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A novel mechanism of PHB2-mediated mitophagy participating in the development of Parkinson's disease

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Neural Regeneration Research 2024年第8期19卷 1828-1834页

作者： Yongjiang Zhang shiyi Yin Run Song Xiaoyi Lai Mengmeng shen Jiannan Wu Junqiang Yan Key Laboratory of Neuromolecular Biology The First Affiliated HospitalCollege of Clinical Medicine of Henan University of Science and TechnologyLuoyangHenan ProvinceChina department of Neurology The First Affiliated HospitalCollege of Clinical Medicine of Henan University of Science and TechnologyLuoyangHenan ProvinceChina

Endoplasmic reticulum stress and mitochondrial dysfunction play important roles in Parkinson s disease,but the regulato ry mechanism remains ***-2(PHB2)is a newly discove red autophagy receptor in the mitochondrial inner membrane,and its role in Parkinson’s disease remains *** kinase R(PKR)-like endoplasmic reticulum kinase(PERK)is a factor that regulates cell fate during endoplasmic reticulum *** is regulated by PERK and is a target of the unfolded protein *** is unclear whether PERK regulates PHB2-mediated mitophagy thro ugh *** this study,we established a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)-induced mouse model of Parkinson’s *** used adeno-associated virus to knockdown PHB2 *** res ults showed that loss of dopaminergic neurons and motor deficits were aggravated in the MPTP-induced mouse model of Parkinson’s *** rexpression of PHB2 inhibited these *** also established a 1-methyl-4-phenylpyridine(MPP+)-induced SH-SY5Y cell model of Parkinson’s *** found that ove rexpression of Parkin increased co-localization of PHB2 and microtubule-associated protein 1 light chain 3,and promoted *** addition,MPP+regulated Parkin involvement in PHB2-mediated mitophagy through phosphorylation of *** findings suggest that PHB2 participates in the development of Parkinson’s disease by intera cting with endoplasmic reticulum stress and Parkin.

关键词： endoplasmic reticulum dopaminergic neuron microtubule-associated protein 1 light chain 3 mitophagy oxidative stress Parkin Parkinson’s disease PKR-like endoplasmic reticulum kinase reactive oxygen species prohibitin-2

STRONG CODING THEOREM AND ASYMPTOTICERROR EXPONENT OF ARBITRARILY VARYING SOURCE WITH A FIDELITY CRITERION

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Systems Science and Mathematical Sciences 1998年第2期11卷 168-174页

作者： FU Fangwei shen shiyi(department Of mathematics, nankai university, Tiawtn 300071, china)

When the error probability is less than 2--"", the minimum compression rate(r-optimal rate) of arbitrarily varying source with a fidelity criterion is determined. Thisgeneralizes the result of Arutyunyan and Mekaushll] for discrete memoryless source witha fidelity criterion, and is called strong coding theorem of arbitrarily varying source witha fidelity criterion. We also determine the asymptotic error exponellt for arbitrarily varying source with a fidelity criterion. This generalizes Marton’s result in [2] for discretememoryless source with a fidelity criterion.

关键词： Arbitrarily varying sourcel coding theorem error exponent information quantity rate-distortion theory.

FKBP23 in ER binds to BiP specifically

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Science china Chemistry 2004年第1期47卷 17-23页

作者： ZHANG Wanqi, LI Hui, ZHANG Xiaobin, shen Ye, WANG Yinong, Ml Huaifeng & HE BinglinState Key Laboratory of Functional Polymer Materials for Adsorption and Separation, Chemical School of nankai university, tianjin 300071, china Hygienic School of tianjin Medical university, tianjin 300071, china Medical School of nankai university, tianjin 300071, china State Key Laboratory of Functional Polymer Materials for Adsorption and Separation Chemical School of Nankai University Tianjin China Hygienic School of tianjin Medical university Tianjin China Medical School of nankai university Tianjin China

