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Sickle Cell Disease in Children: An Exploration of Family Resilience through the Experiences of Family Caregivers

Open Journal of Nursing 2019年第4期9卷 347-363页

作者： Dorothy C. Nwanonyiri Catherine Jirak Monetti sharon Boyd-jackson Department of Nursing Kean University Union NJ USA Department of Psychology Kean University Union NJ USA

Background: Sickle cell disease (SCD) is a chronic and potentially life-threatening genetic blood disorder with childhood onset. Caring for children with SCD can precipitate greater than average time demands, medical costs, employment constraints, and childcare challenges. Research has shown that family resilience is a key construct capable of enhancing family health and well-being, as well as neutralizing the burden of caring for an ill child. Aim: Applying the Family Resilience Model, this qualitative study involved exploring the phenomenon of family resilience through the perceptions and lived experiences of family caregivers of children with SCD. Methods: 10 self-identified primary SCD caregivers were recruited with the help of the Sickle Cell Association of New Jersey (SCANJ). Three researches and five open-ended interview questions elicited participants’ descriptions of their lived experiences. Results: Using an Interpretive Phenomenological Approach and Donabedian’s conceptual model to analyze data, three categories emerged from verbatim transcriptions of interviews: family experiences and caring for a child with SCD (Structure);family strengths (Process);and resilience & adaptation (Outcome). The emergent theme was Key Family Strengths Fosters Family Resilience and Adaptation. Conclusions: Findings from this study offered insight into the diverse experiences of caring for children with SCD in the framework of family resilience. Results can facilitate the enhancement of family resilience and adaptation for future families and in designing care specifically tailored for these family caregivers. Recognizing resilience processes utilized by family caregivers of children with SCD is important for future research and to render support by healthcare practitioners.

关键词： Chronic Illness Family Adaptation Family Resilience Sickle Cell Disease

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Screening Helicobacter pylori genes induced during infection of mouse stomachs

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World Journal of Gastroenterology 2012年第32期18卷 4323-4334页

作者： Aparna Singh Nathaniel Hodgson Ming Yan Jungsoo Joo Lei Gu Hong Sang Emmalena Gregory-Bryson William G Wood Yisheng Ni Kimberly Smith sharon H jackson William G Coleman Laboratory of Biochemistry and Genetics National Institute of Diabetes and Digestive and Kidney Diseases National Institutes of Health Bethesda MD 20892 United States Laboratory of Host Defenses National Institute of Allergy and Infectious Diseases National Institutes of Health Bethesda MD 20892 United States

AIM:To investigate the effect of in vivo environment on gene expression in Helicobacter pylori(***) as it relates to its survival in the ***:In vivo expression technology(IVET) systems are used to identify microbial virulence *** modified the IVET-transcriptional fusion vector,pIVET8,which uses antibiotic resistance as the basis for selection of candidate genes in host tissues to develop two unique IVET-promoter-screening vectors,pIVET11 and *** novel IVET systems were developed by the fusion of random Sau3A DNA fragments of *** and a tandem-reporter system of chloramphenicol acetyltransferase and ***,each vector contains a kanamycin resistance *** used a mouse macrophage cell line,RAW 264.7 and mice,as selective media to identify specific genes that *** expresses in *** expression studies were conducted by infecting RAW 264.7 cells with *** was followed by real time polymerase chain reaction(PCR) analysis to determine the relative expression levels of in vivo induced ***:In this study,we have identified 31 in vivo induced(ivi) genes in the initial *** 31 genes belong to several functional gene families,including several well-known virulence factors that are expressed by the bacterium in infected mouse *** factors,vacA and cagA,were found in this screen and are known to play important roles in *** infection,colonization and *** detection validates the efficacy of these screening *** of the identified ivi genes have already been implicated to play an important role in the pathogenesis of *** and other bacterial pathogens such as Escherichia coli and Vibrio *** profiles of allivi genes were confirmed by real time PCR analysis of *** RNA isolated from *** infected RAW 264.7 *** compared the expression profile of *** and RAW 264.7 coculture with that of *** *** ge

关键词： Helicobacter pylori In vivo expression technology Virulence genes Mice Infection

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体重调整固定剂量普通肝素与低分子肝素治疗急性静脉血栓栓塞的比较

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美国医学会杂志（中文版） 2007年第5期26卷 259-264页

作者： Clive Kearon Jeffrey S. Ginsberg Jim A. Julian James Douketis Susan Solymoss Paul Ockelford sharon jackson Alexander G. Turpie Betsy MacKinnon Jack Hirsh Michael Gent 王春玲（译）孙艺红（译）胡大一（校） McMaster University and the Henderson Research Centre Hamilton Ontario McGill University Montreal Quebec McGill University and University of Auckland Auckland New Zealand

背景：普通肝素用于治疗急性静脉血栓栓塞时，通常在监测血凝下静脉输注给药，患者需要住院治疗。然而，体重调整后皮下注射固定剂量普通肝素可能既适用于住院也适用于门诊静脉血栓栓塞患者的治疗。目的：确定皮下注射体重调整固定剂量... 详细信息

