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Workplace Wellness,Mental Health Literacy,and Usage Intention of E-Mental Health amongst Digital Workers during the COVID-19

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International Journal of Mental Health Promotion 2023年第1期25卷 99-126页

作者： Choon-Hong Tan ah-Choo Koo Hawa Rahmat Wei-Fern Siew Alexius Weng-Onn Cheang Elyna Amir Sharji Faculty of Creative Multimedia Multimedia UniversityCyberjaya63000Malaysia Faculty of Applied Communication Multimedia UniversityCyberjaya63000Malaysia International Medical University(IMU) Bukit Jalil57000Malaysia

The prevalence of mental health problems in both Malaysian and global workplaces has signiﬁcantly increased due to the presence of the coronavirus disease(COVID-19)pandemic,globalization,technology advancement in Industry 4.0,and other contributing *** pervasiveness of the issue poses a huge challenge to improving the occupational safety and health(OSH)of workers in various industries,especially in the digital *** emergence of the innovative industry is evident mainly due to the rapid development of Industry 4.0 and the rele-vant demands of multiple businesses in the digital ***,limited studies and academic dis-cussions were conducted on the OSH topic of digital ***,the current study serves toﬁll the existing gap and provide academic contributions by scrutinising the perceptions of digital workers regarding their work-place well-being,mental health literacy,and the impression of employing e-mental *** objectives of this study are:1)To examine the mental health literacy and workplace wellness of digital workers,2)to explore the e-mental health usage intention and actual e-mental health utilization,and 3)to identify digital workers’feedback on e-mental *** the current context,e-mental health focuses on three dimensions,namely,1)“health in our hand(HIOH)”,2)“interacting for health(IFH)”,and 3)“data enabling health(DEH)”.The present study employed an online cross-sectional survey and received 326 digital workers’completed ***,such as“mental health literacy(MHL)”,“workplace wellness(WW)”,and e-mental health intention and usage were explicated by analysing the data through descriptive *** study results indicated a moderate to a high level of the MHL and the *** than half of the workers possessed a high intention level to employ e-mental health,with the HIOH dimension being the most prevalent ***,the actual e-mental health usage was very low,owing to the online r

关键词： E-mental health intention digital workers digital industry workplace wellness mental health literacy

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Nrf2-mediated antioxidant and detoxifying enzyme induction by a combination of curcumin and sulforaphane

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Journal of Chinese Pharmaceutical Sciences 2016年第8期25卷 559-569页

作者： Francisco Fuentes Yury Gomez Ximena Paredes-Gonzalez Avantika Barve Sujit Nair Siwang Yu Constance Lay Lay Saw ah-Ng Tony Kong Facultad de Agronomia e Ingenieria Forestal Pontificia Universidad Cato1ica de Chile Casilla 306-22 Santiago Chile Department of Pharmaceutics Ernest Mario School of Pharmacy Rutgers The State University of New Jersey New Jersey 08854 USA Novartis Institutes for Biomedical Research East Hanover NJ-07470 USA Amrita Cancer Discovery Biology Laboratory Amrita Vishwa Vidyapeetham University Amritapuri Clappana P.O. Kollam Kerala-690525 India School of Pharmaceutical Sciences Peking University Health Science Center Beo'ing 100191 China

The dietary phytochemicals curcumin （CUR） and sulforaphane （SFN） have shown remarkable cancer chemopreventive effects in many model systems. This study was designed to investigate the induction of Nrf2-mediated antioxidant enzymes by combining doses of CUR and SFN and the effect of their combination on the Nrf2-ARE （antioxidant response element） response in HepG2-C8 cells. We hypothesized that the combination of the polyphenol CUR and the isothiocyanate SFN could enhance the induction of AREs and Nrf2-target enzymes. HepG2-C8 cells were treated with a combination of low doses of CUR, SFN or both. The induction of Nrf2-mediated antioxidant and phase II detoxifying enzymes-heme oxygenase-1 （HO-I） and UDP-glucuronosyltransferase-1A （UGT1A）-was measured by real-time RT-PCR and western blotting. ARE-luciferase activity was also quantified. Low doses of CUR （10 ~tM） and SFN （12.5 ~tM） significantly induced the expression of HO-1 and UGT 1 A1 proteins. Through the use of chemical inhibitors of mRNA and protein synthesis, the combination of CUR and SFN was shown to affect the transcriptional regulation of both HO-1 and UGT1A1. Additionally, the combination of CUR and SFN synergistically induced the expression of Nrf2- and ARE-luciferase activity in HepG2-C8 cells. Thus, CUR and SFN at low concentrations augment therapeutic effects in HepG2-C8 cells. The enhanced ARE-luciferase activity of combined CUR and SFN treatment could partly explain the significant induction of the Nrf2-target enzymes HO-1 and UGT1A1. Taken together, our results suggest that combining low doses of CUR and SNF could be a promising strategy for cancer chemoprevention in humans.

