检索结果-南通市图书馆

非小细胞肺癌组织AIP1、EDIL3表达变化观察

在线全文

学校读者我要写书评

暂无评论

山东医药 2024年第15期64卷 30-34页

作者：马志飞陈文张爱平沈晓康郑琳南京市第一医院南京医科大学附属南京医院胸心外科南京210006

目的观察非小细胞肺癌(NSCLC)组织凋亡信号调节激酶1-相互作用蛋白1(AIP1)、表皮生长因子样结构域3(EDIL3)表达变化,分析其与微血管密度(MVD)、临床病理特征及预后的关系,为NSCLC的靶向治疗提供新的干预靶点。方法纳入155例NSCLC患者,... 详细信息

目的观察非小细胞肺癌(NSCLC)组织凋亡信号调节激酶1-相互作用蛋白1(AIP1)、表皮生长因子样结构域3(EDIL3)表达变化,分析其与微血管密度(MVD)、临床病理特征及预后的关系,为NSCLC的靶向治疗提供新的干预靶点。方法纳入155例NSCLC患者,免疫组织化学法检测癌组织和癌旁组织中AIP1、EDIL3蛋白,Weidner法检测癌组织MVD。比较不同AIP1、EDIL3表达的NSCLC患者MVD值及不同临床病理特征NSCLC患者癌组织AIP1、EDIL3表达水平。Kaplan-Meier生存曲线分析不同AIP1、EDIL3表达的NSCLC患者生存情况,多因素Cox回归分析NSCLC患者预后的影响因素。结果与癌旁组织比较,NSCLC癌组织中EDIL3阳性表达率高、AIP1阳性表达率低(P均<0.05)。不同分化程度、淋巴结转移、肿瘤直径、TNM分期的NSCLC患者癌组织中AIP1、EDIL3蛋白阳性表达率比较,P均<0.05。AIP1阳性表达的NSCLC患者癌组织MVD值低于AIP1阴性表达者(P<0.05),EDIL3阳性表达的NSCLC患者癌组织MVD值高于EDIL3阴性表达者(P<0.05)。EDIL3阳性表达的NSCLC患者3年总生存(OS)率低于EDIL3阴性表达者(P<0.05),AIP1阳性表达的NSCLC患者3年OS率高于AIP1阴性表达者(P<0.05)。淋巴结转移、TNM分期ⅢA期、EDIL3阳性表达是NSCLC患者预后不良的危险因素(P均<0.05),AIP1阳性表达是保护因素(P<0.05)。结论NSCLC癌组织中AIP1阳性表达率降低,EDIL3阳性表达率升高;癌组织中AIP1、EDIL3阳性表达率与MVD、分化程度、淋巴结转移、肿瘤直径、TNM分期有关,是NSCLC预后不良的影响因素。

关键词：凋亡信号调节激酶1―相互作用蛋白1 表皮生长因子样结构域3 微血管密度非小细胞肺癌

补肾生髓益智汤联合甘露特钠胶囊治疗老年髓海不足型阿尔茨海默病痴呆临床研究

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

新中医 2024年第10期56卷 73-76页

作者：潘亚平沈校康魏红辉孙宁宁浙江省立同德医院老年科浙江杭州311122 浙江省立同德医院康复科浙江杭州311122

目的:观察补肾生髓益智汤联合甘露特钠胶囊治疗老年髓海不足型阿尔茨海默病痴呆的临床疗效。方法:选取124例老年髓海不足型阿尔茨海默病痴呆进行研究,按照随机数字表法分为治疗组与对照组各62例。治疗组给予补肾生髓益智汤联合甘露特钠... 详细信息

目的:观察补肾生髓益智汤联合甘露特钠胶囊治疗老年髓海不足型阿尔茨海默病痴呆的临床疗效。方法:选取124例老年髓海不足型阿尔茨海默病痴呆进行研究,按照随机数字表法分为治疗组与对照组各62例。治疗组给予补肾生髓益智汤联合甘露特钠胶囊治疗,对照组给予甘露特钠胶囊治疗。比较2组临床疗效,以及治疗前后简易精神状态量表(MMSE)、阿尔茨海默病评定量表-认知部分(ADAS-cog)、长谷川痴呆量表(HDS)、痴呆行为量表(BEHAVE-AD)评分。结果:治疗后,治疗组总有效率为90.32%,对照组为75.81%。2组比较,差异有统计学意义(P<0.05)。治疗后,2组MMSE评分均较治疗前上升(P<0.05),且治疗组MMSE评分高于对照组(P<0.05);2组ADAS-cog评分均较治疗前下降(P<0.05),且治疗组ADAS-cog评分低于对照组(P<0.05)。治疗后,2组HDS评分均较治疗前上升(P<0.05),且治疗组HDS评分高于对照组(P<0.05);2组BEHAVE-AD评分均较治疗前下降(P<0.05),且治疗组BEHAVE-AD评分低于对照组(P<0.05)。结论:补肾生髓益智汤联合甘露特钠胶囊治疗老年髓海不足型阿尔茨海默病痴呆临床疗效良好,可改善患者认知功能及痴呆症状。

