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Urinary nuclear magnetic resonance spectroscopy of a Bangladeshi cohort with hepatitis-B hepatocellular carcinoma: A biomarker corroboration study

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World Journal of Gastroenterology 2016年第16期22卷 4191-4200页

作者： I Jane Cox Abil E Aliev mary mE Crossey mahvish Dawood mamun Al-mahtab sheikh m akbar Salimur Rahman Antonio Riva Roger Williams Simon D Taylor-Robinson Institute of Hepatology London Foundation for Liver Research Department of Chemistry University College London Division of Digestive Diseases Department of Surgery and Cancer Imperial College London Department of Hepatology Bangabandhu Sheikh Mujib Medical University Department of medical Sciences Toshiba General Hospital

AIm: To establish if a distinct urinary metabolic profile could be identified in Bangladeshi hepatitis-B hepatocellular carcinoma (HCC) patients compared to cirrhosis patients and ***: Urine samples from 42 Bangladeshi patients with HCC (39 patients with hepatitis-B HCC), 47 with cirrhosis on a background of hepatitis B, 46 with chronic hepatitis B, and seven ethnically-matched healthy controls were analyzed using nuclear magnetic resonance (NmR) spectroscopy. A full dietary and medication history was recorded for each subject. The urinary NmR data were analyzed using principal component analysis (PCA) and orthogonal partial least squared discriminant analysis (OPLS-DA) techniques. Differences in relative signal levels of the most discriminatory metabolites identified by PCA and OPLS-DA were compared between subject groups using an independent samples Kruskal-Wallis one-way analysis of variance (ANOVA) test with all pairwise multiple comparisons. Within the patient subgroups, the mann-Whitney U test was used to compare metabolite levels depending on hepatitis B e-antigen (HBeAg) status and treatment with anti-viral therapy. A Benjamini-Hochberg adjustment was applied to acquire the level of significance for multiple testing, with a declared level of statistical significance of P mass index (P m alanine aminotransferase (ALT) was significantly higher in the HCC group compared to controls (P m α-fetoprotein was generally markedly elevated in HCC compared to controls; and serum creatinine levels were significantly reduced in the HCC group compared to the cirrhosis group (P = 0.004). A three-factor PCA scores plot showed clustering of the urinary NmR spectra from the four subgroups. metabolites that contributed to the discrimination between the subgr

关键词： Urinary metabolic profiling Hepatocellular carcinoma Nuclear magnetic resonance spectroscopy Hepatitis B Bangladesh

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managing the surge:A comprehensive review of the entire disposal framework for retired lithium-ion batteries from electric vehicles

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Journal of Energy Chemistry 2024年第5期92卷 648-680页

作者： Ruohan Guo Feng Wang m.akbar Rhamdhani Yiming Xu Weixiang Shen Department of Engineering Technologies School of ScienceComputing and Engineering TechnologiesSwinburne University of TechnologyMelbourne VIC 3122Australia Department of Chemistry and Biotechnology School of ScienceComputing and Engineering TechnologiesSwinburne University of TechnologyMelbourne VIC 3122Australia Department mechanical and Product Design Engineering School of EngineeringSwinburne University of TechnologyMelbourne VIC 3122Australia

Anticipating the imminent surge of retired lithium-ion batteries(R-LIBs)from electric vehicles,the need for safe,cost-effective and environmentally friendly disposal technologies has *** paper seeks to offer a comprehensive overview of the entire disposal framework for R-LIBs,encompassing a broad spectrum of activities,including screening,repurposing and ***,we delve deeply into a thorough examination of current screening technologies,shifting the focus from a mere enumeration of screening methods to the exploration of the strategies for enhancing screening ***,we outline battery repurposing with associated key factors,summarizing stationary applications and sizing methods for R-LIBs in their second life.A particular light is shed on available reconditioning solutions,demonstrating their great potential in facilitating battery safety and lifetime in repurposing scenarios and identifying their techno-economic *** the realm of battery recycling,we present an extensive survey of pre-treatment options and subsequent material recovery ***,we introduce several global leading recyclers to illustrate their industrial processes and technical ***,relevant challenges and evolving trends are investigated in pursuit of a sustainable end-of-life management and disposal *** hope that this study can serve as a valuable resource for researchers,industry professionals and policymakers in this field,ultimately facilitating the adoption of proper disposal practices.

