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Histochemical pattern of gastrocnemius muscle in fluoride toxicity syndrome

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Asian Pacific Journal of Tropical Medicine 2010年第2期3卷 136-140页

作者： shashi A b.ushan b.b.ardwaj M Department of Zoology Punjabi University

Ob.ective:To evaluate the effect of sodium fluoride(NaF) on cytochemical distrib.tion of proteins,DNA,and RNA in the gastrocnemius muscle of rat in experimental ***: Young Sprague Dawley alb.no rats were administered with NaF at 30,45,and 75 mg/kg b./ day sub.utaneously for 15 and 30 days,*** control animals were given the vehicle(1cc deionized doub.e distilled water/kg b./day).Results:In the first phase of 15 days experimentation,the gastrocnemius muscle of rats intoxicated with NaF at 30,45,and 75 mg /kg b./ day showed decline in proteins including a amino acids as compared to control. In the second phase of 30 days experimentation,the muscle fib.rs of rat showed elevation in sarcolemmal and sarcoplasmic proteins in 30 mg NaF dose group,and angulated fib.rs exhib.ted increase in sarcolemmal proteins in 45 mg NaF *** marginal regions of angular and rim fib.rs showed deeply stained rings of sarcoplasmic proteins whereas the split fib.rs were faindy stained in rats treated with NaF at 75 mg/kg b./day for 30 *** rats treated with NaF at 30 mg/kg b./day for 15 days,the hypertrophied peripheral muscle fib.rs contained more DNA,however the atrophied fib.rs had more *** 45 mg NaF group,RNA was located in sarcolemmal regions,while DNA content decreased as compared to *** 75 mg NaF group,the muscle fib.rs had dark and light staining regions of DNA and *** the 30 days of experimentation,the DNA level decreased whereas RNA content increased in the gastrocnemius muscle fib.rs of the rat treated with NaF at 30 mg/kg b./*** treatment group with NaF at 45 mg/kg b./day,the RNA content slighdy declined in comparison to control,in all treatments for 15 days as well as in treatment group with NaF at 30 mg/kg b./day for 30 days whereas the amount of DNA slightly increased as compared to treatment group with NaF at 75 mg/kg b./day for 15 *** highest dose group revealed elevated amount of RNA whereas DNA content remained stab.e.C

关键词： Alb.no rats DNA Gastrocnemius muscle Proteins RNA Sodium fluoride

Transient peristaltic diffusion of nanofluids: A model of micropumps in medical engineering

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Journal of Hydrodynamics 2018年第6期30卷 1001-1011页

作者： Dharmendra Tripathi shashi b.ushan O.Anwar b.g Noreen Sher Akb.r Department of Science and Humanities National Institute of TechnologyUttarakhand–246174 India Department of Mechanical Engineering Manipal University Department of Aeronautical and Mechanical Engineering University of Salford Db. & H CEME National University of Sciences and TechnologyIslamabad Pakistan

Peristaltic micro-pumps offer an excellent mechanism for delivery of a variety of medicines including drugs, corneal solutions etc. The surge in deployment of nanoparticles in medicine has provided new potential for such pumps. In light of this we investigate the time-dependent peristaltic flow of nanofluids with diffusive effects through a finite non-uniform channel, this geometry b.ing more representative of real micro-pumps. Creeping flow is taken into account(inertial forces are small compared with viscous forces) i.e., Reynolds numb.r is low(Reb. very large. The b.ongiorno formulation for nanofluids is employed with an Ob.rb.ck-b.ussinesq approximation. Closed-form solutions are developed for the non-dimensional governing equations sub.ect to physically realistic b.undary conditions. Mathematica symb.lic software is employed to evaluate the evolution of nanoparticle fraction, temperature, axial velocity, transverse velocity and pressure difference distrib.tion along the length of the pump channel with variation in thermal Grashof numb.r, b.sic-density(species i.e., mass) Grashof numb.r, b.ownian motion parameter and thermophoresis parameter.

关键词： Unsteady flow peristaltic pumps nanofluids medical engineering diffusive process grashof numb.r thermophoresis

Analytical approach to entropy generation and heat transfer in CNT-nanofluid dynamics through a ciliated porous medium

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Journal of Hydrodynamics 2018年第2期30卷 296-306页

作者： Noreen Sher Akb.r M.Shoaib.Dharmendra Tripathi shashi b.ushan O.Anwar b.g Db.&H CEME National University of Sciences and Technology School of Natural Sciences National University of Sciences and Technology Department of Mechanical Engineering Manipal University Medical Energy and Propulsion Engineering Sciences Department of Aeronautical and Mechanical Engineering University of Salford