背景：普通肝素用于治疗急性静脉血栓栓塞时，通常在监测血凝下静脉输注给药，患者需要住院治疗。然而，体重调整后皮下注射固定剂量普通肝素可能既适用于住院也适用于门诊静脉血栓栓塞患者的治疗。目的：确定皮下注射体重调整固定剂量普通肝素治疗静脉血栓栓塞是否与低分子肝素同样安全有效。设计、地点及患者：随机、开标、裁定者盲法、非劣效试验。708例急性静脉血栓栓塞患者来自加拿大和新西兰6所大学附属临床中心，年龄≥18岁。试验于1998年9月至2004年2月进行。在随机分组的患者中，11例从疗效分析中排除，8例从安全性分析中排除。干预：普通肝素皮下注射初始剂量为333U／kg，以后给予固定剂量250U／kg，每12小时1次（n=345）。低分子肝素（依诺肝素或达肝素）按100IU／kg剂量皮下注射，每12小时1次（n=352）。两种治疗均可院外进行，配合华法林治疗3个月。主要观测指标：随机分组后3个月内复发性静脉血栓栓塞事件及10天内严重出血情况。结果：普通肝素组有13例患者（3．8％）发生静脉血栓栓塞复发，而低分子肝素组有12例患者复发（3．4％；绝对差值，0．4％；95％可信区间，-2．6％～3．3％）。开始治疗后10天内普通肝素组有4例患者（1．1％）发生严重出血，而低分子肝素组有5例（1．4％；绝对差值，-0．3％；95％可信区间，-2．3％～1．7％）。院外治疗患者在普通肝素组占72％，低分子肝素组占68％。结论：对于急性静脉血栓栓塞患者而言，皮下注射固定剂量普通肝素与低分子肝素一样安全有效，适于门诊治疗。

关键词：低分子肝素治疗静脉血栓栓塞普通肝素固定剂量急性体重安全性分析皮下注射

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美国Paradox盆地盐构造新生代的拉伸活化(英文)

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高校地质学报 2008年第1期14卷 49-63页

作者：戈红星 jackson Martin P．A MOSHER sharon ConocoPhillipsCompany P．D．Box2197HoustonTexas77252USA． Bureau of Economic Geology The University of Texas at AustinAustinTexas 78713USA Department of Geological Sciences The University of Texasat AustinAustinTexas 78713USA

美国科罗拉多高原Paradox盆地中的裂口盐墙和盐背斜,主要是在古生界和中生界沉积物的差异负载作用下发育起来的。盐构造顶部的平缓褶皱,通常被认为是晚白垩纪至古新世拉腊米挤压运动的产物,而其脊顶地堑与山谷,则被认为是挤压后的松弛... 详细信息

美国科罗拉多高原Paradox盆地中的裂口盐墙和盐背斜,主要是在古生界和中生界沉积物的差异负载作用下发育起来的。盐构造顶部的平缓褶皱,通常被认为是晚白垩纪至古新世拉腊米挤压运动的产物,而其脊顶地堑与山谷,则被认为是挤压后的松弛拉伸及盐溶作用所造成的。基于野外调查、物理模拟以及现代盐构造学理论,研究认为这些平缓褶皱和脊顶地堑,主要是新生代始新世至渐新世北北东向区域拉伸作用的产物。因为岩盐较其围岩软弱,拉伸形变主要集中在早先形成的盐墙、盐背斜及其较薄的顶板中,使盐构造发生活化并形成新的拉伸构造。顶板中的拉伸构造主要包括正断层、地堑、断层滑移(断滑)褶皱以及滚动褶皱。由于区域拉伸方向斜交盐构造走向,断层分布多呈羽列状。在母盐层较厚地区,拉伸使盐刺穿在正断层之下次动上升;而在母盐层较薄地区,拉伸使盐刺穿下降。在初始盐刺穿较高地区,盐构造的侧翼下降;而在初始盐刺穿较低地区,盐构造整体下降。拉伸使盐刺穿变宽,脊顶地堑下沉,形成拉伸型下降盐刺穿特征性的尖角盐体构造。局部地区,盐体从破碎的顶板间溢出,覆盖了下沉的脊顶地堑。

关键词： Paradox盆地盐构造拉伸活化下降盐刺穿断滑褶皱滚动褶皱构造地质学

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GFP Expression from A Biologically Active Minireplicon of Sonchus Yellow Net Virus

GFP Expression from A Biologically Active Minireplicon of So...

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中国植物病理学会2011年学术年会

作者： Andrew O.jackson Uma Ganesan Manling Shi Jennifer N.Bragg Mi-Yeon Lee Justin Kappel Cole Peters sharon Marr University of California BerkeleyCA 94720

＜正＞Sonchus yellow net virus（SYNV） is an extensively characterized plant rhabdovirus that replicates in the nucleus and undergoes morphogenesis at the inner nuclear *** minimum infectious unit of SYNV is a ribonucleoprotein core complex,consisting of the nucleocapsid（N） protein,the phosphoprotein（P） and the polymerase（L） protein complexed with the negative-strand genomic（g） *** genetic analysis of plant negative strand viruses,in contrast to animal negative strand

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