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Protective effect of Ocimum sanctum Linn. leaf extract on ethanol withdrawal syndrome in Wistar rats

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Asian Pacific Journal of Tropical Medicine 2018年第8期11卷 467-472页

作者： Lalit sharma aditi sharma G.L.Gupta Gopal Singh Bisht Department of Pharmacy Jaypee University of Information Technology School of Pharmaceutical Sciences Sholini University Department of Pharmacology SPPSPTM SVKM'S NMIMS University Department of BT and BI Jaypee University of Information Technology

Objective: To evaluate the effects of Oscimum sanctum L(O. sanctum), an important medicinal herb, on alcohol withdrawal syndrome in Wistar rats. Methods: Liquid diet with 7.2%, v/v ethanol was administered to the rats for 21 d. Control group animals received sucrose as an isocaloric liquid diet. After alcohol withdrawal, rats were examined at 6 th and 24 th hour for major withdrawal signs that included anxiety and hyper locomotor activity. Ethanol withdrawal anxiety was tested using elevated plus maze, light and dark model; the hyper locomotor activity using actophotometer. O. sanctum leaf extract(100, 200 and 300 mg/kg, oral) and diazepam(2 mg/kg, i.p) were administered to the treatment group animals 30 min before alcohol withdrawal estimation. Drug treatment was also given 30 min before the second observation at 24 th hour. On the last day of the protocol, rats were sacrificed by cervical dislocation liver, kidney and brain were isolated and preserved in formalin for further histopathological examination. Results: Findings from the present study revealed that O. Sanctum leaf extract treatment at doses 100, 200 and 300 mg/kg, oral had a significant protective effect on signs and symptoms of ethanol withdrawal in alcohol-dependent rats. However, no remarkable pathological and microscopic alterations were observed in histopathological examination. Conclusions: O. sanctum seems to be an active drug for the treatment of alcohol abstinence syndrome.

关键词： Oscimum sanctum Ethanol withdrawal syndrome Anxiety Hyperlocomotor activity Histopathology

Antifertility potential of leaves and seeds of Delonix regia in female rats

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Asian pacific Journal of Reproduction 2023年第3期12卷 117-123,I0001,I0002页

作者： Garg Megha sharma aditi Choudhary Manjusha Kaur Prabhjeet Institute of Pharmaceutical Sciences Kurukshetra UniversityKurukshetraIndia

Objective:To evaluate the antifertility activity of hydroalcoholic extract of Delonix regia(*** Hook.)*** and seeds which are traditionally being used by Yanadi tribe to treat ***:Three experimental animal models,including anti-implantation,early abortifacient,and estrogenic activity in female rats,were used for evaluation of the antifertility activity of both extracts at two dose levels(250 and 500 mg/kg,orally).There were five groups in the anti-implantation and early abortifacient activity while six groups in estrogenic activity including the *** number of implants,resorptions,vaginal cornification,body weight,uterus weight,and biochemical parameters were ***:At doses 250 and 500 mg/kg,the leaf extract was found to have strong anti-implantation *** extract administered at the same doses also caused a significant rise in the number of resorptions,showing early abortifacient activity,increased uterine weight,and altered numerous biochemical ***,the seed extract only displayed slight anti-implantation activity at both ***:Based on these preliminary findings,we can conclude that the leaf extract outperformed the seed extract in terms of antifertility activity,exhibiting potent estrogenic,anti-implantation and early abortifacient activities in a dose-dependent *** findings are consistent with the literature study and corroborate to the antifertility activity of the plant.

关键词： Delonix regia Anti-implantation Early abortifacient Estrogenic Gulmohar Ovariectomy

Cluster sampling methodology to evaluate immunization coverage

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World Journal of Methodology 2024年第3期14卷 78-89页

作者： Aishwarya sharma RB Jain Jitesh Satija aditi sharma Avani sharma Sudhir Shekhawat Department of Community Medicine School of Medical Sciences&ResearchSharda UniversityGreater Noida 201306UPIndia Department of Community Medicine World College of Medical Sciences&ResearchJhajjar 124103HaryanaIndia Department of Community Medicine ESIC Medical College&HospitalFaridabad 121012HaryanaIndia Department of Community Medicine Hamdard Institute of Medical Sciences&ResearchNew Delhi 110062India Department of Community Medicine Pt.B.D.Sharma Post Graduate Institute of Medical SciencesRohtak 124001HaryanaIndia Independent Biostatistician Ghaziabad 201014UPIndia

