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江苏省糖尿病眼病研究中阜宁县50岁以上2型糖尿病患者盲和中重度视力损伤的流行病学调查

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中华眼科杂志 2020年第8期56卷 593-599页

作者：沈亚琴杨梅刘必红孙大军梁从凯王诗逸朱蓉嵘南通大学附属医院眼科 226001 江苏省盐城市阜宁县施庄眼科医院 224000 江苏省盐城市阜宁县疾病预防控制中心 224000

目的:了解江苏省盐城市阜宁县50岁以上2型糖尿病患者盲和中重度视力损伤的患病率、致病原因和危险因素。方法:横断面研究。采用整群随机抽样抽取84个调查地点,对江苏省盐城市阜宁县疾病预防控制中心慢病信息中心登记的50岁以上2型糖尿... 详细信息

目的:了解江苏省盐城市阜宁县50岁以上2型糖尿病患者盲和中重度视力损伤的患病率、致病原因和危险因素。方法:横断面研究。采用整群随机抽样抽取84个调查地点,对江苏省盐城市阜宁县疾病预防控制中心慢病信息中心登记的50岁以上2型糖尿病患者进行眼部检查。分别计算不同年龄、性别盲和中重度视力损伤的患病率,确定盲和视力损伤的原因,并采用单因素和多因素Logistic回归分析其影响因素。结果:共调查2 067人,纳入统计分析1 909人,受检率为92.4%。以日常生活视力计算,盲和中重度视力损伤分别为101和354例,患病率分别为5.29%[95%可信区间( CI):4.29%~6.30%]和18.54%(95% CI:16.80%~20.29%),盲的患病率与年龄、婚姻状况、文化程度、糖尿病患病时间、是否患糖尿病肾病、收缩压高低及晶状体核混浊度相关,中重度视力损伤与年龄、性别、文化程度、糖尿病治疗方法、是否锻炼及糖化血红蛋白相关;以最佳矫正视力计算,盲和中重度视力损伤分别为70和187例,患病率分别为3.67%(95% CI:2.82%~4.51%)和9.80%(95% CI:8.46%~11.13%),盲的患病率与年龄、婚姻状况、文化程度、糖尿病患病时间、是否患糖尿病肾病、是否锻炼及收缩压高低相关,中重度视力损伤与年龄、文化程度、糖尿病治疗方法及晶状体核混浊度相关。导致盲和视力损伤的首要原因均为白内障,其次是糖尿病视网膜病变。结论:江苏省盐城市阜宁县2型糖尿病患者中盲和中重度视力损伤的患病率较高,其主要原因为白内障和糖尿病视网膜病变。 (中华眼科杂志,2020,56:593-599)

关键词：糖尿病,2型盲视觉障碍患病率危险因素流行病学江苏

Metronomic capecitabine inhibits liver transplant rejection in rats by triggering recipients’T cell ferroptosis

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World Journal of Gastroenterology 2023年第20期29卷 3084-3102页

作者： Hao Wang Zheng-Lu Wang Sai Zhang De-Jun Kong Rui-Ning Yang Lei Cao Jian-Xi Wang Sei Yoshida Zhuo-Lun Song Tao Liu Shun-Li Fan Jia-Shu Ren Jiang-Hong Li Zhong-Yang shen Hong Zheng The First Central Clinical School Tianjin Medical UniversityTianjin 300190China department of Organ Transplant Tianjin First Central HospitalSchool of MedicineNankai UniversityTianjin 300190China Key Laboratory of Transplant Medicine Chinese Academy of Medical SciencesTianjin 300190China School of Medicine Nankai UniversityTianjin 300190China Research Institute of Transplant Medicine Nankai UniversityTianjin 300071China tianjin Key Laboratory for Organ Transplantation Tianjin First Central HospitalSchool of MedicineNankai UniversityTianjin 300071China National Health Commission’s Key Laboratory for Critical Care Medicine Tianjin First Central HospitalTianjin 300071China

