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Transition Metal Free Chemoselective Reduction ofα,β-Unsaturated Ketones to Saturated Ketones Using Tosyl Hydrazide as a Hydrogen Donor

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中国化学:英文版 2015年第2期33卷 181-184页

作者： Yarabally R Girish Kanchipura R Raghavendra Dasappa Nagaraja Kothanahally S Sharath Kumar sheena Shashikanth Deparment of Studies in Chemistry ManasagangothriUniversity of MysoreMysore 570006India Department of PG Studies in Chemistry Government Science CollegeChitradurga 577501India

An efficient,inexpensive and simple method for the reduction of variousα,β-unsaturated ketones to corre-sponding saturated ketones using tosyl hydrazide as a hydrogen donor in DMF using calcium oxide powder has been reported.A variety of enones underwent reduction without forming undesirable side *** chemose-lectivity,broad functional group tolerance and good yields are the noteworthy features of this protocol.

关键词： α,β-unsaturated carbonyl compounds tosyl hydrazide transition metal free saturated ketones

Pathways of nanotoxicity:Modes of detection,impact,and challenges

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Frontiers of Materials Science 2021年第4期15卷 512-542页

作者： Deepshikha GUPTA Parul YADAV Devesh garg Tejendra K.GUPTA Amity Institute of Applied Sciences Amity University Uttar PradeshNoida 201301India

Nanotoxicology has become the subject of intense research for more than two *** of articles have been published but the space in understanding the nanotoxicity mechanism and the assessment is still *** researches clearly show potential benefits of nanomaterials(NMs)in diagnostics and treatment,targeted drug delivery,and tissue engineering owing to their excellent physicochemical ***,these NMs display hazardous health effect then to the greater part of the materials because of small size,large surface area-to-volume ratio,quantum size effects,and environmental ***,a large number of NMs are used in industrial products including several medical applications,consumer,and healthcare ***,they came into the environment without any safety *** measurement of toxicity level has become important because of increasing toxic effects on living *** realistic mechanism-based strategies are still needed to determine the toxic effects of *** the assessment of NMs toxicity,reliable and standardized procedures are *** review article provides systematic studies on toxicity of NMs involving manufacturing,environmental factors,eco-toxic and genotoxic effects,some parameters which have been ignored of NMs versus their biological counterparts,cell heterogeneity,and their current challenges and future perspectives.

关键词： nanomaterial nanotoxicity cytotoxicity,genotoxicity in-vivo and in-vitro toxicity reactive oxygen species

A Fast Charging–Cooling Coupled Scheduling Method for a Liquid Cooling-Based Thermal Management System for Lithium-Ion Batteries

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Engineering 2021年第8期7卷 1165-1176页

作者： Siqi Chen Nengsheng Bao Akhil garg Xiongbin Peng Liang Gao State Key Laboratory of Digital Manufacturing Equipment and Technology School of Mechanical Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China Intelligent Manufacturing Key Laboratory of Ministry of Education Shantou UniversityShantou 515063China

Efficient fast-charging technology is necessary for the extension of the driving range of electric ***,lithium-ion cells generate immense heat at high-current charging *** order to address this problem,an efficient fast charging–cooling scheduling method is urgently *** this study,a liquid cooling-based thermal management system equipped with mini-channels was designed for the fastcharging process of a lithium-ion battery module.A neural network-based regression model was proposed based on 81 sets of experimental data,which consisted of three sub-models and considered three outputs:maximum temperature,temperature standard deviation,and energy *** sub-model had a desirable testing accuracy(99.353%,97.332%,and 98.381%)after *** regression model was employed to predict all three outputs among a full dataset,which combined different charging current rates(0.5C,1C,1.5C,2C,and 2.5C(1C=5 A))at three different charging stages,and a range of coolant rates(0.0006,0.0012,and 0.0018 kg·s^(-1)).An optimal charging–cooling schedule was selected from the predicted dataset and was validated by the *** results indicated that the battery module’s state of charge value increased by 0.5 after 15 min,with an energy consumption lower than 0.02 *** maximum temperature and temperature standard deviation could be controlled within 33.35 and 0.8C,*** approach described herein can be used by the electric vehicles industry in real fast-charging ***,optimal fast charging-cooling schedule can be predicted based on the experimental data obtained,that in turn,can significantly improve the efficiency of the charging process design as well as control energy consumption during cooling.

