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世界核心医学期刊文摘（胃肠病学分册） 2006年第9期2卷 26-27页

作者： sharma b.c. Agarwal N. Garg S. 孟欣颖 Department of Gastroenterology GB Pant HospitalNew Delhi 110002India Dr.

b.c.ground and Study Aims:The formation of a communication between liver ab.c.sses or cysts and intrahepatic bile ducts is an uncommon cause of significant bile *** management of biliary fistulas is associated with high morbidity and *** performed a prospective study of endoscopic management of this type of biliary *** and Methods:We studied 26 patients who had either liver ab.c.sses or hepatic cysts that had ruptured into the intrahepatic bile *** presence of a biliary fistula was suspected by jaundice and/or by the appearance of bile in percutaneous drainage effluent from a liver ab.c.ss and was confirmed by endoscopic retrograde *** the route of the fistula between the liver ab.c.ss or cyst and the intrahepatic bile duct had been defined by cholangiography,patients underwent treatment by sphincterotomy,and either biliary stenting or nasobiliary *** drains or biliary stents(both 7 Fr)were placed according to standard *** drains were removed when bile leakage stopped and closure of the fistula was confirmed by cholangiography;stents were removed after an interval of 4-6 ***:Of a total of 525 patients with hepatic ab.c.sses or cysts who were seen over a 5-year period,there were 26 patients who developed a demonstrable communication between liver ab.c.sses(n = 20;16 ameb.c.four pyogenic)or hydatid cysts(n = 6)and intrahepatic bile ducts(right intrahepatic bile ducts in 22 patients,left intrahepatic bile ducts in four patients).We performed either sphincterotomy with insertion of a nasobiliary drain(n = 20)or sphincterotomy with biliary stenting(n = 6).The fistulas healed in all patients after a mean time of 4 days(range 2-20 days)after endoscopic *** were able to remove the nasobiliary drainage catheters and stents 6-34 days after their ***:In this case series,endoscopic therapy appears to be an effective mode of treatment for bilia

关键词：左肝内胆管包虫囊肿内镜治疗肝脓肿经内镜逆行胰胆管造影鼻胆管引流术括约肌切开胆管支架

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急性胆管炎患者经鼻胆管引流或放置支架内镜下胆管引流

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世界核心医学期刊文摘（胃肠病学分册） 2005年第9期1卷 18-19页

作者： sharma b.c. Kumar R. Agarwal N. Sarin S.K. 徐小洁 Department of Gastroenterology G B Pant Hospital New Delhi 110002 India Dr.

b.c.ground and study aims: Endoscopic biliary drainage is an established mode of treatment for acute cholangitis. We compared the safety and efficacy of nasobiliary drain (NbD) placement and stent placement for biliary drainage in patients with acute cholangitis. Patients and methods: We recruited a total of 150 patients with severe cholangitis who required endoscopic biliary drainage. Patients were randomized to have either a 7-Fr NbD or a 7-Fr straight flap stent placed during endoscopy. Outcome measures included complications related to endoscopic retrograde cholangiopancreatography (ERcP) and the clinical outco- me. Results: Of the 150 patients, 75 were randomized to the NbD group and 75 to the stent group. The most common causes of biliary obstruction were common bile duct stones (n = 102) and biliopancreatic malignancies (n = 37). The site of the biliary obstruction was predominantly found to be the lower part of common bile duct in both the NbD group (n = 58) and the stent group (n = 59). Indications for biliary drainage were: a fever of > 100.4°F (n = 140), hypotension (n = 23), peritonism (n = 40), impaired consciousness (n = 29), and failure to improve with conservative management (n = 45). biliary drainage was achieved in 147 patients. Abdominal pain, fever, jaundice, hypotension, peritonism and altered sensorium improved after a median period of 2 days in both groups. Leukocyte counts b.c.me normal after a median time of 7 days in the NbD group and 6 days in the stent group. There were no ERcP-related complications. There were no instances of displacement or kinking of an NbD, occlusion of an NbD or stent, or of stent migration. Four patients died (two in the NbD group and two in the stent group) as a result of uncontrolled cholangitis after 1, 2, 4, and 6 days of biliary drainage. The success rates of biliary drainage in cholangitis were not affected by the type of endoprosthesis used (72/74 for NbD patients vs. 71/73 for stent patients), the etiology o