关键词： Lithium-ion battery Battery reproposing and recycling miaieiials recovery technologies Techno-economic issues End-of-life management Disposal framework

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Analysis of travelling wave solutions of double dispersive sharma-Tasso-Olver equation

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Journal of Ocean Engineering and Science 2024年第5期9卷 461-474页

作者： Kamruzzaman Khan Henk Koppelaar m.Ali akbar Syed Tauseef mohyud-Din Department of mathematics Pabna University of Science and TechnologyPabna 6600Bangladesh Fac.of Electrical Eng. Mathematics and Comp.ScienceUniversity of DelftNetherlands Department of Applied mathematics University of RajshahiRajshahi 6205Bangladesh Department of mathematics HITEC University Taxila CanttPakistan School of Science and Technology University of New EnglandArmidaleNSW 2351Australia

Travelling wave solutions have been played a vital role in demonstrating the wave character of nonlinear problems arising in the field of ocean engineering and *** describe the propagation of the nonlinear wave phenomenon in the ocean(for example,wind waves,tsunami waves),a variety of evolution equations have been suggested and investigated in the existing *** paper studies the dynamic of travelling periodic and solitary wave behavior of a double-dispersive non-linear evolution equation,named the Sharma-Tasso-Olver(STO)*** evolution equations with double dispersion enable us to describe nonlinear wave propagation in the ocean,hyperplastic rods and other mediums in the field of science and *** analyze the wave solutions of this model using a combination of numerical simulations and Ansatz *** analysis shows that the travelling wave solutions involve a range of parameters that displays important and very interesting properties of the wave *** relevance of the parameters in the travelling wave solutions is also *** simulating numerically,we demonstrate how parameters in the solutions influence the phase speed as well as the travelling and solitary ***,we discuss instantaneous streamline patterns among the obtained solutions to explore the local direction of the components of the obtained solitary wave solutions at each point in the coordinate(x,t).

关键词： Travelling wave Solitary wave Streamline Enhanced(G'/G)-expansion method STO equation

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Superior rectus/levator complex in acquired anophthalmic socket repaired with spheric implant—a computed tomography scan and topographic study

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International Journal of Ophthalmology(English edition) 2024年第8期17卷 1483-1488页

作者： Shaikha Al Eid Hamad m AlSulaiman Sahar m Elkhamary Osama Al sheikh Alicia Ferrero-Galindo Rajiv Kandekhar Silvana A Schellini Oculoplastic Division King Khaled Eye Specialist HospitalRiyadh 11462Saudi Arabia Radiology Division King Khaled Eye Specialist HospitalRiyadh 11462Saudi Arabia Department of Diagnostic Radiology Mansoura Faculty of MedicineMansoura 35511Egypt University Hospital Rio Hortega Valladolid 47012Spain Research Department King Khaled Eye Specialist HospitalRiyadh 11462Saudi Arabia Ophthalmology Department Medical SchoolState University of Sao PauloBotucatu 18618-687Brazil

AIm:To determine whether the levator palpebrae superioris(LPS)/superior rectus(SR)muscle complex,can influence the position of the upper lid and fornix in acquired anophthalmic ***:This comparative non-randomized and non-interventional study included retrospective data of 21 patients with unilateral acquired anophthalmic sockets repaired with spheric ***-resolution computed tomography(CT)measurements of the LPm/SR muscle complex and clinical topographic position of the upper lid,superior and inferior fornix depth in primary gaze position were *** data were presented as frequency and percentage proportions and quantitative variables comparing the socket measurements with the normal contralateral orbit was statistically analyzed using non-parametric tests considering Pmic orbits had a significantly shorter LPS length(P=0.01)and significantly thicker SR(P=0.02)than the normal *** was present in anophthalmic sockets but not in normal orbits(P=0.002),while levator function was normal in both(P>0.05,all comparisons).The superior fornix depth was similar in the anophthalmic socket and the contralateral normal orbit(P=0.192)as well the inferior fornix depth(P=0.351).CONCLUSION:Acquired anophthalmic sockets repaired with spheric implants have shorter LPS,thicker SR,and more lagophthalmos than normal *** relationship of the LPS and SR with other orbital structures,associated with passive or active forces acting in the final position of the lids and external ocular prosthesis should be further investigated.

