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Pleiotrophin and N-syndecan promote perineural invasion and tumor progression in an orthotopic mouse model of pancreatic cancer

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World Journal of Gastroenterology 2017年第21期23卷 3907-3914页

作者： Jun Yao Lu-Lin Zhang Xu-Mei Huang Wen-Yao Li she-gan gao Henan Key Laboratory of Cancer Epigenetics Cancer Institute the First Affiliated Hospital and College of Clinical Medicine of Henan University of Science and Technology Simmons Comprehensive Cancer Center UT Southwestern Medical Center

AIM To detect the expression of pleiotrophin(PTN) and N-syndecan in pancreatic cancer and analyze their association with tumor progression and perineural invasion(PNI).METHODS An orthotopic mouse model of pancreatic cancer was created by injecting tumor cells subcapsularly in a root region of the pancreas beneath the spleen. Pancreatic cancer tissues were taken from 36 mice that survived for more than 90 d. PTN and N-syndecan proteins were detected by immunohistochemistry and analyzed for their correlation with pathological features, PNI, and *** The expression rates of PTN and N-syndecan proteinswere 66.7% and 61.1%, respectively, in cancer tissue. PTN and N-syndecan expression was associated with PNI(P = 0.019 and P = 0.032, respectively). High PTN expression was closely associated with large bloody ascites(P = 0.009), liver metastasis(P = 0.035), and decreased survival time(P = 0.022). N-syndecan expression was significantly associated with tumor size(P = 0.025), but not with survival time(P = 0.539). CONCLUSION High PTN and N-syndecan expression was closely associated with metastasis and poor prognosis, suggesting that they may promote tumor progression and PNI in the orthotopic mouse model of pancreatic cancer.

关键词： Pleiotrophin N-syndecan Pancreatic cancer Perineural invasion

N-linked glycoproteomic profiling in esophageal squamous cell carcinoma

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World Journal of Gastroenterology 2022年第29期28卷 3869-3885页

作者： Qi-Wei Liu Hao-Jie Ruan Wei-Xia Chao Meng-Xiang Li Ye-Lin Jiao Douglas G Ward she-gan gao Yi-Jun Qi Henan Key Laboratory of Microbiome and Esophageal Cancer Prevention and Treatment/Henan Key Laboratory of Cancer Epigenetics/Cancer Hospital The First Affiliated HospitalCollege of Clinical MedicineHenan University of Science and TechnologyLuoyang 471003Henan ProvinceChina Department of Pathology The First People’s Hospital of Luo YangLuoyang 471000Henan ProvinceChina Institute of Cancer and Genomic Sciences College of Medical and Dental SciencesUniversity of BirminghamBirmingham B152TTUnited Kingdom

BACKGROUND Mass spectrometry-based proteomics and glycomics reveal post-translational modifications providing significant biological insights beyond the scope of genomic *** To characterize the N-linked glycoproteomic profile in esophageal squamous cell carcinoma(ESCC)via two complementary *** Using tandem multilectin affinity chromatography for enrichment of N-linked glycoproteins,we performed N-linked glycoproteomic profiling in ESCC tissues by two-dimensional gel electrophoresis(2-DE)-based and isobaric tags for relative and absolute quantification(iTRAQ)labeling-based mass spectrometry quantitation in parallel,followed by validation of candidate glycoprotein biomarkers by Western *** 2-DE-based and iTRAQ labeling-based quantitation identified 24 and 402 differentially expressed N-linked glycoproteins,respectively,with 15 in common,demonstrating the outperformance of iTRAQ labeling-based quantitation over 2-DE and complementarity of these two *** showed the distinct compositions of functional categories between proteins and glycoproteins with differential expression associated with *** blot analysis validated the up-regulation of total procathepsin D and high-mannose procathepsin D,and the downregulation of total haptoglobin,high-mannose clusterin,and GlcNAc/sialic acid-containing fraction of 14-3-3ζ in ESCC *** serum levels of glycosylated fractions of clusterin,prolinearginine-rich end leucine-rich repeat protein,and haptoglobin in patients with ESCC were remarkably higher than those in healthy *** Our study provides insights into the aberrant N-linked glycoproteome associated with ESCC,which will be a valuable resource for future investigations.

