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Tea tree oil,a vibrant source of neuroprotection via neuroinflammation inhibition:a critical insight into repurposing Melaleuca alternifolia by unfolding its characteristics

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2023年第7期24卷 554-573页

作者： Md Atiar RAHMAN Abida SULTANA Mohammad Forhad KHAN Rachasak BOONHOK sharmin afroz Department of Biochemistry and Molecular Biology University of ChittagongChittagong-4331Bangladesh School of Allied Health Sciences Walailak UniversityNakhon Si Thammarat 80160Thailand Department of Chemistry University of Massachusetts BostonBostonMA 02125USA Department of Medical Technology School of Allied Health Sciencesand Research Excellence Center for Innovation and Health Products(RECIHP)Walailak UniversityNakhon Si Thammarat 80160Thailand Department of Theoretical and Computational Chemistry University of DhakaDhaka-1000Bangladesh

Over the past few decades,complementary and alternative treatments have become increasingly popular *** purported therapeutic characteristics of natural products have come under increased scrutiny both in vitro and in vivo as part of efforts to legitimize their *** such product is tea tree oil(TTO),a volatile essential oil primarily obtained from the native Australian plant,Melaleuca alternifolia,which has diverse traditional and industrial applications such as topical preparations for the treatment of skin *** anti-inflammatory-linked immunomodulatory actions have also been *** systematic review focuses on the anti-inflammatory effects of TTO and its main components that have shown strong immunomodulatory *** extensive literature search was performed electronically for data curation on worldwide accepted scientific databases,such as Web of Science,Google Scholar,PubMed,ScienceDirect,Scopus,and esteemed publishers such as Elsevier,Springer,Frontiers,and Taylor&*** that the majority of pharmacological studies were conducted on crude oils only,the extracted data were critically analyzed to gain further insight into the prospects of TTO being used as a neuroprotective agent by drug formulation or dietary *** addition,the active constituents contributing to the activity of TTO have not been well justified,and the core mechanisms need to be unveiled especially for anti-inflammatory and immunomodulatory effects leading to ***,this review attempts to correlate the anti-inflammatory and immunomodulatory activity of TTO with its neuroprotective mechanisms.

关键词： Tea tree oil Anti-inflammatory Anti-viral Antibacterial Terpinen-4-ol18-Cineole Neuroprotective effect

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茶树油抑制神经炎症并提供神经保护——探索互花千层的潜力（英文）

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2023年第7期 554-574页

作者： Md Atiar RAHMAN Abida SULTANA Mohammad Forhad KHAN Rachasak BOONHOK sharmin afroz Department of Biochemistry and Molecular Biology University of Chittagong School of Allied Health Sciences Walailak University Department of Chemistry University of Massachusetts Boston Department of Medical Technology School of Allied Health Sciences and Research Excellence Center for Innovation and Health Products(RECIHP) Walailak University Department of Theoretical and Computational Chemistry University of Dhaka

在过去的几十年里，补充和替代治疗在世界范围内越来越受欢迎。为使天然产品使用合法化，其治疗特性在体外和体内都受到了越来越多的审查。其中一种产品茶树油（TTO）是一种主要从澳大利亚本土植物互叶千层获得的挥发性精油，具有多种... 详细信息

在过去的几十年里，补充和替代治疗在世界范围内越来越受欢迎。为使天然产品使用合法化，其治疗特性在体外和体内都受到了越来越多的审查。其中一种产品茶树油（TTO）是一种主要从澳大利亚本土植物互叶千层获得的挥发性精油，具有多种传统和工业应用，如用于治疗皮肤感染的外用制剂，或参与抗炎相关的免疫调节作用。本系统综述重点关注TTO及其主要成分的抗炎作用。我们对全球公认的科学数据库（如Web of Science、Google Scholar、Pub Med、Science Direct、Scopus）和知名出版商（如Elsevier、Springer、Frontiers、和Taylor&Francis）进行了电子文献检索和数据管理。考虑到大多数药理学仅研究原油，因此我们对提取的数据进行了严格的分析，了解TTO通过药物制剂或膳食补充剂作为神经保护剂的前景。此外，促进TTO活性的有效成分还没有被很好地证明，特别是导致神经保护的抗炎和免疫调节作用的核心机制需要被揭示。因此，本综述试图将TTO的抗炎和免疫调节活性与其神经保护机制联系起来。

关键词：茶树油抗炎抗病毒抗菌萜烯-4-醇 1,8-桉叶素神经保护作用

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FIAs(Foliation Intersection/Inflection Axes) Preserved in Porphyroblasts,the DNA of Deformation:A Solution to the Puzzle of Deformation and Metamorphism in the Colorado,Rocky Mountains,USA

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Acta Geologica Sinica(English Edition) 2009年第5期83卷 971-984页

作者： SHAH afroz Ahmad School of Earth and Environmental Sciences James Cook UniversityTownsville Queensland Australia

FIAs have been used extensively for more than a decade to unravel deformation and metamorphic puzzles. Orogenic processes developing early during the history or orogenesis challenge scientists because compositional layering in rocks always reactivates where multiple deformations have occurred, leaving little evidence of the history of foliation development preserved in the matrix. The foothills of the Rocky Mountains in Colorado, USA contain a succession of four FIA sets （trends） that would not have been distinguishable if porphyroblasts had not grown during the multiple deformation events that affected these rocks or if they had rotated as these events took place. They reveal that both the partitioning of deformation and the location of isograds changed significantly as the deformation proceeded.

