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左心室室壁瘤的外科治疗

中国胸心血管外科临床杂志 2004年第4期11卷 290-291页

作者：王玺胜何学志 Devi shetty 大连市中心医院心胸血管外科大连116033 Manipal Hospital India

目的　探讨左心室室壁瘤 (left ventricular aneurysm,L VA)的外科治疗效果。　方法　 33例 L VA患者行闭式折叠术 1例 ,L VA切除后行标准线性修补术 14例 ,心内膜荷包环缩法 10例 ,心内室壁瘤缝合法 8例。其中 2 0例在心脏不停跳下完... 详细信息

目的　探讨左心室室壁瘤 (left ventricular aneurysm,L VA)的外科治疗效果。　方法　 33例 L VA患者行闭式折叠术 1例 ,L VA切除后行标准线性修补术 14例 ,心内膜荷包环缩法 10例 ,心内室壁瘤缝合法 8例。其中 2 0例在心脏不停跳下完成手术。所有患者均同期行冠状动脉旁路移植术 (CABG) ,每例移植血管 3.2± 1.1支。应用主动脉内球囊反搏 (IABP) 6例。　结果　 32例手术成功 ,手术死亡 1例 ;术后发生并发症 9例 ,其中低心排血量 6例、室性心律失常 2例、脑并发症 1例。术后早期随访 1～ 3个月 ,超声心动图示患者心功能均获改善 ,心绞痛缓解或消失。结论　L VA的外科治疗中 ,应用左心室几何重建技术和心脏不停跳及同期行 CABG能获得较好的临床治疗效果。

关键词：室壁瘤左心室患者并发症外科治疗 CABG 血量几何结论图示

Stress Degradation Behavior of a Polypill and Development of Stability Indicating UHPLC Method for the Simultaneous Estimation of Aspirin, Atorvastatin, Ramipril and Metoprolol Succinate

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American Journal of Analytical Chemistry 2011年第4期2卷 401-410页

作者： Satheesh Kumar shetty K.V Surendranath P Radhakrishnanand Roshan M Borkar Prashant S Devrukhakar Johnson Jogul Upendra Mani Tripathi United States Pharmacopeia-India Private Limited Research and Development Laboratory ICICI Knowledge Park Turkapally Shameerpet Hyderabad India

A novel, sensitive and precise UHPLC method has been developed and validated for the simultaneous determination of the all the active components of a Polypill viz Zycad, i.e., Aspirin (ASP) Atorvastatin (ATV), Ramipril (RMP) and Metoprolol (MTP) in Zycad tablet dosage form in the presence of degradation products. Forced degradation of individual as well as combination of all the drug substances components of Polypill was conducted in accordance with ICH guidelines. Acidic, basic, neutral, and oxidative hydrolysis, thermal stress, and photolytic degradation were used to assess the stability-indicating power of the method. Use of 100 × 2.1 mm, 1.7 μm stationary phases with simple mobile phase combination buffer consisting of 0.1% Perchloric acid (adjusted to pH 2.5) and Acetonitrile, delivered in a gradient mode and quantitation was carried out using ultraviolet detection at 215 nm with a flow rate of 0.6 mL?min–1. The method was optimized using samples generated by forced degradation studies. The method was validated for linearity, accuracy (recovery), precision, Specificity and robustness. The method was linear in the range of 37.5 to 150.0 μg?mL–1 for ASP, 5.0 to 20.0 μg?mL–1 for ATV and 2.5 to 10.0 μg?mL–1 for RMP and 25.0 to 100.0 μg?mL–1 for MTP.

关键词： Liquid Chromatography UHPLC Polypill Aspirin Atorvastatin Ramipril And Metoprolol Succinate Forced Degradation Validation Stability Indicating

Regaining birth weight and predicting ROP-a prospective, pilot study

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Annals of Eye Science 2017年第1期2卷 260-264页

作者： Anand Vinekar Shwetha Mangalesh Madhurya Mallavarapu Chaitra Jayadev Praveen Sharma Bhujang shetty Department of Pediatric Retina Narayana Nethralaya Eye InstituteBangaloreIndia

