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Chinese Physics C 2022年第7期46卷 220-220页

作者： A.Gandhi Aman sharma Rebecca Pachuau Namrata Singh L.S.Danu S.V.Suryanarayana B.K.Nayak A.Kumar Department of Physics Banaras Hindu UniversityVaranasi 221005India Nuclear Physics Division Bhabha Atomic Research CentreMumbai 400085India

Experimentally measured neutron activation cross sections are presented for the^(65)Cu(n,α)^(62m)Cu,^(41)K(n,α)^(38)Cl,and^(65)Cu(n,2n)^(64)Cu reactions with detailed uncertainty *** neutron cross sections were measured at an incident energy of 14.92±0.02 MeV,and the neutrons were based on the t(d,n)αfusion ***^(27)Al(n,α)^(24)Na reaction was used as a reference reaction for the normalization of the neutron *** pre-calibrated lead-shielded HPGe detector was used to detect the residues'γ-ray *** data from the measured cross sections are compared to the previously measured cross sections from the EXFOR database,theoretically calculated cross sections using the TALYS and EMPIRE codes,and evaluated nuclear data.

关键词： nuclear reactions (na)and(n,2n)reactions t(d,n)a neutron source uncertainty propagation covariance analysis TALYS-1.9 and EMPIRE-3.2 code

Recovery of the injured neural system through gene delivery to surviving neurons in Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2855-2861页

作者： Chanchal sharma Sehwan Kim Hyemi Eo Sang Ryong Kim School of Life Science Kyungpook National UniversityDaeguKorea BK21 FOUR KNU Creative BioResearch Group Kyungpook National University DaeguKorea Brain Science and Engineering Institute Kyungpook National UniversityDaeguKorea

A critical unaddressed problem in Parkinson’s disease is the lack of therapy that slows or hampers *** medications effectively manage symptoms,they offer no long-term benefit because they fail to address the underlying neuronal *** highlights that the elusive goals of halting progression and restoring damaged neurons limit the long-term impact of current *** clinical trials using gene therapy have demonstrated the safety of various vector delivery systems,dosages,and transgenes expressed in the central nervous system,signifying tangible and substantial progress in applying gene therapy as a promising Parkinson’s disease ***,at diagnosis,many dopamine neurons remain in the substantia nigra,offering a potential window for recovery and *** propose that modulating these surviving dopamine neurons and axons in the substantia nigra and striatum using gene therapy offers a potentially more impactful therapeutic approach for future ***,innovative gene therapies that focus on preserving the remaining elements may have significant potential for enhancing long-term outcomes and the quality of life for patients with Parkinson’s *** this review,we provide a perspective on how gene therapy can protect vulnerable elements in the substantia nigra and striatum,offering a novel approach to addressing Parkinson’s disease at its core.

关键词： adeno-associated virus gene therapy neuroprotection neurorestoration neurotrophic factor nigrostriatal dopamine pathway pro-survival protein

Recognition and quality mapping of traditional herbal drugs:way forward towards artificial intelligence

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Traditional Medicine Research 2025年第1期10卷 12-26页

作者： Sanyam sharma Subh Naman Ashish Baldi Faculty of Pharmacy Pacific Academy of Higher Education and Research UniversityUdaipur 313024India Pharma Innovation Lab Department of Pharmaceutical Sciences and TechnologyMaharaja Ranjit Singh Punjab Technical UniversityBathinda 151001India Faculty of Pharmaceutical Sciences The ICFAI UniversityBaddi 174103India.

The use of traditional herbal drugs derived from natural sources is on the rise due to their minimal side effects and numerous health ***,a major limitation is the lack of standardized knowledge for identifying and mapping the quality of these herbal *** article aims to provide practical insights into the application of artificial intelligence for quality-based commercialization of raw herbal *** focuses on feature extraction methods,image processing techniques,and the preparation of herbal images for compatibility with machine learning *** article discusses commonly used image processing tools such as normalization,slicing,cropping,and augmentation to prepare images for artificial intelligence-based *** also provides an overview of global herbal image databases and the models employed for herbal plant/drug *** will gain a comprehensive understanding of the potential application of various machine learning models,including artificial neural networks and convolutional neural *** article delves into suitable validation parameters like true positive rates,accuracy,precision,and more for the development of artificial intelligence-based identification and authentication techniques for herbal *** article offers valuable insights and a conclusive platform for the further exploration of artificial intelligence in the field of herbal drugs,paving the way for smarter identification and authentication methods.

