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Comparison of trigeminal lateralization with differing stimulants

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World journal of Otorhinolaryngology-Head and Neck Surgery 2024年第1期10卷 66-69页

作者： Tiffany Chen Nicolas S.Poupore Michael C.Shih Thomas S.Edwards shaun A.Nguyen Zachary M.Soler Rodney j.Schlosser Department of Otolaryngology‐Head and Neck Surgery Medical University of South CarolinaCharlestonSouth CarolinaUSA

Trigeminal-specific stimulants have been shown to activate different receptors preferentially and this likely accounts for variation in sensory *** is unclear whether trigeminal sensitivity is similar across different transient receptor potential(TRP)receptors or if dysfunction of different receptors results in differing patient ***,a prospective cohort study was conducted,consisting of trigeminal lateralization testing with three different stimulants(eucalyptol,isothiocyanate,acetic acid),olfaction testing with Sniffin'Sticks,and measurement of various patient‐reported outcome measures(PROMs).A total of 50 participants were enrolled across the olfactory *** TDI score was 27.1±8.3(range 7.0–39.5)with 38%normosmic and 62%*** trigeminal lateralization scores out of 20 in the overall cohort were 16.18(2.78)for eucalyptol,14.94(3.49)for mustard oil,and 15.28(3.68)for *** showed a significant correlation with threshold scores of Sniffin'Sticks.A significant correlation was found between acetic acid and various *** of the lateralization scores of the trigeminal stimulants correlated to each other significantly and there was no correlation to *** lack of correlation suggests that the measured sensitivity of one type of TRP receptor may not translate to similar sensitivity of the other *** investigations with TRPV1 and TRPA1 agonists are needed to corroborate our findings.

关键词： chemosensory olfaction trigeminal TRP receptor

To forage or hide？ Threat-sensitive foraging behaviour in wild, non-reproductive passerine birds

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Current Zoology 2014年第6期60卷 719-728页

作者： shaun TURNEY jean-Guy j. GODIN Department of Biology Carleton University Ottawa ON K1 S 5B6 Canada Department of Biology McGill University Montreal QC H3A 1B 1 Canada

Because antipredator behaviours are costly, the threat-sensitive predator avoidance hypothesis predicts that individual animals should express predator-avoidance behaviour proportionally to the perceived threat posed by the predator. Here, we experimentally tested this hypothesis by providing wild passerine birds supplemental food （on a raised feeding platform） at either 1 or 4 m from the edge of forest cover （potential refuge）, in either the presence or absence of a nearby simulated predation threat （a sharp-shinned hawk Accipiter striatus model）. Compared with the control treatment, we observed proportionally fewer bird visits to the food patch, and the birds took longer to re-emerge from forest refuge and return to feed at the food patch, after the hawk presentation than before it. The observed threat-sensitive latency-to-return response was stronger when the food patch was further away from the nearest refuge. Overall, our results are consistent with the predictions of the threat-sensitive predator avoidance hypothesis in that wild passerine birds （primarily black-capped chickadees Poecile atricapillus） exhibited more intense antipre- dator behavioural responses with increasing level of apparent threat. The birds were thus sensitive to their local perceived threat of predation and traded-off safety from predation （by refuging） and foraging gains in open habitat in a graded, threat-sensitive manner [Current Zoology 60 （6）： 719-728, 2014].

关键词： Foraging Predation risk Threat sensitivity Risk taking Distance-to-refuge Birds

A rare case of failed healing in previously burned skin after a secondary burns

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Burns & Trauma 2017年第4期5卷 268-271页

作者： Stephen j. Goldie shaun Parsons Hana Menezes Andrew Ives Heather Cleland Victorian Adult Burns Service Alfred Hospital Melbourne Australia Department of Surgery Monash University Melbourne Australia Victorian Adult Burns Service Alfred Hospital Melbourne Australia

Background:Patients presenting with large surface area burns are common in our practice;however, patients with a secondary large burn on pre-existing burn scars and grafts are rare and not reported. Case presentation:We report on an unusual case of a patient sustaining a secondary large burn to areas previously injured by a burn from a different mechanism. We discuss the potential implications when managing a case like this and suggest potential biological reasons why the skin may behave differently. Our patient was a 33-year-old man who presented with a 5%TBSA burn on skin scarred by a previous 40%total body surface area (TBSA) burn and skin grafts. Initially assessed as superficial partial thickness in depth, the wounds were treated conservatively with dressings;however, they failed to heal and became infected requiring surgical management. Conclusions:Burns sustained in areas of previous burn scars and grafts may behave differently to normal patterns of healing, requiring more aggressive management and surgical intervention at an early stage.