关键词： Esophageal squamous cell carcinoma N-linked glycoprotein Post-translational modification Lectin Cathepsin D Haptoglobin 14-3-3ζ

Therapeutic effects of combined oxaliplatin and S-1 in older patients with advanced gastric cardiac adenocarcinoma

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World Journal of Gastroenterology 2011年第47期17卷 5221-5226页

作者： she-gan gao Rui-Nuo Jia Xiao-Shan Feng Xuan-Hu Xie Tan-You Shan Li-Xian Pan Na-Sha Song Yu-Feng Wang Kai-Li Ding Li-Dong Wang Department of Oncology First-Affiliated HospitalCancer Institute Henan University of Science and TechnologyLuoyang 471003 Henan Province China Henan Key Laboratory for Esophageal Can-cer Laboratory for Cancer Research Basic Medical CollegeZhengzhou University Zhengzhou 450052 Henan ProvinceChina

AIM:To evaluate the effects and safety of combination chemotherapy with oxaliplatin (L-OHP) and S-1 (SOX regimen) in older patients with advanced gastric cardiac adenocarcinoma (GCA). METHODS: Seventy patients with advanced GCA were classified according to age into an older group (≥ 75 years) and a control group ( 0.05). CONCLUSION: The SOX regimen is an effective, safe and well-tolerated regimen for older patients with advanced GCA.

关键词： Gastric cardiac adenocarcinoma Oxalipla-tin S-1 Treatment effect

Histochemical studies on intestinal metaplasia adjacent to gastric cardia adenocarcinoma in subjects at high-incidence area in Henan, north China

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World Journal of Gastroenterology 2005年第30期11卷 4634-4637页

作者： she-gan gao Li-Dong Wang Zong-Min Fan Ji-Lin Li Xin He Rui-Feng Guo Dong-Ling Xie Xin-Wei He Shan-Shan gao Hua-Qin Guo Jun-Kuan Wang Xiao-Shan Feng Bao-Gen Ma Laboratory for Cancer Research College of Medicine Zhengzhou University Zhengzhou 450052 Henan Province China Department of Pathology Linzhou Esophageal Cancer Hospital Linzhou Henan Province China Dep-artment of Clinical Oncology The First Affiliated Hospital of Henan Science and Technology University Luoyang 471001 Henan Province China Department of Oncology Henan Tumor Hospital Zhengzhou 450003 Henan Province China

AIM： To characterize the histochemical type and pattern of intestinal metaplasia （IM） adjacent to gastric cardia adenocarcinoma （GCA） and distal gastric cancer （GC） in Unzhou, Henan Province, China. METHODS： Alcian-blue-periodic acid Schiff and high iron diamine-Alcian blue histochemical methods were performed on 142 cases of IM, including 49 cases of GCA and 93 cases of GC. All the patients were from Linzhou, Henan Province, China, the highest incidence area for both GCA and squamous cell carcinoma. Radio- or chemotherapy was not applied to these patients before surgery. RESULTS： The detection rate of IM in tissues adjacent to GCA tissues was 44.9%, which was significantly lower than that in GC tissues （80.64%, P〈0.01）. The rates of both incomplete small intestinal and colonic IM types identified by histochemistry in GCA tissues （31.82% and 63.64%, respectively） were significantly higher than those in GC （5.33% and 21.33%, respectively, P〈0.01）. CONCLUSION： IM in GCA and GC should be considered as a separate entity. Further research is needed to evaluate whether neoplastic progression of IM is related to its mucin profile in GCA.

关键词： Gastric cardia Intestinal metaplasia Histochemistry

Pleiotrophin promotes perineural invasion in pancreatic cancer

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World Journal of Gastroenterology 2013年第39期19卷 6555-6558页

作者： Jun Yao Xiu-Feng Hu Xiao-Shan Feng she-gan gao Department of Oncology the First Affiliated Hospital of Henan University of Science and Technology

Perineural invasion(PNI)in pancreatic cancer is an important cause of local recurrence,but little is known about its ***(PTN)is an important neurotrophic *** is of interest that our recent experimental data showed its involvement in PNI of pancreatic *** strongly presents in the cytoplasm of pancreatic cancer cells,and high expression of PTN and its receptor may contribute to the high PNI of pancreatic ***,PNI is prone to happen in PTN-positive *** thus hypothesize that,as a neurite growth-promoting factor,PTN may promote PNI in pancreatic *** is released at the time of tumor cell necrosis,and binds with its highaffinity receptor,N-syndecan on pancreatic nerves,to promote neural growth in pancreatic ***,neural destruction leads to a distorted neural *** and Schwann cells produce more N-syndecan in an effort to repair the pancreatic ***,the abundance of N-syndecan attracts further PTN-positive cancer cells to the site of injury,creating a vicious ***,increased PTN and N-syndecan levels,due to the continuous nerve injury,may promote cancer invasion and propagation along the neural ***,it is meaningful to discuss the relationship between PTN/N-syndecan signaling and PNI in pancreatic cancer,which may lead to a better understanding of the mechanism of PNI in pancreatic cancer.

