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A 100-pw compressor based on single-pass single-grating pair

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High Power Laser Science and Engineering 2023年第1期11卷 26-37页

作者： Shuman Du Xiong shen Wenhai Liang Peng Wang Jun Liu Ruxin Li State Key Laboratory of High Field Laser Physics and CAS Center for Excellence in Ultra-intense Laser Science Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghaiChina Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijingChina Zhangjiang Laboratory ShanghaiChina

A multistep pulse compressor(MPC)based on a single-pass single-grating pair(SSGP)is proposed to simplify the entire multi-petawatt(pw)*** one grating pair with relatively long perpendicular distance is used to generate the same amount of spectral chirp compared with a four-grating main *** SSGP compressor induces the largest spatial chirp,it can introduce the best beam-smoothing effect to the laser beam on the last *** considering the diffraction loss of only two gratings,the total compression efficiency of the SSGP compressor is even larger than that of a four-grating main ***,the wavefront aberration induced by the SSGP compressor can be better compensated by using deformable mirrors;however,it is difficult or complicated to be well compensated in a four-grating *** 50-100 pw laser pulses can be obtained using this SSGP-based multistage-smoothing MPC with a single laser beam.

关键词： beam smoothing multistep pulse compressor petawatt single-grating-pair compressor

丰富环境对大鼠缺血再灌注后星形胶质细胞A1/A2表型转换和认知功能的影响

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中国康复医学杂志 2024年第8期39卷 1094-1103页

作者：申鑫雅高振坤韩宇韩萍萍毕霞上海健康医学院附属周浦医院康复医学科上海市201203 上海中医药大学研究生院上海体育学院运动健康学院

目的:探究丰富环境对大鼠缺血再灌注(ischemia-reperfusion,I/R)后星形胶质细胞A1/A2表型转换和认知功能的影响。方法:选用42只成年雄性SD大鼠,体重(220±20)g,接受大脑中动脉闭塞(middle cerebral artery occlusion,MCAO)手术,2h后拔... 详细信息

目的:探究丰富环境对大鼠缺血再灌注(ischemia-reperfusion,I/R)后星形胶质细胞A1/A2表型转换和认知功能的影响。方法:选用42只成年雄性SD大鼠,体重(220±20)g,接受大脑中动脉闭塞(middle cerebral artery occlusion,MCAO)手术,2h后拔出线栓实现再灌注。术后3天,将造模成功的30只大鼠随机分为标准环境组(standard environment,SE)和丰富环境组(enriched environment,EE),另选用10只大鼠作为假手术组(sham)。EE组饲养于丰富环境笼子中,其余两组饲养于标准环境中。21天后,使用Bederson评分和m Nss评分检测各组大鼠的神经功能缺损情况,使用Morris水迷宫对大鼠的认知功能进行检测;随后使用蛋白质印迹分析星形胶质细胞标志物胶质纤维酸性蛋白(GFAP)的激活情况;实时PCR和ELISA对A1型星形胶质细胞标志物(C3)和A2型星形胶质细胞标志物(S100A10)的表达情况进行检测;苏木素-伊红(HE)染色观察梗死周围皮层组织病理学变化;TUNEL染色检测细胞凋亡情况。结果:与SE组相比,EE组GFAP的蛋白表达量显著减少(P<0.05)。EE组A1型星形胶质标志物C3的表达量显著低于SE组(P<0.05),而A2型星形胶质标志物S100A10的表达量则显著高于SE组(P<0.05)。与这一结果相对应,在EE组中,A1星形胶质细胞分泌的细胞因子TNF-α显著低于SE组(P<0.05),A2星形胶质细胞分泌的细胞因子BDNF显著高于SE组(P<0.05)。TUNEL染色和HE染色显示,EE组细胞凋亡和损伤情况更少(P<0.05)。此外,EE组大鼠的神经功能缺血情况较轻,包括Bederson评分和m Nss评分的显著差异(P<0.01);与SE组相比,EE组的大鼠有着更好的认知功能,表现为水迷宫实验中的潜伏期更短(P<0.05),在目标象限的停留时间更长(P<0.01),穿越平台的次数更多(P<0.05)。结论:丰富环境可以抑制星形胶质细胞的激活,同时引导已激活的星形胶质细胞转化为神经保护的A2型,抑制其转化为神经毒性的A1型,从而改善大鼠缺血性卒中后的认知功能。

