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Advanced non-alcoholic steatohepatitis cirrhosis: A high-risk population for pre-liver transplant portal vein thrombosis

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World Journal of Hepatology 2017年第3期9卷 139-146页

作者： Jonathan G Stine Curtis K Argo shawn J pelletier Daniel G Maluf Stephen H Caldwell patrick G Northup Division of Gastroenterology and Hepatology Department of Medicine Center for the Study of Coagulation Disorders in Liver Disease University of Virginia Division of Transplant Department of Surgery University of Virginia

AIMTo examine if liver transplant recipients with high-risk non-alcoholic steatohepatitis (NASH) are at increased risk for pre-transplant portal venous thrombosis. METHODSData on all liver transplants in the United States from February 2002 through September 2014 were analyzed. Recipients were sorted into three distinct groups: High-risk (age > 60, body mass index > 30 kg/mp>2p>, hypertension and diabetes), low-risk and non-NASH cirrhosis. Multivariable logistic regression models were constructed. RESULTSThirty-five thousand and seventy-two candidates underwent liver transplantation and of those organ recipients, 465 were transplanted for high-risk and 2775 for low-risk NASH. Two thousand six hundred and twenty-six (7.5%) recipients had pre-transplant portal vein thrombosis; 66 (14.2%) of the high-risk NASH group had portal vein thrombosis vs 328 (11.8%) of the low-risk NASH group. In general, all NASH recipients were less likely to be male or African American and more likely to be obese. In adjusted multivariable regression analyses, high-risk recipients had the greatest risk of pre-transplant portal vein thrombosis with OR = 2.11 (95%CI: 1.60-2.76, p CONCLUSIONLiver transplant candidates with high-risk NASH are at the greatest risk for portal vein thrombosis development prior to transplantation. These candidates may benefit from interventions to decrease their likelihood of clot formation and resultant downstream hepatic decompensating events. prospective study is needed.

关键词： Liver transplantation Non-alcoholic fatty liver disease portal hypertension Hepatology Coagulopathy

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Mashing up Geographic Information for Emergency Response—An Earthquake prototype

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Journal of Geographic Information System 2014年第5期6卷 533-547页

作者： shawn Dias Chaowei Yang Anthony Stefanidis Mathew Rice Department of Geography and GeoInformation Science George Mason University Fairfax VA USA

Important?information pertaining to emergencies and responses to?the?emergencies is often distributed across numerous Internet sites. In the event of a disaster like an earthquake, rapid access to such information is critical. At such moments the general public usually has a hard time navigating through numerous sites to retrieve and integrate information, and this may?severely affect our capability to make?critical decisions in a timely manner. Common earthquake mashups often lack relevant information like locations of first responders and routing to important facilities (e.g. hospitals and fire stations) which could save important time and lives. To address the challenges, we developed an Earthquake Information Mashup prototype. This prototype demonstrates a mashup approach to providing?a Web visualization of real-time earthquake monitoring and complementary information, such as traffic conditions, the location of important facilities and routing to them. It also offers users the ability to communicate local condition. Users are thus able to better integrate information from various near real-time sources, obtain better situational awareness, and make?smarter?informed?critical decisions.

关键词： CyberGIS Natural Hazards Social Media performance CloudGIS

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Improved Recovery of Erythropoietin and Darbepoetin from Equine plasma by the Application of a Wheat Germ Agglutinin Mediated pre-Extraction prior to Immunoaffinity Chromatography

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Advances in Bioscience and Biotechnology 2014年第7期5卷 651-660页

作者： shawn M. R. Stanley Danny Chua The Singapore Turf Club Laboratory 1 Turf Club Ave Singapore Singapore

We describe a two-step method that uses wheat germ agglutinin immobilized on Sepharose gel followed by immunoaffinity chromatography (IAC) to extract recombinant human erythropoietin and Darbepoetin from equine plasma. Lectin affinity chromatography was shown to be an effective approach for isolating these epoetins from plasma and in combination with IAC;this method gave superior recovery when compared to the use of the latter technique alone. Moreover, due to the ease with which it can be scaled up, it is particularly well suited for pre-concentrating larger volumes of samples prior to IAC and this provides a facile way of improving the overall sensitivity with which these foreign proteins can be detected in equine plasma.

关键词： Erythropoietin Darbepoetin Alfa Immunoaffinity Extraction Lectin Affinity Extraction Wheat Germ Agglutinin Horseracing

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Considering a Relationship Between Dysfunctional Coaching Styles in Youth Sports and the Development of Hazardous Attitudes in players

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psychology Research 2017年第8期7卷 445-452页

作者： Mark Cogburn Rita Horton shawn E. McNeil Louisiana State University Health Sciences Center Shreveport USA

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Emergency department management of an occult renal laceration following a minor fall

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Discussion of Clinical Cases 2021年第1期8卷 11-14页

作者： Kimberly A.Hubbard shawn M.Varney Department of pediatrics University of Arkansas for the Medical SciencesLittle RockARUSA Department of Emergency Medicine University of Texas Health-San AntonioSan AntonioTXUSA

We present a case of a pediatric patient with high grade renal injury following a minor fall,where clinical suspicion of occult injury resulted in ***,we review the management of high grade renal lacerations in childr... 详细信息

关键词： High grade renal laceration pediatric renal trauma Nonoperative management Ultrasound imaging in renal trauma

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*** 2.0经典案例教程 1版

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2007年

作者：（美）IMAR SpAANJAARS pAUL WILTON shawn LIVERMORE

1817041103010901

ISBN: (数字)9787115158925

ISBN: (纸本)7115158924

1817041103010901

关键词：教材主页制作程序设计

来源：畅想之星图书光盘版（南... 评论

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基于有限元软件的子结构拟动力试验技术

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沈阳建筑大学学报（自然科学版） 2010年第6期26卷 1085-1089页

