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经颈静脉肝内门体分流术后再入院率:14年的单中心诊疗经验

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Gastroenterology Report 2020年第2期8卷 98-103,I0001页

作者： Catherine F.Vozzo Tavankit Singh Jennifer Bullen shashank sarvepalli Arthur McCullough Baljendra Kapoor Department of Internal Medicine Cleveland ClinicClevelandOHUSA Department of Gastroenterology and Hepatology Cleveland ClinicClevelandOHUSA Department of Quantitative Health Sciences Cleveland ClinicClevelandOHUSA Department of Inflammation and Immunity Cleveland ClinicClevelandOHUSA Department of Radiology Cleveland ClinicClevelandOHUSA

背景:经颈静脉肝内门体分流术(TIPS)常用于治疗门脉高压并发症。然而,关于TIPS术后再入院率的数据十分有限,而且尚无研究关注其再入院的原因。为此,本研究旨在明确本中心TIPS术后30天再入院率,并分析再入院的可能原因及预测因素。方法:... 详细信息

背景:经颈静脉肝内门体分流术(TIPS)常用于治疗门脉高压并发症。然而,关于TIPS术后再入院率的数据十分有限,而且尚无研究关注其再入院的原因。为此,本研究旨在明确本中心TIPS术后30天再入院率,并分析再入院的可能原因及预测因素。方法:我们通过Cleveland Clinic电子病案系统检索2004-2017年间接受初次TIPS治疗(采用聚四氟乙烯覆膜支架)的肝病患者,统计这些患者术后30天再入院率。采用单因素逻辑回归模型评估30天再入院的潜在预测因素。结果:566例TIPS患者纳入分析,其术后30天再入院率为36%。最常见的再入院原因包括意识模糊(48%)、感染(15%)、出血(11%)和液体过剩(7%)。终末期肝病模型(MELD)评分越高,再入院率越高(MELD评分每增加1分:OR¼1.06,95%CI:1.02–1.09,P¼0.001)。其他再入院的潜在预测因素(包括TIPS适应证)则未获本研究证实。结论:采用覆膜支架行TIPS术,其术后30天再入院率较高,且近半数的再入院是因为肝性脑病(一种已知的TIPS并发症)。未来应重点研发一些新的干预措施以降低TIPS再入院率。

关键词： transjugular intrahepatic portosystemic shunt portal hypertension liver cirrhosis hospital readmission

Epidemiology of EGFR Mutation in Adenocarcinoma NSCLC Patients in India: A Systematic Review and Meta-Analysis

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Advances in Lung Cancer 2024年第1期13卷 1-21页

作者： Ankita Jain Kumar Prabhash Venkatraman Radhakrishnan shashank Srinivasan Pfizer Products India Private Limited Mumbai India Tata Memorial Hospital Mumbai India Cancer Institute (W.I.A.) Chennai India

Studies reporting the Indian prevalence of Epidermal Growth Factor Receptor (EGFR) mutation are mostly single centers with small sample sizes. This systematic review and meta-analysis summarized the available evidence of EGFR mutation epidemiology in Indian patients with adenocarcinoma (ADC) Non-Small Cell Lung Cancer (NSCLC). We conducted a structured literature search in PubMed, and EMBASE databases from January 2004 through October 2019. The primary outcome of interest was prevalence of EGFR mutation by gender, smoking status, and mutation subtype. The review included 34 studies. EGFR mutation prevalence was 39.5% in patients with ADC, and significantly higher in females, non-smokers, and patients with exon 19 deletions. The EGFR mutation frequency in Indian patients with ADC was higher than reported in Caucasians but at a lower range of that reported in East Asians. These findings support the use of EGFR mutation testing to guide choice of treatment.

关键词： Epidemiology Epidermal Growth Factor Receptor Adenocarcinoma Non-Small Cell Lung Cancer India

Ca^(2+) binding to the C_(2)E domain of otoferlin is required for hair cell exocytosis and hearing

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Protein & Cell 2024年第4期15卷 305-312页