关键词： Antioxidant response element, Curcumin, HepG2-C8 cell-s, HO-1, Nrf2, Sulforaphane, UGT 1A1

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Investigations on Structural Safety of Office Room Based on Fire Simulation and Transient Heat Transfer Analysis

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World Journal of Engineering and Technology 2014年第3期2卷 20-26页

作者： ah Young An Eun Mi Ryu Hee Sun Kim Department of Architectural Engineering Ewha Woman’s University Seoul Korea

This study aims at investigating heat propagations inside the structural members due to fire using fire simulation and transient heat transfer analysis. Toward that goal, fire simulation and transient heat transfer analysis for a 5-story building are carried out sequentially using Fire Dynamics Simulator (FDS) and ABAQUS 6.10-3, respectively. As results from fire simulation, temporal temperature information is obtained depending on various locations of the building, which is used as boundary condition for the structural elements generated in transient heat transfer analysis. Predictions from the transient heat transfer analysis show that the structural members are exposed spatially non-uniform temperatures which can cause significant eccentric deformation and aceleration of structural damages.

关键词： Fire Simulation Heat Transfer Structural Safety Fire

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Comparison of the efficacy and safety of once-daily dosing and on-demand use of udenafil for type 2 diabetic patients with erectile dysfunction

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Asian Journal of Andrology 2015年第1期17卷 143-148,I0011,I0012页

作者： Soon Hyun Park Sung Woo Park Bong Yun Cha Ie Byung Park Kyung Wan Min Yeon ah Sung Tae Hwa Kim Jae Min Lee Kang Seo Park Department of Internal Medicine Eulji University School of Medicine Daejeon 302-799 South Korea Department of Endocrinology and Metabolism Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine Seou1110-746 South Korea Department of Endocrinology and Metabolism College of Medicine the Catholic University of Korea Seou1137-701 South Korea Department of Internal Medicine Gachon University of Medicine and Science Graduate School of Medicine Incheon 405-760 South Korea Department of Internal Medicine Eulji University School of Medicine Seou1139-872 South Korea Department of Endocrinology Ewha Woman's University School of Medicine Seoul 158-710 South Korea Department of Internal Medicine College of Medicine Hanyang University Seoul 133-792 South Korea.

We compared the efficacy and safety between once-daily dosing and on-demand use of udenafil for type 2 diabetic patients with erectile dysfunction （ED）. A multi-center, randomized, open-label, parallel-group, 12-week study was conducted. 161 patients who improved with on-demand 200 mg of udenafil according to Sexual Encounter Profile （SEP） diary Question 2 and 3 （Q2 and Q3） were randomized into 200 mg on-demand （n = 80） or 50 mg once-daily （n = 81） dosing groups for 8 weeks. The dosing period was followed by a 4-week treatment-free period. The primary efficacy endpoint was the change of the International Index of Erectile Function （IIEF） erectile function domain （EFD） score. The secondary efficacy endpoints included changes to the SEP diary Q2, Q3, IIEF Q3, Q4, other domains of IIEF, Global Assessment Question, and shift to the normal rate （EFD 〉 26）. Vascular endothelial markers were also assessed. The IIEF-EFD score of both groups improved after 8 weeks of treatment （P 〈 0.0001）. There was no statistically significant difference between two groups. Improvement was not maintained after the treatment-free follow-up period. Similar results were observed in the secondary efficacy endpoints. There was also no significant difference in vascular endothelial markers. Daily udenafil was well-tolerated, and there was no significant difference in the adverse drug reactions and adverse events between the two groups. Flushing and headache were the most frequent adverse events. Both regimens improved ED in diabetic patients and were well-tolerated. Further studies are needed to assess the effect of daily udenafil treatment in diabetic patients.