BACKGROUND Capecitabine(CAP)is a classic antimetabolic drug and has shown potential antirejection effects after liver transplantation(LT)in clinical *** previous study showed that metronomic CAP can cause the programmed death of T cells by inducing oxidative stress in healthy ***,a newly defined non-apoptotic cell death that occurs in response to iron overload and lethal levels of lipid peroxidation,is an important mechanism by which CAP induces cell ***,ferroptosis may also play an important role in CAP-induced T cell death and play an immunosuppressive role in acute rejection after *** To investigate the functions and underlying mechanisms of antirejection effects of metronomic *** A rat LT model of acute rejection was established,and the effect of metronomic CAP on splenic hematopoietic function and acute graft rejection was evaluated 7 d after *** vitro,primary CD3+T cells were sorted from rat spleens and human peripheral blood,and co-cultured with or without 5-fluorouracil(5-FU)(active agent of CAP).The levels of ferroptosis-related proteins,ferrous ion concentration,and oxidative stress-related indicators were *** changes in mitochondrial structure were observed using electron *** With no significant myelotoxicity,metronomic CAP alleviated graft injury(Banff score 9 vs 7.333,P<0.001),prolonged the survival time of the recipient rats(11.5 d vs 16 d,P<0.01),and reduced the infiltration rate of CD3+T cells in peripheral blood(6.859 vs 3.735,P<0.001),liver graft(7.459 vs 3.432,P<0.001),and spleen(26.92 vs 12.9,P<0.001),thereby inhibiting acute rejection after *** vitro,5-FU,an end product of CAP metabolism,induced the degradation of the ferritin heavy chain by upregulating nuclear receptor coactivator 4,which caused the accumulation of ferrous *** also inhibited nuclear erythroid 2 p45-related factor 2,heme oxygenase-1,and glutathione peroxidase 4,eventually leading to oxidati

关键词： Capecitabine Ferroptosis T Lymphocytes Immunosuppressive agents Graft rejection Liver transplantation

Micro-nanofiber composite biomimetic conduits promote long-gap peripheral nerve regeneration in canine models

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Bioactive Materials 2023年第12期30卷 98-115页

作者： Xianhao Dong Yueyue Yang Zheheng Bao Adam C.Midgley Feiyi Li Shuxin Dai Zhuangzhuang Yang Jin Wang Lihua Liu Wenlei Li Yayuan Zheng Siyang Liu Yang Liu Weijian Yu Jun Liu Meng Fan Meifeng Zhu Zhongyang shen Gu Xiaosong Deling Kong State Key Laboratory of Medicinal Chemical Biology The Key Laboratory of Bioactive MaterialsMinistry of EducationCollege of Life ScienceNankai UniversityTianjinChina department of Orthopaedics Tianjin First Central HospitalSchool of MedicineNankai UniversityTianjinChina department of Radiology Tianjin First Central HospitalTianjin Medical Imaging InstituteSchool of MedicineNankai UniversityTianjinChina Institute of Transplantation Medicine NHC Key Laboratory for Critical Care MedicineTianjin First Central HospitalSchool of MedicineNankai UniversityTianjinChina Haihe Laboratory of Sustainable Chemical Transformations Keyan West RoadTianjin300192China Jiangsu Key Laboratory of Neuroregeneration Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury RepairCo-innovation Center ofNeuroregenerationNMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology ProductsNantong UniversityNantongChina Outpatient department Tianjin First Central HospitalSchool of MedicineNankai UniversityTianjinChina Clinical School/College of Orthopedics Tianjin Medical UniversityTianjinChina department of Joint Tianjin HospitalTianjinChina

Peripheral nerve injuries may result in severe long-gap interruptions that are challenging to *** is the gold standard surgical approach for repairing long-gap nerve injuries but can result in prominent donor-site ***,imitating the native neural microarchitecture using synthetic conduits is expected to offer an alternative strategy for improving nerve ***,we designed nerve conduits composed of high-resolution anisotropic microfiber grid-cordes with randomly organized nanofiber sheaths to interrogate the positive effects of these biomimetic structures on peripheral nerve ***tropic microfiber-grids demonstrated the capacity to directionally guide Schwann cells and *** sheaths conveyed adequate elasticity and permeability,whilst exhibiting a barrier function against the infiltration of *** then used the composite nerve conduits bridge 30-mm long sciatic nerve defects in canine *** 12 months post-implant,the morphometric and histological recovery,gait recovery,electrophysiological function,and degree of muscle atrophy were *** newly regenerated nerve tissue that formed within the composite nerve conduits showed restored neurological functions that were superior compared to sheaths-only scaffolds and Neurolac nerve conduit *** findings demonstrate the feasibility of using synthetic biophysical cues to effectively bridge long-gap peripheral nerve injuries and indicates the promising clinical application prospects of biomimetic composite nerve conduits.