关键词：阿尔茨海默病痴呆髓海不足型补肾生髓益智汤甘露特钠胶囊长谷川痴呆量表痴呆行为量表

Preparation of lithium carbonate by microwave assisted pyrolysis

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemical Engineering 2022年第12期52卷 146-153页

作者： shen Wang xiaokang Pei Yong Luo Guangwen Chu Haikui Zou Baochang Sun State Key Laboratory of Organic-Inorganic Composites Beijing University of Chemical TechnologyBeijing 100029China Research Center of the Ministry of Education for High Gravity Engineering and Technology Beijing University of Chemical TechnologyBeijing 100029China

Investigations were conducted to purify crude Li_(2)CO_(3)via direct carbonation with CO_(2)at atmospheric pressure and pyrolysis with both water bath heating method and microwave heating *** reaction kinetics of LiHCO_(3)pyrolysis was studied and the effect of different operating conditions including initial concentration of LiHCO_(3)solution,pyrolysis temperature and stirring speed on the purity of Li_(2)CO_(3)was investigated to obtain the optimal operating *** showed that the effect law is similar in the two pyrolysis *** purity of the Li_(2)CO_(3)increases firstly and then decreases with the increase of the initial concentration of LiHCO_(3)solution and the stirring speed,while the purity of Li_(2)CO_(3)first decreases and then increases with the increase of pyrolysis *** product yield increases with the increase of initial concentration of LiHCO_(3)solution and pyrolysis temperature and is essentially unaffected by the stirring *** the optimal operating conditions,the purity of Li_(2)CO_(3)can reach up to 99.86%and 99.81%in water bath heating and microwave heating process,*** addition,the pyrolysis rate of microwave assisted pyrolysis is 6 times that of water bath heating process,indicating that the microwave heating technology can significantly improve pyrolysis efficiency and reduce energy consumption.

关键词： Lithium bicarbonate Pyrolysis process Traditional heating Microwave heating Product yield

Roof collapse mechanism of weak surrounding rock for deep-buried tunnels under high geostress conditions

在线全文

学校读者我要写书评

暂无评论

Journal of Mountain Science 2024年第7期21卷 2408-2426页

作者： ZHANG Qi GUO xiaokang YAN Zhiguo LEI Zhongdai shen Yixin School of Civil Engineering Southeast UniversityNanjing 211189China Department of Geotechnical Engineering Tongji UniversityShanghai 200092China

High geostress,a typical attribute of tunnels located at significant depths,is crucial in causing stress-induced failure and influencing the stability of the tunnel *** study developed an analytical method for the failure mechanism that occurs in deep-buried tunnel roofs,taking into account the influence of *** limit analysis theory was utilized for deriving analytical solutions about the geometry of the collapsing surface and the limit supporting *** collapsing surface obtained by the analytical solution was validated by the findings of the physical model test,which shows a high level of agreement with the actual *** extensive investigation was done to explore the effects of the lateral pressure coefficients,the tunnel buried depth,the geological conditions of the surrounding rock,the long-short axis ratio,and the size of the tunnel *** findings indicate that an increase in the lateral pressure coefficient from 0.5 to 1.5 results in a reduction in the height of the collapsing zone by 2.08 m and the width of the collapsing zone by 1.15 m,while simultaneously increases the limit supporting pressure by 18.9%.The proposed upper bound method accurately determines the limit supporting pressure and the geometry of the collapsing surface,which aligns well with the results acquired through numerical modelling and on-site monitoring in actual engineering *** proposed analytical method can serve as a reference for similar crown failure issues of deep-buried tunnels.

关键词： Geostress Deep-buried tunnels Collapse mechanism Pressure arch Limit analysis HoekBrown criterion

精神康复群组管理对社区精神分裂症患者生活技能的影响

在线全文

学校读者我要写书评

暂无评论

中华现代护理杂志 2017年第17期23卷 2259-2262页

作者：吕月娣姜杨沈校康刘雪珍俞银华浙江省立同德医院精神科杭州310012 浙江省立同德医院内科杭州310012

目的探讨精神康复群组管理模式对提高社区精神分裂症患者生活技能的有效性.方法选择2014年1月—2016年8月杭州市某街道卫生服务中心建卡建册的社区精神障碍患者106例,采用随机数字表法分为干预组和对照组,每组53例.两组患者均维持原... 详细信息

