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Exosomes derived from tumor adjacent fibroblasts efficiently target pancreatic tumors

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Acta Pharmaceutica Sinica B 2024年第7期14卷 3009-3026页

作者： Saini Setua Shabia Shabir Poornima Shaji Ana Martinez Bulnes Anupam Dhasmana Swathi Holla Nivesh K.Mittal Nirakar Sahoo Tripti Saini Francesco Giorgianni Mohammad Sikander Andrew E.Massey Bilal B.Hafeez Manish K.Tripathi Vincent P.Diego Meena Jaggi Junming Yue Nadeem Zafar Murali M.Yallapu Stephen W.Behrman sheema khan Subhash C.Chauhan Department of Pharmaceutical Sciences College of Pharmacyand College of MedicineUniversity of Tennessee Health Science Center(UTHSC)MemphisTN 36163USA Department of Computer Science Islamic University of Science and TechnologyAwantiporaJ&K 192122India Department of Immunology and Microbiology School of MedicineUniversity of Texas Rio Grande ValleyMcAllenTX 78504USA South Texas Center of Excellence in Cancer Research School of Medicinethe University of Texas Rio Grande ValleyMcAllenTX 78504USA Himalayan School of Biosciences and Cancer Research Institute Himalayan Institute of Medical SciencesSwami Rama Himalayan UniversityDehradun 248016India Plough Center for Sterile Drug Delivery Solutions UTHSCMemphisTN 38104USA Department of Biology College of SciencesUTRGVMcAllenTX 78539USA National Institute of Biomedical Imaging and Bioengineering(NIBIB) National Institutes of HealthBethesdaMD 20892USA South Texas Diabetes and Obesity Institute UTRGVMcAllenTX 78504USA Dept.of Laboratory Medicine&Pathology University of WashingtonSeattleWA 98195USA Department of Surgery Baptist Memorial Medical EducationBaptist Memorial HospitalMemphisTN 38120USA Baptist Health Sciences University MemphisTN 38104USA

The application of extracellular vesicles,particularly exosomes(EXs),is rapidly expanding in the field of medicine,owing to their remarkable properties as natural carriers of biological *** study investigates utilization of exosomes derived from stromal cells of tumor adjacent normal tissues(NAF-EXs)for personalized medicine,which can be derived at the time of diagnosis by endoscopic ***,we show that exosomes(EXs)derived from NAFs demonstrate differential bio-physical characteristics,efficient cellular internalization,drug loading efficiency,pancreatic tumor targeting and delivery of ***-derived EXs(NAF-EXs)were used for loading ormeloxifene(ORM),a potent anti-cancer and desmoplasia inhibitor as a model *** found that ORM maintains normal fibroblast cell phenotype and renders them incompatible to be triggered for a CAF-like phenotype,which may be due to regulation of Ca^(2+) influx in fibroblast ***-EXs-ORM effectively blocked oncogenic signaling pathways involved in desmoplasia and epithelial mesenchymal transition(EMT)and repressed tumor growth in xenograft mouse *** conclusion,our data suggests preferential tropism of NAF-EXs for PDAC tumors,thus imply feasibility of developing a novel personalized medicine for PDAC patients using autologous NAF-EXs for improved therapeutic outcome of anti-cancer ***,it provides the opportunity of utilizing this biological scaffold for effective therapeutics in combination with standard therapeutic regimen.

关键词： Pancreatic cancer Tumor adjacent normal tissue fibroblasts(NAF) Desmoplasia Extracellular vesicles Exosomes Tumor targeting Ormeloxifene Personalized medicine

A Synergistic Multi-Attribute Decision-Making Method for Educational Institutions Evaluation Using Similarity Measures of Possibility Pythagorean Fuzzy Hypersoft Sets

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 501-530页

作者： Khuram Ali khan Saba Mubeen Ishfaq Atiqe Ur Rahman Salwa El-Morsy Department of Mathematics University of SargodhaSargodha40100Pakistan Department of Mathematics University of Management and TechnologyLahore54000Pakistan Department of Mathematics College of ScienceQassim UniversityBuraydah51452Saudi Arabia

Due to the numerous variables to take into account as well as the inherent ambiguity and uncertainty,evaluating educational institutions can be *** concept of a possibility Pythagorean fuzzy hypersoft set(pPyFHSS)is more flexible in this regard than other theoretical fuzzy set-like models,even though some attempts have been made in the literature to address such *** study investigates the elementary notions of pPyFHSS including its set-theoretic operations union,intersection,complement,OR-and *** results related to these operations are also modified for ***,the similarity measures between pPyFHSSs are formulated with the assistance of numerical examples and ***,an intelligent decision-assisted mechanism is developed with the proposal of a robust algorithm based on similarity measures for solving multi-attribute decision-making(MADM)problems.A case study that helps the decision-makers assess the best educational institution is discussed to validate the suggested *** algorithmic results are compared with the most pertinent model to evaluate the adaptability of pPyFHSS,as it generalizes the classical possibility fuzzy set-like theoretical ***,while considering significant evaluating factors,the flexibility of pPyFHSS is observed through structural comparison.