关键词： composite fiber injuries

Wnt5a Signaling A New and Attractive Target for Specific Anticancer Therapy

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Clinical oncology and cancer resexreh 2010年第1期7卷 1-6页

作者： Xiao-hong shen Dong LI Hong-yue LI Qiang LI Medical College of nankai university Tianjin 300071 China department of Hepatobiliary Surgery Tianjin Medical University Cancer Institute and Hospital Tianjin 300060 China

Wnt signaling has been shown to engage a multifunctional pathway that is involved in the regulation of a wide variety of normal and pathologic processes, including embryogenesis, differentiation and tumorigenesis. Recent studies have demonstrated that Wnt5a expression is frequently seen in various human cancers. In contrast to the transforming members of the Wnt family, shown to be upregulated in many cancers, the role of Wnt5a is still controversial in its expression in different tumors. There is increasing evidence that Wnt5a has tumor suppressor function in some malignancies, and in addition, it elicits promigratory and proinvasive effects via the planar cell polarity pathway, which suggests that Wnt5a might be an effective marker for the progression and prognosis of tumors. Obviously, the outcome of Wnt5a signaling is dependent on a multitude of variables, ranging from receptors, downstream effectors and inhibitors, to external influences coming from the tumor microenvironment. This review will focus on the role of Wnt5a signaling and, as a consequence, provide an outline describing the expression and functions of Wnt5a in cancer progression.

关键词：信号转化肿瘤发生治疗抗癌病理过程胚胎发育抑制功能恶性肿瘤

基于轮廓分析的电针长强穴对FMR1基因敲除小鼠CREB表达的多脑区联动效应研究

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世界科学技术-中医药现代化 2020年第8期22卷 2686-2694页

作者：齐诗仪张志灿林燊章思佳林丽莉林栋福建中医药大学针灸学院福州350122

目的观察电针长强穴对脆性X智障基因(Fragile X mental retardation 1,FMR1)敲除小鼠不同脑区环磷腺苷效应元件结合蛋白(cAMP-response element binding protein,CREB)及磷酸化CREB(p-CREB)蛋白表达量影响,以探讨针刺的多脑区联动效应... 详细信息

目的观察电针长强穴对脆性X智障基因(Fragile X mental retardation 1,FMR1)敲除小鼠不同脑区环磷腺苷效应元件结合蛋白(cAMP-response element binding protein,CREB)及磷酸化CREB(p-CREB)蛋白表达量影响,以探讨针刺的多脑区联动效应。方法选取适龄FMR1基因敲除小鼠,通过PCR鉴定其基因表型。将24只纯合子基因敲除小鼠通过随机数字表法分为3组,每组8只,即空白组(仅给予抓取动作)、非经非穴组(电针肋弓最低点上1 cm处)和长强组(电针长强穴)。2组针刺组采用电针仪进行干预,电针刺激频率2 Hz,强度2 mA,连续波,每日20 min,连续干预14天。干预结束后通过免疫组化法检测海马、皮质及小脑CREB及p-CREB蛋白的表达情况。结果空白组海马的CREB表达量较皮质(P0.05)。轮廓分析结果示:CREB平行轮廓分析示差异有统计学意义(P<0.05),提示三个脑区的总体轮廓不平行,即脑区的联动变化不一致。p-CREB及p-CREB率水平轮廓分析差异有统计学意义(P<0.01),提示三个脑区联动变化一致,且各组间变化程度一致,但各组中蛋白表达不相等,其中小脑最高。结论通过轮廓分析能初步观察针刺的多脑区联动效应,且针刺刺激可能通过影响CREB磷酸化使得FMR1基因敲除小鼠多脑区效应方式发生改变。

关键词：长强基因敲除脑区联动效应环磷腺苷效应元件结合蛋白

白脂素与2型糖尿病和非酒精性脂肪性肝病的关系

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沈阳医学院学报 2020年第5期22卷 480-482,490页

作者：郭庆陈诗意沈静雪沈阳医学院辽宁沈阳110034 沈阳医学院附属中心医院内分泌科

随着肥胖人口的增多,2型糖尿病(type 2 diabetes mellitus,T2DM)和非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)患病率也在逐年增加。两者有着共同的发病机制,如胰岛素抵抗。白脂素(asprosin)是一种新发现的细胞因子,... 详细信息

随着肥胖人口的增多,2型糖尿病(type 2 diabetes mellitus,T2DM)和非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)患病率也在逐年增加。两者有着共同的发病机制,如胰岛素抵抗。白脂素(asprosin)是一种新发现的细胞因子,参与糖脂代谢,并且增加胰岛素抵抗,在T2DM和NAFLD的发展进程中起着重要作用,但作用机制尚不十分清楚,其有望成为治疗T2DM和NAFLD的新靶点。

关键词：白脂素 2型糖尿病非酒精性脂肪性肝病胰岛素抵抗

3-羧-4-甲-5-丙基呋喃戊酮酸与2型糖尿病合并非酒精性脂肪性肝病的研究进展

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沈阳医学院学报 2020年第6期22卷 596-598页