关键词：鼻胆管引流急性胆管炎胆汁引流胆总管发热体温胆管阻塞胰胆管白细胞计数上段意识障碍

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Field topologies in ideal and near-ideal magnetohydrodynamics and vortex dynamics

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Science china(Physics,Mechanics & Astronomy) 2015年第1期58卷 12-31页

作者： LOW b.c. High Altitude Observatory National Center for Atmospheric Research

Magnetic field topology frozen in ideal magnetohydrodynamics （MHD） and its breakage in near-ideal MHD are reviewed in two parts, clarifying and expanding basic concepts. The first part gives a physically complete description of the frozen field topology derived from magnetic flux conservation as the fundamental property, treating four conceptually related topics： Eulerian and La- grangian descriptions of three dimensional （3D） MHD, chandrasekhar-Kendall and Euler-potential field representations, magnetic helicity, and inviscid vortex dynamics as a fluid system in physical contrast to ideal MHD. A corollary of these developments clar- ifies the challenge of achieving a high degree of the frozen-in condition in numerical MHD. The second part treats field-topology breakage centered around the Parker Magnetostatic Theorem on a general incompatibility of a continuous magnetic field with the dual demand of force-free equilibrium and an arbitrarily prescribed, 3D field topology. Preserving field topology as a global con- straint readily results in formation of tangential magnetic discontinuities, or, equivalently, electric current-sheets of zero thickness. A similar incompatibility is present in the steady force-thermal balance of a heated radiating fluid subject to an anisotropic thermal flux conducted strictly along its frozen-in magnetic field in the low-fl limit. In a weakly resistive fluid the thinning of current sheets by these general incompatibilities inevitably results field notwithstanding the small resistivity. Strong Faraday in sheet dissipation, resistive heating and topological changes in the induction drives but also macroscopically limits this mode of energy dissipation, trapping or storing free energy in self-organized ideal-MHD structures. This property of MHD turbulence captured by the Taylor hypothesis is reviewed in relation to the Sun＇s corona, calling for a basic quantitative description of the breakdown of flux conservation in the low-resistivity li

关键词： magnetic topology magnetic reconnection current sheets magnetic helicity thermal conduction solar corona magnetohy-drodynamics interstellar clouds

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Recovery of the injured neural system through gene delivery to surviving neurons in Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2855-2861页

作者： chanchal sharma Sehwan Kim Hyemi Eo Sang Ryong Kim School of Life Science Kyungpook National UniversityDaeguKorea bK21 FOUR KNU creative bioResearch Group Kyungpook National University DaeguKorea brain Science and Engineering Institute Kyungpook National UniversityDaeguKorea

A critical unaddressed problem in Parkinson’s disease is the lack of therapy that slows or hampers *** medications effectively manage symptoms,they offer no long-term benefit b.c.use they fail to address the underlying neuronal *** highlights that the elusive goals of halting progression and restoring damaged neurons limit the long-term impact of current *** clinical trials using gene therapy have demonstrated the safety of various vector delivery systems,dosages,and transgenes expressed in the central nervous system,signifying tangible and substantial progress in applying gene therapy as a promising Parkinson’s disease ***,at diagnosis,many dopamine neurons remain in the substantia nigra,offering a potential window for recovery and *** propose that modulating these surviving dopamine neurons and axons in the substantia nigra and striatum using gene therapy offers a potentially more impactful therapeutic approach for future ***,innovative gene therapies that focus on preserving the remaining elements may have significant potential for enhancing long-term outcomes and the quality of life for patients with Parkinson’s *** this review,we provide a perspective on how gene therapy can protect vulnerable elements in the substantia nigra and striatum,offering a novel approach to addressing Parkinson’s disease at its core.