作者：王强冯帆 shawn You 刘明沈阳建筑大学土木工程学院辽宁沈阳110168 MTS System Corporation USAMN55344-2290

目的研究有限元软件与电液伺服加载系统联机的子结构拟动力试验技术.方法运用OpenFresco试验协调系统,实现通用有限元软件OpenSees与电液伺服加载系统MTS Flextest GT的数据传递,并开展单层单跨钢结构框架在地震作用下的反应分析.结果MT... 详细信息

目的研究有限元软件与电液伺服加载系统联机的子结构拟动力试验技术.方法运用OpenFresco试验协调系统,实现通用有限元软件OpenSees与电液伺服加载系统MTS Flextest GT的数据传递,并开展单层单跨钢结构框架在地震作用下的反应分析.结果MTS Flextest GT可以有效地接收并响应OpenSees发出的位移命令,作动器的目标位移与反馈位移基本一致,MTS Flextest GT与OpenSees的通信稳定可靠.子结构拟动力试验结果与OpenSees模拟结果吻合较好,该试验方法完全能够满足试验精度的要求.结论采用OpenFresco协调试验系统能够实现结构构件层次上的子结构拟动力试验,极大地扩展了拟动力试验的功能.

关键词：拟动力试验子结构技术有限元电液伺服加载系统 OpenFresco

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On the cratonization of the Arabian-Nubian Shield: Constraints from gneissic granitoids in south Eastern Desert, Egypt

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Geoscience Frontiers 2021年第4期12卷 215-243页

作者： Ali A.Khudeir Jean-Louis paquette Kirsten Nicholson Åke Johansson Tyrone O.Rooney Sadiq Hamid Mohamed A.El-Fadly Loretta Corcoran shawn J.Malone Mohamed Ali Abu El-Rus Geology Department Faculty of ScienceAssiut University71516Egypt UniversitéClermont Auvergne CNRSIRDOPGCLaboratoire Magmas et VolcansF-63000 Clermont-FerrandFrance Ball-State University Department of EnvironmentGeology and Natural Resources117 Fine Art BuildingMuncieIN 47306USA Department of Geosciences Swedish Museum of Natural HistoryBox 50007SE-10405 StockholmSweden Department of Earth and Environmental Sciences Michigan-State UniversityEast LansingMI 48824USA Notre Dame University Department of Civil and Environmental Engineering and Earth Sciences156 Fitzpatrick HallNotre DameIN 46556USA

The Shaitian granite complex(SGC)spans more than 80 Ma of crustal growth in the Arabian–Nubian Shield in southeast *** is a voluminous composite intrusion(60 km2)comprising a host tonalite massif intruded by subordinate dyke-like masses of trondhjemite,granodiorite and *** host tonalite,in turn,encloses several,fine-grained amphibolite enclaves.U-pb zircon dating indicates a wide range of crystallization ages within the SGC(800±18Ma for tonalites;754±3.9 Ma for trondhjemite;738±3.8 Ma for granodiorite;and 717±3.2 Ma for monzogranite),suggesting crystallization of independent magma *** high positiveεNdi(+6–+8)indicate that the melting sources were dominated by juvenile material without any significant input from older *** of zircon saturation geothermometry indicates increasing temperatures during the generation of melts from 745±31℃ for tonalite to 810±25℃ for trondhjemite;840±10℃ for granodiorite;and 868±10℃ for *** pressure of partial melting is loosely constrained to be below the stability of residual garnet(pattern((Gd/Lu)N=0.9–1.1),but>3 kbar for the stability of residual amphibole as inferred from the significantly lower NbN and TaN compared with LREEN and the sub-chondrite Nb/Ta ratios exhibited by the granitic *** inverse relation between the generation temperatures and the ages estimates of the granitoid lithologies argue against a significant role of fractional *** major and trace element contents indicate the emplacement of the SGC within a subduction zone *** lacks distinctive features for melt derived from a subducted slab(*** Sr/Y and high(La/Yb)N ratios),and the relatively low MgO and Ni contents in all granite phases within the SGC suggest melting within the lower crust of an island arc overlying a *** melts produced during melting experiments indicates an amphibolite of basaltic composition is th

关键词： Arabian-Nubian Shield(ANS) Cratonization Fractional crystallization partial melting Subduction zones Tonalite-Trondhjemite-granodiorite(TTG)

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Toxicity of abdominal fat

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Health 2013年第8期5卷 96-99页

作者： shawn Mathew Constantine EKosmas Robert RSiegel Timothy JVittorio New York Institute of Technology Old WestburyNew YorkUSA Zena and Michael A.Wiener Cardiovascular Institute Mount Sinai School of MedicineNew YorkUSA Division of Cardiology Albert Einstein College of MedicineBronx Municipal Hospital CenterBronxUSA St.Francis Hospital—The Heart Center^(■) Division of CardiologyCenter for Advanced Cardiac TherapeuticsRoslynUSA

Abdominal fat or truncal obesity consists of both subcutaneous and visceral fat. It has been found that visceral fat is more metabolically active than subcutaneous fat. The low-level inflammation linked with abdominal fat is associated with insulin resistance and with increases in the release of inflammatory adipokines and cytokines. As a result of these changes, abdominal fat can cause a variety of health conditions. In this review, we focus on the adverse effects of abdominal fat on the body and how it can lead to the development of cardiovascular disease, hypertension, type 2 diabetes mellitus, hyperlipidemia, stroke and cancer. Additionally, we discuss how abdominal fat can be reduced as a result from correction of hormonal deficiencies.

关键词： Adipokines Cytokines Fat Hormonal Inflammation Obesity

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爱上Raspberry pi

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作者： (美)Matt Richardson (美)shawn Wallace

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