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Neural Regeneration Research 2025年第7期20卷 2011-2012页

作者： sharon J.Brown Rafael J.Yáñez-Muñoz Heidi R.Fuller School of Pharmacy and Bioengineering Keele UniversityKeeleUK Wolfson Center for Inherited Neuromuscular Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

Spinal muscular atrophy(SMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of SMA was understood in 1995 when loss or impairment of the survival motor neuron 1(SMN1)gene was identified as the main contributing factor(Lefebvre et al.,1995).This,in combination with the discovery that humans have a“back-up”gene,SMN2,which can produce low levels(approximately 10%)of the full-length functional SMN protein,has led to the generation of SMA-specific gene *** was traditionally classified according to age of symptom onset and developmental milestones achieved,with life expectancy and severity varying between ***,SMN2 copy number is used as a proxy for the prediction of disease severity,with higher SMN2 copy number typically being associated with reduced severity of SMA,although this relationship is not absolute:some individuals with low SMN2 copy number have less severe SMA phenotypes and vice ***,the etiology of SMA is further complicated by other factors,such as non-typical nucleotide variants and SMN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute

Sampling: Design and Analysis 1

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1999年

作者： sharon L. Lohr

ISBN: (纸本)9780534353612

sharon L. Lohr's SAMPLING: DESIGN AND ANALYSIS provides a modern introduction to the field of sampling. With a multitude of applications from a variety of disciplines, the book concentrates on the statistical aspects of taking and analyzing a sample. Overall, the book gives guidance on how to tell when a sample is valid or not, and how to design and analyze many different forms of sample surveys

关键词： Sampling (Statistics)

Role of farnesoid X receptor and bile acids in alcoholic liver disease

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Acta Pharmaceutica Sinica B 2015年第2期5卷 158-167页

作者： sharon Manley Wenxing Ding Department of Pharmacology Toxicology and Therapeutics the University of Kansas Medical Center

Alcoholic liver disease(ALD) is one of the major causes of liver morbidity and mortality worldwide. Chronic alcohol consumption leads to development of liver pathogenesis encompassing steatosis, inflammation, fibrosis, cirrhosis, and in extreme cases, hepatocellular carcinoma. Moreover,ALD may also associate with cholestasis. Emerging evidence now suggests that farnesoid X receptor(FXR) and bile acids also play important roles in ALD. In this review, we discuss the effects of alcohol consumption on FXR, bile acids and gut microbiome as well as their impacts on ALD. Moreover, we summarize the findings on FXR, Fox O3a(forkhead box-containing protein class O3a) and PPARα(peroxisome proliferator-activated receptor alpha) in regulation of autophagy-related gene transcription program and liver injury in response to alcohol exposure.

关键词： Farnesoid X receptor Bile acids Autophagy Alcoholic liver disease FoxO3

Hotspot of Adult Cuban Treefrog and Cane Toad Multi-organ Abnormality in Suburban South-west Florida

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Asian Herpetological Research 2020年第2期11卷 139-154页

作者： sharon Pratt ANZALDUA Javier GOLDBERG Private University 27427 Horne Ave Bonita SpringsFlorida 34135USA Instituto de Bio y Geociencias del NOA(IBIGEO-CONICET) CCT-Salta9 de Julio 14Rosario de LermaSalta 4405Argentina

This study represents a continuation of the Florida hotspot of tadpole abnormality found in the Southwest Florida suburban roadside drainage ditches in 2012 to determine if the adult frogs and toads frequenting the study sites were anatomically *** gross examination of all organs included 397 adult anurans and 40 metamorphs representing five anuran species:Osteopilus septentrionalis(N=364),Rhinella marina(N=60),Lithobates sphenocephala(N=7),Anaxyrus terrestris(N=5)and Anaxyrus americanus(N=1).The gonads,liver,kidney and intestines were abnormal at a frequency of 87.4%.The few normal anurans(12.6%)were females and young male *** found a significant difference in organ abnormality type and f requency between *** all f rog and toad males had testicular abnormality(92%)with only 6%with normal testes,whereas the female gonad abnormality was lower,at 41.6%.Hermaphroditism was found in both sexes at a frequency of 26.2%.The toads had a significantly higher frequency of hermaphroditism than the *** toad hermaphroditism frequency was found to be 40%,whereas the frog hermaphroditism 23.3%.A hermaphrodite Cane toad male with a female phenotype coexisted with the normal male phenotype *** fertility of 27 in situ pairs was *** fertile testicular abnormal male and hermaphrodite pairs produced offspring with abnormal larval *** information adds new evidence of the effect of chemicals on wild populations and the effect on non-target species which has always been underestimated.