Background:Poor postnatal weight gain is a well-known risk factor for developing retinopathy of prematurity(ROP).Algorithms that predict ROP based on serial weight gain have not been generalizable in non-Caucasian *** duration taken to regain the lost weight is culturally important among Indian *** report the correlation between this duration and the risk of developing ***:Sixty-eight Asian Indian infants born<2,000 grams at birth or<34 weeks of gestation were *** number of days taken for these infants to regain baseline birth weight(BW)was *** measure was correlated with the eventual ROP outcome categorized as“no ROP”,ROP that regressed spontaneously(type 2 ROP),and ROP that required treatment(type 1).Results:The mean BW of the cohort was 1,270±340 grams and mean gestational age(GA)was 31±2 ***-three infants(48.5%)developed no ROP,20 infants(29.4%)developed type 2 ROP and 15 infants(22.1%)developed type 1 *** mean number of days to regain the lost weight was 11.9+4.6,17.9+7.9 and 26.6+12.9 days for the No ROP,type 2 and type 1 groups respectively(P<0.0001,one-way ANOVA with Boneferroni correction).Those babies who regained their BW within 10 days were at least risk of developing any stage ROP,moderate risk if they took between 11-20 days and highest risk if they took more than 21 days for developing type 2 or type 1 ***:The date when a child regains its lost BW is culturally important and easily recalled by *** report the use of this simple estimate as a predictor of *** method could be useful in stratifying risk and predicting the development of“treatment requiring ROP”even before 21 days of life,which is the first mandated screening visit in India.

关键词： Retinopathy of prematurity(ROP) birth weight(BW)

Epidermoid and dermoid cysts of the head and neck region

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Plastic and Aesthetic Research 2016年第1期3卷 347-350页

作者： Samrat S.Sabhalok Lakshmi S.shetty Pallavi H.Sarve Sneha V.Setiya Swati R.Bharadwaj Department of Oral and Maxillofacial Surgery D.Y.Patil Dental College and HospitalPimpri Pune 411018MaharashtraIndia

Epidermoid cysts,dermoid cysts and teratoid cysts are cystic malformations lined with squamous *** present as soft nodular lesions with a sessile *** prevalence is 7%in head and neck patients and 1.6%within the oral *** authors present a case series of 21 patients with dermoid and epidermoid cysts who underwent surgical *** year of follow-up was carried out without evidence of *** removal of these cysts is of great concern as it can cause serious social stigma,aesthetic and functional impairment,dysphagia and dysphonia.

关键词： Epidermoid cyst dermoid cyst cystic malformations

Clinical and scientific innovations in auditory brainstem implants

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2021年第2期7卷 109-115页

作者： Kunal R.shetty Sarah E.Ridge Vivek Kanumuri Angela Zhu M.Christian Brown Daniel J.Lee Department of Otorhinolaryngology Head and Neck Surgery McGovern Medical School at the University of Texas Health Science Center at HoustonHoustonTXUSA Eaton-Peabody Laboratories Massachusetts Eye and Ear InfirmaryHarvard Medical SchoolBostonMAf USA

The auditory brainstem implant(ABI)was originally developed to provide rehabilitation of retrocochlear deafness caused by neurofibromatosis type 2(NF2).Recent studies of the ABI have investigated outcomes in non-NF2 cohorts,such as patients with cochlear nerve aplasia or cochlear ossification and more recently,intractable *** technologies that improve the ABI-neural tissue interface are being explored as means to improve performance and decrease side *** discoveries in optogenetics and bioengineering present opportunities to continually evolve this technology into the future,enhancing spatial selectivity of neuronal activation in the cochlear nucleus and preventing side effects through reduction in activation of non-target neuronal *** advances will improve surgical planning and ultimately improve patients1 audiological *** research has rapidly increased in the 21st century and applications of this technology are likely to continually ***,we aim to characterize ongoing clinical,basic science,and bioengineering advances in ABIs and discuss future directions of this technology.