BACKGROUND Immunization is a key component of primary health care and an indisputable human *** are critical to the prevention and control of infectious disease *** coronavirus disease 2019(COVID-19)pandemic and associated disruptions over the past two years have strained the health systems,with many children missing out on essential childhood *** To evaluate the immunization coverage among 12-23-month-old children in the rural areas of Community Health Centre(CHC)Dighal and to determine the factors influencing the existing immunization *** A coverage evaluation survey was conducted according to the 30-cluster sampling technique,which is the standard methodology for such surveys devised by World Health Organization.A total of 300 children aged 12-23 months were included,whose immunization details were noted from their immunization *** Full immunization rate was noted in 86.7%of the children,with partial and non-immunized children accounting for 9%and 4.3%*** full immunization dropout rate was 4.2%.The common reasons for partial or non-immunization were family problem including illness of mother,vaccine not being available and child being *** of birth(P=0.014)and availability of immunization card(P<0.001)were significant predictors of the immunization *** the study was conducted in 2020/2021,health services were disrupted due to the COVID-19 *** Due to the coverage being higher than the national average,it was concluded that the immunization coverage was optimal and not affected by the COVID-19 pandemic.

关键词： Immunization coverage Children COVID 19 pandemic Vaccines Family health Routine immunization

Comparison of two incisions for open reduction and internal fixation of mandibular body fractures: A randomised controlled clinical trial evaluating the surgical outcome

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Chinese Journal of Traumatology 2019年第1期22卷 34-40页

作者： Sasikala Balasubramanian Elavenil Panneerselvam Gayathri Gopi Komagan Prabhu Nakkeeran aditi Rajendra sharma Krishnakumar Raja VB Department of Oral & Maxillofacial Surgery SRM Dental College & Hospital Ramapuram Campus Ramapuram Chennai 600089 India

Purpose: The purpose of the study is to compare the surgical access and post-operative outcome of two intra-oral incisions used for approaching a mandibular body fracture. Methods: This clinical trial involved 60 patients with mandibular body fractures who were randomly allocated to control and study groups. The fractures were approached using the routine vestibular incision in the control group and crevicular incision with vertical release in the study group. The effects of incision design on the post-surgical outcome variables like swelling, trismus, paresthesia, wound healing and gingival recession were statistically analysed with non-parametric tests by using SPSS 22.0 software. Comparison of continuous variables between the groups and time points was done using Mann Whitney test and Friedman test respectively. Chi-square test was used to compare proportions between groups. Dunn's test with Bonferroni correction was used for pair wise comparisons. Results: The study group demonstrated favourable surgical outcome in the immediate postoperative phase as compared to the control group. The difference in mouth opening, swelling and neurosensory impairment between the two groups was found to be statistically significant (p < 0.05). Conclusion: Crevicular incision was found to be an ideal alternative to vestibular incision in achieving surgical access and fixation of mandibular body fractures with reduction in postoperative patient discomfort and better surgical outcome.

关键词： Mandibular fractures Incision Nerve injury

Integrative genomics reveals paths to sex dimorphism in Salix purpurea L

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Horticulture Research 2021年第1期8卷 2305-2318页

作者： Brennan Hyden Craig H.Carlson Fred E.Gouker Jeremy Schmutz Kerrie Barry Anna Lipzen aditi sharma Laura Sandor Gerald A.Tuskan Guanqiao Feng Matthew S.Olson Stephen P.DiFazio Lawrence B.Smart Horticulture Section School of Integrative Plant ScienceCornell UniversityCornell AgriTechGenevaNYUSA Floral and Nursery Plants Research Unit US National ArboretumUnited States Department of AgricultureAgricultural Research ServiceBeltsvilleMDUSA United States Department of Energy Joint Genome InstituteBerkeleyCAUSA HudsonAlpha Institute for Biotechnology HuntsvilleALUSA The Center for Bioenergy Innovation Oak Ridge National LaboratoryOak RidgeTNUSA Department of Biology Texas Tech UniversityLubbockTXUSA Department of Biology West Virginia UniversityMorgantownWVUSA

