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The genome and gene editing system of sea barleygrass provide a novel platform for cereal domestication and stress tolerance studies

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Plant Communications 2022年第5期3卷 101-116页

作者： Liuhui Kuang Qiufang Shen Liyang Chen Lingzhen Ye Tao Yan Zhong-Hua Chen Robbie waugh Qi Li Lu Huang Shengguan Cai Liangbo Fu Pengwei Xing Kai Wang Jiari Shao Feibo Wu Lixi Jiang Dezhi Wu Guoping Zhang Department of Agronomy Key Laboratory of Crop Germplasm Resource of Zhejiang ProvinceZhejiang UniversityHangzhou 310058China Novogene Bioinformatics Institute Beijing 100083China College of Agronomy Hunan Agricultural UniversityChangsha 410128China School of Science Hawkesbury Institute for the EnvironmentWestern Sydney UniversityRichmondNSW 2753Australia The James Hutton Institute Dundee DD25DAUK The Division of Plant Sciences School of Life SciencesUniversity of DundeeDundee DD25DAUK School of Agriculture and Wine&Waite Research Institute University of AdelaideWaite CampusGlen OsmondSA 5064Australia

The tribe Triticeae provides important staple cereal crops and contains elite wild species with wide geneticdiversity and high tolerance to abiotic stresses. Sea barleygrass (Hordeum marinum Huds.), a wildTriticeae species, thrives in saline marshlands and is well known for its high tolerance to salinity and waterlogging. Here, a 3.82-Gb high-quality reference genome of sea barleygrass is assembled de novo, with 3.69Gb (96.8%) of its sequences anchored onto seven chromosomes. In total, 41 045 high-confidence (HC)genes are annotated by homology, de novo prediction, and transcriptome analysis. Phylogenetics, nonsynonymous/synonymous mutation ratios (Ka/Ks), and transcriptomic and functional analyses provide genetic evidence for the divergence in morphology and salt tolerance among sea barleygrass, barley, andwheat. The large variation in post-domestication genes (e.g. IPA1 and MOC1) may cause interspecies differences in plant morphology. The extremely high salt tolerance of sea barleygrass is mainly attributed tolow Na+ uptake and root-to-shoot translocation, which are mainly controlled by SOS1, HKT, and NHX transporters. Agrobacterium-mediated transformation and CRISPR/Cas9-mediated gene editing systems weredeveloped for sea barleygrass to promote its utilization for exploration and functional studies of hubgenes and for the genetic improvement of cereal crops.

关键词： sea barleygrass salt tolerance genome transcriptome divergence

Bella Fleace Gave a Party

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英语学习 1998年第5期 30-34页

作者： EVELYN waugh 惠风

Miss Annabel Rochfortdoyle-Fleace,to give her the fullname under which she appearedin books of reference,thoughshe was known to the entire countryside asBella Fleace,was the last of her *** had been Fleaces living about

关键词： Bella Fleace Gave a Party 贵族之家短篇小说爱尔兰

Drug-Seeking Behavior Is Significantly Attenuated in Nutritionally Supplemented Cocaine Withdrawn Sprague-Dawley Rats

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Journal of Behavioral and Brain Science 2021年第7期11卷 143-156页

作者： Lauriann Young Annice Webber-waugh Karen Thaxter Physiology Section Department of Basic Medical Sciences The University of the West Indies (UWI) Mona Jamaica

Aim: The effect of patented nutritional supplementation on drug-seeking behavior in cocaine addicted rats during acute drug withdrawal was investigated using a biased Conditioned Place Preference (CPP) paradigm. Method: Twenty-four (24) male Sprague-Dawley rats with pre-conditioned preference for the black chamber of the CPP box were randomly divided into Cocaine (COC) or Saline (SAL) treated groups. Rats (n = 12) treated with cocaine hydrochloride 20 mg/kg/ml, i.p. (COC group) were confined individually to the white chamber on days 1, 3, 5 and 7. On alternate days, they were given 1 ml saline vehicle, i.p. and confined to the black chamber. Control rats (SAL group, n = 12) received only vehicle on all 8 days and were confined on alternate days to the white or black chamber. Positive place preference was confirmed for COC rats, which subsequently received 6 increasing daily doses of cocaine. CPP performances of both COC and SAL rats were recorded following an acute 3-day withdrawal period. All animals were then randomly assigned to rats fed either chow reconstituted with the nutritional supplement (COC-S and SAL-S) or standard rat chow (COC-N and SAL-N) for 8 weeks, followed by final CPP performances. Results: Following supplementation, COC-S rats made significantly less entries and time spent in the white chamber (p Conclusion: Drug-seeking behavior that persisted during cocaine withdrawal was significantly diminished in the nutritionally supplemented.

