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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2024年第2期25卷 161-182页

作者： shen liu Xieping HUANG Xiangzhen KONG Qin FANG Center for Hypergravity Experiment and Interdisciplinary Research Zhejiang UniversityHangzhou310058China Institute of Geotechnical Engineering Zhejiang UniversityHangzhou310058China State Key Laboratory of Disaster Prevention&Mitigation of Explosion&Impact Army Engineering University of PLANanjing210007China

This paper presents a numerical study to improve the understanding of the complex subject of penetration and perforation of concrete targets impacted by low-velocity *** main focus is on the damage mechanisms and the major factors that account for the target resistance of the *** improved continuous surface cap model recently proposed was *** model was first equipped with element erosion criteria and was adequately validated by comparisons with ballistic *** numerical simulations were carried out where the individual influence of tensile,shear,and volumetric behaviors(pore collapse)of a concrete target on its ballistic performance was *** demonstrated that cratering on the front face and scabbing on the rear face of the concrete target were mainly dominated by its tensile *** major target resistance came from the second tunneling stage which was primarily governed by the shear and volumetric behaviors of the ***,this study captured the pore collapse-induced damage phenomenon during the high-pressure tunneling stage,which has been extensively reported in experiments but has usually been neglected in previous numerical investigations.

关键词： Penetration Perforation Damage mechanism Target resistance Projectile impact Pore collapse

Diamond-Like Carbon Depositing on the Surface of Polylactide Membrane for Prevention of Adhesion Formation During Tendon Repair

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Nano-Micro Letters 2024年第9期16卷 478-499页

作者： Yao Xiao Zaijin Tao Yufeng Ju Xiaolu Huang Xinshu Zhang Xiaonan liu Pavel A.Volotovski Chao Huang Hongqi Chen Yaozhong Zhang shen liu Department of Orthopaedics Shanghai Jiao Tong University School of Medicine Affiliated Sixth People’s Hospital600 Yishan RdShanghai 200233People’s Republic of China Shanghai Tongji Hospital 389 Xincun RdShanghai 200065People’s Republic of China Key Laboratory for Thin Film and Microfabrication of Ministry of Education Research Institute of Micro/Nano Science and TechnologyShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China Orthopedic Trauma Department Belarus Republic Scientific and Practical Center for Traumatology and OrthopedicsKizhevatova str.60/4220024 MinskBelarus Shanghai Haohai Biological Technology Limited Liability Company 1386 Hongqiao RdShanghai 200336People’s Republic of China Department of General Surgery Shanghai Jiao Tong University School of Medicine Affiliated Sixth People’s Hospital600 Yishan RdShanghai 200233People’s Republic of China Shanghai Key Laboratory for High Temperature Materials and Precision Forming School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

Post-traumatic peritendinous adhesion presents a significant challenge in clinical *** study proposes the use of diamond-like carbon(DLC)deposited on polylactic acid(PLA)membranes as a biophysical mechanism for anti-adhesion barrier to encase ruptured tendons in tendon-injured *** results indicate that PLA/DLC composite membrane exhibits more efficient anti-adhesion effect than PLA membrane,with histological score decreasing from 3.12±0.27 to 2.20±0.22 and anti-adhesion effectiveness increasing from 21.61%to 44.72%.Mechanistically,the abundant C=O bond functional groups on the surface of DLC can reduce reactive oxygen species level effectively;thus,the phosphorylation of NF-κB and M1 polarization of macrophages are ***,excessive inflammatory response augmented by M1 macrophage-originated cytokines including interleukin-6(IL-6),interleukin-1β(IL-1β),and tumor necrosis factor-α(TNF-α)is largely *** biocompatibility evaluation,PLA/DLC membrane is slowly absorbed within tissue and displays prolonged barrier effects compared to traditional PLA *** studies show the DLC depositing decelerates the release of degradation product lactic acid and its induction of macrophage M2 polarization by interfering esterase and PLA ester bonds,which further delays the fibrosis *** was found that the PLA/DLC membrane possess an efficient biophysical mechanism for treatment of peritendinous adhesion.