关键词： Lithium-ion battery module Fast-charging Neural network regression Scheduling State of charge Energy consumption

WNT/β-catenin signaling in urothelial carcinoma of bladder

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World Journal of Nephrology 2019年第5期8卷 83-94页

作者： Minal garg Niharika Maurya Department of Biochemistry University of Lucknow

Urothelial carcinoma of bladder is the second most prevalent genitourinary *** is a highly heterogeneous disease as it represents a spectrum of neoplasms,including non-muscle invasive bladder cancer(NMIBC),muscle invasive bladder cancer(MIBC)and metastatic ***-wide approaches and candidate gene analysis suggest that malignant transformation of the bladder is multifactorial and a multitude of genes are involved in the development of MIBC or NMIBC *** signaling is being examined to control and maintain balance between stemness and differentiation in adult stem cell *** to its participation in urothelial development and maintenance of adult urothelial tissue homeostasis,the components of Wnt signaling are reported as an important diagnostic and prognostic markers as well as novel therapeutic ***/epigenetic alterations in the key molecules of Wnt/β-catenin canonical pathway have been linked with tumorigenesis,development of drug resistance and enhanced *** review extends our understanding on the functions of key regulatory molecules of canonical Wnt/β-catenin pathway in urothelial tumorigenesis by inducing cancer stem cell phenotype(UCSCs).UCSCs may be responsible for tumor heterogeneity,high recurrence rates and complex biological behavior of bladder ***,understanding the role of UCSCs and the regulatory mechanisms that are responsible for high relapse rates and metastasis could help to develop pathway inhibitors and augment current *** implications in the treatment of urothelial carcinoma of bladder by targeting this pathway primarily in UCSCs as well as in bulk tumor population that are responsible for high relapse rates and metastasis may facilitate potential therapeutic avenues and better prognosis.

关键词： Chemoresistance Therapeutic approaches Urothelial carcinoma of bladder Urothelial cancer stem cells Wnt/β-catenin

Observations on the Function of Mucous Cells in the Epidermis of the Cat-fish Clarias batrachus Exposed to Sodium Dodecyl Sulfate

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Biomedical and Environmental Sciences 1993年第2期6卷 119-133页

作者： TARUN KUMAR garg AJAY KUMAR MITTAL Skin Skin Physiology LaboratoryDepartment of ZoologyBanaras Hindu UniversityVaranasi-221005IndiaPhysiology LaboratoryDepartment of ZoologyBanaras Hindu UniversityVaranasi-221005India

Response of mucous cells, in the epidermis of the catfish Clarias batrachus, to a sublethal concentration of sodium dodecyl sulfate was studied and correlated with the alteration in the status of their secretory activity after different durations of the treatment. At 4h, 8h, 24h,48h and 72h of the detergent treatment, most mucous cells attained voluminous dimensions and appeared closely approximating to or even overlapping the adjacent ones. At 12h, 36h, and 60h, in contrast, the mucous cells appeared small and slender, and seemed to be located at greater intervals. These changes in dimensions were responsible for the apparent increase or decrease in the density of mucous cells after different durations of detergent treatment. Statistically, however, no significant change was observed in the total number of the mucous cells throughout the experiment.The mucous cells appeared enlarged towards the end of the experiment signifying increased mucus production. This is considered as an adaptation, for protection, assisting the fish to adjust to the changed environment.A shift in the histochemical nature of the secretory contents at the middle and basal parts of the mucous cells, from a mixture of neutral and acid glycoproteins to neutral glycoproteins, during the early stages of the treatment suggests that acid moities could not simultaneously be synthesized as an immediate response to enhanced mucous secretion. The apical parts of the mucous cells, however, showed no histochemical change throughout the experiment.

关键词： Observations on the Function of Mucous Cells in the Epidermis of the Cat-fish Clarias batrachus Exposed to Sodium Dodecyl Sulfate

Characterization of the tensile properties of friction stir welded aluminum alloy joints based on axial force, traverse speed, and rotational speed

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Frontiers of Mechanical Engineering 2016年第3期11卷 289-298页

作者： Biranchi PANDA A. garg Zhang JIAN Akbar HEIDARZADEH Liang GAO IDMEC Instituto Superior Tecnico Universidade de Lisboa Lisboa1040-001 Portugal Department of Mechatronics Engineering Shantou University Shantou515063 China Department of Materials Engineering Azarbaijan Shahid MadaniUniversity Tabriz Iran The State Key Laboratory of Digital Manufacturing Equipment andTechnology Huazahong University of Science and Technology Wuhan430074 China

Friction stir welding （FSW） process has gained attention in recent years because of its advantages over the conventional fusion welding process. These advantages include the absence of heat formation in the affected zone and the absence of large distortion, porosity, oxidation, and cracking. Experimental investigations are necessary to understand the physical behavior that causes the high tensile strength of welded joints of different metals and alloys. Existing literature indicates that tensile properties exhibit strong dependence on the rotational speed, traverse speed, and axial force of the tool that was used. Therefore, this study introduces the experimental procedure for measuring tensile properties, namely, ultimate tensile strength （UTS） and tensile elongation of the welded AA 7020 A1 alloy. Experimental findings suggest that a welded part with high UTS can be achieved at a lower heat input compared with the high heat input condition. A numerical approach based on genetic programming is employed to produce the functional relationships between tensile properties and the three inputs （rotational speed, traverse speed, and axial force） of the FSW process. The formulated models were validated based on the experimental data, using the statistical metrics. The effect of the three inputs on the tensile properties was investigated using 2D and 3D analyses. A high UTS was achieved, including a rotational speed of 1050 r/min and traverse speed of 95 mm/min. The results also indicate that 8 kN axial force should be set prior to the FSW process.