关键词： gonad hermaphrodite malformation Osteopilus septentrionalis Rhinella marina

MULTIFAMILY AFFORDABLE HOUSING THAT IS HEALTHY,EFFICIENT,COST EFFECTIVE AND LEED PLATINUM

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Journal of Green Building 2017年第1期12卷 36-44页

作者： sharon Patterson Grant Eco Edge.PO Box 6205 KetchumID 83340

INTRODUCTION A developer who had chronic asthma as a child built the first LEED^(■)(Leadership in Energy and Environmental Design)Platinum certified apartment complex in *** has also heard from two residents that their asthma no longer resulted in attacks due to eliminating triggers in the interior *** years and a dozen multifamily affordable housing projects later,the LEED consultant on these projects has gathered insight on best practices,lessons learned and strate-gies that result in resident,owner and project team *** projects have achieved LEED Platinum certification(two more are still under construction,but are on track for Platinum),and the HERS(Home Energy Rating System)scores are as low as *** has been collected on what works,what doesn’t and what matters most:from low energy bills to living in a healthy home and not having asthma *** projects debunk the assumptions that energy effi-ciency adds too much cost or that green homes are only for the wealthy.

关键词： LEED healthy homes energy efficient cost effective asthma affordable housing green building integrated design design charrette high performance

循证医学实践和教学 how to practice and teach EBM 3版

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丛书名：北京大学循证医学中心循证医学系列丛书

2006年

作者： sharon E. Straus等原詹思延主译

本书提出循证医学的临床问题，论述了如何发现当前的最佳证据、诊断和筛检、治疗、危害、教学方法、评价等内容。并附词汇表。

ISBN: (纸本)7811161931

本书提出循证医学的临床问题，论述了如何发现当前的最佳证据、诊断和筛检、治疗、危害、教学方法、评价等内容。并附词汇表。

关键词：临床医学研究

Medical-surgical nursing : assessment and management of clinical problems /

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2004年

作者： Lewis sharon Mantik.

Sampling : :design and analysis / 影印

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丛书名：外国优秀统计学教材系列丛书

2002年

作者： Lohr sharon L.

本书以原版英文的方式对抽样进行了详细介绍，具体包括：引言；简单概率抽样；比率和回归估计；分层抽样；等概率整群抽样；不等概率抽样；复杂调查；无响应；在复杂调查中的方差估计；复杂调查的分类数据分析；复杂调查数据回归；抽样... 详细信息

ISBN: (纸本)7503739533

本书以原版英文的方式对抽样进行了详细介绍，具体包括：引言；简单概率抽样；比率和回归估计；分层抽样；等概率整群抽样；不等概率抽样；复杂调查；无响应；在复杂调查中的方差估计；复杂调查的分类数据分析；复杂调查数据回归；抽样中的其他话题；附录。

关键词：抽样调查

Pilot testing of CO_(2) capture from a coal-fired power plant-Part 1:Sorbent characterization

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Clean Energy 2019年第2期3卷 144-162页

作者： sharon Sjostrom and Constance Senior ADA-ES-Inc. 640 Plaza DriveSuite 270Highlands RanchCO 80129USA

Post-combustion CO_(2)capture followed by sequestration is one of the only feasible means to significantly reduce CO_(2)emissions from existing fossil-fuel-fired power *** paper is Part 1 of a two-part paper highlighting key results from a project sponsored by the US Department of Energy and supported by industrial groups with the objective of demonstrating the viability of solid sorbents for CO_(2)*** overall objective of the effort was to validate solid sorbent-based post-combustion CO_(2)capture through slipstream pilot testing at a coal-fired power plant using a temperature-swing adsorption *** Part 1 of this work,the results from laboratory characterization of the sorbent selected for the pilot-scale demonstration are presented.A great deal of research related to sorbent development and evaluation has occurred to date but,for the most part,these promising materials have yet to be paired with a feasible process and demonstrated at the pilot *** sorbent selected for pilot-scale evaluation under this project consisted of an ion-exchange resin that incorporated amines that were covalently bonded to the *** the sorbent characterization portion of this work,the sorbent was characterized by a range of methods intended to provide information to support the design and operation of the pilot-scale CO_(2)-capture process,including equilibrium adsorption isotherms,adsorption and regeneration kinetics,impact of moisture and oxygen on CO_(2)working capacity,sorbent thermal properties,sorbent strength and attrition,and optimum particle-size *** paper reports results from sorbent characterization testing and how these characteristics influenced the type and size of the CO_(2)-capture process *** Part 2 of this work,results from tests of 1-MWe pilot-scale process equipment loaded with the sorbent described in Part 1 will be presented and analysed.

关键词： CO_(2)capture coal-fired power plant solid sorbent temperature-swing adsorption