Sex dimorphism and gene expression were studied in developing catkins in 159 F 2 individuals from the bioenergy crop Salix purpurea,and potential mechanisms and pathways for regulating sex development were *** expression,eQTL,bisulfite sequencing,and network analysis were used to characterize sex dimorphism,detect candidate master regulator genes,and identify pathways through which the sex determination region(SDR)may mediate sex *** genes are presented as candidates for master regulators of sex,supported by gene expression and network *** include genes putatively involved in hormone signaling,epigenetic modification,and regulation of *** analysis revealed a suite of transcription factors and genes involved in secondary metabolism and floral development that were predicted to be under direct control of the sex determination ***,data from bisulfite sequencing and small RNA sequencing revealed strong differences in expression between males and females that would implicate both of these processes in sex dimorphism *** data indicate that the mechanism of sex determination in Salix purpurea is likely different from that observed in the related genus *** further demonstrates the dynamic nature of SDRs in plants,which involves a multitude of mechanisms of sex determination and a high rate of turnover.

关键词： purpurea metabolism likely

Recovery of the injured neural system through gene delivery to surviving neurons in Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2855-2861页

作者： Chanchal sharma Sehwan Kim Hyemi Eo Sang Ryong Kim School of Life Science Kyungpook National UniversityDaeguKorea BK21 FOUR KNU Creative BioResearch Group Kyungpook National University DaeguKorea Brain Science and Engineering Institute Kyungpook National UniversityDaeguKorea

A critical unaddressed problem in Parkinson’s disease is the lack of therapy that slows or hampers *** medications effectively manage symptoms,they offer no long-term benefit because they fail to address the underlying neuronal *** highlights that the elusive goals of halting progression and restoring damaged neurons limit the long-term impact of current *** clinical trials using gene therapy have demonstrated the safety of various vector delivery systems,dosages,and transgenes expressed in the central nervous system,signifying tangible and substantial progress in applying gene therapy as a promising Parkinson’s disease ***,at diagnosis,many dopamine neurons remain in the substantia nigra,offering a potential window for recovery and *** propose that modulating these surviving dopamine neurons and axons in the substantia nigra and striatum using gene therapy offers a potentially more impactful therapeutic approach for future ***,innovative gene therapies that focus on preserving the remaining elements may have significant potential for enhancing long-term outcomes and the quality of life for patients with Parkinson’s *** this review,we provide a perspective on how gene therapy can protect vulnerable elements in the substantia nigra and striatum,offering a novel approach to addressing Parkinson’s disease at its core.

关键词： adeno-associated virus gene therapy neuroprotection neurorestoration neurotrophic factor nigrostriatal dopamine pathway pro-survival protein

Recognition and quality mapping of traditional herbal drugs:way forward towards artificial intelligence

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Traditional Medicine Research 2025年第1期10卷 12-26页

作者： Sanyam sharma Subh Naman Ashish Baldi Faculty of Pharmacy Pacific Academy of Higher Education and Research UniversityUdaipur 313024India Pharma Innovation Lab Department of Pharmaceutical Sciences and TechnologyMaharaja Ranjit Singh Punjab Technical UniversityBathinda 151001India Faculty of Pharmaceutical Sciences The ICFAI UniversityBaddi 174103India.

The use of traditional herbal drugs derived from natural sources is on the rise due to their minimal side effects and numerous health ***,a major limitation is the lack of standardized knowledge for identifying and mapping the quality of these herbal *** article aims to provide practical insights into the application of artificial intelligence for quality-based commercialization of raw herbal *** focuses on feature extraction methods,image processing techniques,and the preparation of herbal images for compatibility with machine learning *** article discusses commonly used image processing tools such as normalization,slicing,cropping,and augmentation to prepare images for artificial intelligence-based *** also provides an overview of global herbal image databases and the models employed for herbal plant/drug *** will gain a comprehensive understanding of the potential application of various machine learning models,including artificial neural networks and convolutional neural *** article delves into suitable validation parameters like true positive rates,accuracy,precision,and more for the development of artificial intelligence-based identification and authentication techniques for herbal *** article offers valuable insights and a conclusive platform for the further exploration of artificial intelligence in the field of herbal drugs,paving the way for smarter identification and authentication methods.