关键词： tensile properties ultimate tensile strength tensile elongation friction stir welding tool rotational speed genetic programming welding speed

Unstable cardiac injury complicated with septic shock—a challenge

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Burns & Trauma 2016年第2期4卷 164-166页

作者： Neha garg Kapil Dev Soni Richa Aggarwal Department of Anaesthesia and Intensive Care All India Institute of Medical SciencesAnsari Nagar EastGautam NagarNew Delhi 110029India Division of Critical&Intensive care All India Institute of Medical SciencesAnsari Nagar EastGautam NagarNew Delhi 110029India

Background:Road traffic accident accounts for 70%to 80%of the blunt cardiac *** true incidence varies in the literature due to non-uniform criteria for *** Presentation:Here,we describe the case of a young male presenting after blunt chest injury and hemodynamic ***,the patient had frequent episodes of arrhythmias and hypotension due to cardiac injury per ***,he was stabilized by day ***,patient developed cellulitis followed by septic shock and succumbed to cellulitis on day 5 of ***:Sepsis is difficult to be diagnosed and treated in the presence of cardiac *** depression has been found in sepsis,which contributes as an added comorbidity in an already compromised heart *** also interferes with the diagnosis and follow-up of progress of blunt cardiac injury.

关键词： Blunt cardiac injury Sepsis Myocardial depression Troponin

Fecal diversion in complex anal fistulas:Is there a way to avoid it?

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World Journal of Clinical Cases 2021年第25期9卷 7306-7310页

作者： Pankaj garg Vipul D Yagnik Sushil Dawka Colorectal Surgery Garg Fistula Research InstitutePanchkula 134113HaryanaIndia Colorectal Surgery Indus International HospitalMohali 140201PunjabIndia Surgical Gastroenterology Nishtha Surgical Hospital and Research CenterPatan 384265GujaratIndia Surgery SSR Medical CollegeBelle Rive 744101Mauritius

Temporary fecal diversion by a diverting colostomy or ileostomy is occasionally performed for serious complex *** main indications are highly complex and extensive cryptoglandular anal fistula,anal fistula associated with severe anorectal Crohn’s disease,recurrent rectovaginal fistula,radiation-induced fistula and anal fistula with associated necrotizing *** purpose of stoma formation is to divert the fecal stream away from the anorectum and the perianal region so as to control the infective process and prevent trauma to the operated repaired *** the fistula has healed,the diverting stoma is ***,two questions are ***,is it certain that the same disease would not relapse(or the fistula would not recur)once the colostomy is closed?Second,is there a non-surgical method which can obviate the need for a diverting colostomy?An attempt is made to answer both these questions in this review.

关键词： Anal fistula Fecal diversion Diverting stoma Colostomy Crohn’s disease Rectovaginal fistula

Densities and excess molar volumes of mixtures containing diesel,biodiesel and alkanols at temperatures from 288.15 to 313.15 K

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Chinese Journal of Chemical Engineering 2021年第6期34卷 198-207页

作者： Sunita Malik Poonam Jangra Darolia S.K.garg V.K.Sharma Department of Chemistry Maharshi Dayanand UniversityRohtakHaryanaIndia J.C.Bose University of Science and Technology YMCAFaridabadHaryanaIndia

The present work is focusing on the synthesization and physico-chemical properties of Jatropha curcas biodiesel with diesel and *** densities of binary diesel(2)+1-alkanols(C_(3) or C_(4))(3)and ternary Jatropha curcas biodiesel(1)+diesel(2)+1-alkanols(C_(3)or C_(4))(3)blends have been reported over full range of composition at temperatures within range 288.15 to 313.15 *** densities of Jatropha curcas biodiesel(1)+diesel or 1-alkanols(C_(3) or C_(4))(2)blends have been measured at 313.15 *** molar volumes,V^E,V^E_(123)of binary and ternary blends were calculated from the measured data and the derived properties were correlated to composition using Redlich-Kister equation.A reasonable agreement was found between the measured and estimated ***,densities and excess molar volumes data were reasoned to discuss molecular interactions taking into consideration effect of composition and temperature.

关键词： Jatropha curcas biodiesel Diesel Alcohols Blends Density Excess molar volumes