作者： Han Chen Mehar Monga Qinghua Fang Loujin Slitin Jakob Neef shashank S.Chepurwar Regina Célia Mingroni Netto Karina Lezirovitz Alfredo Tabith,Jr. Fritz Benseler Nils Brose Kathrin Kusch Carolin Wichmann Nicola Strenzke Barbara Vona Julia Preobraschenski Tobias Moser Institute for Auditory Neuroscience and InnerEarLab University Medical Center Göttingen37075 GöttingenGermany Collaborative Research Center 889 University of Göttingen37075 GöttingenGermany Auditory Neuroscience and Synaptic Nanophysiology Group Max Planck Institute for Multidisciplinary Sciences37075 GöttingenGermany Göttingen Graduate Center for Neurosciences Biophysics and Molecular BiosciencesUniversity of Göttingen37075 GöttingenGermany Biochemistry of Membrane Dynamics Group Institute for Auditory NeuroscienceUniversity Medical Center Göttingen37075 GöttingenGermany Molecular Architecture of Synapses Group Institute for Auditory Neuroscience and InnerEarLabUniversity Medical Center Göttingen37075 GöttingenGermany Center for Biostructural Imaging of Neurodegeneration University Medical Center Göttingen37075 GöttingenGermany Auditory Systems Physiology Group Institute for Auditory Neuroscience and InnerEarLabUniversity Medical Center Göttingen37075 GöttingenGermany Departamento de Genética e Biologia Evolutiva Centro de Pesquisas sobre o Genoma Humano e Células-TroncoInstituto de BiociênciasUniversidade de São PauloSão Paulo 05508-220Brazil Laboratório de Otorrinolaringologia/LIM32 Faculdade de MedicinaHospital das ClínicasUniversidade de São PauloSão PauloSP 05508-220Brazil DERDIC Pontifícia Universidade Católica de São PauloSão Paulo 05508-220Brazil Department of Molecular Neurobiology Max Planck Institute for Multidisciplinary Sciences37075 GöttingenGermany Multiscale Bioimaging Cluster of Excellence(MBExC) University of Göttingen37075 GöttingenGermany Functional Auditory Genomics Group Auditory Neuroscience and Optogenetics LaboratoryGerman Primate Center37077 GöttingenGermany Hearing Genomics Group Institute for Auditory Neuroscience and InnerEarLabUniversity Medical Center Göttingen37075 GöttingenGermany Institute of Human Genetics University Medical Center Göttingen37075 GöttingenGermany

Dear Editor,Afferent synapses of cochlear inner hair cells(IHCs)employ a unique molecular machinery(see extended background in Supplementary Materials).Otoferlin is a key player in this machinery and its defects cause human auditory synaptopathy(Moser and Starr,2016).Otoferlin,a tail-anchored(Vogl et al.,2016)multi-C_(2)-domain protein(Fig.1Ai)specific to hair cells(Roux et al.,2006),is a member of the ferlin protein family involved in membrane trafficking and repair that are of major disease relevance(Pangršičet al.,2012),also see Supplementary *** is distributed broadly within IHCs(Fig.2Ai-Aiii;Pangrsic et al.,2010;Roux et al.,2006).

关键词： auditory hair

Applicability of unique scarf joint configuration in friction stir welding of AA6061-T6:Analysis of torque,force,microstructure and mechanical properties

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Defence Technology（防务技术） 2022年第4期18卷 567-582页

作者： Durjyodhan Sethi Uttam Acharya shashank Shekhar Barnik Saha Roy Department of Mechanical Engineering National Institute of Technology AgartalaBarjalaJiraniaWest TripuraPin-799046India Department of Materials Science and Engineering Indian Institute of Technology KanpurKanpur208016India

The present research introduces a unique concept of scarf joint technique in friction stir welding(FSW) of aluminum alloy AA 6061-T6 plates and an investigation on weld quality.A new joint configuration with two distinct scarf angles(75°and 60°) was considered in this *** various aspects of welding were compared with contemporary simple square butt(SSB) joint *** was carried out at a constant tool rotation speed(TRS),tool traverse speed(TTS) and tool tilt angle of 1100 rpm,2 mm/s and2°,*** results are analyzed in terms of force and torque distribution,microstructure,macrostructure,and mechanical property perspective for different joint *** study reveals the minimum amount of force and torque at 60°scarf angle joint configuration compared to that of square butt joint *** study shows that all the joints were defect-free,and a prominent onion ring was present in the lower portion of the weld nugget(WN).Fine equiaxed grains with a minimum average grain size diameter of 6.82 μm were obtained in the WN of scarf joint configuration(SJC).The maximum ultimate tensile strength(UTS) and maximum average NZ hardness of 267 MPa and83.82 HV0.1were obtained in SJC3 at a scarf angle of 60°.It has been observed from the investigation that the joint efficiency increases from 72.5%(SSB) to 86%(SJC3) at a 60° scarf *** unique characteristic may lay an impetus on probable joint strength enhancement technique without increasing the production cost.