关键词： Auditory brainstem implant Cochlear nucleus Neurofibromatosis type 2 Optogenetics ABI Conformable electrode array Otology Neurotology

Spectrally Efficient Multi-Carrier Modulation Using Gabor Transform

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Wireless Engineering and Technology 2013年第2期4卷 112-116页

作者： Shravan Sriram Naveenkumar Vijayakumar P. Aditya Kumar Akash S. shetty V. P. Prasshanth K. A. Narayanankutty Department of Electronics and Communication Engineering Amrita School of Engineering Amrita Vishwa Vidyapeetham University Coimbatore India

Non Orthogonal Frequency Division Multiplexing (NOFDM) systems make use of a transmission signal set which is not restricted to orthonormal bases unlike previous OFDM systems. The usage of non-orthogonal bases generally results in a trade-off between Bit Error Rate (BER) and receiver complexity. This paper studies the use of Gabor based on designing a Spectrally Efficient Multi-Carrier Modulation Scheme. Using Gabor Transform with a specific Gaussian envelope;we derive the expected BER-SNR performance. The spectral usage of such a NOFDM system when affected by a channel that imparts Additive White Gaussian Noise (AWGN) is estimated. We compare the obtained results with an OFDM system and observe that with comparable BER performance, this system gives a better spectral usage. The effect of window length on spectral usage is also analyzed.

关键词： Non-Orthogonal Frequency Division Multiplexing (NOFDM) Spectrally Efficient Frequency Division Multiplexing (SEFDM) Gabor Transform OFDM Reisz Bases Multi Carrier Modulation (MCM)

Quantitative Application to a Polypill by the Development of Stability Indicating LC Method for the Simultaneous Estimation of Aspirin, Atorvastatin, Atenolol and Losartan Potassium

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American Journal of Analytical Chemistry 2010年第2期1卷 59-69页

作者： Satheesh K. shetty Koduru V. Surendranath Pullapanthula Radhakrishnanand Roshan M. Borkar Prashant S. Devrukhakar Johnson Jogul Upendra M. Tripathi United States Pharmacopeia-India Private Limited Research and Development Laboratory Department of Chemistry Jawaharlal Nehru Technological University

Polypill is a fixed-dose combination (FDC) containing three or more drugs in a single pill with the intention of reducing the number of tablets or capsules that need to be taken. Developing a single analytical method for the estimation of individual drugs in a Polypill is very challenging, due to the formation of drug-drug and drug-excipients interaction impurities. Here an attempt was made to develop a new, sensitive, single stability-indicating HPLC method for the simultaneous quantitative determination of Aspirin (ASP) Atorvastatin (ATV), Atenolol (ATL) and Losartan potassium (LST) in a polypill form in the presence of degradation products. Efficient chromatographic separation was achieved on a C18 stationary phase with simple mobile phase combination of buffer and Acetonitrile. Buffer consists of 0.1% Orthophosphoric acid (pH 2.9), delivered in a gradient mode and quantitation was carried out using ultraviolet detection at 230 nm with a flow rate of 1.0 mL/min. The retention times of Atenolol, Aspirin, Losartan potassium, and Atorvastatin were 3.3, 7.6, 10.7 and 12.9 min respectively. The combination drug product are exposed to thermal, acid/base hydrolytic, humidity and oxidative stress conditions, and the stressed samples were analyzed by proposed method. The method was validated with respect to linearity;the method was linear in the range of 37.5 to 150.0 μg/mL for ASP, 5.0 to 20.0 μg/mL for ATV and 25.0 to 100.0 μg/mL for ATL and LST. Acceptable precision and accuracy were obtained for concentrations over the standard curve ranges. The validated method was successfully applied to the analysis of Starpill tablets constituting all the four drugs;the percentage recoveries obtained were 99.60% for ASP, 99.30% for ATV, 99.41% for ATL and 99.62% for LST.

关键词： Liquid Chromatography Polypill Aspirin Atorvastatin Atenolol and Losartan Potassium Forced Degradation Validation Stability Indicating

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电视辅助胸腔镜钳闭治疗动脉导管未闭

中华外科杂志 2001年第6期39卷 446-448页

作者：谢斌张镜芳庄健 Devi shetty 广东省人民医院心外科广州510010 印度班加罗尔Manipal心脏基地

目的　总结电视辅助胸腔镜钳闭未闭动脉导管的经验。　方法　用电视辅助胸腔镜技术对 130例动脉导管未闭患儿进行了手术。在全麻和单侧肺通气的情况下 ,在左侧第 3肋间脊柱肩胛骨旁做 2cm的切口 ,用以导入器械。在左侧第 4肋间腋中线做... 详细信息

