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海洋与湖沼 1962年第Z2期 177-179页

作者： У Бао-лин(Инcmumym (?) ah KHP) Ян Дз-цзянь(Шанboyhckuu Океан(?) uhcmumym)

(Hartman, 1959) 1957 Saccocirrus Saccocirrus Saccocirrus

关键词：八刀 Ho Ba Te 心水 SACCOCIRRUS BOBRETZKY,1871 ARCHIANNELIDA Be

Selexipag as Add-on Therapy for Patients with Pulmonary Arterial Hypertension Associated with Congenital Heart Disease:A Single-Center Retrospective Study

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Congenital Heart Disease 2021年第3期16卷 233-244页

作者： Se Yong Jung Doyoung Jung ah Young Kim Jae Hee Seol Jung Min Park Jo Won Jung Jae Young Choi Division of Pediatric Cardiology Congenital Heart Disease CenterSeverance Cardiovascular HospitalDepartment of PediatricsYonsei University College of MedicineSeoulKorea

Purpose:This study examined the efficacy and safety of selexipag in treating pulmonary arterial hypertension(Pah)associated with congenital heart disease(CHD).Materials and Methods:We conducted a retrospective study of patients with CHD-associated Pah,treated with selexipag since December *** adult patients(mean age,45.4 years;women,77%)were treated with selexipag as add-on *** characteristics,World Health Organization functional class,6-minute walking distance(6MWD)test results,N-terminal pro-B-type natriuretic peptide levels,echocardiographic data,and incidence of side effects were ***:The majority of patients(12/13,92.3%)experienced more than one treatment-associated complication;one patient dropped out of the study due to intolerable *** results of 6MWD test(from 299.2±56.2 m to 363.8±86.5 m,p=0.039)and tricuspid regurgitation(TR)pressure gradient(from 84.7±20.5 mmHg to 61.6±24.0 mmHg,p=0.018)improved and remained improved after selexipag treatment in 12 *** on the results of a non-invasive risk assessment,8(66.7%)patients showed improvement,3(25.0%)showed no interval change,and the status of one patient(8.3%)***,compared to patients treated with a low dosage,patients treated with a medium-to-high dosage showed a greater increase in 6MWD results(88.3±26.4 m vs.55.3±27.6 m,p=0.043)and a greater reduction in the TR pressure gradient(-33.7±10.9 mmHg vs.-12.5±12.0 mmHg,p=0.015).Conclusion:Selexipag is an efficient pulmonary vasodilator as add-on therapy in treating CHD-associated Pah.

关键词： Selexipag congenital heart disease pulmonary arterial hypertension

Nutritional risk index as a predictor of postoperative wound complications after gastrectomy

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World Journal of Gastroenterology 2012年第7期18卷 673-678页

作者： Cheong ah Oh Dae Hoon Kim Seung Jong Oh Min Gew Choi Jae Hyung Noh Tae Sung Sohn Jae Moon Bae Sung Kim Department of Surgery Samsung Medical CenterSungkyunkwan University School of Medicine50 Irwon-dongGangnamguSeoul 135-710South Korea

AIM： To investigate the correlation between the nutri- tional risk index （NRI） and postoperative wound com- plications.

关键词： Nutritional risk index Wound complication Gastric cancer

Pembrolizumab-induced psoriatic arthritis treated with disease-modifying anti-rheumatic drugs in a patient with gastric cancer:A case report

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World Journal of Clinical Cases 2023年第1期11卷 218-224页

作者： Sehan Kim Jong Hee Sun Hongsik Kim Hee Kyung Kim Yaewon Yang Jun Su Lee In ah Choi Hye Sook Han Department of Internal Medicine Chungbuk National University HospitalCheongju 28644South Korea Department of Gastroenterology Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505South Korea Department of Internal Medicine Chungbuk National University HospitalChungbuk National University College of MedicineCheongju 28644South Korea