关键词： Diamond-like carbon Reactive oxygen species scavenging Foreign body reaction Biodegradation Antioxidant Peritendinous adhesion

Multi-omics analysis of human tendon adhesion reveals that ACKR1-regulated macrophage migration is involved in regeneration

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Bone Research 2024年第2期12卷 390-406页

作者： Xinshu Zhang Yao Xiao Bo Hu Yanhao Li Shaoyang Zhang Jian Tian Shuo Wang Zaijin Tao Xinqi Zeng Ning-Ning liu Baojie Li shen liu Department of Orthopaedics Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine600 Yishan RdShanghai 200233PR China Section of Spine Surgery Department of OrthopaedicsChangzheng HospitalNaval Medical UniversityShanghai 200003PR China Bio-X Institutes Key Laboratory for the Genetics of Developmental and Neuropsychiatric DisordersMinistry of EducationShanghai Jiao Tong UniversityShanghai 200241PR China Department of Orthopaedics Wuxi Ninth People’s Hospital Affiliated to Soochow UniversityWuxi 214062PR China State Key Laboratory of Systems Medicine for Cancer Center for Single-Cell OmicsSchool of Public HealthShanghai Jiao Tong University School of MedicineShanghai 200025China

Tendon adhesion is a common complication after tendon injury with the development of accumulated fibrotic tissues without effective anti-fibrotic therapies,resulting in severe *** are widely recognized as a fibrotic trigger during peritendinous adhesion ***,different clusters of macrophages have various functions and receive multiple regulation,which are both still *** our current study,multi-omics analysis including single-cell RNA sequencing and proteomics was performed on both human and mouse tendon adhesion tissue at different stages after tendon *** transcriptomes of over 74000 human single cells were *** results,we found that SPP1^(+)macrophages,RGCC^(+)endothelial cells,ACKR1^(+)endothelial cells and ADAM12^(+)fibroblasts participated in tendon adhesion ***,despite specific fibrotic clusters in tendon adhesion,FOLR2^(+)macrophages were identified as an antifibrotic cluster by in vitro experiments using human ***,ACKR1 was verified to regulate FOLR2^(+)macrophages migration at the injured peritendinous site by transplantation of bone marrow from Lysm-Cre;R26R^(tdTomato) mice to lethally irradiated Ackr1^(-/-)mice(Ackr1^(-/-)chimeras;deficient in ACKR1)and control mice(WT chimeras).Compared with WT chimeras,the decline of FOLR2^(+)macrophages was also observed,indicating that ACKR1 was specifically involved in FOLR2^(+)macrophages *** together,our study not only characterized the fibrosis microenvironment landscape of tendon adhesion by multi-omics analysis,but also uncovered a novel antifibrotic cluster of macrophages and their *** results provide potential therapeutic targets against human tendon adhesion.

关键词： tendon analysis landscape

Overexpression of low-density lipoprotein receptor prevents neurotoxic polarization of astrocytes via inhibiting NLRP3 inflammasome activation in experimental ischemic stroke

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Neural Regeneration Research 2025年第2期20卷 491-502页

作者： Shuai Feng Juanji Li Tingting liu Shiqi Huang Xiangliang Chen shen liu Junshan Zhou Hongdong Zhao Ye Hong Department of Neurology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Neurology Nanjing Jinling HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina

Neurotoxic astrocytes are a promising therapeutic target for the attenuation of cerebral ischemia/reperfusion ***-density lipoprotein receptor,a classic cholesterol regulatory receptor,has been found to inhibit NLR family pyrin domain containing protein 3(NLRP3)inflammasome activation in neurons following ischemic stroke and to suppress the activation of microglia and astrocytes in individuals with Alzheimer’s ***,little is known about the effects of low-density lipoprotein receptor on astrocytic activation in ischemic *** address this issue in the present study,we examined the mechanisms by which low-density lipoprotein receptor regulates astrocytic polarization in ischemic stroke ***,we examined low-density lipoprotein receptor expression in astrocytes via immunofluorescence staining and western blotting *** observed significant downregulation of low-density lipoprotein receptor following middle cerebral artery occlusion reperfusion and oxygen-glucose deprivation/***,we induced the astrocyte-specific overexpression of low-density lipoprotein receptor using astrocyte-specific adeno-associated ***-density lipoprotein receptor overexpression in astrocytes improved neurological outcomes in middle cerebral artery occlusion mice and reversed neurotoxic astrocytes to create a neuroprotective ***,we found that the overexpression of low-density lipoprotein receptor inhibited NLRP3 inflammasome activation in oxygen-glucose deprivation/reoxygenation injured astrocytes and that the addition of nigericin,an NLRP3 agonist,restored the neurotoxic astrocyte *** findings suggest that low-density lipoprotein receptor could inhibit the NLRP3-meidiated neurotoxic polarization of astrocytes and that increasing low-density lipoprotein receptor in astrocytes might represent a novel strategy for treating cerebral ischemic stroke.