关键词： anophthalmic socket spheric implant levator palpebrae superioris superior rectus lagophthalmos fornix depth

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Al^(3+) doped CeO_(2) for proton conducting fuel cells

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International Journal of minerals,metallurgy and materials 2024年第10期31卷 2253-2262页

作者： Sarfraz Shahzad Rasool muhammad Khalid mAKYousaf Shah Bin Zhu Jung-Sik Kim muhammad Imran Asghar Nabeela akbar Wenjing Dong Jiangsu Provincial Key Laboratory of Solar Energy Science and Technology/Energy Storage joint Research Center School of Energy and EnvironmentSoutheast UniversityNanjing 210096China School of microelectronics Hubei UniversityWuhan 430062China Sino-French Engineer School/School of General Engineering Beihang UniversityBeijing 100191China Renewable Energy Technologies Group Faculty of Engineering and Natural SciencesTampere UniversityFI-33014Finland

Developing high ionic conducting electrolytes is crucial for applying proton-conducting fuel cell(PCFCs)*** cur-rent study investigates the effect of alumina on the structural,morphological,electrical,and electrochemical properties of CeO_(2).Lattice oxygen vacancies are induced in CeO_(2) by a general doping concept that enables fast ionic conduction at low-temperature ranges(300-500℃)for *** refinement of the X-ray diffraction(XRD)patterns established the pure cubic fluorite structure of Al-doped CeO_(2)(ADC)samples and confirmed Al ions’fruitful integration in the CeO_(2) *** electronic structure of the alumina-doped ceria of the materials(10ADC,20ADC,and 30ADC)has been *** a result,it was found that the best composition of 30ADC-based electrolytes induced maximum lattice oxygen *** corresponding PCFC exhibited a maximum power output of 923 mW/cm^(2)at 500℃.moreover,the investigation proves the proton-conducting ability of alumina-doped ceria-based fuel cells by using an oxide ion-blocking layer.

关键词： proton ceramic fuel cells oxygen vacancies higher fuel cell performance doping fast ions transportation

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A new hydrophobic deep eutectic solvent composed of menthol and tris(2-ethylhexyl) phosphate for solvent bar microextraction of parabens from biological fluids

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Emerging Contaminants 2024年第2期10卷 135-145页

作者： Nabil N.AL-Hashimi Husam Abed Alfattah Khaleel I.Assaf Asma A.Fakhoury Saja H.Hamed Amjad H.El-sheikh Khairi m.Fahelelbom The Hashemite University Faculty of Pharmaceutical SciencesDepartment of Pharmaceutical ChemistryP.O.Box 330127Zarqa13133Jordan The Hashemite University Faculty of ScienceDepartment of ChemistryP.O.Box 150459Zarqa13115Jordan Al-Balqa Applied University Faculty of ScienceDepartment of Chemistry19117 Al-SaltJordan The Hashemite University Faculty of Pharmaceutical SciencesDepartment of Pharmaceutics and Pharmaceutical TechnologyP.O.Box 330127Zarqa13133Jordan Al Ain University College of PharmacyDepartment of Pharmaceutical SciencesP.O.Box 64141Al AinAl AinUnited Arab Emirates

