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Risk Factors Associated with Anthracycline Induced Cardiac Dysfunction in Pediatric Patients

World Journal of Cardiovascular Diseases 2014年第7期4卷 377-383页

作者： Abdul Sattar Shaikh Muhammad Matloob Alam shazia samad mohsin Qalab Abbas Zehra Fadoo Mehnaz Atiq Department of Paediatrics and Child Health Aga Khan University Hospital Karachi Pakistan Department of Pediatrics Liaquat National Hospital and Medical College Karachi Pakistan

Anthracyclines (i.e., doxorubicin, daunorubicin) have significant impact on outcome in many pediatric chemotherapy protocols and therefore remain the mainstay of treatment. The objective of this study was to identify the risk factors for anthracycline induced cardiac dysfunction in pediatric patients. Multiple logistic regression model was applied to assess the risk factors for development of cardiac dysfunction. 110 pediatric oncology patients were available for final analysis. 75 (66%) children were males and mean age was 74 ± 44 months. ALL (n = 70, 64%) was the most common primary diagnosis followed by lymphoma (n = 19;17%) and AML (n = 12, 11%). Daunorubicin alone or in combination with doxorubicin was used in (n = 94, 85%) patients and cumulative dose n = 95;86%) children. 24 (22%) children received radiation therapy as per protocol and sepsis were observed in 47 (43%) cases. Post anthracycline, 15 (14%) children had cardiac dysfunction within a month;out of them 10/15 (67%) had isolated diastolic dysfunction, while 28 (25%) developed dysfunction within a year. 19 (17%) had pericardial effusion. 11 expired and out of them, 7 had significant cardiac dysfunction. Cumulative dose > 300 mg/m2 (p p = 0.009;AOR 3.5) and sepsis (p = 0.002;AOR 2.6) were found to be independent risk factors associated anthracycline induced cardiac dysfunction. At univariant level use of daunorubicin alone or in combination therapy (p p 0.048, OR 9.7) were also found statistically significant. In conclusion anthracycline induced cardiac dysfunction is mostly related to cumulative dose > 300 mg/m2, use of Daunorubicin alone or in combination with doxorubicin, mode of delivery, radiation therapy and sepsis. Regular long term follow-up with cardiologist is the key point for early diagnosis and therapy for a long term survival.

关键词： Anthracycline Cardiac Dysfunction Risk Factors Pediatric Oncology

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A Rare Case of Successive Pregnancies in a Woman with Complex Cyanotic Congenital Heart Disease after Glenn Palliation

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World Journal of Cardiovascular Diseases 2017年第12期7卷 423-428页

作者： Marwa Mohamed shazia mohsin Merna Atiyah Ahmed Al Zahrani Khalid Alnajashi Prince Sultan Cardiac Center Riyadh KSA

The bidirectional Glenn procedure is an integral step in the optimal palliation for single ventricular physiology in many forms of complex congenital heart disease. An increasing number of women who have undergone this connection in childhood are now reaching childbearing years. Low pulmonary blood flow and volume over load on the single ventricle pose several problems during pregnancy. We are reporting a 33-year-old lady with congenital tricuspid atresia and mild pulmonary stenosis who had late Bidirectional Glenn procedure with pulmonary forward flow and later underwent six successful pregnancies, with delivery of six low birth weight babies with no reported complications.

关键词： Glenn Palliation Pregnancy Tricuspid Atresia

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Effects of different colours in the visible region on <i>Leishmania Tropica</i>

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Advances in Bioscience and Biotechnology 2011年第5期2卷 380-384页

作者： Samina. T. Yousuf Azeemi S. mohsin Raza Masoom Yasinzai A. samad Manzoor Iqbal Khattak 不详

The aim of this study was to investigate the wavelength-dependency of chromotherapy effects on cutaneous Leishmaniasis parasite growth. Chromotherapy uses visible range radiations to improve healing;however, its effects on parasite are not well understood. Leishmania Tropica was irradiated using seven (7) different wavelengths of visible region. Optical density was observed, which showed that red colour (644 nm) wavelength inhibited the growth of parasite while other colour wavelengths also affected the growth of parasite. It is, therefore, suggested that as red colour inhibits the growth of parasite so patients suffering from *** can be treated with the application of red colour.

关键词： Leishmania Tropica Chromotherapy Photo Stimulation

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