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Neural Regeneration Research 2025年第7期20卷 2011-2012页

作者： sharon j.brown Rafael j.Yáñez-Muñoz Heidi R.Fuller School of Pharmacy and Bioengineering Keele UniversityKeeleUK Wolfson Center for Inherited Neuromuscular Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

Spinal muscular atrophy(SMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of SMA was understood in 1995 when loss or impairment of the survival motor neuron 1(SMN1)gene was identified as the main contributing factor(Lefebvre et al.,1995).This,in combination with the discovery that humans have a“back-up”gene,SMN2,which can produce low levels(approximately 10%)of the full-length functional SMN protein,has led to the generation of SMA-specific gene *** was traditionally classified according to age of symptom onset and developmental milestones achieved,with life expectancy and severity varying between ***,SMN2 copy number is used as a proxy for the prediction of disease severity,with higher SMN2 copy number typically being associated with reduced severity of SMA,although this relationship is not absolute:some individuals with low SMN2 copy number have less severe SMA phenotypes and vice ***,the etiology of SMA is further complicated by other factors,such as non-typical nucleotide variants and SMN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute

XGBoost model for electrocaloric temperature change prediction in ceramics

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npj Computational Materials 2022年第1期8卷 1308-1317页

作者： jie Gong sharon Chu Rohan K.Mehta Alan j.H.McGaughey Department of Mechanical Engineering Carnegie Mellon UniversityPittsburghPA15213USA

An eXtreme Gradient Boosting(XGBoost)machine learning model is built to predict the electrocaloric(EC)temperature change of a ceramic based on its composition(encoded by Magpie elemental properties),dielectric constant,Curie temperature,and characterization conditions.A dataset of 97 EC ceramics is assembled from the experimental *** sampling data from clusters in the feature space,the model can achieve a coefficient of determination of 0.77 and a root mean square error of 0.38 K for the test *** analysis shows that the model captures known physics for effective EC *** Magpie features help the model to distinguish between materials,with the elemental electronegativities and ionic charges identified as key *** model is applied to 66 ferroelectrics whose EC performance has not been ***-free candidates with a predicted EC temperature change above 2 K at room temperature and 100 kV/cm are identified.

关键词： ceramics materials ceramic

Role of farnesoid X receptor and bile acids in alcoholic liver disease

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Acta Pharmaceutica Sinica B 2015年第2期5卷 158-167页

作者： sharon Manley Wenxing Ding Department of Pharmacology Toxicology and Therapeutics the University of Kansas Medical Center

Alcoholic liver disease(ALD) is one of the major causes of liver morbidity and mortality worldwide. Chronic alcohol consumption leads to development of liver pathogenesis encompassing steatosis, inflammation, fibrosis, cirrhosis, and in extreme cases, hepatocellular carcinoma. Moreover,ALD may also associate with cholestasis. Emerging evidence now suggests that farnesoid X receptor(FXR) and bile acids also play important roles in ALD. In this review, we discuss the effects of alcohol consumption on FXR, bile acids and gut microbiome as well as their impacts on ALD. Moreover, we summarize the findings on FXR, Fox O3a(forkhead box-containing protein class O3a) and PPARα(peroxisome proliferator-activated receptor alpha) in regulation of autophagy-related gene transcription program and liver injury in response to alcohol exposure.

关键词： Farnesoid X receptor Bile acids Autophagy Alcoholic liver disease FoxO3

Featuring the Nd:YAG laser capsulotomy in the operating room

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International journal of Ophthalmology(English edition) 2020年第3期13卷 523-524页

作者： Veronique Promelle sharon Armarnik Christopher j Lyons Department of Ophthalmology and Visual Sciences University of British ColumbiaVancouver V5Z 3N9Canada

Dear Editor,We read with interest the article of Kinori et al[1]titled’Pediatric Nd:YAG laser capsulotomy in the operating room:review of 87 cases’.Facilities for laser capsulotomy under general anesthesia are essen... 详细信息

关键词： Featuring the Nd:YAG laser capsulotomy in the operating room YAG

Hotspot of Adult Cuban Treefrog and Cane Toad Multi-organ Abnormality in Suburban South-west Florida

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Asian Herpetological Research 2020年第2期11卷 139-154页

作者： sharon Pratt ANZALDUA javier GOLDBERG Private University 27427 Horne Ave Bonita SpringsFlorida 34135USA Instituto de Bio y Geociencias del NOA(IBIGEO-CONICET) CCT-Salta9 de Julio 14Rosario de LermaSalta 4405Argentina