关键词： erectile dysfunction International Index of Erectile Function once-daily dosing ptiosphodiesterase type 5 inhibitor type 2 diabetes mellitus udenafil

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子宫内膜异位症临床预测因素研究进展

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中华生殖与避孕杂志 2018年第9期38卷 779-783页

作者： IM Min ah 易晓芳复旦大学附属妇产科医院上海200011

子宫内膜异位症(endometriosis,EMS)好发于育龄妇女,常导致盆腔疼痛与不孕等。EMS从症状出现到诊断平均需耗时3.3~12.1年,可能与对疾病的本质认知不足以及缺乏敏感的血清学标志物等有关。近年来,综合分析患者疼痛程度、不孕情况、手术... 详细信息

子宫内膜异位症(endometriosis,EMS)好发于育龄妇女,常导致盆腔疼痛与不孕等。EMS从症状出现到诊断平均需耗时3.3~12.1年,可能与对疾病的本质认知不足以及缺乏敏感的血清学标志物等有关。近年来,综合分析患者疼痛程度、不孕情况、手术史等构建的预测模型在加快EMS早期诊断方面起到积极推动作用。本文从早期诊断预测的角度综述了EMS患者的典型症状与体征、实验室检查、影像学检查及相关模型研究的最新进展,期待通过有效的临床预测使患者得到及早诊治。

关键词：子宫内膜异位症(EMS) 延迟诊断临床表现血清标志物预测模型

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思维导图技术汉语词汇教学中的实证研究——以印尼Atirah初中为例

思维导图技术汉语词汇教学中的实证研究——以印尼Atirah初中为例

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作者： MIR’ah AZIZah（利华）南昌大学

学位级别：硕士

本研究的目的是确定思维导图技术在词汇学习中的有效性,以及学生对应用该技术的看法。笔者采用定性与定量相结合的方法,采用前测,思维导图技术,后测,问卷调查和访谈等研究手段。然后对数据进行分析,以找出学生的总体平均分数以及学生改... 详细信息

本研究的目的是确定思维导图技术在词汇学习中的有效性,以及学生对应用该技术的看法。笔者采用定性与定量相结合的方法,采用前测,思维导图技术,后测,问卷调查和访谈等研究手段。然后对数据进行分析,以找出学生的总体平均分数以及学生改进分数的百分比。此外,来自观察,问卷调查和访谈的数据通过描述性表示进行分析和呈现。这项研究的样本来自Atirah初中的30名学生。结果表明,学生使用思维导图技术学习非常热情,课堂气氛变得更加愉快。此外,应用思维导图技术后,学生的词汇能力提高。在预测试中学生的总体平均分是42.2,被归类为非常差分。另一方面,在测试后的学生的总平均分为83.89,这被归类为良好分数。学生改善分数的百分比也增加到98.79%。这些证明使用思维导图技术在学习词汇方面非常有效。

关键词：词汇思维导图实证

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电子商务Drop-shipping背景下MVMT公司的数字营销策略

电子商务Drop-shipping背景下MVMT公司的数字营销策略

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作者： Christopher Samuel ah-Low 宁波大学

学位级别：硕士

本研究的目的是通过STP和4C分析MVMT的数字营销营销策略。STP分析将有助于了解MVMT使用的目标受众是什么,以及他们如何在市场上与竞争对手进行竞争。研究中使用了 MVMT公司的案例研究。所使用的研究方法是定性的,使用文档、观察和参与... 详细信息

本研究的目的是通过STP和4C分析MVMT的数字营销营销策略。STP分析将有助于了解MVMT使用的目标受众是什么,以及他们如何在市场上与竞争对手进行竞争。研究中使用了 MVMT公司的案例研究。所使用的研究方法是定性的,使用文档、观察和参与者观察的组合来了解MVMT使用的不同工具和策略,以实现电子商务的快速增长。通过本论文,还解释了直销方式及其相关的数字营销策略,主要是SMMA。Chung Shing Lee(2001)用于评估电子商务商业模式和策略的分析框架用于寻找MVMT电子商务直销方法需要关注的最重要因素。Yadav and Rahman(2017)消费者对电子商务行业社交媒体营销活动的看法被用来寻找MVMT数字营销策略关注的关键因素。研究结果表明,与传统电子商务相比,代发货方式是一种更具吸引力的选择,有助于确定在进入竞争激烈且饱和的市场时,可以使用哪些策略来实现电子商务的快速增长。