关键词：缺血再灌注丰富环境星形胶质细胞大鼠认知功能

不同饮用水对高脂饮食诱导的大鼠脂质代谢紊乱和肝损伤的影响

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营养学报 2024年第1期46卷 75-80页

作者：王亚婷魏飞张曦赵辰谌志强李超滨州医学院烟台264003 军事科学院军事医学研究院环境医学与作业医学研究所天津300050

目的探究不同饮用水对高脂饮食条件下大鼠脂质代谢紊乱和肝损伤的影响。方法实验用水为溶解性总固体(TDS)和镁含量明显不同的自来水、纯净水、天然矿泉水1、天然矿泉水2。25只雄性Wistar大鼠随机分为5组,分组及干预如下:对照组(TN)饲喂... 详细信息

目的探究不同饮用水对高脂饮食条件下大鼠脂质代谢紊乱和肝损伤的影响。方法实验用水为溶解性总固体(TDS)和镁含量明显不同的自来水、纯净水、天然矿泉水1、天然矿泉水2。25只雄性Wistar大鼠随机分为5组,分组及干预如下:对照组(TN)饲喂自来水+基础饲料,自来水组(TW)饲喂自来水+高脂饲料,纯净水组(pw)饲喂纯净水+高脂饲料,天然矿泉水1组(VW)饲喂天然矿泉水1+高脂饲料,天然矿泉水2组(SW)饲喂天然矿泉水2+高脂饲料。每日记录大鼠饮水量及摄食量,每周称重1次,20w后收集大鼠血液和肝脏标本,测定大鼠肝脏重量和肝脏指数,检测血清总胆固醇(total cholesterol,TC)、甘油三酯(triglyceride,TG)、低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)、高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)、谷丙转氨酶(alanine aminotransferase,ALT)和谷草转氨酶(aspartate aminotransferase,AST),以及肝脏丙二醛(malondialdehyde,MDA)、超氧化物歧化酶(superoxide dismutase,SOD)、过氧化氢酶(catalase,CAT)、谷胱甘肽过氧化物酶(glutathione peroxidase,GPH-Px)活性,观察肝脏切片病理变化。结果饮水干预20w后,与pw组大鼠相比,VW组和SW组大鼠体重增长显著减缓,VW组和SW组肝脏重量和肝脏指数显著下降。SW组大鼠血清TC、TG、LDL-C水平显著降低,而血清HDL-C水平显著升高,VW组和SW组大鼠的血清ALT和AST水平显著降低,VW组和SW组肝脏MDA水平显著下降,SW组肝脏抗氧化酶SOD、CAT和GPH-Px水平显著升高,VW组肝脏抗氧化酶GPH-Px水平显著升高,VW组和SW组大鼠肝脏脂滴沉积出现不同程度减少。结论天然矿泉水在不同程度上减轻高脂饮食所致的肝脏重量、肝脏指数和体重的异常增长,改善血脂参数异常变化,减轻高脂饮食造成的肝脏脂肪变性,提高抗氧化功能。相比于低镁天然矿泉水,高镁天然矿泉水在调节血脂代谢、增强抗氧化酶活性方面表现更为突出。

关键词：饮用水脂质血症血脂代谢抗氧化

Brostrom-Gould修复术联合Internal Brace加强治疗慢性踝关节外侧不稳定的临床疗效

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中华骨与关节外科杂志 2024年第4期17卷 321-325页