关键词： inflammation ischemia/reperfusion injury ischemic stroke low-density lipoprotein receptor neuroprotective astrocytes neurotoxic astrocytes NLRP3 inflammasome polarization

量子认知的研究回溯、核心应用领域与未来展望

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自然辩证法通讯 2024年第4期46卷 41-48页

作者：刘燊安徽农业大学人文社会科学学院心理学系安徽合肥230036

量子认知是当代认知科学哲学体系中的一个新型的边缘分支学科,借助量子力学理论的数学方法对认知科学哲学领域中的现象构建模型,从而研究与描述人类认知,最为核心的应用领域是决策行为。近年来,一种基于量子理论的量子决策模型为解决传... 详细信息

量子认知是当代认知科学哲学体系中的一个新型的边缘分支学科,借助量子力学理论的数学方法对认知科学哲学领域中的现象构建模型,从而研究与描述人类认知,最为核心的应用领域是决策行为。近年来,一种基于量子理论的量子决策模型为解决传统决策模型难以解决的问题提供了新的思路。该模型打破了传统决策模型中经典概率理论的禁锢,为决策理论的发展指明了新的方向。然而,相较于其他较为成熟的认知科学哲学分支,量子认知的研究仍处于起步和发展阶段,还需要深入开展量子认知的基础理论研究、积极探索量子认知的神经生理基础、构建类量子贝叶斯网络以优化决策、发展量子博弈以拓宽量子认知疆域等。

关键词：量子认知量子决策类量子贝叶斯网络量子心灵量子博弈

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基于空化时空分布特征的调节阀空蚀风险预测

华中科技大学学报（自然科学版） 2024年第6期52卷 71-79页

作者：张雨佳刘秀梅李贝贝刘申中国矿业大学机电工程学院江苏徐州221116

针对煤液化工程中的关键设备高压差调节阀耐空蚀能力差、使用寿命短的问题,利用高速相机拍摄获取调节阀空化流场图像,提出空隙率λ表征气相体积分数、空隙率变化速率β表征空蚀风险指标,实现了调节阀空蚀破坏的准确预测.结果表明:空隙... 详细信息

针对煤液化工程中的关键设备高压差调节阀耐空蚀能力差、使用寿命短的问题,利用高速相机拍摄获取调节阀空化流场图像,提出空隙率λ表征气相体积分数、空隙率变化速率β表征空蚀风险指标,实现了调节阀空蚀破坏的准确预测.结果表明:空隙率数值与气相体积分数正相关;随着入口压力的增大,阀芯头部和喉部对应空隙率数值增大,空化得到充分发展向扩张段延伸并溃灭,调节阀内空化呈初生、发展、脱落和溃灭的周期性变化趋势.当空隙率变化速率β<0时,表示空泡处于溃灭状态,据此可以判断该处存在空蚀风险;随着入口压力的增加,附着型空泡溃灭位置较为固定在调节阀头部,是阀芯发生空蚀破坏的主要原因.游离型空化损伤区域随着入口压力增加逐渐向调节阀下游延伸,调节阀流道上方和下方空化损伤区域为非对称结构,下方的空化损伤区域整体超前于上方.

关键词：空化调节阀空隙率空蚀破坏风险预测

基于微震特征参数的秦岭隧洞岩爆实时预测模型

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水利学报 2024年第7期55卷 757-767页

作者：胡晶刘慎陈祖煜中国水利水电科学研究院北京 100048 浙江大学岩土工程研究所浙江杭州 310058 中国水利水电科学研究院北京 100048 浙江大学岩土工程研究所浙江杭州 310058

岩爆是深地工程施工中的主要灾害之一,微震监测是岩爆短期预测的主要方法.为了解决岩爆事故短期预测主要依靠经验的问题,基于引汉济渭工程秦岭隧洞,建立微震监测及岩爆事件的机器学习样本库.采用卷积神经网络模型,将一段时间内所有微震... 详细信息

岩爆是深地工程施工中的主要灾害之一,微震监测是岩爆短期预测的主要方法.为了解决岩爆事故短期预测主要依靠经验的问题,基于引汉济渭工程秦岭隧洞,建立微震监测及岩爆事件的机器学习样本库.采用卷积神经网络模型,将一段时间内所有微震事件的能量、位置、震级等特征参数作为输入,并考虑掌子面位置对岩爆的影响,建立基于微震特征参数的岩爆实时预测模型.采用样本库对模型进行训练、验证和测试,针对模型结构、回溯时间段、预测时间段、训练世代对模型进行了优化.模型可以合理描述微震事件分布特征、施工进度等因素对岩爆可能性的影响.经测试,该模型能够实时预测未来48 h的岩爆发生概率,预测准确率超过80％,可为岩爆实时预测提供一种有效的技术途径.

