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航海技术 2024年第3期 19-23页

作者：沈勇宁波引航站

随着船舶日益大型化,特定区域的潮流对超大型船舶操纵的影响愈发显著。为解决流场中切变线影响船舶通航安全问题,基于船舶操纵数学模型,运用船舶操纵模拟仿真试验,对q.max型液化天然气(LNG)船舶靠离光明码头的风险进行分析,在此基础上给... 详细信息

随着船舶日益大型化,特定区域的潮流对超大型船舶操纵的影响愈发显著。为解决流场中切变线影响船舶通航安全问题,基于船舶操纵数学模型,运用船舶操纵模拟仿真试验,对q.max型液化天然气(LNG)船舶靠离光明码头的风险进行分析,在此基础上给出q.max型LNG船舶过切变线的靠离泊安全措施,为后续码头投产营运船舶的靠离泊操纵作业提供参考。

关键词：切变线通航安全模拟操纵时间窗口

Novel compound heterozygous mutations in the hemojuvelin gene in a juvenile hemochromatosis patient:A case report

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World Journal of Clinical Cases 2024年第19期12卷 3961-3970页

作者： Ling-Ding Xie Xiao-Mu Kong Jing-Xia shen Tai-Ling Wang Jing Ma Yun-Fen Zhang Xiao-Ping Chen Department of Endocrinology China-Japan Friendship HospitalBeijing 100029China Department of Tumor Radiotherapy and Chemotherapy Qian’an People’s HospitalQian’an 064400Hebei ProvinceChina Department of Pathology China-Japan Friendship HospitalBeijing 100029China Department of Endocrinology Aksu First People's HospitalAksu Region 843000Xinjiang Uygur Autonomous RegionChina Department of Metabolic Diseases Qian’an Traditional Chinese Medical HospitalQian’an 064400Hebei ProvinceChina

BACKGROUND Juvenile hemochromatosis(JH)is an early-onset,rare autosomal recessive disorder of iron overload observed worldwide that leads to damage in multiple *** mutations in the hemojuvelin(HJV)gene are the major cause of *** SUMMARY A 34-year-old male Chinese patient presented with liver fibrosis,diabetes,hypogonadotropic hypogonadism,hypophysis hypothyroidism,and skin *** test revealed a markedly elevated serum ferritin level of 4329μg/L and a transferrin saturation rate of 95.4%.Targeted exome seq.encing and Sanger seq.encing revealed that the proband had a novel mutation c.863G>A(p.R288q.in the HJV gene which was transmitted from his father,and two known mutations,c.18G>C(p.q.H)and c.962_963delGCinsAA(p.C321*)in cis,which were inherited from his *** p.R288W mutation was previously reported to be pathogenic for hemochromatosis,which strongly supported the pathogenicity of p.R288q.reported for the first time in this *** 72 wk of intensive phlebotomy therapy,the patient achieved a reduction in serum ferritin to 160.5μg/*** patient's clinical symptoms demonstrated a notable *** This study highlights the importance of screening for hemochromatosis in patients with diabetes and hypogonadotropic *** also suggests that long-term active phlebotomy could efficiently improve the prognosis in severe JH.

关键词： Juvenile hemochromatosis Liver cirrhosis Diabetes Iron overload Phlebotomy Case report

Heavy fermions in high magnetic fields

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Chinese Physics B 2019年第1期28卷 25-38页

作者： M Smidman B shen C Y Guo L Jiao X Lu H q.Yuan Center for Correlated Matter and Department of Physics Zhejiang UniversityHangzhou 310058China Collaborative Innovation Center of Advanced Microstructures Nanjing UniversityNanjing 210093China

Heavy fermion materials are prototypical strongly correlated electron systems, where the strong electron–electron interactions lead to a wide range of novel phenomena and emergent phases of matter. Due to the low energy scales, the relative strengths of the Ruderman–Kittel–Kasuya–Yosida(RKKY) and Kondo interactions can often be readily tuned by non-thermal control parameters such as pressure, doping, or applied magnetic fields, which can give rise to q.antum criticality and unconventional superconductivity. Here we provide a brief overview of research into heavy fermion materials in high magnetic fields, focussing on three main areas. Firstly we review the use of magnetic fields as a tuning parameter,and in particular the ability to realize different varieties of q.antum critical behaviors. We then discuss the properties of heavy fermion superconductors in magnetic fields, where experiments in applied fields can reveal the nature of the order parameter, and induce new novel phenomena. Finally we report recent studies of topological Kondo systems, including topological Kondo insulators and Kondo–Weyl semimetals. Here experiments in magnetic fields can be used to probe the topologically non-trivial Fermi surface, as well as related field-induced phenomena such as the chiral anomaly and topological Hall effect.

