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Failure analysis of crevice corrosion on 304 stainless steel tube heat exchanger

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Journal of Iron and Steel Research International 2023年第8期30卷 1490-1498页

作者： Chen Dong shen qu Chang-ming Fu Zhe-feng Zhang Failure Analysis Center for Materials Institute of Metal ResearchChinese Academy of SciencesShenyang 110016LiaoningChina

The cause of the premature failure of 304 stainless steel tube heat exchanger was *** unique skeleton structure inside the leakage point reveals that this is a new damage mechanism caused by a δ+γ two-phase structure and crevice *** three-dimensional structure of the leakage point was demonstrated using X-ray diffraction *** results of scanning electron microscope examination show the microstructure of the weld to be columnar and *** is found by electron probe microscope analysis and transmission electron microscopy that columnar dendrites consisted of γ-dendrite and an amount of δ-ferrite phases at the dendrite *** corrosion test results confirmed that the corrosion medium was the chloride *** corrosion of chloride ions occurred at weld defects on the inner wall thus forming a concentration *** of columnar dendrites were then corroded by chloride ions and δ-ferrite phases on the grain boundaries were retained,which formed the particular skeleton corrosion *** a result,it led to leakage when the corrosion of weld occurred from the inner wall to the outer wall.

关键词： Crevice corrosion Weld defect Chloride ions δ-ferrite Skeleton structure 304 stainless steel

Cross-talk between the thyroid and liver:A new target for nonalcoholic fatty liver disease treatment

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World Journal of Gastroenterology 2013年第45期19卷 8238-8246页

作者： Yue-Ye Huang Aaron M Gusdon shen qu Department of Endocrinology and Metabolism Shanghai 10th People’s Hospital School of Medicine Tongji University Department of Neurology and Neuroscience Weill Cornell Medical College New York NY 10065 United States Department of Endocrinology and Metabolism Nanjing Medical University

Nonalcoholic fatty liver disease(NAFLD)has been recognized as the most common liver metabolic disease,and it is also a burgeoning health problem that affects one-third of adults and is associated with obesity and insulin resistance *** hormone(TH)and its receptors play a fundamental role in lipid metabolism and lipid accumulation in the *** is found that thyroid receptor and its isoforms exhibit tissue-specific expression with a variety of ***β1 is predominantly expressed in the brain and adipose tissue and TRβ2 is the major isoform in the liver,kidney and *** have different functions and play important roles in lipid ***,there are many studies on the treatment of NAFLD with TH and its *** review here that thyroid hormone and TR are a potential target for pharmacologic *** metabolism and lipid accumulation can be regulated and reversed by TH and its analogues.

关键词： Thyroid hormone Thyroid hormone receptor Nonalcoholic fatty liver disease Obesity

Effect of Mg and Si on infiltration behavior of Al alloys pressureless infiltration into porous SiCp preforms

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International Journal of Minerals,Metallurgy and Materials 2011年第6期18卷 703-708页

作者： Shu-bin Ren Xiao-yu shen Xuan-hui qu Xin-bo He School of Materials Science and Engineering University of Science and Technology Beijing Beijing 100083 China

The effect of Mg and Si additon to Al matrix on infiltration kinetics and rates of Al alloys pressureless infiltration into porous SiCp preform was investigated by observing the change of infiltration distance with time as the Al alloys infiltrate into SiCp preforms at different *** results show that infiltration of SiCp preforms by Al melt is a thermal activation process and there is an incubation period before the infiltration becomes *** the increase of Mg content in the Al alloys from 0wt% to 8wt%,the infiltration will become much easier,the incubation period becomes shorter and the infiltration rate is faster,but these effects are not obvious when the Mg content is higher than 8wt%.As for Si addition to the Al alloys,it has no obvious effect on the incubation period,but the infiltration rate increases markedly with the increase of Si content from 0wt% to 12wt% and the rate has no obvious change when the content is bigger than 12wt%.The effect of Mg and Si on the incubation period is related to the infiltration mechanism of Al pressureless infiltration into SiCp preforms and their impact on the infiltration rate is a combined result from viscosity and surface tension of Al melt and SiC-Al wetting ability.