关键词：电子商务直销业务数字营销社交媒体市场营销

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Inhibitive efficacy of Nymphoides indica rhizome extract onα-glucosidase, and cross-link formation of advanced glycation end products

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Journal of Traditional Chinese Medicine 2021年第3期41卷 376-380页

作者： Muhammad Hanif Muzammil ahmad Khan Muhammad Ramzan Abdul Rafey Ali Zaman Imran Aziz Ama'null'ah Adnan Amin Gomal Centre of Biochemistry and Biotechnology(GCBB) Gomal University D.I.Khan29050Pakistan NPRL Department of PharmacognosyFaculty of PharmacyGomal University D.I.Khan29050Pakistan FVAS Gomal University D.I.Khan29050Pakistan

OBJECTIVE: To investigate the inhibitive efficacy of Nymphoides Indica(L.) Kuntze rhizome extract onα-glucosidase and on cross-link formation of advanced glycation end products(AGEs).METHODS: The plant extracts were prepared by cold maceration and fractionated in solvents of diverse polarity. The in vitro α-glucosidase inhibition assay, fluorescence spectrometry and SDS-PAGE analysis was performed for antiglycation ***: During α-glucosidase inhibition assay significant inhibition by chloroform(0.43 mg/mL)and methanol fractions(0.66 mg/mL) was *** the AGEs inhibition assay, both oxidative(BSA-MGO) and non-oxidative(BSA-glucose)modes were employed. The inhibition of AGEs by total extract was considered moderate(IC_(50)0.10 mg/mL) as a result of non-oxidative mode, whereas in case of oxidative mode(BASA-MGO) no activity was recorded. Among fractions the methanolic fraction presented significant results both in oxidative(IC_(50)0.01 mg/mL) and non-oxidative modes(IC_(50) 0.3 mg/mL). Likewise the ethyl acetate fraction was more active in non-oxidative mode(IC_(50)0.04 mg/mL) compared to oxidative mode(IC_(50)0.32 mg/mL).During assay for inhibition of cross-link formation,the chloroform fraction significantly inhibited cross-link formation in a dose dependent ***: It was finally concluded that N. Indica rhizome extract possesses significant properties that inhibit α-glucosidase, and AGEs cross-link formation.

关键词： Nymphoides Indica alpha-glucosidases glycation end products advanced protein cross links antiglycation

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^(153)Sm-EDTMP:有效地治疗骨癌疼痛

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国外医学（放射医学核医学分册） 1993年第1期17卷 30-32页

作者： Richard ah 刘静波

^(153)Sm-EDTMP试用于转移性骨癌疼痛病人的治疗,估计65.4%的病人疼痛可得到缓解,且只有轻度和短暂的骨髓毒性。为使^(153)Sm-EDTMP获得临床应用,必须进一步研究证明其作为止痛剂的功效,以排除“配体止痛作用”。

关键词：骨肿瘤疼痛放射性药治疗

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^(201)TI作为肿瘤显像剂的现状和展望

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国外医学（放射医学核医学分册） 1993年第4期17卷 178-181页

作者： Elgazzar ah 张锦明

应用^(201)T1在不同肿瘤内摄取研究发展很快。大量的报告用^(201)T1研究了甲状腺癌、乳腺癌、骨癌、软组织癌、淋巴瘤、Daposi肉瘤、单灶骨病变、头颈部肿瘤和其它恶性肿瘤等。^(201)T1的显像技术也作了改进,包括增加放射性核素给药量... 详细信息

应用^(201)T1在不同肿瘤内摄取研究发展很快。大量的报告用^(201)T1研究了甲状腺癌、乳腺癌、骨癌、软组织癌、淋巴瘤、Daposi肉瘤、单灶骨病变、头颈部肿瘤和其它恶性肿瘤等。^(201)T1的显像技术也作了改进,包括增加放射性核素给药量、改变显像时间、使用SPECT和采用各种肿瘤/正常的吸收比。本综述概括了铊在诊断不同肿瘤中的作用现况,试图辩明一些悬而未决的问题。

关键词：铊201 肿瘤放射性核素成象

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