关键词： foliation intersection/inflection axes porphyroblast deformational partitioning

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Distinguishing and Correlating Multiple Phases of Metamorphism across Multiply Deformed Regions Using the Axes of Inclusion Trails in Porphyroblasts

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Acta Geologica Sinica(English Edition) 2011年第4期85卷 784-791页

作者： Ahmad afroz SHAH Asghar ALI School of Earth and Environmental Sciences James Cook UniversityTownsvilleQld 4811Australia

Successions of FIAs（foliation inflection/intersection axes preserved within porphyroblasts） provide a relative time scale for deformation and ***-situ dating of monazite grains preserved as inclusions within garnet and staurolite porphyroblasts within the foliations defining each FIA from such successions provides a rigorous approach to grouping ages that formed over extended periods of deformation and *** age and FIA progressions confirms the suitability of this approach plus provides access to lengthy histories that cannot otherwise be *** in the Big Thompson region of the Colorado Rocky Mountains,USA began about a SW-NE trending axis defined by FIA set 1 at around 1761±13 *** periods of tectonism occurred around 1712±25 and 1672±21 Ma about W-E and NW-SE trending FIAs 2 and 3, *** in the Balcooma Metamorphic Group NW of Greenvale in NE Queensland, Australia began around 470 Ma with the growth of garnet porphyroblasts about a W-E trending axis defined by FIA set *** monazite grains were preserved as inclusions in this mineral phase but they were in subsequently grown *** then occurred around 443.2±3.8,424±4 and 408.9±8.9 Ma about NNW-SSE,SSW-NNE and W-E trending FIAs 2,3 and 4,*** test of a FIA based approach to monazite dating in tectonic regimes in different parts of the world and with dramatically different ages suggests it can be used in all orogens containing porphyroblasts preserving inclusion trails.

关键词： FIAs porphyroblast monazite Colorado Balcooma Metamorphic Group

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Decoding the Regional～1700 Ma Deformational History from the Rocks of Big Thompson Canyon Region of Colorado Using Monazite Dating of Foliations Preserved within Garnet and Staurolite Porphyroblastic Phases

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地学前缘 2009年第S1期16卷 199-200页

作者： afroz A Shah SAMRI School of Earth and Environmental Sciences James Cook University

Dating of monazite grains preserved within foliations defining FIAs(foliation inflection/intersection axes preserved within porphyroblasts)have provided a detailed chronology of deformational and metamorphic events during a regional～1700 Ma orogeny,in Big Thompson region of the Colorado Rockies in the *** controlled dating of monazite grains preserved within multiple-foliations of garnet and staurolite porphyroblast have complemented and potentially revolutionized all traditional dating approaches *** this technique it is possible to accurately differentiate the

关键词： FIAs MnNCKFMASH pseudosection Big Thompson Canyon

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Gravitational Tectonics versus Plate Tectonics in the Himalayan Intermontane Basins: NW Himalaya

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Acta Geologica Sinica(English Edition) 2021年第S1期95卷 3-6页

作者： afroz Ahmad SHAH Nurhafizah MANAN Department of Geosciences Universiti of Brunei DarussalaamJalan Tungku LinkGadong BE 1410Brunei Darussalam

The intermontane basins are some of the critical regions to investigate the formation,growth,and development of basins during the collisional orogenesis,and in the NW Himalaya several such basins are observed to have ... 详细信息

关键词： gravitational tectonics active tectonics Himalaya normal faults deformation domains

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Quality and Pharmaceutical Equivalence Determinations of Commercially Available Amlodipine Besylate Immediate Release Tablets

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Pharmacology & Pharmacy 2022年第5期13卷 129-139页

作者： Farhana afroz Suriya sharmin Satyajit Roy Rony Fatema Moni Md. Hossain Sohrab Pharmaceutical Sciences Research Division BCSIR Laboratories Bangladesh Council of Scientific and Industrial Research Dhaka Bangladesh Department of Applied Chemistry and Chemical Engineering University of Dhaka Dhaka Bangladesh

Counterfeit and substandard drugs possess serious health risks. Regular quality screening is very important to ensure the standard and efficacy of pharmaceutical products. The study aimed to compare the quality of amlodipine besylate tablets available in the Bangladesh drug market and examine their physical and pharmaceutical equivalence. The various physico-chemical parameters such as diameter, shape, size, weight variation, thickness, hardness, loss on drying (LOD), friability, disintegration, dissolution, and assay have been determined according to the methods mentioned in the United States Pharmacopoeia (USP) and British Pharmacopoeia (BP). Four brands of amlodipine besylate were purchased from different local retail stores and coded as ALT1, AMT2, AMT3, and AST4 on the basis of their market share. All four brands met official USP specifications. Pharmaceutical equivalence was determined from the dissolution profile which gives acceptable difference (f1) and similarity (f2) factor values for all the brands compared with the benchmark brand for its highest market share. All the brands also met the USP criteria for assay of not less than 90.0% and not more than 110.0% of the labeled amount of amlodipine (C20H25N2O5Cl).