关键词： artificial intelligence Ayurveda machine learning models herbal drugs image pre-processing medicinal plants

Comparative efficacy of hyperbaric bupivacaine vs hyperbaric ropivacaine in spinal anesthesia for cesarean section:A metaanalysis

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World Journal of Methodology 2025年第2期15卷 154-165页

作者： Rishi Anand Deb Sanjay Nag Roushan Patel Prashant sharma Vamsi Krishna Uppalapati Umesh Kumar Singh Department of Anaesthesiology Tata Main HospitalJamshedpur 831001JhārkhandIndia

BACKGROUND Intrathecal bupivacaine is the traditional anesthetic drug used in spinal anesthesia for caesarean sections(CSs),but ropivacaine has emerged as a potential *** meta-analysis compares the efficacy and safety of intrathecal hyper-baric bupivacaine vs hyperbaric ropivacaine for cesarean *** To systematically evaluate and compare the efficacy and safety of intrathecal hyperbaric bupivacaine and hyperbaric ropivacaine for spinal anesthesia in *** A thorough search of electronic databases was carried out to find pertinent randomized controlled trials(RCTs)comparing intrathecal hyperbaric ropi-vacaine and hyperbaric bupivacaine during ***,Cochrane database,Google Scholar,and Scopus were searched,and papers from January 2000 to January 2024 were deemed eligible and filtered using predetermined inclusion and exclusion *** were assessed for methodological quality,and data were extracted for time to adequate anesthesia(sensory and motor blockade),duration of sensory and motor block,hemodynamic changes and side effect *** standardized mean difference with 95%CI was used for continuous *** variables were assessed using the Mantel-Haenszel test and the random effect model to compute the odds *** Total 8 RCTs were selected from a pool of 119 search results for *** meta-analysis evaluated pooled effect sizes and assessed heterogeneity among the *** primary objective was to compare key outcomes to identify any significant variances in efficacy and safety profiles between two local *** analysis revealed that the difference in the onset of sensory blockade between the two local anesthetics was statistically insignificant(P=0.1586).However,the onset of motor blockade appeared to be faster with bupivacaine(P=0.03589).Additionally,the regression of sensory and motor blockade occurred earlier in the ropivacaine ***,the duration of the first analgesic

关键词： Ropivacaine Bupivacaine Anesthesia Spinal Cesarean section Meta-analysis

Prevalence of transfusion transmissible infections among various donor groups:A comparative analysis

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World Journal of Virology 2025年第1期14卷 108-117页

作者： Sanjay K Thakur Anil K Sinha Santosh K sharma Aarzoo Jahan Dinesh K Negi Ruchika Gupta Sompal Singh Regional Blood Transfusion Centre Hindu Rao Hospital and NDMC Medical CollegeNorth Delhi 110007DelhiIndia Department of Zoology Veer Kunwar Singh UniversityAra 802301BiharIndia Regional Blood Transfusion Centre and Pathology Hindu Rao Hospital and NDMC Medical CollegeNorth Delhi 110007DelhiIndia Department of Cytopathology ICMR-National Institute of Cancer Prevention and ResearchNoida 201301Uttar PradeshIndia