关键词： Friction stir welding Joint configuration Al alloys Force and torque Microstructure Mechanical property

Blockchain-based Peer-to-Peer Transactive Energy System for Community Microgrid with Demand Response Management

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CSEE Journal of Power and Energy Systems 2022年第1期8卷 198-211页

作者： Hanumantha Rao Bokkisam shashank Singh Ritesh Mohan Acharya M.P.Selvan National Institute of Technology Tiruchirappalli Tamilnadu 620015India Department National Institute of Technology TiruchirappalliTamilnadu 620015India

Interest in transactive energy frameworks(TEFs)is proliferating due to the modern smart grid *** paper proposes a TEF,which applies auction-theory,incorporates a system of agents,and facilitates a transactive energy market(TEM)through an ***,it also enables peer-to-peer(P2P)energy trading among the residential buildings in community microgrid for possible monetary *** this framework,there are three agents,namely,auctioneer,participants,and *** auctioneer is a managing agent modeled using auction theory to determine day-ahead internal market-clearing price and *** participants are autonomous and rational decision-makers;they aim to minimize their electricity bills through the demand response(DR)*** types of architectures,one with the third-party agent demonstrated using the MATLAB environment and the other with the virtual agent(without third-party)implemented using the blockchain environment are *** simulation results reflect significant monetary benefits to each market participant,improved community selfsufficiency,self-consumption,and reduced reliance on the utility grid.

关键词： Blockchain demand response optimization P2P energy trading smart contracts and transactive energy

A Micro-Structure Dependent Buckling Analysis of Partially-Cracked Generally Orthotropic Plate under Thermal Domain

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Advances in Applied Mathematics and Mechanics 2023年第1期15卷 244-266页

作者： Ankur Gupta shashank Soni N.K.Jain Department of Mechanical Engineering National Institute of TechnologyRaipurChhattisgarh 492010India

In this work,a non-classical analytical approach for buckling analysis of partially cracked generally orthotropic plate is proposed under the thermal *** derivation for the governing equation is based on the non-classical approach using Kirchhoff’s thin plate theory and the modified couple stress *** effect of fibre orientation on critical buckling temperature is incorporated by considering the coefficients of mutual *** spring model is applied with some modifications to formulate all the crack terms while the thermal effects are introduced in form of thermal in-plane moments and *** final governing equation is solved using Galerkin’s method and the relation for critical buckling temperature as affected by fibre orientation is *** variation of critical buckling temperature as affected by fibre orientation for different values of crack length,crack location and length scale parameter is ***,the effect of fibre orientation on fundamental frequency under the thermal domain is analysed.

关键词： Orthotropic plate fibre orientation crack microstructure thermal domain

Mechanism and recent updates on insulin-related disorders

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世界临床病例杂志 2023年第25期11卷 5840-5856页

作者： shashank Kumar Sabyasachi Senapati Neetu Bhattacharya Amit Bhattacharya shashank Kumar Maurya Hadiya Husain Jasvinder Singh Bhatti Abhay Kumar Pandey Department of Biochemistry Central University of PunjabBathinda 151401PunjabIndia Department of Human Genetics and Molecular Medicine Central University of PunjabBathinda 151401PunjabIndia Department of Zoology Dyal Singh CollegeUniversity of DelhiNew Delhi 110003India Department of Zoology Ramjas CollegeUniversity of DelhiNew Delhi 110007India Department of Zoology University of DelhiNew Delhi 110007India Department of Zoology University of LucknowLucknow 226007India Department of Biochemistry University of AllahabadAllahabad(Prayagraj)211002India

Insulin,a small protein with 51 amino acids synthesized by pancreatic β-cells,is crucial to sustain glucose homeostasis at biochemical and molecular *** metabolic dysfunctions are related to insulin-mediated altered glucose *** of the significant pathophysiological conditions linked to the insulin associated disorder is diabetes mellitus(DM)(type 1,type 2,and gestational).Insulin resistance(IR)is one of the major underlying causes of metabolic disorders despite its association with several physiological *** syndrome(MS)is another pathophysiological condition that is associated with IR,hypertension,and ***,several other pathophysiological disorders/diseases are associated with the insulin malfunctioning,which include polycystic ovary syndrome,neuronal disorders,and *** are an uncommon type of pancreatic β-cell-derived neuroendocrine tumor that makes up 2% of all pancreatic *** revealed that different biochemical events,molecular signaling pathways,microRNAs,and microbiota act as connecting links between insulin disorder and associated pathophysiology such as DM,insuloma,neurological disorder,MS,and *** this review,we focus on the insulin-related disorders and the underlying mechanisms associated with the pathophysiology.

