half-quantized Hall conductance,*** propose an effective model to describe the three phases and show that the low-energy dispersion of the surface bands inherits from the surface Dirac *** gapped surface band manifests a nearly half-quantized Hall conductance at low energy near the center of Brillouin zone,but is compensated by another nearly half-quantized Hall conductance at high energy near the boundary of Brillouin zone because a single band can only have an integer-quantized Hall *** gapless band hosts a zero Hall conductance at low energy but is compensated by another half-quantized Hall conductance at high energy,and thus the half-quantized Hall conductance can only originate from the gapless ***,we calculate the layer-resolved Hall conductance of the *** conclusion suggests that the individual gapped surface band alone does not support the half-quantized surface Hall effect in a lattice model.

关键词： magnetic topological insulator Dirac equation half-quantized Hall conductance

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Exploring Long-Memory Process in the Prediction of Interval-Valued Financial Time Series and Its Application

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Journal of Systems Science & Complexity 2024年第2期37卷 759-775页

作者： shen Tingting TAO Zhifu chen Huayou School of Economics Anhui UniversityHefei 230601China Center for Financial and Statistical Research Anhui UniversityHefei 230061China Stony Brook Institute at Anhui University Anhui UniversityHefei 230601China Center for Applied Mathematics Anhui UniversityHefei 230601China

Long-memory process has been widely studied in classical financial time series analysis,which has merely been reported in the field of interval-valued financial time *** aim of this paper is to explore long-memory process in the prediction of interval-valued time series(IvTS).To model the long-memory process,two novel interval-valued time series prediction models named as interval-valued vector autoregressive fractionally integrated moving average(IV-VARFIMA)and ARFIMAX-FIGARCH were *** the developed long-memory pattern,both of the short term and long-term influences contained in IvTS can be *** an application of the proposed models,interval-valued form of WTI crude oil futures price series is *** to current IvTS prediction models,IV-VARFIMA and ARFIMAX-FIGARCH can provide better in-sample and out-of-sample forecasts.

关键词： ARFIMAX-FIGARCH interval-valued time series IV-VARFIMA long-memory process WTI crude oil futures price

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Ferroelectric perovskite PbTiO_(3)for advanced photocatalysis

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Rare Metals 2024年第9期43卷 4038-4055页

作者： Shuang Zhao Shi-Shi shen Lu Han bo-Chao Tian Na Li Wei chen Xi-Bao Li School of Materials and Metallurgy University of Science and Technology LiaoningAnshan 114051China School of Materials Science and Engineering Nanchang Hangkong UniversityNanchang 330063China Department of Chemistry National University of SingaporeSingapore 117543Singapore

The ferroelectric semiconductor material PbTiO_(3)exhibits remarkable spontaneous polarization and photoelectric properties,positioning it as a promising polar *** internal electric field of ferroelectrics can separate photocarriers and enhance the catalytic performance of ***,when combined with other semiconductors,PbTiO_(3)contributes to the construction of a depolarization field,extending the catalytic applications of PbTiO_(3)***_(3)exhibits optical absorption,semiconductor,and piezoelectric *** piezoelectric polarization field enhances charge separation,modulates band structure,surface charge conduction,and heterojunction interface charge conduction,thereby amplifying photocatalytic *** paper begins by examining the structure,properties,and preparation methods of PbTiO_(3).Subsequently,it delves into the optimization of PbTiO_(3)'s structure and performance,exploring applications in photocatalysis as a ferroelectric *** is placed on the detailed discussion of surface modification,heterostructure formation,and ferroelectric polarization of PbTiO_(3)*** aspects are thoroughly explored for their role in regulating activity and optimizing the performance of photocatalysis and photopiezoelectric *** conclusion,the paper addresses the current research status of PbTiO_(3)ferroelectric materials and highlights the challenges that lie *** intention is to provide valuable references for the ongoing research in PbTiO_(3)ferroelectric materials.

关键词： PbTiO_(3) Ferroelectric polarization Photocatalysis Piezoelectric catalysis Polarization

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