BACKGROUND Transfusion transmissible infections(TTIs)are illnesses spread through contaminated blood or blood *** India,screening for TTIs such as hepatitis B virus(HBV),hepatitis C virus(HCV),human immunodeficiency virus(HIV)-I/II,malaria,and syphilis is mandatory before blood ***,HCV,HBV,and HIV are the leading viruses causing mortality,affecting millions of people globally,including those with co-infections of HIV/HCV and HIV/*** highlight the impact of TTIs on life expectancy and health risks,such as liver cirrhosis,cancer,and other diseases in individuals with chronic ***,millions of blood donations take place annually,emphasizing the importance of maintaining blood *** To study the prevalence of TTIs,viz.,HBV,HCV,HIV I/II,syphilis,and malaria parasite(MP),among different blood donor *** The study assessed the prevalence of TTIs among different blood donor groups in Delhi,*** included total donors,in-house donors,total camp donors,institutional camp donors,and community camp *** for HIV,HBV,and HCV were done using enzyme-linked immunosorbent assay,while syphilis was tested with rapid plasma reagins and MP rapid card *** prevalence of HBV,HCV,HIV,and syphilis,expressed as *** in infection rates between the groups were analyzed usingχ²tests and P-values(less than 0.05).RESULTS The study evaluated TTIs among 42158 blood donors in *** overall cumulative frequency of TTIs in total blood donors was 2.071%,and the frequencies of HBV,HCV,HIV-I/II,venereal disease research laboratory,and MP were 1.048%,0.425%,0.221%,0.377%,and 0.0024%,***-house donors,representing 37656 donors,had the highest transfusion transmissible infection(TTI)prevalence at 2.167%.Among total camp donors(4502 donors),TTIs were identified in 1.266%of donors,while community camp donors(2439 donors)exhibited a prevalence of 1.558%.Institutional camp donors(2063 donors)had the l

关键词： Blood donors Transfusion transmissible infections Hepatitis B virus Human immunodeficiency virus Hepatitis C virus Malaria parasite Syphilis

Strategic insights of telehealth platforms and strengths,weaknesses,opportunities,and threats analysis of Amazon's clinical endeavors

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World Journal of Methodology 2025年第2期15卷 145-153页

作者： Harpreet Grewal Gagandeep Dhillon Venkata Buddhavarapu Ram Kishun Verma Ripudaman Singh Munjal Pranjal sharma Gurmanpreet Sidhu Rahul Kashyap Salim Surani Department of Radiology Ascension Sacred Heart HospitalPensacolaFL 32503United States Department of Medicine UM Baltimore Washington Medical CenterGlen BurnieMD 21061United States Department of Medicine Banner Baywood Medical CenterBanner HealthMesaAZ 85206United States Department of Sleep Medicine Parkview Health SystemFort WayneIN 46845United States Department of Medicine Touro university College of Osteopathic MedicineVallejoCA 94592United States Department of Nephrology Northeast Ohio Medical CenterRootstownOH 44272United States Department of Pathology Government Medical College PatialaPatiala 147001PunjabIndia Department of Research Wellspan HealthYorkPA 17403United States Division of Pulmonary and Critical Care Medicine Mayo ClinicRochesterMN 55905United States Department of Medicine&Pharmacology Texas A&M UniversityCollege StationTX 77843United States

BACKGROUND The adoption of telehealth services surged after the coronavirus disease 2019 pandemic,revolutionizing traditional healthcare delivery *** Clinic's recent nationwide launch marks a significant milestone in this *** study aims to offer a strengths,weaknesses,opportunities,and threats(SWOT)analysis of Amazon Clinic and compare its features with leading virtual healthcare *** To evaluate Amazon Clinic's telehealth services through a SWOT analysis and compare its features with other leading virtual healthcare *** The initial search terms included were,amazon clinic odds ratio(OR)amwell OR Teladoc OR Walmart virtual health service OR CVS minute clinic OR CirrusMD OR brightside health,from 2000 to *** search yielded 111 articles,from which duplicates were removed,and unrelated titles were filtered *** articles were retained for a final review,including comparative studies,usability research,retrospective analyses,observational studies,and review *** data was organized and analyzed using Rayyan software and summarized in a table and PRISMA *** The review included eight articles focusing on various aspects of *** studies highlighted differences between Teladoc and traditional physician offices,noting lower diagnostic imaging orders and antibiotic prescriptions for *** demographics for Teladoc showed younger,less engaged *** studies emphasized the importance of website design for telemedicine ***-mental health platforms like Brightside showed superior outcomes in treating depression compared to traditional *** for specialized fields like skin reconstruction demonstrated cost efficiency and reduced waiting *** SWOT analysis identified Amazon Clinic's strengths,such as its vast consumer base and transparent pricing,and weaknesses like the lack of pediatric *** included potential partnerships and servi

关键词： Tele-health Amazon COVID-19 Primary Care Outpatient clinic SWOT Telemedicine

Chemical, mechanical, and thermal expansion properties of a carbon nanotube-reinforced aluminum nanocomposite

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International Journal of Minerals,Metallurgy and Materials 2016年第2期23卷 222-233页