关键词： Previous burns Burn scar Non-healing

Socioeconomic status and anterior epistaxis in adult population

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World journal of Otorhinolaryngology-Head and Neck Surgery 2018年第4期4卷 263-267页

作者： Pourya Masoudian j.Ted McDonald Andrea Lasso shaun j.Kilty Faculty of Medicine University of OttawaOttawaONCanada Department of Economics University of New BrunswickFrederictonNBCanada The Ottawa Hospital Research Institute(OHRI) OttawaONCanada Department of Otolaryngology-Head and Neck Surgery The University of OttawaOttawaONCanada

Objective:Little was known about the role of socioeconomic status as a risk factor for epistaxis in adult *** objective of this study was to determine whether socioeconomic status influences the presentation to emergency department for anterior epistaxis in an adult ***:Retrospective review of emergency department visits from january 2012 to May *** setting is in an emergency department of a Canadian tertiary care *** patients with primary diagnosis of anterior epistaxis in the emergency department were included in this *** main outcome was emergency department visits for anterior epistaxis ***:A total of 351 cases of anterior epistaxis were *** mean age was 70 years and 51%of patients were *** patients were stratified into two groups based on whether their age was equal to and above,or below 75 *** analysis indicated that those 75 years or older in higher income quintiles have an increased risk of anterior epistaxis compared to the subjects in the lower income quintiles(P<0.05).This association did not hold true for those younger than 75 years or for all age groups ***:There is an association between higher socioeconomic status and the presentation to the emergency department with anterior epistaxis in the population older than 75 years but not in younger patients.

关键词： Epistaxis Anterior Socioeconomicstatus Income Social determinants of health

Femoroacetabular impingement with chronic acetabular rim fracture- 3D computed tomography, 3D magnetic resonance imaging and arthroscopic correlation

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World journal of Orthopedics 2015年第6期6卷 498-504页

作者： Avneesh Chhabra shaun Nordeck Vibhor Wadhwa Sai Madhavapeddi William j Robertson Department of Radiology University of Texas Southwestern Medical Center Department of Orthopaedics University of Texas Southwestern Medical Center

Femoroacetabular impingement is uncommonly associated with a large rim fragment of bone along the superolateral acetabulum. We report an unusual case of femoroacetabular impingement(FAI) with chronic acetabular rim fracture. Radiographic, 3D computed tomography, 3D magnetic resonance imaging and arthroscopy correlation is presented with discussion of relative advantages and disadvantages of various modalities in the context of FAI.

关键词： 3D computed tomography 3D magnetic resonance imaging Femoroacetabular impingement Rim fracture

Identification of microbial contaminants in sinus rinse squeeze bottles used by allergic rhinitis patients

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World journal of Otorhinolaryngology-Head and Neck Surgery 2019年第1期5卷 26-29页

作者： shaun A.Nguyen Marc P.Camilon Rodney j.Schlosser Medical University of South Carolina Department of OtolaryngologyHead&Neck SurgeryCharlestonSCUSA Medical University of South Carolina Department of OtolaryngologyHead&Neck SurgeryCharlestonSCUSARalph H.Johnson VA Medical CenterCharlestonSCUSA

Objective:To identify whether irrigation devices become contaminated when used by patients with allergic rhinitis (AR).Methods:Ten AR patients with no clinical or endoscopic evidence of active sinonasal infection were given a sinus rinse system and instructed on its proper use,cleaning,and *** squeeze bottles (bottle A and bottle B) were given to each patient for twice-a-day *** A was used in the morning and analyzed after four *** B was used in the evening and analyzed after 8 weeks of *** contaminants were cultured from the nose pieces and the inner surface of the bottles obtained from ***:Seventeen sinus rinse devices (17/20) from all individuals in this study grew bacteria commonly in the ***-four bacterial isolates consisting of 14 different species were cultured and identified with most common organisms being bacilli and *** addition,no correlation was apparent between the length of bottle use and the degree of contamination (r =0.13,p =0.76).During the study period,no patient developed acute sinus ***:Microbial contamination of the sinus rinse system occurs commonly,even in uninfected AR patients;however no evidence exists linking this to clinically relevant sinus infections.

关键词： Allergic rhinitis Microbial contaminants Sinus irrigation Sinus rinse Squeeze bottles

Mind the “Gap”: A Comparison of the Weekly Training Loads of English Premier League Academy Soccer Players in Under 23, Under 18 and Under 16 Age-Groups

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journal of Science in Sport and Exercise 2023年第1期5卷 34-43页

作者： jonathan M.Taylor jonathan L.Madden Frances Hunter Ben j.Thorne shaun j.McLaren School of Health and Life Sciences Teesside UniversityMiddlesbroughUK Leeds United Football Club LeedsUK Middlesbrough Football Club MiddlesbroughUK Hintsa Performance LondonUK Department of Sport and Exercise Sciences Durham UniversityDurhamUK