关键词： metallic matrix composites infiltration aluminum alloys silicon carbide preforms

CRISPR-mediated gene editing to rescue haploinsufficient obesity syndrome

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Protein & Cell 2019年第10期10卷 705-708页

作者： Zhifeng Wang Liu Yang shen qu Chao Zhang Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalShan ghai Key Laboratory of Signaling and Disease ResearchSchool of Life Sciences and Technologylongji UniversityShanghai 200092China Research&Development Department Sinoneural Cell and Gene Engineering Holdings Co.Ltd.ShanghaiChina Department of Endocri no logy and Metabolism National Metabolic Management CenterShanghai Tenth People's HospitalSchool of MedicineTongji UniversityShanghai 200092China

CRISPR and adeno-associated virus are becoming powerful tools to remedy genetic disorders in somatic cells of adulthood.A recent study published in Science(Matharu et al.,2019)safely targeted the non-coding genomic region of Sim1 and MC4R with rAAV packed with CRISPRa,and successfully rescued the obesity syndrome caused by hap?loinsufficiency in a murine model,which shed light on their potential therapeutic applications in the future(Matharu et al.,2019).

关键词： CRISPR packed becoming

Effects of glucagon-like peptide-1 receptor agonists on non-alcoholic fatty liver disease and inflammation

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World Journal of Gastroenterology 2014年第40期20卷 14821-14830页

作者： Xing-Chun Wang Aaron M Gusdon Huan Liu shen qu Department of Endocrinology and Metabolism Shanghai 10th People’s Hospital Tongji University Nanjing Medical University Department of Neurology and Neuroscience Weill Cornell Medical College New York NY 10065 United States

Glucagon-like peptide1 (GLP-1) is secreted from Langerhans cells in response to oral nutrient intake. Glucagon- like peptide-1 receptor agonists (GLP-1RAs) are a new class of incretin-based anti-diabetic drugs. They function to stimulate insulin secretion while suppressing glucagon secretion. GLP-1-based therapies are now well established in the management of type 2 diabetes mellitus (T2DM), and recent literature has suggested potential applications of these drugs in the treatment of obesity and for protection against cardiovascular and neurological diseases. As we know, along with change in lifestyles, the prevalence of non-alcoholic fatty liver disease (NAFLD) in China is rising more than that of viral hepatitis and alcoholic fatty liver disease, and NAFLD has become the most common chronic liver disease in recent years. Recent studies further suggest that GLP-1RAs can reduce transaminase levels to improve NAFLD by improving blood lipid levels, cutting down the fat content to promote fat redistribution, directly decreasing fatty degeneration of the liver, reducing the degree of liver fibrosis and improving inflammation. This review shows the NAFLD-associated effects of GLP-1RAs in animal models and in patients with T2DM or obesity who are participants in clinical trials. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.

关键词： Glucagon-like peptide-1 receptor agonists Liver function Fat content Non-alcoholic fatty liver disease Inflammation

Different compression sutures combined with intracameral air injection for acute corneal hydrops

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International Journal of Ophthalmology(English edition) 2022年第9期15卷 1538-1543页

作者： Xin Liu Hua Li shen qu Qiao Yu Hui Lin Yan-Long Bi Department of Ophthalmology Tongji HospitalSchool of MedicineTongji UniversityShanghai 200092China Department of Ophthalmology Guizhou Provincial People’s HospitalGuiyang 550002Guizhou ProvinceChina

·AIM:To evaluate the efficacy and safety of full-thickness sutures combined with intracameral air injection(FTS-AI)versus pre-Descemet’s membrane sutures combined with intracameral air injection(PDS-AI)in the management of acute corneal hydrops in keratoconus.·METHODS:The research included 8 patients(8 eyes)suffering from acute corneal hydrops caused by *** patients were randomly assigned to *** the other four were randomly assigned to *** oedema,visual acuity,corneal thickness were assessed during follow-up.·RESULTS:The demographics,preoperative duration of symptoms and severity of corneal hydrops between the two groups were not significantly *** mean corneal oedema resolution time after FTS-AI and PDSAI were 11±1.15 and 15±1.41 d,respectively(P=0.005).The maximum corneal thickness of the scarred region decreased in both groups at one week postoperatively(P<0.05).No obvious difference was found in the mean maximal corneal thickness between the two groups *** BCVA improved significantly after FTS-AI and PDS-AI at three months *** obvious difference was found in the BCVA after FTS-AI and PDS-AI at three months postoperatively.·CONCLUSION:FTS-AI and PDS-AI are safe and effective therapies to accelerate the resolution of corneal oedema in acute corneal hydrops secondary to *** faster resolution of corneal oedema in the FTS-AI group,we recommend PDS-AI to avoid potential endothelium cell damage.