作者：张琳袁吴佳俊崔崟付备刚蔡攀贾永伟沈超上海健康医学院附属周浦医院骨科上海201318

目的:探讨Brostrom⁃Gould修复术联合Internal Brace加强治疗慢性踝关节外侧不稳定(CLAI)的临床疗效。方法:回顾性分析2018年3月至2022年12月行Brostrom⁃Gould修复术联合Internal Brace加强治疗的32例CLAI患者的临床资料。其中男19例,女1... 详细信息

目的:探讨Brostrom⁃Gould修复术联合Internal Brace加强治疗慢性踝关节外侧不稳定(CLAI)的临床疗效。方法:回顾性分析2018年3月至2022年12月行Brostrom⁃Gould修复术联合Internal Brace加强治疗的32例CLAI患者的临床资料。其中男19例,女13例,年龄36(29,41)岁(23~56岁);运动损伤13例,日常扭伤15例,交通事故等其他损伤4例。记录术前及末次随访时美国足踝外科协会(AOFAS)踝-后足评分及踝关节Kofoed评分以评估踝关节功能,并记录疼痛视觉模拟评分(VAS),同时观察并发症发生情况。结果:所有患者均顺利完成手术,切口均一期愈合,术后1例患者出现腓浅神经损伤。所有患者均获得随访,随访时间17(14,18)个月(12~38个月)。末次随访时患者AOFAS踝-后足评分由术前的(68.4±10.4)分增加至(92.2±11.2)分;踝关节Kofoed评分由术前的(64.6±14.1)分增加至(90.0±7.9)分,疼痛VAS评分由术前的3.2(2.5,3.6)分降低至0.8(0.5,1.0)分,且差异均有统计学意义(P均<0.05)。1例患者术后6个月出现踝关节外侧紧缚感,经功能锻炼后好转。结论:Brostrom⁃Gould修复术联合Internal Brace加强治疗CLAI,提供了可靠的即刻稳定性,并发症发生率低,有利于患者早期功能锻炼,尽快恢复负重行走及日常生活。

关键词：慢性踝关节外侧不稳定 Brostrom-Gould修复术 Internal Brace

Effects of mesencephalic astrocyte-derived neurotrophic factor on sepsis-associated acute kidney injury

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World Journal of Emergency Medicine 2023年第5期14卷 386-392页

作者： Saifeng Chen Xuewei Hao Guo Chen Guorong Liu Xiaoyan Yuan Peiling shen Dongfeng Guo Postgraduate Training Base at Shanghai Gongli Hospital Ningxia Medical CollegeShanghai 200135China Department of Emergency Medicine Shanghai Gongli HospitalShanghai 200135China

BACKGROUND:To determine the protective role of mesencephalic astrocyte-derived neurotrophic factor(MANF) in regulating sepsis-associated acute kidney injury(S-AKI).METHODS:A total of 96 mice were randomly divided into the control group,control+MANF group,S-AKI group,and S-AKI+MANF *** S-AKI model was established by injecting lipopolysaccharide(LPS) at 10 mg/kg ***(200 μg/kg) was administered to the control+MANF and S-AKI+MANF *** equal dose of normal saline was administered daily intraperitoneally in the control and S-AKI *** and kidney tissue samples were obtained for biochemical *** blotting was used to detect the protein expression of MANF in the kidney,and enzyme-linked immunosorbent assay(ELISA) was used to determine expression of MANF in the serum,pro-inflammatory cytokines(tumor necrosis factor-α [TNF-α] and interleukin-6 [IL-6]).Serum creatinine(SCr),and blood urea nitrogen(BUN)were examined using an automatic biochemical *** addition,the kidney tissue was observed for pathological changes by hematoxylin-eosin *** comparison between two groups was performed by unpaired Student’s t-test,and statistics among multiple groups were carried out using Tukey’s post hoc test following one-way analysis of variance(ANOVA).A P-value <0.05 was considered statistically ***:At the early stage of S-AKI,MANF in the kidney tissue was up-regulated,but with the development of the disease,it was *** function was worsened in the S-AKI group,and TNF-α and IL-6 were *** administration of MANF significantly alleviated the elevated levels of SCr and BUN and inhibited the expression of TNF-α and IL-6 in the *** pathological changes were more extensive in the S-AKI group than in the S-AKI+MANF ***:MANF treatment may significantly alleviate renal injury,reduce the inflammatory response,and alleviate or reverse kidney tissue *** may have a protective