Parabens are antimicrobial preservatives with extensive applications in cosmetics,toiletries,pharmaceuticals,and *** the legitimate concerns relating to their potential to disrupt multiple endocrine functions,it becomes imperative to prioritize the development of innovative bioanalytical techniques for effectively monitoring their presence in biological *** this study,an efficient solvent bar microextraction(SBmE)was established,utilizing new hydrophobic deep eutectic solvents(DEs)to determine methylparaben and propylparaben in urine and plasma *** DEs comprising menthol and tris(2-ethylhexyl)phosphate(m-TEHP)at various molar ratios were synthesized for the first time to enhance the extraction capacity and promote the eco-friendliness of the DE used as an extraction ***-transform infrared(FT-IR)and proton nuclear magnetic resonance(1H NmR)spectroscopies were employed to confirm and investigate the properties of the successful synthesis(m-TEHP)DE at a molar ratio of 1:*** synthesized DE exhibits low microbial toxicity and can be considered an eco-friendly solvent for ***,quantum-chemical calculations were utilized to predict synthesized DE's structure and interaction energy with selected *** influential operational factors of DE-SBmE on the extraction efficiency(EE%)of both parabens were evaluated using response surface methodology based on central composite design,and a total of 30 extraction tests were conducted to determine the optimal *** optimized DE-SBmE,in combination with HPLC-DAD,exhibited low detection limits(0.54–0.91μg L^(−1)),excellent linearity(R^(2)≥0.9993),precise results(RSDs≤7.6%),satisfactory recoveries(92–97%)and negligible matrix ***,it had remarkable effectiveness and applicability in determining selected parabens in real urine and plasma samples.

关键词： Hydrophobic deep eutectic solvent Solvent bar microextraction Parabens Response surface methodology and central composite design HPLC-DAD Urine and plasma

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Blockade of Rho-associated kinase prevents inhibition of axon regeneration of peripheral nerves induced by anti-ganglioside antibodies

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Neural Regeneration Research 2024年第4期19卷 895-899页

作者： Andrés Berardo Cristian R.Bacaglio Bárbara B.Báez Rubén Sambuelli Kazim A.sheikh Pablo H.H.Lopez Laboratorio de Neurobiología Instituto de Investigación Médica Mercedes y Martin Ferreyra(INIMEC)-Consejo Nacional de Investigaciones Cientificas y Técnicas(CONICET)Universidad Nacional de Córdoba Departamento de Química Biológica-Centro de Investigaciones en Química Biológica de Córdoba(CIQUIBIC)-Consejo Nacional de Investigaciones Cientificas y Técnicas(CONICET) Facultad de Cs.QuímicasUniversidad Nacional de Córdoba Servicio de Anatomía Patológica Clínica Universitaria Reina FabiolaUniversidad Católica de Córdoba Department of Neurology University of Texas Medical School at Houston

Anti-ganglioside antibodies are associated with delayed/poor clinical recovery in Guillain-Barrèsyndrome,mostly related to halted axon ***-linking of cell surface gangliosides by anti-ganglioside antibodies triggers inhibition of nerve repair in in vitro and in vivo paradigms of axon *** effects involve the activation of the small GTPase Rho A/ROCK signaling pathways,which negatively modulate growth cone cytoskeleton,similarly to well stablished inhibitors of axon regeneration described so *** aim of this work was to perform a proof of concept study to demonstrate the effectiveness of Y-27632,a selective pharmacological inhibitor of ROCK,in a mouse model of axon regeneration of peripheral nerves,where the passive immunization with a monoclonal antibody targeting gangliosides GD1a and GT1b was previously reported to exert a potent inhibitory effect on regeneration of both myelinated and unmyelinated *** results demonstrate a differential sensitivity of myelinated and unmyelinated axons to the pro-regenerative effect of *** with a total dosage of 9 mg/kg of Y-27632 resulted in a complete prevention of anti-GD1a/GT1b monoclonal antibody-mediated inhibition of axon regeneration of unmyelinated fibers to skin and the functional recovery of mechanical cutaneous *** contrast,the same dose showed toxic effects on the regeneration of myelinated ***,scale down of the dosage of Y-27632 to 5 mg/kg resulted in a significant although not complete recovery of regenerated myelinated axons exposed to anti-GD1a/GT1b monoclonal antibody in the absence of toxicity in animals exposed to only ***,these findings confirm the in vivo participation of Rho A/ROCK signaling pathways in the molecular mechanisms associated with the inhibition of axon regeneration induced by anti-GD1a/GT1b monoclonal *** findings open the possibility of therapeutic pharmacological intervention targeting Rho A/R