FKBP23 was found in mouse endoplasmic reticulum (ER) in 1998. It consists of an N-terminal peptidyl-prolyl cis-trans isomerase (PPIase) domain and a C-terminal domain with Ca2+ binding sites. The fusion protein of mouse FKBP23 and glutathione S-transferase (GST), GST-FKBP23, and the fusion protein of BiP, a member of heat shock protein 70 (Hsp 70) in ER, and GST, GST-BiP, were subcloned in E. coli, expressed and purified. The fusion proteins were restrictively digested by Factor Xa (FaXa) to obtain the free cloned proteins FKBP23 and BiP. With the assay of adsorption of free FKBP23 or BiP with GST-BiP or GST-FKBP23 attached to the Glutathione-Sepharose 4B, the adsorbed FKBP23 or BiP could be detected by Immunoblot. It means that FKBP23 binds to BiP. Furthermore, BiP in leukocyte ER-extract can be adsorbed with GST-FKBP23 attached to the glutathione-Sepharose 4B. It shows that FKBP23 binds to natural BiP in ER, too. These experiments show that a PPIase binds to a molecular chaperone of the Hsp70 family.

关键词： peptidyl-prolyl cis/trans isomerase, FKBP23, BiP, endoplasmic reticulum, specific binding.

Ni-catalyzed highly regio- and stereo-selective diborylative cyclization of 1,6-enynes with diboron reagent

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Science china Chemistry 2024年第3期67卷 981-989页

作者： Qitao Guan Zhen shen Yiqiang Tian Genping Huang Chun Zhang Institute of Molecular Plus Tianjin Key Laboratory of Molecular Optoelectronic ScienceDepartment of ChemistrySchool of SciencesTianjin UniversityTianjin 300072China State Key Laboratory of Elemento-Organic Chemistry Nankai UniversityTianjin 300071China

The Ni-catalyzed highly selective diborylative cyclization of 1,6-enynes with diboron reagent has been developed. When pinB-Bdan was used, multiple types of boron-containing functional groups could be installed into organic molecule with great chemoselectivity and regioselectivity though this reaction. Meanwhile, if B_2pai_2 was employed, the asymmetric diborylative cyclization could be well induced by using strategy of dynamic kinetic resolution. Importantly, the above reactions could afford desired product with 100% atomic economy, and could be compatible with different series of substituents. The studies of further transformation well illustrated that different type products could serve diverse synthetic strategy. Notably, the reaction mechanism was intensively studied by density functional theory(DFT) calculations, which could reveal the mechanism of regio- and enantio-selective control.

关键词： nickel-catalyzed organoboron cyclization regioselectivity enantioselectivity

Activation of Carcinogenic Non-aminoazo Compounds in Horseradish Peroxidase/H_2O_2 System

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Chinese Chemical Letters 1997年第11期8卷 979-982页

作者： Min ZHU Xue Mei HUANG and Han Xi shen (department of Chemistry, nankai university, tianjin, 300071) department of Chemistry Nankai University Tianjin 300071 China

Eriochrome black T and Nitrosulfophenol S were advocated as the chemical models of carcinogenic non-aminoazo compounds. The main products of their oxidative cleavage in horseradish peroxidase/H2O2 system was identified as the benezenediazonium ion, the ultimate carcinogens, which could bind to DNA. The reaction conditions were investigated preliminarily. Some inhibitors and inducers of the reaction were discovered.

关键词： Miller Activation of Carcinogenic Non-aminoazo Compounds in Horseradish Peroxidase/H2O2 System

ON THE MEAN VALUE AND VARIANCE OF DISTANCE DISTRIBUTION OF NON-LINEAR CODES IN GF(q)

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Journal of Electronics(china) 1998年第1期15卷 58-62页

作者： Fu Fangwei shen shiyi(department of mathematics, nankai university, tianjin 300071)

This paper presents the lower bounds and upper bounds for the mean value and variance of distance distribution of non-linear codes in GF(q). By presenting several examples, it is shown that these bounds could be achie... 详细信息

关键词： Coding theory Distance distribution Althofer-Sillke inequality MacWilliams-Delsarte identity

Key role of interferon regulatory factor 1(IRF-1)in regulating liver disease:progress and outlook

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Journal of Zhejiang university-Science B(Biomedicine & Biotechnology) 2024年第6期25卷 451-470页