关键词： Insulin disorder Diabetes Metabolic syndrome Neurological disorder Obesity Cancer

Role of prostate cancer stem-like cells in the development of antiandrogen resistance

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Cancer Drug Resistance 2022年第2期5卷 459-471页

作者： Prem Prakash Kushwaha Shiv Verma shashank Kumar Sanjay Gupta Department of Urology Case Western Reserve UniversityClevelandOH 44106USA. The Urology Institute University Hospitals Cleveland Medical CenterClevelandOH 44106USA. Molecular Signaling and Drug Discovery Laboratory Department of BiochemistryCentral University of PunjabBathinda 151401India. Department of Pathology Case Western Reserve UniversityClevelandOH 44106USA. Department of Pharmacology Case Western Reserve UniversityClevelandOH 44106USA. Department of Nutrition Case Western Reserve UniversityClevelandOH 44106USA. Divison of General Medical Sciences Case Comprehensive Cancer CenterClevelandOH 44106USA.

Androgen deprivation therapy(ADT)is the standard of care treatment for advance stage prostate *** with ADT develops resistance in multiple ways leading to the development of castration-resistant prostate cancer(CRPC).Present research establishes that prostate cancer stem-like cells(CSCs)play a central role in the development of treatment resistance followed by disease *** CSCs are capable of self-renewal,differentiation,and regenerating tumor *** stemness properties in prostate CSCs arise due to various factors such as androgen receptor mutation and variants,epigenetic and genetic modifications leading to alteration in the tumor microenvironment,changes in ATP-binding cassette(ABC)transporters,and adaptations in molecular signaling *** reprograms prostate tumor cellular machinery leading to the expression of various stem cell markers such as Aldehyde Dehydrogenase 1 Family Member A1(ALDH1A1),Prominin 1(PROM1/CD133),Indian blood group(CD44),SRY-Box Transcription Factor 2(Sox2),POU Class 5 Homeobox 1(POU5F1/Oct4),Nanog and ABC *** markers indicate enhanced self-renewal and stemness stimulating CRPC evolution,metastatic colonization,and resistance to *** this review,we discuss the role of ADT in prostate CSCs differentiation and acquisition of CRPC,their isolation,identification and characterization,as well as the factors and pathways contributing to CSCs expansion and therapeutic opportunities.

关键词： Prostate cancer second-generation antiandrogens cancer stem cells castration resistance prostate cancer androgen deprivation therapy

A Numerical Study of the Irradiated Ignition of Obliquely Oriented Thermally-Deformable Polymer

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Open Journal of Fluid Dynamics 2022年第4期12卷 277-303页

作者： shashank Singh Independent Researcher Chandigarh India

This study numerically investigates the influence of molten matter dynamics on the gasification and subsequent ignitability of an inclined thermoplastic specimen subjected to localized irradiation heat flux normal to the surface. A thermoplastic material is modeled as a phase change material with predefined solidification and melting temperatures, respectively, and the gasification process is modeled by the Arrhenius law of molten matter. Gas phase kinetics is not considered for simplicity purposes;instead, the onset of ignition of polymer is estimated on the basis of the critical mass flux concept. According to the numerical results, as the inclination angle becomes steeper (toward the vertical angle), the estimated ignition delay becomes shorter, showing ignition is promoted, whereas it is turned to be difficult to occur when inclination angles are above the vertical angle (>90?) having a longer delay time for the onset of gasification. With careful observation, the thermal interaction between the hot molten matter and unmelted (cold) solid is found to play an important role in gasification. The formation of a bulge due to resolidification to suppress the dripping downstream could be the source to promote ignition. By contrast, the hot molten matter is enforced to detach from the unmelted solid and “freely fall-off” to prohibit ignition for inclination angles beyond 90?. This supports the notion that high-enthalpy caused by the external heating is simply lost because of dripping, and there is less chance of catching fire there.

关键词： Numerical Modeling Dripping Resolidification Gasification Phase Change Material Critical Mass Flux