关键词： Hypersoft set Pythagorean fuzzy hypersoft set computational complexity multi-attribute decision-making optimization similarity measures uncertainty

Comparative study of living donor kidney transplants:Right vs left

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World Journal of Transplantation 2025年第1期15卷 115-123页

作者： Taqi khan Nadeem Ahmad Qaisar Iqbal Muneeb Hassan Lajward Asnath Naveed khan Sajid Shakeel Kidney Transplant Unit Rehman Medical InstitutePeshawar 25100Khyber PakhtunkhwaPakistan Department of Surgery Princess Noura Binti AbdulRehman UniversityRiyadh 84428Saudi Arabia

BACKGROUND Transplant teams often hesitate to use the right kidney(RK)in living donor(LD)transplants due to the complexities of anastomosing the short,thin-walled right renal veins,which can potentially lead to graft loss or graft ***,circumstances may arise where selecting the RK over the left kidney(LK)is ***,it is crucial to thoroughly examine the implications of such a choice on the overall transplant *** To compare transplant outcomes between recipients of RK and LK while examining the factors that influence these *** We retrospectively analyzed data from adult patients who received LD kidney transplants involving meticulous patient selection and surgical techniques at our center from January 2020 to December *** included all kidney donors who were over 18,fit to donate,and had undergone diethylenetriamine pentaacetic acid split function and/or computed tomography based *** variables examined comprised donor and recipient demographics,and outcome measures included technical graft loss(TGL),delayed or slow graft function(SGF),and post-transplant serum creatinine(SC)*** used a logistic regression model to assess the likelihood of adverse outcomes considering the donor kidney *** Of the 250 transplants performed during the period,56(22%)were *** recipient demographics and transplant factors were comparable for the right and LKs,except that the donor warm and cold ischemia time were shorter for *** and SGF each occurred in 2%(n=1)of RKs and 0.5%(n=1)of LKs,the difference being *** complications,however,were not related to the venous *** RK(2%)developed delayed graft function after 48 hours,which was attributable to postoperative hypoxia rather than the surgical *** post-transplant SC trend and mean SC at the last follow-up were similar across both kidney *** The donor kidney side has little impact on post-transplant

关键词： Living donor Right kidney Right renal vein Venous anastomosis Technical graft loss Early graft function

Exploring Nanoscale Perovskite Materials for Next‑Generation Photodetectors:A Comprehensive Review and Future Directions

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Nano-Micro Letters 2025年第2期17卷 46-108页

作者： Xin Li Sikandar Aftab Maria Mukhtar Fahmid Kabir Muhammad Farooq khan Hosameldin Helmy Hegazy Erdi Akman State Key Laboratory of Pulsed Power Laser Technology National University of Defense TechnologyHefei 230037AnhuiPeople’s Republic of China Anhui Laboratory of Advanced Laser Technology Hefei 230037AnhuiPeople’s Republic of China Nanhu Laser Laboratory Changsha 410015HunanPeople’s Republic of China Department of Semiconductor Systems Engineering and Clean Energy Sejong UniversitySeoul 05006Republic of Korea Department of Artificial Intelligence and Robotics Sejong UniversitySeoul 05006Republic of Korea School of Engineering Science Simon Fraser UniversityBurnabyBC V5A 1S6Canada Department of Electrical Engineering Sejong UniversitySeoul 05006South Korea Department of Physics Faculty of ScienceKing Khalid UniversityP.O.Box 9004AbhaSaudi Arabia Central Labs King Khalid UniversityAlQura’aP.O.Box 96061413 AbhaSaudi Arabia Scientific and Technological Research and Application Center Karamanoglu Mehmetbey University70100 KaramanTurkey

The rapid advancement of nanotechnology has sparked much interest in applying nanoscale perovskite materials for photodetection *** materials are promising candidates for next-generation photodetectors(PDs)due to their unique optoelectronic properties and flexible synthesis *** review explores the approaches used in the development and use of optoelectronic devices made of different nanoscale perovskite architectures,including quantum dots,nanosheets,nanorods,nanowires,and *** a thorough analysis of recent literature,the review also addresses common issues like the mechanisms underlying the degradation of perovskite PDs and offers perspectives on potential solutions to improve stability and scalability that impede widespread *** addition,it highlights that photodetection encompasses the detection of light fields in dimensions other than light intensity and suggests potential avenues for future research to overcome these obstacles and fully realize the potential of nanoscale perovskite materials in state-of-the-art photodetection *** review provides a comprehensive overview of nanoscale perovskite PDs and guides future research efforts towards improved performance and wider applicability,making it a valuable resource for researchers.