作者：陈诗意郭庆沈静雪沈阳医学院辽宁沈阳110034 沈阳医学院附属中心医院内分泌科

随着糖尿病及代谢综合征的发病率逐年增高,非酒精性脂肪性肝病(NAFLD)的发病率也平行性升高,胰岛素抵抗是这些代谢性疾病的共同发病机制。3-羧-4甲-5-丙基呋喃戊酮酸(CMPF)是近几年来新发现的一种内源性呋喃脂肪酸代谢产物,可通过抑制... 详细信息

随着糖尿病及代谢综合征的发病率逐年增高,非酒精性脂肪性肝病(NAFLD)的发病率也平行性升高,胰岛素抵抗是这些代谢性疾病的共同发病机制。3-羧-4甲-5-丙基呋喃戊酮酸(CMPF)是近几年来新发现的一种内源性呋喃脂肪酸代谢产物,可通过抑制胰岛素的生物合成及释放,导致胰岛素分泌障碍,降低葡萄糖氧化,增加脂肪酸β氧化。研究发现,CMPF治疗的小鼠肝脂质清除率提高,从而防止肝脂质积累和高脂饮食诱导的肝脏胰岛素抵抗。本文主要就CMPF与2型糖尿病(T2DM)及NAFLD的关系进行综述。

关键词： 2型糖尿病非酒精性脂肪性肝病 3-羧-4-甲-5-丙基呋喃戊酮酸胰岛素抵抗

面部刮痧联合穴位按摩应用于周围性面瘫患者中的效果

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反射疗法与康复医学 2023年第16期4卷 1-3页

作者：沈悦天津市中西医结合医院(天津市南开医院)针灸科天津300100

目的研究面部刮痧联合穴位按摩在周围性面瘫患者中的应用效果.方法选取天津市中西医结合医院针灸科2022年1月—2023年4月收治的60例周围性面瘫患者为研究对象,随机将其分为对照组(n=30)及观察组(n=30).对照组采用穴位按摩干预,观察组在... 详细信息

目的研究面部刮痧联合穴位按摩在周围性面瘫患者中的应用效果.方法选取天津市中西医结合医院针灸科2022年1月—2023年4月收治的60例周围性面瘫患者为研究对象,随机将其分为对照组(n=30)及观察组(n=30).对照组采用穴位按摩干预,观察组在此基础上采用面部刮痧干预.比较两组患者的干预效果.结果干预后,观察组的Sunnybrook面神经评定量表评分为(2.73±0.63)分,低于对照组的(4.07±1.15)分,差异有统计学意义(P<0.05);观察组的中医症状评分为(10.41±1.61)分,低于对照组的(13.63±1.94)分,差异有统计学意义(P<0.05);观察组的健康调查简表评分为(87.57±5.91)分,高于对照组的(73.57±5.79)分,差异有统计学意义(P<0.05).结论周围性面瘫患者接受面部刮痧联合穴位按摩干预,能有效改善其面部神经功能,减轻中医症状,显著提升患者的日常生活质量,值得临床推广使用.

关键词：周围性面瘫面部刮痧穴位按摩生活质量

TiC/C core/shell nanowires arrays as advanced anode of sodium ion batteries

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Chinese Chemical Letters 2020年第3期31卷 846-850页

作者： Yanbin shen Yahao Li shengjue Deng Guoxiang Pan Qinqin Xiong Xiaokun Ding Yangfan Lu Qi Liu Xinhui Xia Xiuli Wang Jiangping Tu State Key Laboratory of Silicon Materials Key Laboratory of Advanced Materials and Applications for Batteries of Zhejiang Provinceand School of Materials Science and EngineeringZhejiang UniversityHangzhou 310027China department of Materials Chemistry Huzhou UniversityHuzhou 313000China College of Materials and Environmental Engineering Hangzhou Dianzi UniversityHangzhou 310018China department of Chemistry Zhejiang UniversityHangzhou 310027China department of Physics City University of Hong KongHong Kong 999077China Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) College of ChemistryNankai UniversityTianjin 300071China

High-perfo rmance anodes of sodium ion batteries(SIBs)largely depends on rational architecture design and binder-free smart ***,we report TiC/C core/shell nanowires arrays prepared by a one-step chemical vapor deposition(CVD)method and apply it as the anode of SIBs for the first *** conductive TiC core is intimately decorated with carbon *** as-obtained TiC/C nanowires are homogeneously grown on the substrate and show core/shell heterostructure and porous architecture with high electronic conductivity and reinforced *** to these merits,the TiC/C electrode displays good rate performance and outstanding cycling performance with a capacity of 135.3 mAh/g at 0.1 A/g and superior capacity retention of 90.14%after 1000 cycles at 2 A/*** reported strategy would provide a promising way to construct binder-free arrays electrodes for sodium ion storage.

关键词： Sodium ion batteries Nanowires Core/shell structure Carbon Titanium carbide