关键词： anti-ganglioside antibodies anti-glycan antibodies axon regeneration ganglioside Guillain-Barrésyndrome nerve repair ROCK Y-27632

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Handgrip strength in type 2 diabetics and nondiabetics:A comparative cross-sectional study among adults in rural mysore

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Journal of Integrative Nursing 2024年第3期6卷 150-154页

作者： Deepak ANIL m.RAKESH Shabeena akbar Vijaylakshmi Rao VADAGA D.Sunil KUmAR Department of Community medicine JSS Medical CollegeJSS Academy of Higher Education and ResearchMysoreKarnatakaIndia

Objectives:The objective of this study is to assess the handgrip strength(HGS)in patients with type 2 diabetes,compare it with nondiabetes age-matched individuals,and assess the correlation between diabetic status and HGS among diabetic *** and methods:A community-based cross-sectional study was conducted in rural mysore,India,for 4 ***-eight clinically diagnosed type 2 diabetics and 58 nondiabetics participated in the *** handheld dynamometer was used to test the HGS of all subjects in their dominant *** t-test was used to analyze the differences in HGS between patients with and without ***:The mean dynamometer reading among diabetics was 19.08±7.51,whereas that in nondiabetics was 27.474±*** was a significant difference in HGSs between diabetics and nondiabetics(Pmuscle strength and quality in the upper extremities are associated with type 2 diabetes and can lead to functional and physical *** patients’HGS should be evaluated promptly to identify any disabilities and plan for appropriate therapy.

关键词： Diabetics dynamometer handgrip muscle strength

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Synthesis of Hierarchical SnO2 Nanowire–TiO2 Nanorod Brushes Anchored to Commercially Available FTO-coated Glass Substrates

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Nano-micro Letters 2017年第3期9卷 93-100页

作者： Derek R.miller sheikh A.akbar Pat A.morris Department of materials Science and Engineering The Ohio State UniversityColumbusOH 43212USA

Growth of single-crystal Sn O_2 nanowires using a fluorine-doped Sn O_2(FTO) thin film as both the source and substrate is demonstrated for the first time at relatively low temperature(580 °C) which preserves the integrity of the underlying glass support and improves scalability to devices. Furthermore, a microwave hydrothermal process is shown to grow Ti O_2 nanorods on these nanowires to create a hierarchical nanoheterostructure that will lead to efficient photogenerated charge carrier separation and rapid transport of electrons to the substrate. This process simplifies nanowire growth by using commercially available and widely used FTO substrates without the need for an additional upstream Sn source and can be used as a high surface area host structure to many other hierarchical structures.

关键词： SnO2 Nanowire Fluorine-doped SnO2(FTO) Vapor–liquid–solid(VLS) TiO2 Nanorod brush

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Thermodynamic Interpretation of Field Equations at Horizon of BTZ Black Hole

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Chinese Physics Letters 2007年第5期24卷 1158-1161页

作者： m. akbar Institute of Theoretical Physics Chinese Academy of Sciences PO Box 2735 Beijing 100080

A spacetime horizon comprising with a black hole singularity acts like a boundary of a thermal system associated with the notions of temperature and entropy. In the case of static metric of Banados-Teitelboim-Zanelli （BTZ） black hole, the field equations near the horizon boundary can be expressed as a thermal identity dE = TdS＋ Pr dA, where E = m is the mass of BTZ black hole, dA is the change in the area of the black hole horizon when the horizon is displaced infinitesimally small, Pr is the radial pressure provided by the source of Einstein equations, S = 41πa is the entropy and T =κ/2π is the Hawking temperature associated with the horizon. This approach is studied further to generalize it for non-static BTZ black hole, showing that it is also possible to interpret the field equation near horizon as a thermodynamic identity dE = TdS ＋ PrdA ＋Ω＋dJ, where Ω＋ is the angular velocity and J is the angular momentum of BTZ black hole. These results indicate that the field equations for BTZ black hole possess intrinsic thermodynamic properties near the horizon.

关键词： SITTER SPACETImES 1ST LAW GRAVITY ENTROPY

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