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Predicting the presence of adenomatous polyps during colonoscopy with National Cancer Institute Colorectal Cancer Risk-Assessment Tool

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World Journal of Gastroenterology 2018年第34期24卷 3919-3926页

作者： Hassan Tariq Muhammad Umar Kamal Harish Patel Ravi Patel Muhammad Ameen shehi elona Maram Khalifa Sara Azam Aiyi Zhang Kishore Kumar Ahmed Baiomi Danial Shaikh Jasbir Makker Division of Gastroenterology Department of Medicine BronxC are Health system Department of Medicine Bronx Care Health system

AIM To evaluate the National Cancer Institute(NCI)Colorectal Cancer(CRC)Risk Assessment Tool as a predictor for the presence of adenomatous polyps(AP) found during screening or surveillance *** This is a retrospective single center observational *** collected data of adenomatous polyps in each colonoscopy and then evaluated the lifetime CRC *** calculated the AP prevalence across risk score quintiles,odds ratios of the prevalence of AP across risk score quintiles,area under curves(AUCs)and Youden’s indexes to assess the optimal risk score cut off value for AP prevalence *** The prevalence of AP gradually increased throughout the five risk score quintiles:i.e.,27.63%in the first and 51.35%in the fifth *** odd ratios of AP prevalence in the fifth quintile compared to the first and second quintile were 2.76[confidence interval(CI):1.71-4.47]and 2.09(CI:1.32-3.30).The AUC for all patients was 0.62(CI:0.58-0.66).Youden’s Index indicated the optimal risk score cutoff value discriminating AP prevalence status was *** Patients with the higher NCI risk score have higher risk of AP and subsequent CRC;therefore,measures to increase the effectiveness of CRC detection in these patients include longer withdrawal time,early surveillance colonoscopy,and choosing flexible colonoscopy over other CRC screening modalities.

关键词： National Cancer Institute Colorectal Cancer Risk-Assessment Tool Colorectal cancer Predictors of colorectal cancer Adenomatous polyps Colonoscopy

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Dimension of Solar Panels Surface Based to the Net Present Value for the Albanian Conditions

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Journal of Environmental Science and Engineering(A) 2013年第7期2卷 464-467页

作者： Mirel Mico elona ciqolli Department of Environmental Engineering Faculty of Civil Engineering ST Muhamet Gjollesha Tirana 1000 Albania Designs and Study Institute of Defence Tirane I000 Albania

Active exploitation of solar energy is achieved in systems that absorb this energy through flat collectors. Hot water can be used for space heating, when its temperature is high, but it is used largely for DHW （domestic hot water） needs. Now days, this technology has resulted as the most viable for exploitation of solar energy, and various countries such as Israel, Turkey, and Greece provide hot water for residential and service sectors using systems of solar panels. In this proceeding we are writing about the dimension of the solar panels surface based to the net present value in Hotels of Albania.

关键词： Solar panel net present value solar energy.

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Carbonic anhydrase VII–a potential prognostic marker in gliomas

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Health 2011年第1期3卷 6-12页

作者： Fatemeh Bootorabi Joonas Haapasalo elona Smith Hannu Haapasalo Seppo Parkkila 不详

Carbonic anhydrase VII (CA VII) is a cytosolic enzyme expressed in several organs, including the human brain, but it has not been investigated earlier in any tumors. We designed the present study to evaluate CA VII expression in a cohort of human diffuse astrocytomas, mixed oligoastrocytomas and oligodendrogliomas. CA VII immunostaining was correlated to clinico-pathologic findings, survival data, and expres-sion of other molecular factors, including Ki-67, p53 protein and epidermal growth factor receptor. CA VII-positive staining was observed in 94% of astrocytomas and 85% of oligodendrogliomas. In the tumor specimens, strong positive areas were often located in close proximity to necrosis. The CA VII immunoreactivity showed positive correlation with tumor malignancy grades of astrocytomas (p = 0.02, chi-square test). In all tumor categories, CA VII-positive staining was often seen in the en-dothelial cells of neovessels in addition to the tumor cells. CA VII intensity showed no significant association with p53 nor did it correlate with the amplification of epidermal growth factor receptor (analyzed only in astrocytomas) or cell proliferation. Our present results show that CA VII may act as a useful biomarker in histopathologic diagnostics of gliomas. The high expression of CA VII in the tumor cells and endothelium suggests important roles for the enzyme in tumor metabolism. The results also led us to conclude that CA VII might serve as a marker of poor prognosis in diffuse astrocytomas.

关键词： Astrocytoma Brain Cancer Carbonic Anhydrase Glioblastoma Glioma Oligodendroglioma pH

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大麻二酚通过调节脑内AMPA受体表达改善痴呆模型大鼠认知损害

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中风与神经疾病杂志 2022年第7期39卷 596-600页

作者：周珊珊刘晓朦 elona Khasanova 武继婷李子欣周悦张黎明哈尔滨医科大学附属第一医院神经内科黑龙江哈尔滨150001 巴什基尔国立医科大学病理生理学系俄罗斯乌法

目的观察大麻二酚(CBD)对双侧脑室内注射链脲菌素(STZ)诱导的散发阿尔茨海默病(sAD)大鼠认知功能和脑内AMPA受体表达的影响。方法40只成年雄性SD大鼠随机分为4组:假手术组(S),大麻二酚(CBD)+假手术组(CBD+S),模型组(STZ),CBD+模型组(CBD... 详细信息

目的观察大麻二酚(CBD)对双侧脑室内注射链脲菌素(STZ)诱导的散发阿尔茨海默病(sAD)大鼠认知功能和脑内AMPA受体表达的影响。方法40只成年雄性SD大鼠随机分为4组:假手术组(S),大麻二酚(CBD)+假手术组(CBD+S),模型组(STZ),CBD+模型组(CBD+STZ)。水迷宫和跳台试验测试大鼠认知功能,western-blot检测大鼠脑内GluR1和GluR2含量。结果Morris水迷宫试验中与S组比较,STZ组大鼠逃逸潜伏期显著延长(P<0.01),与STZ组比较,CBD+STZ组逃逸潜伏期显著缩短(P<0.01)。跳台试验中,与S组潜伏期和错误次数比较,STZ组潜伏期显著缩短(P<0.01),错误次数显著增加(P<0.01);与STZ组比较,CBD+STZ组潜伏期显著延长(P<0.05),错误次数显著减少(P<0.05)。与STZ组比较,CBD+STZ组大鼠皮质和海马GluR1含量显著降低(P<0.01)(P<0.05)。与STZ组比较,CBD+STZ组大鼠皮质和海马GluR2含量显著降低(P<0.01)(P<0.01)。结论大麻二酚通过调节脑内AMPA受体表达改善STZ诱导的大鼠认知损害。

关键词：大麻二酚链脲佐菌素认知损害 AMPA受体

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