关键词： keratoconus acute corneal hydrops fullthickness sutures pre-Descemet’s membrane sutures intracameral air injection

C^3:Consensus Cancer Driver Gene Caller

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Genomics, Proteomics & Bioinformatics 2019年第3期17卷 311-318页

作者： Chen-Yu Zhu Chi Zhou Yun-Qin Chen Ai-Zong shen Zong-Ming Guo Zhao-Yi Yang Xiang-Yun Ye shen qu Jia Wei Qi Liu Department of Endocrinology&Metabolism Shanghai Tenth People’s HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China Department of Ophthalmology Ninghai First HospitalNinghai 315600China R&D Information Innovation Center ChinaAstraZenecaShanghai 201203China Shanghai Chest Hospital Shanghai Jiaotong UniversityShanghai 200240China Department of Pharmacy The First Affiliated Hospital of University of Science and Technology of ChinaHefei 230036China

Next-generation sequencing has allowed identification of millions of somatic mutations in human cancer cells.A key challenge in interpreting cancer genomes is to distinguish drivers of cancer development among available genetic *** address this issue,we present the first webbased application,consensus cancer driver gene caller(C^3),to identify the consensus driver genes using six different complementary strategies,i.e.,frequency-based,machine learning-based,functional bias-based,clustering-based,statistics model-based,and network-based *** application allows users to specify customized operations when calling driver genes,and provides solid statistical evaluations and interpretable visualizations on the integration results.C^3 is implemented in Python and is freely available for public use at http://***/c3.

关键词： Somatic mutation Cancer driver genes Consensus Data integration Web server

Modeling the dynamic impacts of maritime network blockage on global supply chains

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The Innovation 2024年第4期5卷 103-109,102页

作者： shen qu Yunlei She Qi Zhou Jasper Verschuur Lu-Tao Zhao Huan Liu Ming Xu Yi-Ming Wei Center for Energy and Environmental Policy Research Beijing Institute of TechnologyBeijing 100081China School of Management Beijing Institute of TechnologyBeijing 100081China Beijing Key Lab of Energy Economics and Environmental Management Beijing 100081China Oxford Programme for Sustainable Infrastructure Systems(OPSIS) Environmental Change InstituteUniversity of OxfordOX12JD OxfordUK State Key Joint Laboratory of Environment Simulation and Pollution Control School of EnvironmentTsinghua UniversityBeijing 100084China State Environmental Protection Key Laboratory of Sources and Control of Air Pollution Complex Beijing 100084China School of Environment Tsinghua UniversityBeijing 100084China

Recent phenomena such as pandemics,geopolitical tensions,and climate change-induced extreme weather events have caused transportation network interruptions,revealing vulnerabilities in the global supply chain.A salient example is the March 2021 Suez Canal blockage,which delayed 432 vessels carrying cargo valued at$92.7 billion,triggering widespread supply chain *** ability to model the spatiotemporal ramifications of such incidents remains *** fill this gap,we develop an agent-based complex network model integrated with frequently updated maritime *** Suez Canal blockage is taken as a case *** results indicate that the effects of such blockages go beyond the directly affected countries and *** Suez Canal blockage led to global losses of about$136.9($127.5–$147.3)billion,with India suffering 75%of these *** losses show a nonlinear relationship with the duration of blockage and exhibit intricate trends post *** proposed model can be applied to diverse blockage scenarios,potentially acting as an earlyalert system for the ensuing supply chain ***,high-resolution daily data post blockage offer valuable insights that can help nations and industries enhance their resilience against similar future events.

关键词： chains valued extreme

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从指南更新看2型糖尿病管理理念的变迁

中华内分泌代谢杂志 2020年第8期36卷 723-726页

作者：曲伸上海市第十人民医院(同济大学附属第十人民医院)内分泌科 200072

糖尿病的全球患病率高,其主要危害在于各种并发症的发生,如心血管疾病和慢性肾病等。近年来,随着相关临床研究的发展,人们对糖尿病及其并发症的认知和管理也随之发生变化;这在国内外诊疗指南更新中,体现为从以"降糖"为中心到以"结局"为... 详细信息

糖尿病的全球患病率高,其主要危害在于各种并发症的发生,如心血管疾病和慢性肾病等。近年来,随着相关临床研究的发展,人们对糖尿病及其并发症的认知和管理也随之发生变化;这在国内外诊疗指南更新中,体现为从以"降糖"为中心到以"结局"为中心的观念变革,开启了糖尿病治疗的新时代。本文根据循证证据及相关指南的更新对2型糖尿病管理理念的变迁作一综述。

关键词：糖尿病 2型疾病管理指南变迁