关键词： heavy fermions high magnetic fields q.antum phase transitions heavy fermion superconductivity topological Kondo systems

3D－q.AR　STUDY　ON　HUPERZINE　A　ANALOGS　WITH　MOLECULAR　MODELING　AND　COMPARATIVE　MOLECULAR　FIELD　ANALYSIS（COMFA）　METHODS

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Chinese Chemical Letters 1996年第3期7卷 253-256页

作者： Jiang, HL Chen, KX Chen, JZ Tang, Y Wang, q. Li, q.shen, X Ji, RY CHINESE ACAD SCI SHANGHAI INST MAT MEDSHANGHAI 200031PEOPLES R CHINA

On the basis of conformational search for ten huperzine A analogs according to the structure ofAChE active site witll our approach BCSPL,we performed a 3D-q.AR analysis for these compounds usingmolecular modeling and CoMFA method. The calculation results can be used to explain the relationshipbetween the structUre properties and the activities.

关键词： ACETYLCHOLINESTERASE

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表面活性泡沫沥青发泡工艺及流变特性研究

华南理工大学学报（自然科学版） 2024年第3期52卷 41-49页

作者：陶卓辉沈士蕙孙杨邹玉春侯睿同济大学道路与交通工程教育部重点实验室上海200082 美国宾州州立大学宾州16601 江西省交通工程集团有限公司江西南昌330000 上海道淳交通科技有限公司上海215300

温拌沥青技术可降低沥青混合料生产和施工温度,在节能减碳方面极具应用潜力。泡沫温拌沥青技术成本较低,虽存在改性沥青发泡效果不理想、温拌效果不显著等问题,但具有潜在的推广应用前景。表面活性剂兼具“沥青润滑剂”和“泡沫稳定剂... 详细信息

温拌沥青技术可降低沥青混合料生产和施工温度,在节能减碳方面极具应用潜力。泡沫温拌沥青技术成本较低,虽存在改性沥青发泡效果不理想、温拌效果不显著等问题,但具有潜在的推广应用前景。表面活性剂兼具“沥青润滑剂”和“泡沫稳定剂”的作用效能,为改善泡沫温拌沥青发泡特性和温拌效果提供了可能。基于此,本研究采用不同质量分数的表面活性剂水溶液,在不同发泡温度下制备了表面活性泡沫沥青(SAFB6,SAFB8,SAFB10),利用发泡试验、动态剪切流变试验以及弯曲梁流变试验测试了沥青的发泡特性、高温性能、抗疲劳性能和低温性能,并借助傅里叶红外光谱试验分析了作用机理,揭示了表面活性剂与发泡过程对泡沫温拌沥青性能的协同提升作用。试验结果表明:表面活性剂对SBS改性沥青的发泡特性有明显的协同作用,特别是半衰期,最大可达69 s;SAFB沥青最佳发泡条件为发泡温度170℃,表面活性剂含量8%;SAFB沥青制备过程中没有发生复杂的化学反应,但是发泡过程导致SBS改性沥青发生了一定程度的氧化作用;表面活性剂和发泡工艺的协同效应提高了SBS改性沥青的高温性能和抗疲劳性能,而低温抗裂性能与SBS改性沥青相当。总体而言,表面活性剂与发泡技术相结合是可行的,提高了SBS改性沥青的发泡效果和路用性能。

关键词：泡沫温拌沥青表面活性剂发泡行为流变特性

基于多水准的高强钢框架-D形偏心支撑结构层剪力分布研究

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计算力学学报 2024年第4期41卷 734-741页

作者：李慎丁世豪李晓蕾穆林西安理工大学土木建筑工程学院西安710048

高强钢框架GD形偏心支撑结构中耗能梁段采用q.55钢,非耗能构件(即框架梁和柱)采用高强度钢材,形成一种新型结构体系.耗能梁段在结构遭遇罕遇地震时充分发挥塑性变形耗能,保护高强钢框架处于弹性受力状态,高强钢框架GD形偏心支撑结构由... 详细信息

高强钢框架GD形偏心支撑结构中耗能梁段采用q.55钢,非耗能构件(即框架梁和柱)采用高强度钢材,形成一种新型结构体系.耗能梁段在结构遭遇罕遇地震时充分发挥塑性变形耗能,保护高强钢框架处于弹性受力状态,高强钢框架GD形偏心支撑结构由于在塑性状态下结构刚度发生改变,其层剪力分布模式不再符合基于强度的设计理论,因此,本文研究了高强钢框架GD形偏心支撑结构在多水准地震动状态下的层剪力分布模式.本文设计了四种不同层数(4层,8层,12层和16层)和三种不同耗能梁段长度(900mm,1000mm和1100mm)的高强钢框架GD形偏心支撑结构,输入40条近场脉冲地震和40条远场地震记录,得到结构在多遇地震、设防地震、罕遇地震以及极罕遇地震下的层剪力分布模式,并对罕遇地震下的层剪力分布模式进行参数标定,获取塑性状态下结构的弹塑性侧向力分布状态.

关键词： D形偏心支撑层剪力分布模式近场脉冲地震高强钢框架

MOLECULAR　MECHANICAL　AND　q.ANTUM　CHEMICAL　CALCULATION　ON　ACYLATION　REACTIVITY　FOR　1－（NITRO　SUBSTITUTED　ANILINO）－4－SUBSTITUTED－2，6－PIPERAZINEDIONES

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Chinese Chemical Letters 1995年第8期6卷 691-694页

作者： Jiang, HL Li, q.Chen, KX Tang, Y shen, X Ji, RY Xie, YY Chinese Acad Sci Shanghai Inst Mat Med Shanghai 200031 Peoples R China

Molecular mechanical and q.antum chemical methods were used to calculate the conformational and electronic structures of the template molecules of (nitro substituted an ill no)-4 - sub st nut ed -2, 6 -piperazinediones, With the calculation results we explained the acylation reactivity of title compounds satisfactorily.