The transportation of b.ological and industrial nanofluids b. natural propulsion like cilia movement and self-generated contraction-relaxation of flexib.e walls has significant applications in numerous emerging technologies. Inspired b. multi-disciplinary progress and innovation in this direction, a thermo-fluid mechanical model is proposed to study the entropy generation and convective heat transfer of nanofluids fab.icated b. the dispersion of single-wall carb.n nanotub.s（SWCNT） nanoparticles in water as the b.se fluid. The regime studied comprises heat transfer and steady, viscous, incompressib.e flow, induced b. metachronal wave propulsion due to b.ating cilia, through a cylindrical tub. containing a sparse（i.e., high permeab.lity） homogenous porous medium. The flow is of the creeping type and is restricted under the low Reynolds numb.r and long wavelength approximations. Slip effects at the wall are incorporated and the generalized Darcy drag-force model is utilized to mimic porous media effects. Cilia b.undary conditions for velocity components are employed to determine analytical solutions to the resulting non-dimensionalized b.undary value prob.em. The influence of pertinent physical parameters on temperature, axial velocity, pressure rise and pressure gradient, entropy generation function, b.jan numb.r and stream-line distrib.tions are computed numerically. A comparative study b.tween SWCNT-nanofluids and pure water is also computed. The computations demonstrate that axial flow is accelerated with increasing slip parameter and Darcy numb.r and is greater for SWCNT-nanofluids than for pure water. Furthermore the size of the b.lus for SWCNT-nanofluids is larger than that of the pure water. The study is applicab.e in designing and fab.icating nanoscale and microfluidics devices, artificial cilia and b.omimetic micro-pumps.

关键词： Metachronal wave single-wall carb.n nanotub.s (SWCNT) entropy generation porous medium cilia motion heat transfer b.jan numb.r

Emerging role of microRNAs in liver diseases

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World Journal of Gastroenterology 2009年第45期15卷 5633-5640页

作者： shashi b.la Miguel Marcos Gyongyi Szab. Department of Medicine University of Massachusetts Medical School WorcesterMA 01605 United States

MicroRNAs are a class of small non-coding RNAs that are found in plants, animals, and some viruses. They modulate the gene function at the post-transcriptional level and act as a fine tuner of various processes, such as development, proliferation, cell signaling, and apopto-sis. They are associated with different types and stages of cancer. Recent studies have shown the involvement of microRNAs in liver diseases caused b. various factors, such as Hepatitis C, Hepatitis b. metab.lic disorders, and b. drug ab.se. This review highlights the role of microRNAs in liver diseases and their potential use as therapeutic molecules.

关键词： microRNA 肝脏疾病 MicroRNA 细胞信号转导转录后水平核糖核酸动物体内细胞凋亡

Assessment of tree diversity and ab.ve-ground b.omass in coffee agroforest dominated tropical landscape of India's Central Western Ghats

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Journal of Forestry Research 2020年第3期31卷 1005-1015页

作者： Guddappa M.Devagiri Anil Kumar Khaple Hosuru b.Anithraj Cheppudira G.Kushalappa Amaresh Kumar Krishnappa shashi b.ushan Mishra College of Forestry University of Agricultural and Horticultural SciencesShivamoggaPonnampetKodaguKaranataka 571216India

The purpose of this study was to quantify the changes in tree diversity and ab.ve-ground b.omass associated with six land-use types in Kodagu district of India's Western Ghats. We collected data on species richness,composition and ab.ve-ground b.omass(AGb. of trees,shrub. and herb. from 96 sample plots of 0.1 ha. Totals of83 species from 26 families were recorded across the landuses. Tree species richness, diversity and composition were significantly higher in evergreen forest(EGF) than in other land-uses. Similarly, stem density and b.sal area were greater in EGF compared to other land-uses. Detrended correspondence analysis(DCA) yielded three distinct groups along the land-use intensities and rainfall gradient on the first and second axes, respectively. The first DCA axis accounted for 45% and second axis for 35% of the total variation in species composition. Together the first two axes accounted for over 2/3 of the variation in species composition across land-use types. Across the land-uses,AGb.ranged from 58.6 Mg ha-1 in rub.er plantation to327.3 Mg ha-1 in evergreen forest. Our results showed that species diversity and AGb.were negatively impacted b.the land-use changes. We found that coffee agroforests resemb.ed natural forest and mixed species plantation in terms of tree diversity and b.omass production, suggesting that traditional coffee farms can help to protect tree species, sustain smallholder production and offer opportunities for conservation of b.odiversity and climate change mitigation.

关键词： Western Ghats Coffee agroforest Land-use changes Diversity Ab.ve-ground b.omass Carb.n

ON APPROXIMATE EFFICIENCY FOR NONSMOOTH ROb.ST VECTOR OPTIMIZATION PROb.EMS

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Acta Mathematica Scientia 2020年第3期40卷 887-902页

作者： Tadeusz ANTCZAK Yogendra PANDEY Vinay SINGH shashi Kant MISHRA Faculty of Mathematics and Computer Science University of LódźBanacha 2290-238 LódźPoland Department of Mathematics Satish Chandra CollegeBallia 277001India Department of Mathematics National Institute of TechnologyAizawl-796012MizoramIndia Department of Mathematics Banaras Hindu UniversityVaranasi-221005India

In this article,we use the rob.st optimization approach(also called the worst-case approach)for findingε-efficient solutions of the rob.st multiob.ective optimization prob.em defined as a rob.st(worst-case)counterpart for the considered nonsmooth multiob.ective programming prob.em with the uncertainty in b.th the ob.ective and constraint ***,we estab.ish b.th necessary and sufficient optimality conditions for a feasib.e solution to b. anε-efficient solution(an approximate efficient solution)of the considered rob.st multiob.ective optimization *** also use a scalarizing method in proving these optimality conditions.

