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Clinical profile of brucellosis from a tertiary care center in southern India

Asian Pacific Journal of Tropical Medicine 2011年第5期4卷 397-400页

作者： Vishwanath Sathyanarayanan Abdul Razak Kavitha Saravu shastry barkur ananthakrishna Mukhyprana Prabhu M Vandana KE Department of Internal Medicine Kasturba Medical CollegeManipal UniversityKarnatakaIndia Department of Microbiology Kasturba Medical CollegeManipal UniversityKarnatakaIndia

Objective:To highlight the spectrum of clinical manifestations,labs,complications,treatment and outcome of ***:Retrospective study was conducted in Kasturba Medical College,Manipal University,Karnataka,India which included 68 confirmed cases of brucellosis from January 2006- April *** of brucellosis was made by culturing the sera/body fluids by standard BACTEC method(or) by testing the sera for Brucella agglutinins using the standard agglutination test(SAT).A titer of 1:320 or more was considered as *** 16 was used for statistical analysis and Microsoft Excel for graphical ***:Of the 68 patients,46(68%) were male and 22(32%) were female patients with age distribution of 9-75 *** four(64.7%) had history of contact with unpasteurized dairy products or infected *** included fever(68,100%),myalgia(21,31%),musculoskeletal symptoms (23,34%),headache(16,24%),gastrointestinal symptoms(19,28%) and altered sensorium(3, 4%).Co-morbidities and associations included HIV positivity(2,3%),type 2 diabetes mellitus (13,19%),steroid therapy(3,4%) and HBsAg positivity(8,12%).Ten(15%) patients had cervical lymphadenopathy,4(6%) had splenic enlargement,6(7%) had hepatomegaly,19(28%) had hepatosplenomegaly and 2(3%) got meningeal *** was observed in 39(57.3%) cases,high erythrocyte sedimentation rate(ESR) was present in 55(80.8%) cases,leucocytosis in 10(14.7%),leucopenia in 10(14.7%),thrombocytopenia in 23(33.82%) and thrombocytosis in 2(2.94%) ***:In countries like India,where brucellosis and tuberculosis are endemic;rapid,sensitive and highly specific diagnostic methods are required to make early diagnosis and prevent resistance as there is an overlap in therapy.

关键词： Brucella South India BACTEC Standard agglutination test

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Colonization or spontaneous resolution:Expanding the role for Burkholderia pseudomallei

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Asian Pacific Journal of Tropical Medicine 2014年第3期7卷 250-252页

作者： Kushal Naha barkur ananthakrishna shastry Kavitha Saravu Department of Medicine Kasturba Hospital

A 19-year-old Asian Indian female presented with productive cough since the past one month and low grade fever since the pasl two *** was diagnosed with pulmonary tuberculosis and treated with anlilubercular ***,delayed cultures of bronclioalveolar lavage fluid grew Burkholderia pseudomallei(***).On follow up the patient reported significant subjective improvement and ESR progressively returned to *** summary',this case report raises two distinct and equally intriguing roles for ***,*** colonization and spontaneously resolving pulmonary *** pathogenic potential of ***,the eliologic agent of melioidosis,is well *** of eilher colonization or spontaneous resolution,would potentially spare many patients unnecessary and oxpensivo therapy with broad-spectruin antibiotics,and contribute to more rational usage of antibiotics,especially in co-infecliou with Mycobacterium tuberculosis and ***-two bacterial diseases with closely similar clinical,radiologic and histopathologic features.

关键词： Burkholderia pseudomallei Tuberculosis Colonizer Coinfection Spontaneous resolution Melioidosis

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Genetic risk factors and retinal ganglion cell degeneration in primary open-angle glaucoma (POAG): A bird’s eye view

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Advances in Bioscience and Biotechnology 2013年第5期4卷 623-627页

作者： barkur S. shastry Department of Biological Sciences Oakland University Rochester USA

Glaucoma is an optic neuropathy and often associated with elevated intraocular pressure (IOP). It is the second leading cause of irreversible blindness worldwide and is characterized by the optic nerve degeneration and loss of retinal ganglion cells (RGCs). This may lead to loss of vision. The primary cause of glaucoma is unknown but several risk factors including elevated IOP and age have been suggested. In most population, primary open-angle glaucoma (POAG) is the most common type of glaucoma and is often associated with elevated IOP. Genetic analyses have identified at least 14 chromosomal loci but only three genes which when mutated can cause POAG have been well documented. These genes account for less than 5% of all POAG cases suggesting that more than 90% of the genetic contribution of POAG cases is unknown. RGC consists of cell body, axon and dendritic arbor and each of these three parts can independently degenerate. Several molecular signals such as oxidative stress, mitochondrial dysfunction, disruption of neurotrophic factor (NTF), dysfunction of immune system, glial activation and the release of tumor necrosis factor (TNF) have been found to be involved in the optic nerve degeneration. Therefore, therapies aimed at axonal and cell body protection may have a greater protective role in early or progressive glaucoma. In the future, an understanding of gene-gene and gene-environmental factor interaction as well as epigenetic regulation of gene expression by environmental factors may provide an opportunity to develop neuroprotective therapies and DNA based diagnostic tests.

关键词： Degeneration Gene Mutation Retina

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