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Neurological manifestations of COVID-19 infection:A case series

Journal of Acute Disease 2023年第6期12卷 244-249页

作者： Ayimen Khalid Khan Anam Khan Ammar Khalid Khan shayan sirat maheen anwar Department of Radiology Aga Khan UniversityKarachiPakistan Department of Neurosurgery Pakistan Institute of Medical SciencesIslamabadPakistan

Neurological symptoms of COVID-19 infection can be lethal if optimum intervention is not provided at the right ***,it is extremely important to distinguish the non-specific symptoms of COVID-19 according to its severity directly or indirectly caused by the ***,we present five radiological case studies of COVID-19 to highlight the wide array of neurological manifestations associated with COVID-19.

关键词： Case series Coronavirus COVID-19 Infectious disease Neurological MRI

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Does sevoflurane sedation in pediatric patients lead to“pseudo”leptomeningeal enhancement in the brain on 3 Tesla magnetic resonance imaging?

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World Journal of Radiology 2023年第4期15卷 127-135页

作者： Kiran Hilal Kumail Khandwala Saima Rashid Faheemullah Khan shayan sirat maheen anwar Department of Radiology Aga Khan University HospitalKarachi 74800Pakistan Department of Anesthesiology Aga Khan University HospitalKarachi 74800Pakistan

BACKGROUND Prominent leptomeningeal contrast enhancement(LMCE)in the brain is observed in some pediatric patients during sedation for ***,based on clinical history and cerebrospinal fluid analysis,the patients are not acutely ill and do not exhibit meningeal *** study determined whether sevoflurane inhalation in pediatric patients led to this pattern of‘pseudo’LMCE(pLMCE)on 3 Tesla magnetic resonance imaging(MRI).AIM To highlight the significance of pLMCE in pediatric patients undergoing enhanced brain MRI under sedation to avoid misinterpretation in *** A retrospective cross-sectional evaluation of pediatric patients between 0-8 years of age was *** patients underwent enhanced brain MRI under inhaled *** LMCE grade was determined by two radiologists,and interobserver variability of the grade was calculated using Cohen’s *** LMCE grade was correlated with duration of sedation,age and weight using the Spearman rho rank *** A total of 63 patients were ***(22.2%)cases showed mild LMCE,48(76.1%)cases showed moderate LMCE,and 1 case(1.6%)showed severe *** found substantial agreement between the two radiologists in detection of pLMCE on post-contrast T1 imaging(kappa value=0.61;P<0.001).Additionally,we found statistically significant inverse and moderate correlations between patient weight and *** was no correlation between duration of sedation and *** pLMCE is relatively common on post-contrast spin echo T1-weighted MRI of pediatric patients sedated by sevoflurane due to their fragile and immature *** should not be misinterpreted for meningeal *** pertinent clinical history of the child is an essential prerequisite to avoid radiological overcalling and the subsequent burden of additional investigations.

关键词： Brain Pediatrics Gadolinium contrast Pseudo leptomeningeal enhancement 3 Tesla magnetic resonance imaging Sevoflurane

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