关键词： adeno-associated virus gene therapy neuroprotection neurorestoration neurotrophic factor nigrostriatal dopamine pathway pro-survival protein

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Preparation, characterization, and catalysis of mecro-catalysts

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Science china chemistry 1996年第4期39卷 347-353页

作者：肖丰收 b.c. Gates State Key Laboratory for catalysis Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian 116023 China Department of chemistry Jilin University Changchun 130023 China Department of chemical Engineering and Materials Science University of California Davis CA95616 USA

b.c.use catalysis by metals is a surface phenomenon, many technological catalysts contain small (typically nanometre-sired) supported metal particles with a large fraction of the atoms exposed. Many reactions, such as hydrocarbon hydrogenations, are structure-insensitive, proceeding at approximately the same rates on metal particles of various sizes provided that they are larger than 1 nm and show bulk-like metallic behavior. but the catalytic properties are not known when metal particles b.c.me so small that their sizes are indium clusters consisting of several indium atoms. Here the catalytic behavior of precisely defined clusters of just four and six indium atoms on solid supports is shown. It is found that the Ir4 and Ir6 clusters differ in catalytic activity both from each other and from metallic Ir particles.

关键词： metal clusters catalysis preparation characterization toluene hydrogenation EXAFS analysis chemisorption.

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Polarized Ketene Dithioacetals-Versatile Synthons for Different Heterocycles

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chinese Journal of chemistry 2012年第8期30卷 1886-1892页

作者： Venkatesh b.c. Premakumari c. Padmaja A. Padmavathi V. Department of chemistry Sri Venkateswara UniversityTirupati-517502Andhra PradeshIndia

The reactivity of polarized ketene dithioacetals to develop a variety of heterocycles under different conditions was studied.

关键词： polarized ketene dithioacetals thienothiophenes bis-benzoxazolyl/benzothiazolyl/benzimidazolyl-pyrazolidine diones/isoxazolidinediones/pyrimidinetriones/thioxopyrimidinediones cyclocondensation

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THEORETIcAL STUDY OF GIANT MAGNETO-IMPEDANcE IN AMORPHOUS FILMS WITH LONGITUDINAL MAGNETIc ANISOTROPY

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Acta Metallurgica Sinica(English Letters) 2000年第4期13卷 995-1000页

作者： Yu, J.Q. Zhou, Y. cai, b.c. Zhao, X.L. Shanghai Jiaotong Univ Shanghai China

Giant magneto-impedance (MI) effect in thin films with longitudinal magnetic anisotropy was studied theoretically. The effective permeability of films as a function of external magnetic field Ha, anisotropy field and other parameters of films was presented by Landau-Lifshitz-Gilbert theory. The theoretical results agree well with the experimental data, which shows a strong dependence of the impedance on the applied magnetic field.

关键词： Electric currents Magnetic anisotropy Magnetic fields Skin effect

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Structural features of substituted triazole-linked chalcone derivatives as antimalarial activities against D_(10) strains of Plasmodium falciparum: A QSAR approach

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Journal of central South University 2015年第10期22卷 3738-3744页

作者： Mukesh c.sharma Division of Drug Design & Medicinal chemistry Research Lab School of Pharmacy Devi Ahilya University Takshila Campus

A quantitative structure–activity relationship(QSAR) was performed to analyze antimalarial activities against the D10 strains of Plasmodium falciparum of triazole-linked chalcone and dienone hybrid derivatives using partial least squares regression coupled with stepwise forward–b.c.ward variable selection method. QSAR analyses were performed on the available Ic50 D10 strains of Plasmodium falciparum data based on theoretical molecular descriptors. The QSAR model developed gave good predictive correlation coefficient(r2) of 0.8994, significant cross validated correlation coefficient(q2) of 0.7689, r2 for external test set)(2predr of 0.8256, coefficient of correlation of predicted data set)(2sepred,r of 0.3276. The model shows that antimalarial activity is greatly affected by donor and electron-withdrawing substituents. The study implicates that chalcone and dienone rings should have strong donor and electron-withdrawing substituents as they increase the activity of chalcone. Results show that the predictive ability of the model is satisfactory, and it can be used for designing similar group of antimalarial compounds. The findings derived from this analysis along with other molecular modeling studies will be helpful in designing of the new potent antimalarial activity of clinical utility.