关键词： artificial intelligence Ayurveda machine learning models herbal drugs image pre-processing medicinal plants

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全球儿科艾滋病研究议程

全球儿科艾滋病研究议程

Chemically modified silica gel with 1-{4-[(2-hydroxy-benzylidene)amino]phenyl}ethanone:Synthesis, characterization and application as an efficient and reusable solid phase extractant for selective removal of Zn(Ⅱ) from mycorrhizal treated fly-ash samples

作者： Martina Penazzato Cadi Irvine Marissa Vicari Shaffiq M. Essajee aditi sharma Thanyawee Puthanakit Elaine J.Abrams Meg Doherty 买热排提﹒哈力木拉提 Department of HIV and Global Hepatitis Programme World Health Organization

【背景】尽管取得了进展,2016年仍有16万新感染病例和12万名儿童死于艾滋病。在如何最好地诊断、治疗和向感染艾滋病毒的儿童提供服务方面,证据仍然存在差距。世界卫生组织和CIPHER开展了一项全球研究优先次序的工作,以便在资源减少的... 详细信息

【背景】尽管取得了进展,2016年仍有16万新感染病例和12万名儿童死于艾滋病。在如何最好地诊断、治疗和向感染艾滋病毒的儿童提供服务方面,证据仍然存在差距。世界卫生组织和CIPHER开展了一项全球研究优先次序的工作,以便在资源减少的情况下集中研究工作。【方法】如欧文等人所述,采用儿童健康和营养研究倡议方法。专家组对结果进行了审查,并确定了检测、抗逆转录病毒治疗和提供服务的5个优先主题,同时考虑了现有政策、已发表的文献和正在进行的研究。【结果】来自62个国家的269人共提交了749个问题。关于艾滋病毒检测,优先主题包括战略和干预措施,以改善获得、接受和联系到护理,包括使用新的诊断工具和产前护理以外的切入点。在治疗方面,重点包括改善依从性的策略、短期和长期的结果以及对合并感染的管理、最佳药物配方和早期抗逆转录病毒治疗。在提供服务方面,优先事项包括改进获得、接受和保留护理的战略或干预措施,包括心理社会和家庭支持,以及披露艾滋病毒和减少耻辱和歧视的办法。【结论】这是针对艾滋病毒开展的最大规模的儿童健康和营养研究活动。这一结果为今后关注儿童HIV的影响研究提供了指导。迫切需要全球承诺支持优先研究、充分投资和强有力的领导,以改善艾滋病毒携带者和受其影响的儿童的健康和福祉。

关键词：优先事项儿童艾滋病毒抗逆转录病毒药物艾滋病毒诊断服务提供

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Journal of Environmental Sciences 2013年第6期25卷 1252-1261页

作者： R.K.sharma aditi Puri Anil Kumar Alok Adholeya 2 Green Chemistry Network Centre Department of ChemistryUniversity of Delhi Biotechnology and Management of Bioresources Division The Energy and Resource Institute

1-{4-[（2-hydroxy-benzylidene）amino]phenyl}ethanone functionalized silica gel was synthesized and used as a highly efficient, selective and reusable solid phase extractant for separation and preconcentration of trace amount of Zn（II） from environmental matrices. The adsorbent was characterized by fourier transform infrared spectroscopy （FT-IR）, elemental analysis,~3C CPMAS NMR spectroscopy, scanning electron microscopy （SEM）, thermogravimetric analysis （TGA） and BET surface area analysis. The dependence of zinc extraction on various analytical parameters such as pH, type and amount of eluent, sample flow rate and interfering ions were investigated in detail. The material exhibited superior adsorption efficiency for Zn（II） with high metal loading capacity of 1.0 mmol/g under optimum conditions. After adsorption, the recovery （〉 98%） of metal ions was accomplished using 1.0 mol/L HNO3 as an eluent. The sorbent was also regenerated by microwave treatment in milder acidic environment （0.1 mol/L HNO3）. The lower detection limit and preconcentration factor of the present method were found out to be 0.04 ~tg/L and 312.5 respectively. The modified silica surface possessed excellent selectivity for the target analytes and the adsorption/desorption process remained effective for at least ten consecutive cycles. The optimized procedure was successfully implemented for the extraction of Zn（II） from mycorrhizal treated fly ash and pharmaceutical samples with reproducible results.

关键词： solid phase extraction silica gel preconcentration fly-ash zinc