This study represents a continuation of the Florida hotspot of tadpole abnormality found in the Southwest Florida suburban roadside drainage ditches in 2012 to determine if the adult frogs and toads frequenting the study sites were anatomically *** gross examination of all organs included 397 adult anurans and 40 metamorphs representing five anuran species:Osteopilus septentrionalis(N=364),Rhinella marina(N=60),Lithobates sphenocephala(N=7),Anaxyrus terrestris(N=5)and Anaxyrus americanus(N=1).The gonads,liver,kidney and intestines were abnormal at a frequency of 87.4%.The few normal anurans(12.6%)were females and young male *** found a significant difference in organ abnormality type and f requency between *** all f rog and toad males had testicular abnormality(92%)with only 6%with normal testes,whereas the female gonad abnormality was lower,at 41.6%.Hermaphroditism was found in both sexes at a frequency of 26.2%.The toads had a significantly higher frequency of hermaphroditism than the *** toad hermaphroditism frequency was found to be 40%,whereas the frog hermaphroditism 23.3%.A hermaphrodite Cane toad male with a female phenotype coexisted with the normal male phenotype *** fertility of 27 in situ pairs was *** fertile testicular abnormal male and hermaphrodite pairs produced offspring with abnormal larval *** information adds new evidence of the effect of chemicals on wild populations and the effect on non-target species which has always been underestimated.

关键词： gonad hermaphrodite malformation Osteopilus septentrionalis Rhinella marina

Immunological battlefield in gastric cancer and role of immunotherapies

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World journal of Gastroenterology 2016年第28期22卷 6373-6384页

作者： Minyu Wang Rita A Busuttil sharon Pattison Paul j Neeson Alex Boussioutas Cancer Genetics and Genomics Laboratory Peter MacCallum Cancer Centre East Melbourne 3002 Victoria Australia Sir Peter MacCallum Department of Oncology The University of Melbourne Parkville 3050 Victoria Australia Department of Medicine The University of Melbourne Royal Melbourne Hospital Parkville 3050 Victoria Australia Department of Medicine Dunedin School of Medicine University of Otago Dunedin 9016 New Zealand Southern Blood and Cancer Service Southern District Health Board Dunedin 9054 New Zealand Cancer Immunology Research Peter MacCallum Cancer Centre East Melbourne 3002 Victoria Australia Pathology Department University of Melbourne Parkville 3050 Victoria Australia

Like the wars predating the First World War where human foot soldiers were deemed tools in the battlefield against an enemy, so too are the host immune cells of a patient battling a malignant gastric cancer. Indeed, the tumour microenvironment resembles a battlefield, where the patient's immune cells are the defence against invading tumour cells. However, the relationship between different immune components of the host response to cancer is more complex than an "us against them" model. Components of the immune system inadvertently work against the interests of the host and become pro-tumourigenic while other components soldier on against the common enemy – the tumour cell.

关键词： Immune Gastric cancer Immune therapy Immunology Tumour microenvironment

A Focused Laser Beam:A Useful and Versatile Tool for 1D Nanomaterials Research:A Review

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journal of Materials Science & Technology 2015年第6期31卷 616-629页

作者： junpeng Lu sharon Xiaodai Lim Chorng Haur Sow Department of Physics National University of Singapore Department of Science Drive National University of Singapore National University of Singapore

One-dimensional(1D) nanomaterials have generated considerable interest amongst researchers because of their potential as fundamental building block in future nano- and micro-electronic *** this article,we present a review of a focused laser beam system as a versatile tool for the manipulation,structural transformation,micropatterning and chemical modification of 1D *** tool was found to be effective in patterning and modifying various physical and chemical properties of the pristine1 D *** also aids in the fabrication process of heterostructures and 1D nanomaterial based ***,we present the implementation of the focused laser beam setup as a valuable tool in the study of the origins and photoresponse mechanism of the 1D nanomaterial devices.