关键词： Assay Disintegration Dissolution Friability Pharmacopoeia

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Cytotoxic, Antimicrobial and Antioxidant Properties of <i>Commelina diffusa</i>Burm. F.

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Pharmacology & Pharmacy 2019年第2期10卷 82-93页

作者： Mahmuda Nasrin Farhana afroz Suriya sharmin Md. Sohel Rana Md. Hossain Sohrab Department of Pharmacy Jahangirnagar University Dhaka Bangladesh Pharmaceutical Sciences Research Division BCSIR Laboratories Dhaka Bangladesh

Commelina diffusa Burm. F. is a herbaceous tropical plant with different traditional medicinal uses. Present study is aimed to isolate the bioactive compounds from DCM-Methanol extract of the powdered whole plant of Commelina diffusa and to investigate the cytotoxic, antimicrobial and antioxidant activities of the crude extract and its twelve vacuum liquid chromatographic fraction (CD1-12). Vacuum Liquid Chromatography (VLC) was employed to isolate bioactive metabolites. The physicochemical properties of the isolated compound were examined and the molecular structure was elucidated by NMR spectroscopy.?Cytotoxic, antibacterial, antioxidant activities were evaluated following brine shrimp lethality bioassay, disc diffusion method and DPPH free radical scavenging assay respectively. The isolated compound was identified as steroid (stigmasterol) which had significant cytotoxic effect on vero cell line. The crude extract and its fractions (CD8-CD12) exhibited strong cytotoxicity in brine shrimp lethality bioassay having LC50 values 3.79, 9.19, 29.49, 16.60, 19.36, 44.58 μg/mL respectively. The crude extract showed mild to strong antibacterial activity. Fractions (CD5-CD12) showed mild to strong antibacterial activity against Escherichia coli in comparison with Kanamycin (standard). Strong antioxidant activities were found in crude extract (IC50 value 30.52 μg/ml), CD11 (IC50 value 39.27 μg/ml) and CD12 (IC50 value 19.50 μg/ml). The study suggests Commelina diffusa plant extract to have strong antioxidant and cytotoxic activity which is indicative of presence of compounds with broad spectrum of curative applications. One compound namely stigmasterol has been isolated from the plant.

关键词： Commelina diffusa Stigmasterol Brine Shrimp Lethality Bioassay Disc Diffusion Method Free Radical Scavenging Assay

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The Discovery of the Banda Bend,a>2000 km-wide Tectonically Formed Extensional Bend in Eastern Indonesia,Southeast Asia

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Acta Geologica Sinica(English Edition) 2024年第S1期98卷 53-57页

作者： afroz Ahmad SHAH Muhammad Gazali RACHMAN Ashar Muda LUBIS Geosciences Programme Faculty of ScienceUniversity Brunei DarussalamBE1410Brunei Universitas Pembangunan Nasional“Veteran” Yogyakarta55283Indonesia Geophysics Study Program Department of PhysicsUniversity of BengkuluIndonesia

The Weber Deep represents a widespread crustal extension system in eastern Indonesia with a huge submarine normal fault system,the Banda Detachment,related to the slab rollback tectonic model(Spakman and Hall,2010;Cummins et al.,2020).However,the cause of tectonic extension remains debated(e.g.,Audley-Charles et al.,1972;McCaffrey,1988;Das,2004;Spakman and Hall,2010;Pownall et al.,2013;Cummins et al.,2020;Hutchings and Mooney,2021;Shah et al.,2023).

关键词： tectonic Eastern crustal

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Satellite Data-based Structural Mapping Reveals Active Panjal Traps Fault(PTF)in Kashmir,NW Himalaya

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Acta Geologica Sinica(English Edition) 2024年第S1期98卷 58-61页

作者： afroz Ahmad SHAH Muhammad Gazali RACHMAN Anushka VASHISTHA Ajay DASHORA Geosciences Programme Faculty of ScienceUniversity Brunei DarussalamBE1410Brunei Universitas Pembangunan Nasional“Veteran” Yogyakarta 55283Indonesia Department of Civil Engineering Indian Institute of Technology GuwahatiAssam 781039India

Exploring the evidence for unidentified earthquake-causing faults in the orogenic zones,and primarily the interior parts(Shah,2013),has been an ongoing quest for centuries(Willis,1923;Baker et al.,1988;Yeats et al.,1992;Wesnousky et al.,1999;Malik et al.,2010;Coudurier-Curveur et al.,2020;Shah et al.,2020).These faults are potentially dangerous due to their unknown risk and deformation budget,two of the most important aspects of mapping and understanding the vulnerability and hazards associated with active faults.

关键词： gravitational tectonics active tectonics normal faults deformation domains Himalaya

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