关键词：微震监测岩爆预测卷积神经网络特征参数

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肌腱病疼痛发生机制研究进展

中华创伤杂志 2024年第1期40卷 80-86页

作者：熊英宏刘申徐大启中南大学湘雅医院运动医学科湖南省器官损伤衰老与再生医学重点实验室国家老年疾病临床医学研究中心长沙410008

肌腱在运动系统中发挥重要作用,但这一结构损伤后会导致疼痛和功能下降,被称为肌腱病,其中疼痛是最早出现的症状,严重影响患者的生活和工作。尽管目前有多种方法用于治疗肌腱病疼痛,但治疗周期长且效果不佳,其主要原因在于肌腱病疼痛发... 详细信息

肌腱在运动系统中发挥重要作用,但这一结构损伤后会导致疼痛和功能下降,被称为肌腱病,其中疼痛是最早出现的症状,严重影响患者的生活和工作。尽管目前有多种方法用于治疗肌腱病疼痛,但治疗周期长且效果不佳,其主要原因在于肌腱病疼痛发生机制仍尚未完全明确。因此,明确肌腱病疼痛的发生机制,对寻找新的治疗策略有重要价值。为此,笔者从组织结构改变、疼痛介质、中枢调控等方面就肌腱病疼痛发生机制的研究进展进行综述,为肌腱病疼痛的机制研究和临床治疗提供参考。

关键词：肌腱病运动损伤疼痛中枢可塑性

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马铃薯蛋白组成、性质及其改性应用研究进展

食品工业科技 2024年第9期45卷 36-44页

作者：孙莹周斌王龙刘申朱秀清哈尔滨商业大学旅游烹饪学院黑龙江哈尔滨150028 哈尔滨商业大学食品工程学院黑龙江哈尔滨150028

我国马铃薯加工业的快速发展可以归因于马铃薯主食工业化战略的实施。马铃薯蛋白以其高营养价值和功能而闻名,具有特殊的溶解度,并含有大量在其他植物蛋白中缺乏的酪氨酸。因此,马铃薯蛋白在各种市场应用上具有巨大的潜力。本文对马铃... 详细信息

我国马铃薯加工业的快速发展可以归因于马铃薯主食工业化战略的实施。马铃薯蛋白以其高营养价值和功能而闻名,具有特殊的溶解度,并含有大量在其他植物蛋白中缺乏的酪氨酸。因此,马铃薯蛋白在各种市场应用上具有巨大的潜力。本文对马铃薯蛋白的组成、功能性质、改性方法和改性应用进行了全面的综述。马铃薯蛋白具有良好的溶解性、发泡化和乳化特性、凝胶性和抗氧化活性。目前,酶法和微生物发酵是马铃薯蛋白改性研究的重点。此外,本文还概述了马铃薯蛋白中普遍存在的主要问题,并根据目前的研究进展提出了未来的发展前景。未来,应深入研究马铃薯蛋白分子结构与其功能活性的联系;马铃薯蛋白与其他植物蛋白的综合利用;酶法和微生物发酵可作为未来改性方向,利用微生物资源降低改性成本。

关键词：马铃薯蛋白组成功能性质蛋白改性应用

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国际多式联运货损责任的法律适用研究

对外经贸 2024年第7期 52-55页

作者：刘申新疆师范大学政法学院新疆乌鲁木齐830000

随着海洋强国战略目标的提出和“一带一路”建设的逐步推进,国际货物多式联运以其多样的运输方式实现了国际货物运输的便捷与高效,突出了其独特的优势。国际货物多式联运途经多个国家或地区,货物灭失、损坏可能发生在某一国家或地区,因... 详细信息

随着海洋强国战略目标的提出和“一带一路”建设的逐步推进,国际货物多式联运以其多样的运输方式实现了国际货物运输的便捷与高效,突出了其独特的优势。国际货物多式联运途经多个国家或地区,货物灭失、损坏可能发生在某一国家或地区,因法律制度的差异,责任认定适用哪个国家或地区的法律,对多式联运各方当事人的利益影响较大。基于此,从多式联运经营人责任如何运用法律进行确定的角度出发,对我国多式联运的进一步发展提出相关建议。

关键词：多式联运比较分析货损责任法律适用