关键词： Pleiotrophin N-syndecan Neurite outgrowth Perineural invasion Pancreatic cancer

Cryptanalysis of efficient semi-quantum secret sharing protocol using single particles

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Chinese Physics B 2024年第4期33卷 254-257页

作者：高甘 Department of Electrical Engineering Tongling UniversityTongling 244061China Anhui Engineering Research Center of Intelligent Manufacturing of Copper-based Materials Tongling UniversityTongling 244061China Anhui Joint Key Laboratory of Critical Technologies for High-End Copper-Based New Materials Tongling UniversityTongling 244061China

In paper[***.B 32070308(2023)],Xing et *** a semi-quantum secret sharing protocol by using single *** study the security of the proposed protocol and find that it is not secure,that is,the three dishonest agents,Bob,C... 详细信息

关键词： security loophole rearranging orders semi-quantum secret sharing single particles

Properties and Characteristics of Regolith-Based Materials for Extraterrestrial Construction

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Engineering 2024年第6期37卷 159-181页

作者： Cheng Zhou Yuyue gao Yan Zhou Wei she Yusheng Shi Lieyun Ding Changwen Miao National Center of Technology Innovation for Digital Construction Huazhong University of Science and TechnologyWuhan 430074China School of Civil and Hydraulic Engineering Huazhong University of Science and TechnologyWuhan 430074China School of Materials Science and Engineering Southeast UniversityNanjing 214135China State Key Laboratory of Materials Processing and Die&Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China

The construction of extraterrestrial bases has become a new goal in the active exploration of deep *** the construction techniques,in situ resource-based construction is one of the most promising because of its good sustainability and acceptable economic cost,triggering the development of various types of extraterrestrial construction materials.A comprehensive survey and comparison of materials from the perspective of performance was conducted to provide suggestions for material selection and *** types of typical construction materials are discussed in terms of their reliability and applicability in extreme extraterrestrial ***,thermal and optical,and radiation-shielding properties are *** influencing factors and optimization methods for these properties are *** the perspective of material properties,the existing challenges lie in the comprehensive,long-term,and real characterization of regolith-based construction ***,the suggested future directions include the application of high-throughput characterization methods,accelerated durability tests,and conducting extraterrestrial experiments.

关键词： Extraterrestrial construction Characterization Mechanical property Thermal property Optical property Radiation-shielding

Fabrication pressures and stack pressures in solid-state battery

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eScience 2024年第4期4卷 27-40页

作者： Zhijun Wu shengnan He Chao Zheng Jiantuo gan Liaona she Mingchang Zhang Yong gao Yaxiong Yang Hongge Pan Institute of Science and Technology for New Energy Xi'an Technological UniversityXi'an 710021China State Key Laboratory of Silicon Materials and School of Materials Science and Engineering Zhejiang UniversityHangzhou 310027China

Solid-state batteries(SSBs)have received widespread attention with their high safety and high energy density ***,solid-solid contacts in the internal electrode material and the electrode material/solid electrolyte(SE)interfaces,as well as the severe electrochemo-mechanical effects caused by the internal stress due to the volume change of the active material,these problems hinder ion/electron transport within the SSBs,which significantly deteriorates the electrochemical *** fabrication pressures and stack pressures are effective measures to improve solid-solid contact and solve electrochemo-mechanical ***,the influences of different pressures on cathode material,anode material,SEs,and electrode/SEs interface are briefly summarized from the perspective of interface ion diffusion,transmission of electrons and ions in internal particles,current density and ion diffusion kinetics,and the volume changes of Li^(+)stripping/plating based on two physical contact models,and point out the direction for the future research direction of SSBs and advancing industrialization by building the relationship between pressures and SSBs electrochemistry.

关键词： Fabrication pressure Stack pressure Solid-state battery Solid electrolyte Ion/electron transport

Regulation of pseudographitic carbon domain to boost sodium energy storage

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Nano Research 2024年第6期17卷 5188-5196页

作者： Zhidong Hou Mingwei Jiang Da Lei Xiang Zhang Yuyang gao Jian-gan Wang State Key Laboratory of Solidification Processing Center for Nano Energy MaterialsSchool of Materials Science and EngineeringNorthwestern Polytechnical University and Shaanxi Joint Lab of Graphene(NPU)Xi’an 710072China

Hard carbon anode has shown extraordinary potentials for sodium-ion batteries(SIBs)owing to the cost-effectiveness and advantaged ***,the widespread application of hard carbon is still hindered by the insufficient sodium storage capacity and depressed rate property,which are mainly induced by the undesirable pseudographitic ***,we develop a molten-salt-mediated strategy to regulate the pseudographitic structure of hard carbon with suitable interlayer spacing and enlarged pseudographitic domain,which is conducive to the intercalation capacity and diffusion kinetics of sodium ***,the optimized hard carbon anode delivers a high reversible capacity of 320 mAh·g^(−1),along with superior rate property(138 mAh·g−1 at 2 A·g^(−1))and stable cyclability over 1800 ***,the in situ Raman spectroscopic study and full-cell assembly further investigate the sodium storage mechanism and practical implement of obtained hard *** work pioneers a low-cost and effective route to regulate the pseudographitic structure of hard carbon materials for advanced SIBs.

关键词： pseudographitic structure molten salt hard carbon anode sodium-ion batteries