关键词： Sepsis-associated acute kidney injury Mesencephalic astrocyte-derived neurotrophic factor Renal function Cytokines Endoplasmic reticulum stress

基于脑卒中居家康复APP的远程指导对患者出院后的疗效研究

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老年医学与保健 2024年第3期30卷 698-705页

作者：李瑛申斌李倩颜凯方应祥毕霞上海健康医学院附属周浦医院康复医学科上海201318 上海市浦东新区周浦社区卫生服务中心康复科上海201318

目的观察脑卒中居家康复APP的远程指导对患者出院后肢体功能、日常生活能力、心理状况、社会支持的疗效。方法选取2022年8月—2023年9月从上海市浦东新区周浦医院康复医学科出院后的脑卒中患者100例,随机分成对照组50例、观察组50例。... 详细信息

目的观察脑卒中居家康复APP的远程指导对患者出院后肢体功能、日常生活能力、心理状况、社会支持的疗效。方法选取2022年8月—2023年9月从上海市浦东新区周浦医院康复医学科出院后的脑卒中患者100例,随机分成对照组50例、观察组50例。对照组进行常规居家康复治疗,观察组在居家康复APP远程指导下进行康复治疗,共3个月。干预前后,采用简化Fugl-Meyer运动功能量表(FMA)、Tinetti平衡与步态量表、改良Barthel指数(MBI)、汉密尔顿抑郁量表(HAMD17)、照顾者压力指数(CSI)进行评估。结果干预前FMA、Tinetti、MBI、HAMD17、CSI 2组患者评分比较,均无显著性差异(P>0.05);干预第1、第3个月后,2组FMA、Tinetti、MBI、HAMD17、CSI评分与干预前相比均有显著性差异(P0.05),但2组间FMA-下肢、Tinetti-平衡、HAMD17差异显著(P<0.05);干预第3个月后,2组间FMA、Tinetti、MBI、HAMD17、CSI差异显著(P<0.05),有统计学意义。结论脑卒中居家康复APP远程指导可有效改善出院后脑卒中患者肢体功能状况和日常生活能力,并降低心理抑郁状况和缓解社会压力。

关键词：老年脑卒中居家康复互联网+ 远程康复指导

双黄升白颗粒防治精气亏虚型肺癌化疗后骨髓抑制疗效的临床观察

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基层中医药 2024年第7期3卷 25-29页

作者：沈璟严桂英邓海滨顾晨奕上海市浦东新区中医医院肿瘤科上海中医药大学附属龙华医院肿瘤科

目的观察双黄升白颗粒防治精气亏虚型肺癌患者化疗后骨髓抑制的临床疗效。方法选取上海市浦东新区中医医院2019年10月—2022年6月收治的92例精气亏虚型肺癌患者为研究对象，采用完全随机设计原则分成两组，治疗组自化疗第1天起予双黄... 详细信息

目的观察双黄升白颗粒防治精气亏虚型肺癌患者化疗后骨髓抑制的临床疗效。方法选取上海市浦东新区中医医院2019年10月—2022年6月收治的92例精气亏虚型肺癌患者为研究对象，采用完全随机设计原则分成两组，治疗组自化疗第1天起予双黄升白颗粒，对照组在化疗开始同步服用利可君片，两组疗程均为14天，评价其临床疗效并评估安全性。结果治疗组化疗后白细胞及中性粒细胞下降幅度小于对照组（P <0.05）；治疗前后治疗组中医证候改善情况较对照组存在优势（P <0.01），治疗组治疗后卡氏评分改善程度相比对照组而言较明显（P <0.05）。结论双黄升白颗粒能够防治精气亏虚证肺癌患者化疗后骨髓抑制的发生。