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Improving weld formability by a novel dual-rotation bobbin tool friction stir welding

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Journal of Materials Science & Technology 2018年第1期34卷 135-139页

作者： F.F.Wang W.Y.Li J.shen q.Wen J.F.dos Santos State Key Laboratory of Solidification Processing Shaanxi Key Laboratory of Friction Welding Technologies Northwestern Polytechnical University Helmholtz-Zentrum Geesthacht Institute of Materials Research Materials Mechanics China Academy of Launch Vehicle Technology Beijing Institute of Astronautical Systems Engineering

A novel dual-rotation bobbin tool friction stir welding （DBT-FSW） was developed, in which the upper shoulder （US） and lower shoulder （LS） have different rotational speeds. This process was tried to weld 3.2 mm thick alunlinum-lithium alloy sheets. The metallographic analysis and torq.e measurement were carried out to characterize the weld formabiliW. Experimental results show that compared to conven- tional bobbin tool friction stir welding, the DBT-FSW has an excellent process stability, and can produce the defect-free joints in a wider range of welding parameters. These can be attributed to the significant improvement of material flow caused by the formation of a staggered layer structure and the unbalanced force between the US and LS during the DBT-FSW process.

关键词： Bobbin tool friction stir welding Dual rotation Material flow Microstructure Microhardness

血糖变异系数对急诊脓毒症患者脓毒症相关性脑病的预测价值

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中国急救医学 2024年第9期44卷 815-821页

作者：陈伟沈琦陈虞红绍兴市上虞人民医院急诊科EICU 浙江绍兴312300

目的分析血糖变异系数(GLUcv)对急诊脓毒症患者脓毒症相关性脑病(SAE)的预测价值。方法采用前瞻性队列研究方法,入选2022年3月至2024年2月在绍兴市上虞人民医院急诊重症监护病房(EICU)诊治的脓毒症患者,检测患者入院24 h内末梢血糖,并计... 详细信息

目的分析血糖变异系数(GLUcv)对急诊脓毒症患者脓毒症相关性脑病(SAE)的预测价值。方法采用前瞻性队列研究方法,入选2022年3月至2024年2月在绍兴市上虞人民医院急诊重症监护病房(EICU)诊治的脓毒症患者,检测患者入院24 h内末梢血糖,并计算GLUcv。以脓毒症确诊28 d内SAE事件为研究终点,将28 d内并发SAE的患者纳入SAE组,未并发SAE患者纳入N-SAE组。比较分组后组间主要资料与指标水平的差异,通过构建Logistic回归模型,分析脓毒症并发SAE与GLUcv及其他主要指标的关系。采用限制性立方样条法,分析GLUcv与脓毒症并发SAE风险的剂量反应关系。绘制受试者工作特征(ROC)曲线与临床决策曲线,分析GLUcv对脓毒症并发SAE的预测价值。结果最终有135例患者完成研究,患者入院24 h内GLUcv结果为12.59~33.60,根据GLUcv四分位数由低到高将135例患者分为q.(1)~q.(4)组,q.(4)组SAE发生率高于q.(1)~q.(3)组,q.(3)和q.(4)组急性生理学和慢性健康状况评价Ⅱ(APACHEⅡ)评分、血清淀粉样蛋白A(SAA)、白细胞介素(IL)-6及神经元特异性烯醇化酶(NSE)水平高于q.(1)和q.(2)组,24 h乳酸清除率低于q.(1)和q.(2)组(P<0.05)。患者确诊后28 d内并发SAE 57例,发生率约42.22%。SAE组入院时APACHEⅡ评分、GLUcv、IL-6及NSE水平高于N-SAE组,24 h乳酸清除率低于N-SAE组(P<0.05)。构建Logistic回归模型结果显示,脓毒症并发SAE可能与入院时APACHEⅡ评分、24 h乳酸清除率、GLUcv、IL-6、NSE及SAA有关(P<0.05)。绘制ROC曲线,GLUcv预测脓毒症患者并发SAE曲线下面积(AUC)为0.797,最佳截断值为23.24。采用限制性立方样条法分析,脓毒症患者入院24 h内GLUcv与入院28 d内SAE发生风险呈线性剂量反应关系(P<0.05),当GLUcv阈值达到23.24时,SAE风险随着GLUcv升高而增加。绘制临床决策曲线,GLUcv预测脓毒症并发SAE临床净收益情况理想,且联合其他指标能提高整体决策获益。结论脓毒症患者并发SAE与GLUcv的升高有关,SAE风险随GLUcv升高而增加,脓毒症患者入院24 h内GLUcv可预测SAE高风险人群,且联合其他指标能提高整体风险预测的净收益率。

关键词：脓毒症脓毒症相关性脑病血糖变异系数预测临床决策曲线