关键词： Nanoscale perovskites Photodetectors Nanosheets Nanorods Nanowires Quantum dots Nanocrystals

Modeling and Comprehensive Review of Signaling Storms in 3GPP-Based Mobile Broadband Networks:Causes,Solutions,and Countermeasures

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 123-153页

作者： Muhammad Qasim khan Fazal Malik Fahad Alturise Noor Rahman Department of Computer Science Iqra National UniversityPeshawar25000Pakistan Department of Cybersecurity College of ComputerQassim UniversityBuraydah52555Saudi Arabia Department of Computer Science and Engineering Al-Fayha CollegeAl Jubayl31961Saudi Arabia

Control signaling is mandatory for the operation and management of all types of communication networks,including the Third Generation Partnership Project(3GPP)mobile broadband ***,they consume important and scarce network resources such as bandwidth and processing *** have been several reports of these control signaling turning into signaling storms halting network operations and causing the respective Telecom companies big financial *** paper draws its motivation from such real network disaster incidents attributed to signaling *** this paper,we present a thorough survey of the causes,of the signaling storm problems in 3GPP-based mobile broadband networks and discuss in detail their possible solutions and *** provide relevant analytical models to help quantify the effect of the potential causes and benefits of their corresponding *** important contribution of this paper is the comparison of the possible causes and solutions/countermeasures,concerning their effect on several important network aspects such as architecture,additional signaling,fidelity,etc.,in the form of a *** paper presents an update and an extension of our earlier conference *** our knowledge,no similar survey study exists on the subject.

关键词： Signaling storm problems control signaling load analytical modeling 3GPP networks smart devices diameter signaling mobile broadband data access data traffic mobility management signaling network architecture 5G mobile communication

Organic micro-pollutant removal in liquid-phase using carbonized silk cotton hull

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Journal of Environmental Sciences 2008年第9期20卷 1046-1054页

作者： M Sathishkumar A R Binupriya D Kavitha R Selvakumar K K sheema J G Choi Department of Food Science and Technology Institute of Agricultural Science and Technology Chonbuk National University Department of Chemical Engineering Yonsei University Department of Biotechnology Bharathiar University Department of Plant biology and Biotechnology Government Arts College National Agricultural Products Quality Management Services

Phenolic compounds constitute one of the major pollutants in the modern world. Although many physical and chemical treatment technologies for their removal exist, most of them are economically not feasible. The present study was aimed at using silk cotton hull, a potent agricultural waste as an adsobent for removal of 2,4-dichlorophenol (2,4-DCP), which was used as a model phenolic compound. The process parameters were investigated and optimized conditions were determined. The equilibrium time was found to ...

关键词： silk cotton hull carbon adsorption 2 4-DCP temperature kinetic study

Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal J.Goldschmidt-Clermont Aisha khan George Jimsheleishvili Patricia Graham Adriana Brooks Risset Silvera Alexander J.P.Goldschmidt Damien D.Pearse W.Dalton Dietrich Allan D.Levi James D.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FDA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of Dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

Pollution of water resources due to industrialization in arid zone of Rajasthan, India

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Journal of Environmental Sciences 2001年第2期13卷 218-223页

作者： khan M A Central Arid Zone Research Institute 印度 342003

In arid zone of Rajasthan, India, nearly 21,900 hm2 area along Bandi River has been affected by industrial effluent discharge into the river bed. Analysis of groundwater samples collected from these sites revealed that area at the vicinity of the river is most affected. The effluent water in the river is the main source of contamination of ground water. Concentration of sodium and chloride has been higher with proportional increase in TDS and EC value in the area within zone A (river water), zone B (0-100 m), zone C (101-250 m), zone D (251-500 m) and zone E (501-1000 m). There is decreasing trend in ion concentration from zone A to zone E and F, reflecting reduced effect of effluents. The pollution of water resources has resulted in the degradation of other natural resources such as land, soil and vegetation. Nearly 4463 hm2 (20.38%) area has been very severely affected. EC value at places exceeds 20 dS/m. Soil and land have become hard, compact and saline. Cropping intensity has declined. In the area (3633 hm2) affected severely, the EC value of water varies from 10-20 dS/m. Irrigation with such water has created problem of salinity, sodicity in soils. Herbal biomass declined considerably. Double cropping has almost stopped. Almost 8494 hm2 area is affected moderately. EC of ground water varies from 5 to 10 dS/m. Fragile surface crust, declining trend of phosphorous and potassium in the soil, poor density of natural vegetation are significant manifestations. Apart from this, 5305 hm2 area is slightly affected.

关键词： India Pollution of water resources due to industrialization in arid zone of Rajasthan

Accumulation of Pb,Cu,and Zn in native plants growing on contaminated sites and their potential accumulation capacity in Heqing,Yunnan

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Journal of Environmental Sciences 2008年第12期20卷 1469-1474页

作者： Sardar khan Department of Soil Environmental Sciences Research Center for Eco-Environmental Sciences Department of Environmental Sciences University of Peshawar25120 Peshawar

Phytoremediation is one of the cost-effective and environmental friendly technologies used to remove contaminants from contaminated soils,which has been intensively studied during the last ***,few economical and effective remediation methods are available for the remediation of Pb contaminated *** study was conducted to assess the potential of 19 plants growing on contaminated sites in Pb mine *** and associated soil samples were collected and analyzed for total metal concentrati...

关键词： accumulation of Pb Cu and Zn cultivated crops accumulator lead mine remediation