Purpose The transition into full-time training represents a key period in the development of young soccer *** we compared the weekly training loads(matches,field-,and resistance-training)of English Premier-League Academy soccer players from under-16(U16),under-18(U18)and under-23(U23)age-groups during a training *** Forty players(U16 n=13,U18 n=15 and U23 n=12)were monitored using global navigation satellite systems and differential ratings of perceived exertion(dRPE).External load metrics were total distance,high-speed running distance,[absolute:≥19.8 km/h,relative:≥87%of 30-15 final-velocity(vIFT)],sprint distance(absolute:≥25.2 km/h,relative:≥80%maximal sprint speed),and dynamic stress *** load metrics were dRPE training *** Other than relative sprint distance,overall weekly external training loads were substantially greater for U18s and U23s when compared with U16s[effect size range:1.09-1.99(moderate to large);±90%confidence limits~0.45].When compared with U16s,overall internal loads were substantially greater for U18s[0.69-0.95(moderate);±~0.40],but not *** in weekly training loads between U18s and U23s were *** Substantial differences in training loads between elite U16 players and their older counterparts,indicates the need for planned increases in training loads in anticipation of the transition into full-time training.

关键词： Team-sports RPE LTAD Individualised training Training load

Is the incidence of anaplastic thyroid cancer increasing: A population based epidemiology study

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World journal of Otorhinolaryngology-Head and Neck Surgery 2019年第1期5卷 34-40页

作者： Tyler A.janz David M.Neskey shaun A.Nguyen Eric j.Lentsch Medical University of South Carolina 135 Rutledge Ave.CharlestonSC.29425USA

Objective:To provide an understanding of the incidence of anaplastic thyroid cancer within the United ***:Patients in the Surveillance,Epidemiology,and End Results (SEER) database were included from 1973 to 2014 based on a diagnosis of anaplastic thyroid cancer using ICDO-3 *** were categorized into cohorts based on their year of ***:1527 patients were diagnosed with anaplastic thyroid cancer within the SEER 18 *** age-adjusted incidence rate was 0.2 per 1,000,000 people (95% CI:0.0-0.5) in 1973 and was 1.2 per 1,000,000 people (95% Cl:0.8-1.6) in 2014 (average annual percent change:3.0% [95% CI:2.2%-3.7%]).Patients tended to be of older age (mean age:70.5 [range 15.0-102.0]),of female sex (62.8%),and Caucasian (81.1%).Finally,survival over time remained the same,as median disease specific survival months was 4.00 (95% CI:2.26-5.74) from 1995 to 1999 and 4.00 (95% Cl:3.26-4.74) from 2010 to ***:The incidence rate of anaplastic thyroid cancer has increased from 1973 to ***,median survival in months did not greatly change *** on this increasing incidence,physicians must act appropriately to identify patients with anaplastic thyroid cancer as it possesses a high morbidity and mortality.

关键词： Anaplastic thyroid cancer Thyroid cancer Head and neck Head and neck endocrine surgery Head and neck oncology

Predictors of occult lymph node metastasis in cutaneous head and neck melanoma

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World journal of Otorhinolaryngology-Head and Neck Surgery 2019年第4期5卷 200-206页

作者： jonathan S.Ni Tyler A.janz shaun A.Nguyen Eric j.Lentsch Department of Otolaryngology-Head and Neck Surgery Medical University of South CarolinaCharleston SC USA

Objective:To use the Surveillance,Epidemiology,and End Results(SEER)database to verify the findings of a recent National Cancer Database(NCDB)study that identified factors predicting occult nodal involvement in cutaneous head and neck melanoma(CHNM)while identifying additional predictors of occult nodal metastasis and comparing two distinct cancer ***:Cases of CHNM in the SEER database diagnosed between 2004 and 2014 were *** information and oncologic data were *** and multivariate analysis were performed to identify factors associated with pathologic nodal ***:There were 34002 patients with CHNM *** this population,16232 were clinically node-negative,1090 of which were found to be pathologically *** multivariate analysis,factors associated with an increased risk of occult nodal metastasis included increasing depth of invasion(stepwise increase in adjusted odds ratio[OR]),nodular histology(aOR:1.47[95%CI:1.21-1.80]),ulceration(aOR:1.74[95%CI:1.48-2.05]),and mitoses(aOR:1.86[95%CI:1.36-2.54]).Factors associated with a decreased risk of occult nodal metastasis included female sex(aOR:0.80[0.67-0.94])and desmoplastic histology(aOR:0.37[95%CI:0.24-0.59]).Between the SEER database and the NCDB,factors associated with occult nodal involvement were similar except for nodular histology and female sex,which did not demonstrate significance in the ***:Regarding clinically node-negative CHNM,the SEER database and the NCDB have similarities in demographic information but differences in baseline population sizes and tumor characteristics that should be considered when comparing findings between the two databases.

关键词： Head and neck melanoma Lymph node metastasis Occult nodal metastasis Sentinel lymph node biopsy