关键词： Laser Nanomaterials Composite Optoelectronic Elect

Effects of oxidation pretreatment temperature on Kovar used as CO_2 reforming catalyst

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燃料化学学报 2014年第5期42卷 573-581页

作者： sharon Rose de la Rama Hiroshi Yamada Tomohiko Tagawa Department of Chemical Engineering Nagoya University Chikusa

The effect of oxidation pretreatment temperature(500 ~ 1 000 ℃) on the catalytic activity of Kovar applied on hydrocarbon CO2reforming was examined. Catalytic performance evaluation using tetradecane at 800 ℃ with 70 μmol/s CO2revealed 700 and 1 000 ℃ as the best pre-oxidation temperature in producing CO and H2,respectively. XRD and SEM-EDX analyses showed that a separate metal oxide layer composed of iron oxide(Fe2O3and F3O4),nickel,cobalt,and possibly their respective oxides started to form when oxidation was conducted at 700 ℃ or *** presence of iron enhanced the stability of nickel in the structure while the compact structure of Fe3O4resulted into the formation of a thick and rigid metal oxide layer on the surface of the Kovar tube. The strong physical bond between the metal oxide layer and Kovar tube provided the catalyst good mechanical strength and consequently good catalytic activity.

关键词：燃烧化学化学原理理论研究

Characterization of nanoparticle mixed 316L powder for additive manufacturing

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journal of Materials Science & Technology 2020年第12期47卷 162-168页

作者： Wengang Zhai Wei Zhou sharon Mui Ling Nai jun Wei School of Mechanical and Aerospace Engineering Nanyang Technological University50 Nanyang Avenue639798Singapore Singapore Institute of Manufacturing Technology 73 Nanyang Drive637662Singapore

Nanoparticles reinforced steels have many advantaged mechanical *** manufacturing offers a new method for fabricating nanoparticles reinforced high performance metal *** this work,we report the application of low energy ball milling in mixing nanoparticles and micron 316 L *** this method,0.3 and 1.0 wt% Y2 O3 nanoparticles can be uniformly distributed on the surface of 316 L powder with the parameters of ball-to-powder ratio at 1:1,speed at 90 rpm and 7 h of *** matrix 316 L powders remain spherical in shape after the mixing *** the meantime,the effect of low energy ball milling and the addition of Y2 O3 nanoparticles on the powder characteristics(flowability,apparent density and tap density) are also *** show that the process of low energy ball milling itself can slightly decrease the flowability and apparent density of the 316 L *** addition of 0.3 and 1.0 wt% Y2 O3 nanoparticles can also decrease the flowability,the tap density and the apparent density compared with the original 316 L *** of these changes result from the rough surface of the mixed powder produced by ball milling and the addition of Y2 O3 *** powder’s rough surface can increase the coefficient of friction of *** mixture of 316 L powder and Y2 O3 nanoparticles can be successfully used for selective laser melting(SLM).The relative density of SLM 316 L-Y2 O3 is measured at 99.5%.However,Y2 O3 agglomerations were observed which is due to the poor wettability between 316 L and Y2 O3.

关键词： Powder mixing Powder characterization Flowability Apparent density Tap density Additive manufacturing

Analysis of the corrosion performance of binder jet additive manufactured magnesium alloys for biomedical applications

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journal of Magnesium and Alloys 2022年第5期10卷 1296-1310页

作者： Kai Xiang Kuah Daniel j.Blackwood Wee Kit Ong Mojtaba Salehi Hang Li Seet Mui Ling sharon Nai Sudesh Wijesinghe Department of Materials Science&Engineering National University of Singapore9 Engineering Drive 1117575 Singapore Reliability and Characterisation Unit Singapore Institute of Manufacturing Technology(SIMTech)Agency forScienceTechnology and Research(A^(∗)STAR)73 Nanyang Drive637662 Singapore Additive Manufacturing Group Singapore Institute of Manufacturing Technology(SIMTech)Agency forScienceTechnology and Research(A^(∗)STAR)73 Nanyang Drive637662 Singapore

Binder jet printing(BjP)is a state-of-the-art additive manufacturing technique for producing porous magnesium *** MgZn-Zr based BjP samples were assessed for corrosion performance in simulated body fluids by electrochemical and hydrogen evolution *** corrosion rates of the BjP specimens were significantly higher than solid controls,even after accounting for their larger surface areas,suggesting that the BjP microstructure is detrimental to corrosion performance.X-ray computed tomography revealed nonuniform corrosion within the porous structure,with corrosion products forming on the pore *** the pores with hydroxyapatite or polymers greatly improved the corrosion resistance of the BjP samples.

关键词： Magnesium Additive manufacturing Binder jetting Porous Corrosion Biodegradability