目的探讨精神康复群组管理模式对提高社区精神分裂症患者生活技能的有效性.方法选择2014年1月—2016年8月杭州市某街道卫生服务中心建卡建册的社区精神障碍患者106例,采用随机数字表法分为干预组和对照组,每组53例.两组患者均维持原有的药物治疗和常规康复训练,干预组在此基础上接受为期4周的精神康复群组管理活动.干预前后采用生活技能训练（SST）评估表、社会功能缺陷筛选表（SDSS）进行评价,比较干预效果.结果 4周后干预组SST评估表总分从（33.11〈1.88）分提高至（70.03〈2.15）分,SDSS量表总分从（16.68〈0.38）分下降至（8.92〈0.32）分,康复效果均优于对照组,差异有统计学意义（t值分别为-12.952、-14.760;P〈0.01）.结论精神康复群组管理模式能有效地改善社区精神分裂症患者的生活技能,提高了患者的人际交往能力,对顺利回归社会有积极的作用.

关键词：精神分裂症精神康复群组管理生活技能康复

在线全文

学校读者我要写书评

暂无评论

群组管理对精神分裂症患者社会功能的影响

中国护理管理 2015年第6期15卷 750-753页

作者：姜杨沈校康王丽娟刘雪珍吕月娣沈国珍俞银华浙江省立同德医院精神科杭州市310012 浙江省立同德医院内科杭州市310012

目的:评价群组管理对住院精神分裂症患者社会功能的影响。方法:将89例住院精神分裂症患者随机分为两组,干预组45例和对照组44例,2组患者均接受常规治疗护理,干预组在此基础上接受为期5周的群组活动。在干预前、后分别用住院精神病患者... 详细信息

目的:评价群组管理对住院精神分裂症患者社会功能的影响。方法:将89例住院精神分裂症患者随机分为两组,干预组45例和对照组44例,2组患者均接受常规治疗护理,干预组在此基础上接受为期5周的群组活动。在干预前、后分别用住院精神病患者社会功能评定量表(SSPI)、生活技能训练(SST)评定量表进行评价。结果:干预组患者训练后SSPI、SST量表总分与对照组相比,差异均有统计学意义(P<0.05)。结论:在常规治疗护理的基础上结合群组管理能有效地改善住院精神分裂症患者的社会功能,提高日常生活技能,值得在精神科推广、应用。

关键词：社会功能人际关系精神分裂症康复

4 - 16 Dynamic Range of High Energy Electron Radiography

在线全文

学校读者我要写书评

暂无评论

IMP & HIRFL Annual Report 2013年第1期 193-193页

作者： Zhao Yongtao Zhang Ziming Gai Wei Du Yingchao Zhao Quantang Cheng Rui Zhou Xianming shen xiaokang Cao Shuchun Wenhui Huang Wang Yanling Zong Yang

6-17 Research Progress of High Energy Electron Radiography

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

IMP & HIRFL Annual Report 2014年第1期 268-268页

作者： Cao Shuchun Zhang Ziming shen xiaokang Zhao Quantang Liu Ming Wang Yanru Zong Yang Zhang Xiaoming Li Zhongping Xiao Rongqing Jing Yi Wei Gai 不详

High Energy Density Physics (HEDP) aims to study the properties of matter under extreme states of temperatureand pressure. The pressure in a high energy density sample exceeds 1 Mbar (100 GPa), thus the hydrodynamicresponse of the sample is a high expansion velocity in the range of km/s (m/ns). Therefore, diagnostics which arecapable of high time resolution (< ns) and space resolution (10 m) are needed. High Energy Electron Radiography(HEER) is a new method suitable for HEDP research that uses a high energy electron beam as a probe for timeresolved imaging measurements of high energy density processes in materials. The device uses an electron bunchtrain with a flexible time structure penetrating a time varying high density target. The electron bunch-lets, eacha few ps long and with charges nC is suitable, traverses the HEDP target where the electrons are scattered bythe nuclei. The angular distribution depends on the density and thickness of the target. The scattered electronsthen travel through the point-to-point imaging lattice with a suitable magnification. A small aperture is used tocollimate the scattered electron beam for off axis particles and bremsstrahlung photons, and the target image willbe detected by a luminescent screen located after the imaging lattice, as shown in the Fig. 1.

关键词： Research Progress Energy

First Industrial Electron Accelerator in IMP

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

近代物理研究所和兰州重离子加速器实验室年报：英文版 2009年第1期 266-266页

作者： Zhang Zimin Cao Shuchun Li Zhongping Liu Ming Wan Ming Zhang Yingfa Wang Bin Yang Chunming Xiao Rongqing Jing Yi shen xiaokang Zhao Quantang Yuan Ping