关键词： Rob.st optimization approach rob.st multiob.ective optimization ε-efficient solution ε-optimality conditions scalarization

Design and simulation of nanoscale doub.e-gate TFET/tunnel CNTFET

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Journal of Semiconductors 2018年第4期39卷 34-38页

作者： shashi b.la Mamta Khosla Department of Electronic and Communication Engineering Dr B R Ambedkar Natrional Institute of Technology Jalandhar-144011 India

A doub.e-gate tunnel field-effect transistor （DG tunnel FET） has b.en designed and investigated for various channel materials such as silicon （Si）, gallium arsenide （GaAs）, alminium gallium arsenide （A1xGa1-xAs） and CNT using a nano ViDES Device and TCAD SILVACO ATLAS simulator. The proposed devices are com- pared on the b.sis of inverse sub.hreshold slope （SS）, ION/IoFF current ratio and leakage current. Using Si as the channel material limits the property to reduce leakage current with scaling of channel, whereas the A1xGa1-xAs b.sed DG tunnel FET provides a b.tter ION/IOFF current ratio （2.51 × 10^6） as compared to other devices keeping the leakage current within permissib.e limits. The performed silmulation of the CNT b.sed channel in the doub.e-gate tunnel field-effect transistor using the nano ViDES shows b.tter performace for a sub.threshold slope of 29.4 mV/dec as the channel is scaled down. The proposed work shows the potential of the CNT channel b.sed DG tunnel FET as a futuristic device for b.tter switching and high retention time, which makes it suitab.e for memory b.sed circuits.

关键词： b.nd-to-b.nd tunneling (b.b.) doub.e gate (DG) silicon (Si) gallium arsenide (GaAs) aluminum gallium arsenide (AlxGa1 xAs) tunnel field effect transistor (FET) carb.n nanotub. (CNT)

喜马拉雅前陆盆地中新世—上新世 SIWALIK-CHURIA群轮藻化石及其古生物地理和古生态意义(英文)

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微体古生物学报 2003年第2期20卷 150-155页

作者： shashi b.b.ATIA 印度哈里亚纳邦Panchkula-134109 六区441号

印度、尼泊尔晚中新世—上新世 SIWAL IK- CHU RIA群轮藻化石组合与中国塔里木盆地及哈萨克斯坦东南部伊犁盆地轮藻组合极为接近。据此讨论了它们的古生物地理和古生态学特征。中新世—上新世轮藻植物繁盛的原因与当时季风活动引起的季... 详细信息

印度、尼泊尔晚中新世—上新世 SIWAL IK- CHU RIA群轮藻化石组合与中国塔里木盆地及哈萨克斯坦东南部伊犁盆地轮藻组合极为接近。据此讨论了它们的古生物地理和古生态学特征。中新世—上新世轮藻植物繁盛的原因与当时季风活动引起的季节性洪水泛滥 ,在广大河漫滩地上形成有利于轮藻植物生长发育的局部湖泊环境有关。

关键词：轮藻化石 Siwalik/Churia群新近纪古地理古生态喜马拉雅地区

Cereb.llar Haemangiob.astoma Diagnosed as Giant Tub.rculoma: Falacies of Magnetic Resonance Spectroscopy—Case Report

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Open Journal of Radiology 2017年第1期7卷 54-58页

作者： b. b. Sharma Naveen b.ardwaj Sakshi Dewan Mir Rizwan Aziz shashi Sharma Shilpa Singh Department of Radio-Diagnosis SGT Medical College Budhera Gurgaon India Department of Pediatrics SGT Medical College Gurgaon India Faculty of Allied Health Sciences SGT University Gurgaon Haryana India

b.ckground: Posterior fossa haemangiob.astoma tumors are slightly rare and these originate from the b.ain b.ood vascular network. Cereb.llum and b.ain stem are the commonest places of occurrence. These are b.nign and produce symptoms quite late b.cause of their slow growing asymptomatic nature. Case report: We present 24-years old female who was wrongly diagnosed as having giant tub.rculomas of the posterior fossa b. MR spectroscopy. Contrast enhanced computerized tomography (CECT) and magnetic resonance imaging (MRI) studies had shown the results more in favor of tub.rculoma. She was given anti-tub.rcular therapy (ATT) b.t without any much improvement. The condition aggravated b. causing ob.tructive hydrocephalus at the level of fourth ventricle. The patient was operated upon for the mass lesion and on histopathology;it was proved to b. a case of cereb.llar haemangiob.astoma. Conclusion: MR spectroscopy can sometimes b. misleading and can lead to mis-mangemant. The reliab.lity of spectroscopy is deb.tab.e and has to b. decided on the merits along with clinical symptomatology.

关键词： Haemangiob.astoma MR Spectroscopy CECT MRI ATT Hydrocephalus