作者： Tao CHEN Shipeng LI Dewen DENG Weiye ZHANG Jianjun ZHANG Zhongyang shen First Central Clinical School Tianjin Medical UniversityTianjin 300192China department of Organ Transplant Tianjin First Central HospitalTianjin 300192China Research Institute of Transplant Medicine Nankai UniversityTianjin 300192China department of Hepatobiliary Surgery Henan Provincial People’s HospitalZhengzhou 450000China Key Laboratory of Organ Transplant Tianjin First Central HospitalTianjin 300192China

Interferon regulatory factor 1(IRF-1)is a member of the IRF *** is the first transcription factor to be identified that could bind to the interferon-stimulated response element(ISRE)on the target gene and displays crucial roles in the interferoninduced signals and ***-1,as an important medium,has all of the advantages of full cell cycle regulation,cell death signaling transduction,and reinforcing immune surveillance,which are well *** studies indicate that IRF-1 is of vital importance to the occurrence and evolution of multifarious liver diseases,including but not limited to inhibiting the replication of the hepatitis virus(A/B/C/E),alleviating the progression of liver fibrosis,and aggravating hepatic ischemiareperfusion injury(HIRI).The tumor suppression of IRF-1 is related to the clinical characteristics of liver cancer patients,which makes it a potential indicator for predicting the prognosis and recurrence of liver cancer;additionally,the latest studies have revealed other effects of IRF-1 such as protection against alcoholic/non-alcoholic fatty liver disease(AFLD/NAFLD),cholangiocarcinoma suppression,and uncommon traits in other liver diseases that had previously received little ***,several compounds and drugs have featured a protective function in specific liver disease models in which there is significant involvement of the IRF-1 *** this paper,we hope to propose a prospective research basis upon which to help decipher translational medicine applications of IRF-1 in liver disease treatment.

关键词： Interferon regulatory factor(IRF-1) Hepatitis virus Liver fibrosis Hepatic ischemia-reperfusion injury(HIRI) Liver cancer

A New Type of Silicone Rubber Membrane for Amperometric Oxygen Gas Sensor

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Chemical Research in Chinese Universities 1996年第1期12卷 114-119页

作者： LIU Shan-jun and shen Han-xi(department of Chemistry, nankai university, tianjin, 300071 )QIU Ying-hua and FENG Jian-xing.(department of Environmental Science, nankai university, Tia’din, 300071) nankai UNIV DEPT CHEMTIANJIN 300071PEOPLES R CHINA nankai UNIV DEPT ENVIRONM SCITIANJIN 300071PEOPLES R CHINA

How variable progenitor clones construct a largely invariant neocortex

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National Science Review 2024年第1期11卷 129-144页

作者： Zhongfu shen Jiajun Yang Qiangqiang Zhang Kuiyu Wang Xiaohui Lv Xiaolin Hu Jian Ma Song-Hai Shi New Cornerstone Science Laboratory IDG/McG overn Institute for Brain Research Tsinghua-Peking Center for Life Sciences Beijing Frontier Research Center for Biological Structure School of Life Sciences Tsinghua University department of Computer Sciences Tsinghua University College of Life Sciences Nankai University Chinese Institute for Brain Research

The neocortex contains a vast collection of diverse neurons organized into distinct layers. While nearly all neocortical neurons are generated by radial glial progenitors(RGPs), it remains largely unclear how a complex yet organized neocortex is constructed reliably and robustly. Here, we show that the division behavior and neuronal output of RGPs are highly constrained with patterned variabilities to support the reliable and robust construction of the mouse neocortex. The neurogenic process of RGPs can be well-approximated by a consistent Poisson-like process unfolding over time, producing deep to superficial layer neurons progressively. The exact neuronal outputs regarding layer occupation are variable; yet, this variability is constrained systematically to support all layer formation, largely reflecting the variable intermediate progenitor generation and RGP neurogenic entry and exit timing differences. Together, these results define the fundamental features of neocortical neurogenesis with a balanced reliability and variability for the construction of the complex neocortex.

关键词： neocortex radial glial progenitor intermediate progenitor neurogenesis clonal variability layer formation