BACKGROUND Immune checkpoint inhibitor(ICI)-induced rheumatic immune-related adverse events(ir AEs)have been infrequently reported,and the treatment of severe or refractory arthritis as ir AEs has not been established *** SUMMARY The patient was a 67-year-old man with a history of well-controlled foot psoriasis who presented with *** had received pembrolizumab for metastatic gastric adenocarcinoma 2 mo *** examination revealed erythematous swelling in the distal interphalangeal joints,left shoulder,and both *** had plaque psoriasis with psoriatic nail dystrophy and dactylitis in the distal joints of the fingers and *** markers including C-reactive protein and erythrocyte sedimentation rate were elevated but rheumatoid factor and anticyclic citrullinated peptide antibody were *** patient was diagnosed with psoriatic arthritis(PsA)and started on methylprednisolone 1 mg/kg/day after pembrolizumab ***,despite 1 wk of methylprednisolone treatment,PsA worsened;hence,leflunomide and methotrexate were *** 4 wk of steroid treatment,PsA worsened and improved repeatedly with steroid ***,the therapy was intensified to include etanercept,a tumor necrosis factor inhibitor,which ultimately resulted in adequate PsA *** This is the first report of ICI-induced PsA in a gastric cancer *** rheumatic ir AEs with refractory severe arthritis may require disease-modifying anti-rheumatic drugs and long-term management.

关键词： Pembrolizumab Psoriatic arthritis Disease-modifying anti-rheumatic drugs Gastric cancer Case report

Perceived risk as a barrier to appropriate diagnosis of irritable bowel syndrome

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World Journal of Gastroenterology 2014年第48期20卷 18360-18366页

作者： Eunmi ahn Ki Young Son Dong Wook Shin Min Kyu Han Hyejin Lee ah Reum An Eun Ho Kim Be Long Cho Department of Family Medicine Seoul National University Hospital Cancer Survivorship Clinic Seoul National University Cancer HospitalSeoul 110-744 South Korea

AIM: To evaluate perceived risk, diagnostic testing, and acceptance of a diagnosis of irritable bowel syndrome (IBS) among the Korean laypersons.

关键词： Diagnostic testing Patient attitude Positive diagnosis Functional gastrointestinal disease Irritable bowel syndrome

Kinetic Rates of the Fischer Tropsch Synthesis on a Co/Nb_2O_5 Catalyst

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Journal of Natural Gas Chemistry 2006年第4期15卷 307-312页

作者： Víctor R.ahón Paulo L.C.Lage Carlos D.D.de Souza Fabiana M.Mendes Martin Schmal Federal University of Rio de Janeiro Programa de Engenharia Química COPPE/UFRJ C.P.6850221941-972Rio de JaneiroRJBrazil

The kinetics of the Fischer-Tropsch reaction over a Co/Nb2O5 catalyst in a fixed bed reactor was investigated experimentally. Experiments were carried out under isothermal and isobaric conditions （T=543 K, P=2.1 MPa） and under different conditions of several H2/CO feed molar ratio （0.49-4.79）, space velocities （0.2-3.8 h^-1）, mass of catalyst （0.3-1.5 g）, and CO conversion （10%-29%）. Synthesis gas conversion was measured and data were reduced to estimate the kinetic parameters for different Langmuir-Hinshelwood rate expressions. Differential and integral reactor models were used for the nonlinear regression of kinetics parameters. One of the rate equations could well explain the data. The hydrocarbon product distributions that were experimentally determined exhibited an unusual behavior, and a possible explanation was discussed.

关键词： Fischer-Tropsch natural gas kinetics selectivity

Cetuximab plus irinotecan in pretreated metastatic colorectal cancer patients:The ELSIE study

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World Journal of Gastroenterology 2011年第14期17卷 1879-1888页

作者： Robert Lim Yan Sun Seock-ah Im Ruey-Kuen Hsieh Tsz Kok Yau Anthony Bonaventura Arkom Cheirsilpa Regina Esser Matthias Mueser Suresh Advani Department of Hematology-Oncology National University Hospital 119074 Singapore Singapore Department of Medical Oncology Cancer Hospital and Institute Chinese Academy of Medical Science Beijing 100021 China Division of Hematology-Oncology Department of Internal Medicine Seoul National University Hospital Seoul 110-744 South Korea Department of Oncology-Hematology Mackay Memorial Hospital Taipei 104 Taiwan China Department of Clinical Oncology Pamela Youde Nethersole Eastern Hospital Hong Kong China Department of Medical Oncology Calvary Mater Newcastle Hospital Waratah New South Wales 2298. Australia National Cancer Institute Bangkok 10400 Thailand Global Clinical Development Unit Oncology Merck KGaA Darmstadt 64293 Germany Medical Affairs Oncology Asia Pacific Merck Serono 609927 Singapore Singapore Jaslok Hospital and Research Centre Mumbai 400026 India