关键词： quantitative structure–activity relationship(QSAR) chalcone antimalarial Plasmodium falciparum stepwise forward–b.c.ward partial least squares

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An overview of deep eutectic solvents:Alternative for organic electrolytes,aqueous systems&ionic liquids for electrochemical energy storage

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Journal of Energy chemistry 2023年第7期82卷 592-626,I0013页

作者： Akshay sharma Renuka sharma Ramesh c.Thakur Lakhveer Singh Department of chemistry Himachal Pradesh UniversitySummer HillShimla171005Himachal PradeshIndia Department of chemistry Sardar Patel UniversityMandi175001Himachal PradeshIndia

As the demand for sustainable energy sources continues to rise,the need for efficient and reliable energy storage systems b.c.mes *** order to effectively store and distribute renewable energy,new and innovative solutions must be *** review examines the deep eutectic solvents(DESs)as a green,safe,and affordable solution for the electrochemical energy storage and conversion field,offering tremendous opportunities and a promising *** are a class of environment-friendly solvents known for their low toxicity and unique properties,such as their good conductivity,high thermal stability,and *** review explores the fundamentals,preparations,and various interactions that often predominate in the formation of DESs,the properties of DESs,and how DESs are better than traditional solvents involving cost-ineffective and unsafe organic electrolytes and ionic liquids as well as inefficient aqueous systems due to low energy density for electrochemical energy storage ***,a particular focus is placed on the various electrochemical applications of DESs,including their role in the electrolytes in batteries/supercapacitors,electropolishing and electrodeposition of metals,synthesis of electrode materials,recycling of electrodes,and their potential for use in cO_(2)*** review concludes by exploring the challenges,research gaps,and future potential of DESs in electrochemical applications,providing a comprehensive overview,and highlighting key considerations for their design and use.

关键词： Deep eutectic solvent Green solventHole theory Energy storage devices Aqueous electrolyte

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Assessment of land use change and its effect on soil carbon stock using multitemporal satellite data in semiarid region of Rajasthan, India

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Ecological Processes 2019年第1期8卷 513-529页

作者： Garima sharma L.K.sharma K.c.sharma Department of Environmental Science Central University of RajasthanNH-8BandarsindriRajasthan 305817India M.D.S.University AjmerRajasthanIndia.

b.c.ground:Land use change plays a vital role in global carbon *** land use change impact on soil carbon stock is crucial for implementing land use management to increase carbon stock and reducing carbon ***,the objective of our study was to determine land use change and to assess its effect on soil carbon stock in semi-arid part of Rajasthan,*** temporal satellite data of Pushkar valley region of Rajasthan acquired on 1993,2003,and 2014 were analyzed to assess land use *** trading of land use was depicted *** organic carbon(SOc)stock was calculated for soil to a depth of 30 cm in each land use type in 2014 using field data *** SOc stock for previous years was estimated using stock change *** effect of land use change on SOc stock was determined by calculating change in SOc stock(t/ha)by deducting the base-year SOc stock from the final year stock of a particular land use ***:The total area under agricultural lands was increased by 32.14%while that under forest was decreased by 23.14%during the time period of 1993–*** land use change shows that in both the periods(1993–2003 and 2003–2014),7%of forest area was converted to agricultural land and about 15%changes occurred among agricultural *** 1993–2003,changes among agricultural land led to maximum loss of soil carbon,i.e.,4.88 Mt c and during 2003–2014,conversion of forest to agricultural land led to loss in 3.16 Mt ***:There was a continuous decrease in forest area and increase in cultivated area in each time *** use change led to alteration in carbon equity in soil due to change or loss in ***,we can conclude that the internal trading of land use area during the 10-year period(1993–2003)led to net loss of SOc stock by 8.29 Mt ***,land use change during 11-year period(2003–2014)caused net loss of SOc by 2.76 Mt *** should be made to implement proper land

关键词： Multitemporal satellite data Land use change dynamics Internal trading of land use SOc stock,Stock change factor change in SOc pool Land use management

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