关键词： Cocaine Conditioned Place Preference Nutritional Supplement Addiction Drug-Seeking Behavior

SHHH! The Refrigerator Can Hear Us

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大学英语 1991年第5期 36-37页

作者： JohnC.waugh 楚安照

Thete’s been a lot of talk about‘extraterzestrial beings2 visiting out planet. I don’t,put much stock in’ that.I am convinced, however, that we are surrounded by sen

关键词： SHHH

Virgin Coconut Oil Improved Discriminative Learning and Working Memory in Aging Cycling and Non-Cycling Female Sprague-Dawley Rats Supporting Its Beneficial Effect in Retarding Age-Related Cognitive Decline

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Advances in Aging Research 2021年第5期10卷 97-112页

作者： Lauriann Young Brittany Smith Annice Webber-waugh Karen Thaxter Physiology Section Department of Basic Medical Sciences The University of the West Indies (UWI) Mona Jamaica

Aim: Beneficial effects of virgin coconut oil (VCO) consumption to improve cognition in menopausal females remain inconclusive. This study examined the effect of VCO supplementation in aging cycling and non-cycling rodents to assess its impact on cognition. Methods: Sprague-Dawley rats (10 - 18 months) were randomly assigned to a supplemented VCO group (SVCO) that received oral doses of 1.42 mL/kg/day VCO (n = 10) and a non-supplemented (NVCO) group (n = 10). Their performance in a biased Y-maze discriminative learning paradigm was assessed over a 16-week period. Rats were initially allowed 3 minutes to explore the maze (habituated) and subsequently pre-trained in the non-preferred, white chamber to associate the presentation of a tone with a treat (reward). Training

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呼吸机波形快速解读

Crohn's disease genotypes of patients in remission vs relapses after infliximab discontinuation

作者： (美)Jonathan B. waugh[等]

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World Journal of Gastroenterology 2012年第36期18卷 5058-5064页

作者： Cathy Lu Alistair waugh Robert J Bailey Raeleen Cherry Levinus A Dieleman Leah Gramlich Kata Matic Mario Millan Karen I Kroeker Daniel Sadowski Christopher W Teshima Dennis Todoruk Clarence Wong Karen Wong Richard N Fedorak Division of Gastroenterology Zeidler Ledcor CenterUniversity of AlbertaEdmontonAB T6G 2X8Canada Division of Gastroenterology Royal Alexandra HospitalEdmontonAB T5H 3V9Canada Division of Gastroenterology Grey Nuns HospitalEdmontonAB T6L 5X8Canada Division of Gastroenterology Misericordia HospitalEdmontonAB T5R 4H5Canada

AIM:To investigate genetic differences between Crohn's disease(CD) patients with a sustained remission vs relapsers after discontinuing infliximab while in corticosteroid-free ***:Forty-eight CD patients received infliximab and were in full corticosteroid-free clinical remission but then discontinued infliximab for reasons other than a loss of response,were identified by review of an electronic database and ***-associated remission was defined as corticosteroid-free plus normalization of clinical disease activity [CD activity index(CDAI) 220) and a therapeutic intervention with CD medication(s),or a hospitalization with complications related to active *** analyses were performed on samples from 14 patients(n = 6 who had a sustained long term remission after stopping infliximab,n = 8 who rapidly relapsed after stopping infliximab).Nucleotide-binding oligomerization domain 2(NOD2)/caspase activation recruitment domain 15(CARD15) polymorphisms(R702W,G908R and L1007fs) and the inflammatory bowel disease 5(IBD5) polymorphisms(IGR2060a1 and IGR3081a1) were analyzed in each ***:Five single nucleotide polymorphisms of IBD5 and NOD2/CARD15 genes were successfully analyzed for all 14 *** was no significant increase in frequency of the NOD2/CARD15 polymorphisms(R702W,G908R and L1007fs) and the IBD5 polymorphisms(IGR2060a1 and IGR3081a1) in either group of patients;those whose disease relapsed rapidly or those who remained in sustained long term remission following the discontinuation of *** a third of patients in full clinical remission who stopped infliximab for reasons other than loss of response remained in sustained clinical remission,while two-thirds relapsed *** was a marked difference in the

关键词：基因型单抗患者复发基因多态性房产管理信息系统糖皮质激素临床疾病