AIM:To evaluate the efficacy and safety of cetuxim-ab plus irinotecan in irinotecan-refractory metastatic colorectal cancer (mCRC) patients from South-East Asia and Australia. METHODS:In this open-label,phase Ⅱ study,the main eligibility criteria were epidermal growth factor receptor-positive mCRC with progressive disease within 3 mo of an irinotecan-based regimen as the most recent chemotherapy. Patients received cetuximab 400 mg/m2 initially,then 250 mg/m2 every week,with the same regimen of irinotecan on which the patients had progressed (4 pre-defined regim-ens allowed). The prim-ary objective was evaluation of progression-free survival (PFS) at 12 wk. Secondary objectives included a further investigation of PFS,and an assessment of the overall response rate (ORR),duration of response,time to treatment failure (TTF),overall survival and the safety profile. RESULTS:One hundred and twenty nine patients were enrolled from-25 centers in the Asia-Pacific region and of these 123 received cetuximab plus irinotecan. The most common recent irinotecan regimen used was 180 mg/m2 every 2 wk which had been used in 93 patients (75.6%). The PFS rate at 12 wk was 50% (95% confidence interval (CI,41-59) and m-edian PFS tim-e was 12.1 wk (95% CI:9.7-17.7). The ORR was 13.8% (95% CI:8.3-21.2) and disease control rate was 49.6% (95% CI:40.5-58.8). Median duration of response was 31.1 wk (95% CI:18.0-42.6) and median overall survival was 9.5 mo (95% CI,7.5-11.7). The median TTF was 11.7 wk (95% CI:9.1-17.4). Treatment was generally well tolerated. The most common grade 3/4 adverse events were diarrhea (13.8%),neutropenia (8.9%),rash (5.7%) and vomiting (5.7%).CONCLUSION:In patients from Asia and Australia,this study confirm-s the activity and safety of cetuxim-ab plus irinotecan observed in previous studies in Europe and South America.

关键词： Epidermal growth factor receptor Cetuximab Irinotecan Metastatic colorectal cancer Asia

Inhibition of advanced glycation endproducts formation by Korean thistle,Cirsium maackii

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Asian Pacific Journal of Tropical Medicine 2015年第1期8卷 1-5页

作者： Hyun ah Jung Jin Ju Park Byung Sun Min Hee Jin Jung Md.Nurul Islam Jae Sue Choi Department of Food Science and Human Nutrition Chonbuk National University Department of Food and Life Science Pukyong National University College of Pharmacy Catholic University of Daegu

Objective:To evaluate inhibitoy potential of seven Korean thistles against the advanced glyeatinn endproducts(AGE) formation as well as to identify responsible compounds from the most active ***:We used an in vitro AGE inhibition assay to evaluate the antidiabetic complication potential of the methanol extracts of the selected Korean ***:Among the seven Korean thistles,the leaves of Cirsium maackii(***) exhibited the most significant inhibitory activity against AGE *** means of bioassay-directed fractionation,a *** acid and 14 flavonoids were isolated from the active ethyl acetate soluble fraction of a methanol extract from *** *** and its 5-O-glueoside have been previously isolated:however,a lignan and 13 known compounds were isolated for the first lime from C maackii leaves in this *** of the isolated compounds exhibited inhibitory activities against potential AGE *** them,cernuoside was shown to be the most potent AGE inhibitor with an IC_(50) value of 21.21 μ mol/*** importantly,two major flavonoids,luteolin and ils 5-O-glucoside,also significantly inhibited AGE formation,with IC_(50) values of36.33 and 37.47 μmol/L,*** activity relationship revealed that the presence of free 3'and 4' dihydroxyl group in flavonoids skeleton played an important role in AGE ***:These results indicate that *** and C maackii-derived flavonoids might be explored further to develop therapeutic agents for the prevention of diabetic eoniplicalions due to their significant inhibitory activity against AGE formation.

关键词： Flavonoids Thistle Advanced glycation endproducts Diabetic complications Cirsium maackii

A Beautiful Screen Tells a Classic Story

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Women of China 1996年第9期 2-3页

作者： TANG XUEGEN ZHU ah ZHU

Scenes from Dream of Red Mansions, a masterpiece of classic Chinese literature, have been recreated in stone. Entitled "Stories from Dream of Red Mansions," the new work of fine workmanship took some three years and more than 80,000 working hours to complete. Fifty-two screens are linked to each other. stretching 70 meters in length, 2.3 meters

关键词： length

The Characteristics of Costume Representation in Modern Society

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The Characteristics of Costume Representation in Modern Soci...