关键词：双黄升白颗粒肺癌精气亏虚化疗后骨髓抑制

Cooper　and　Zinc　Superoxide　dismutase　from　Peking　duck　erythrocytes　forms　a　supramolecular　double－helix　in　the　crystal

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Chinese Chemical Letters 1996年第10期7卷 939-941页

作者： Li, pw Luo, Y Li, GP Shao, MC BEIJING UNIV DEPT CHEMBEIJING 100871PEOPLES R CHINA

The charge isomer fraction(PI 5.9) of the Cu. Zn SOD from duck red blood cell has been crystallized around neutral pH and low ionic strength at 297°*** crystals belong to the trigonel space group P3221, with unit cell a=125.1,c=163.3 and γ=120°. The duck SOD shows a novel packing arrangement consisting of supramolecular double-helix, with 922/972 non-crystallographic border group symmetry in the crystal.

关键词： PULMONARY OXYGEN-TOXICITY REPERFUSION COPPER

Protective Effect of Fresh/Dry Dandelion Extracts on APAP-Overdose-Induced Acute Liver Injury

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Chinese Journal of Integrative Medicine 2022年第8期28卷 683-692页

作者： ZHENG Yao LEI Lei LIANG Shuai AI Jiao DENG Xin LI Yan-qiu ZHANG Tian-pei PU Shi-biao REN Yong-shen School of Pharmaceutical Science South-Central University for NationalitiesWuhan430074China College of Chinese Materia Medica Yunnan University of Chinese MedicineKunming650500China

Objecitvie:To compare the liver protective activity of fresh/dried dandelion extracts against acetaminophen(APAP)-induced ***:Totally 90 Kunming mice were randomly divided into10 groups according to body weight(9 mice for each group).The mice in the normal control and model(vehicle control)groups were administered sodium carboxymethyl cellulose(CMC-Na,0.5%)*** groups were pretreated with high and low-dose dry dandelion extract(1,000 or 500 g fresh herb dried and then decocted into 120 mL solution,DDE-H and DDE-L);low-,medium-and high-dose dandelion juice(250,500,1,000 g/120 mL,DJ-L,DJ-M,and DJ-H);fresh dandelions evaporation juice water(120 mL,DEJW);dry dandelion extract dissolved by pure water(1 kg/120 mL,DDED-pw);dry dandelion extract dissolved by DEJW(120 g/120 mL,DDED-DEJW)by oral gavage for 7 days at the dosage of 0.5 mL solution/10 g body weight;after that,except normal control group,all other groups were intraperitonealy injected with 350 mg/kg APAP to induce liver *** hours after APAP administration,serum and liver tissue were collected and serum alanine aminotransferase(AST),aspartate transaminase(ALT),alkaline phosphatase(AKP),malondialdehyde(MDA),glutathione(GSH),superoxide dismutase(SOD)activities were quantified by biochemical kits;tumor necrosis factor(TNF-α),interleukin(IL)-2,and IL-1β contents in liver tissue were determined by enzyme linked immunosorbent assay *** changes in liver tissues were observed by hematoxylin and eosin staining;TUNEL Assay and Hoechst 33258 staining were applied for cell apoptosis *** expressions of heme oxygenase-1(HO-1),nuclear factor erythroid-2-related factor 2(Nrf-2),caspase-9,B-cell leukemia/lymphoma 2(Bcl-2),Bax and p-JNK were determined by Western blot ***:Pretreatment with fresh dandelion juice(FDJ,including DJ-L,DJ-M,DJ-H,DEJW and DDED-DEJW)significantly decreased the levels of serum ALT,AST,AKP,TNF-α and IL-1β compared with veh

关键词： fresh dandelion juice acetaminophen-induced liver injury oxidative stress anti-inflammation anti-apoptosis