目的　总结电视辅助胸腔镜钳闭未闭动脉导管的经验。　方法　用电视辅助胸腔镜技术对 130例动脉导管未闭患儿进行了手术。在全麻和单侧肺通气的情况下 ,在左侧第 3肋间脊柱肩胛骨旁做 2cm的切口 ,用以导入器械。在左侧第 4肋间腋中线做相似的切口以导入镜头。在左侧第3肋间胸骨旁 2cm和左侧第 4肋间胸骨旁 1cm各做 1孔 ,用以放入长而钝的神经钩暴露术野。通过器械窗导入持Ethicon 1cm钛夹的持夹器钳闭未闭的动脉导管。整个手术过程在电视荧屏上观看 ,食管B超和床边B超监测术中和术后的效果。　结果　本组患儿 ,平均年龄 (2 8± 1 2 )岁 ,平均体重(7 9± 4 5 )kg,平均肺动脉压 (35± 7)mmHg。合并心内畸形包括 :房间隔缺损 2例 ,室间隔缺损 3例。平均动脉导管直径 (6 8± 3 1)mm。手术平均时间 (30± 19)min。术后残余分流 4例 ,开胸结扎残余分流导管 3例 ,喉返神经麻痹 3例 ,5例转为开胸结扎。本组无手术死亡病例 ,无术后出血、手术输血、乳糜胸患儿。　结论　电视辅助胸腔镜钳闭未闭的动脉导管是治疗动脉导管未闭的一种较好方法 ,具有安全、快速、费用少、效果好。

关键词：胸腔镜检查动脉导管未闭心脏外科手术幼儿先天性心脏病

联用噻吗洛尔及非前列腺素类药物患者改用拉坦前列素或定比拉坦前列素噻吗洛尔的有效性

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世界核心医学期刊文摘（眼科学分册） 2006年第8期2卷 56-57页

作者： Magacho L. Reis R. shetty R.K. 张磊 Rua 131 no. 313 Goiania GO CEP: 74093- 200 Brazil Dr.

Purpose: To compare latanoprost with the fixed-combination latanoprost-timolol in glaucoma or ocular hypertension patients switched from a combination glaucoma therapy with timolol and another nonprostaglandin medication. Design: Prospective randomized clinical trial. Methods: Glaucoma or ocular hypertension patients receiving a combined treatment of timolol 0.5% and another nonprostaglandin medication (pilocarpine 4% , α -agonist, or a topical carbonic anhydrase inhibitor) underwent a 30- day washout of their medications. A masked observer then measured their intraocular pressure (IOP). The subjects were randomized to either latanoprost or fixed-combination latanoprost-timolol eyedrops to use once daily at 7 am. The IOP was measured again 30 days after the patients started using one of the study drugs by the same examiner at the same time. Main Outcome Measure: Comparison of the study medications’ hypotensive effect. Results: Fifty-three eyes (28 in the latanoprost group and 25 in the latanoprost-timolol group) from 28 patients were included in the study. The IOP reduction was greater in both study groups compared with the previous combination therapy with timolol and another nonprostaglandin medication in millimeters of mercury (7.7± 2.3 vs. 5.5± 2.3, P < 0.001, for the latanoprost group; 8.5± 3.5 vs. 6.3± 2.7, P < 0.001, for the latanoprost-timolol group) and percentage (35.8± 8.2% vs. 25.6± 8.9% , P < 0.001, for the latanoprost group; 38.6± 8.7% vs. 28.6± 9.0% , P < 0.001, for the latanoprost-timolol group). There was no statistical difference between latanoprost and fixed-combination latanoprost-timolol in reducing IOP, in either millimeters of mercury (P=0.3) or percentage (P=0.2). Conclusions: Both latanoprost and fixed-combination latanoprost-timolol may be viable substitutes for timolol and another nonprostaglandin medication in glaucoma or ocular hypertension patients.

关键词：拉坦前列腺素类药物噻吗洛尔高眼压症碳酸酐酶抑制剂降眼压效果随机临床研究洗脱期匹罗卡品