作者： Manjula sharma Vimal sharma Department of Physics National Institute of Technology Hamirpur

In the present study,the chemical and mechanical properties and the thermal expansion of a carbon nanotube（CNT）-based crystalline nano-aluminum（nano Al） composite were *** properties of nanocomposites were tailored by incorporating CNTs into the nano Al matrix using a physical mixing *** elastic moduli and the coefficient of thermal expansion（CTE） of the nanocomposites were also estimated to understand the effects of CNT reinforcement in the Al *** characterization of the nanocomposite reveals that the CNTs are dispersed and embedded in the Al *** experimental results indicate that the incorporation of CNTs into the nano Al matrix results in the increase in hardness and elastic modulus along with a concomitant decrease in the coefficient of thermal expansion The hardness and elastic modulus of the nanocomposite increase by 21%and 20%,respectively,upon CNT *** CTE of CNT/A1 nanocomposite decreases to 70%compared with that of nano Al.

关键词： metal matrix composites carbon nanotubes nanocomposites chemical properties thermal expansion mechanical properties

Theoretical Study of Screening Dependence of Aluminium Doped MgB_2

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Chinese Physics Letters 2018年第3期35卷 79-83页

作者： Gargee sharma Smita sharma Department of Physics Government Dungar College

The screening dependence of superconducting state parameters （λ, μ＊, Tc, α and NoV） of six alloys of aluminium doped MgB2 systems are studied in the BCS-Eliashberg-MeMillan framework by employing five forms of dielectric screening function, viz. random phase approximation （RPA）, Harrison, Geldart and Vosko （GV）, Hubbard and Overhauser in conjunction with Ashcroft＇s potential. It is observed that electron-phonon coupling strength and Coulomb pseudopotential μ＊ are quite sensitive to the form of dielectric screening, whereas transition temperature Tc, isotope effect exponent α and effective interaction strength NoV show weak dependence on the form of dielectric screening function. It is found that the RPA form of dielectric screening function yields the best results for transition temperature Tc for all alloys of the Mg-Al-B system. The results obtained using GV screening are much higher than the experimental results. This shows that all the four dielectric screenings used here almost describe superconductivity in all the alloys of the Mg-Al-B system, but the GV screening is not suitable for such an alloy system.

关键词： Theoretical Study of Screening Dependence of Aluminium Doped MgB2 Al

Manifestation of earthquake preparation zone in the ionosphere before 2021 Sonitpur,Assam earthquake revealed by GPS-TEC data

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Geodesy and Geodynamics 2022年第3期13卷 230-237页

作者： Gopal sharma North Eastern Space Applications Centre Umiam793103MeghalayaIndia

Global Positioning System(GPS)Continuously Operating Reference Station(CORS)data analysis shows that the ionosphere’s electron density variability is linked to the deformation and stress accumulation in the Earth’s *** in ionosphere total electron content(TEC)variability before 2021 M6.4 Sonitpur,Assam earthquake were detected using L1 and L2 GPS frequencies that showed three distinct abnormalities on April 3,9,10,***’s correlation coefficient(r)of TEC decreases in the CORS that lies away from the earthquake epicenter,indicating the possibilities of a positive relationship between TEC variability and earthquake *** concentration also decreases towards the epicenter within the earthquake preparation zone(EPZ).It is also observed that the Pearson’s correlation coefficient(r)of TEC decreases linearly near the *** study demonstrates the possibilities of determining the TEC anomalous zone in the ionosphere that coincides with the EPZ in the crustal *** research indicated the possibilities of magnitude estimation of an impending earthquake based on the TEC anomalous zone in the ionosphere using closely spaced dense CORS network data.

关键词： GPS TEC Sonitpur earthquake Ionosphere perturbation TEC anomaly Magnitude estimation

Variational Monte Carlo Study of _(ΛΛ)^(4)H

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Chinese Physics Letters 2013年第3期30卷 40-43页

作者： Bhupali sharma Department of Physics Jamia Millia IslamiaNew Delhi-110025India Arya Vidyapeeth College Gauhati UniversityAssamIndia

Variational Monte Carlo calculations are carried out for _(ΛΛ)^(4)H to explore the possibility of its existence,using realistic NN,NNN,and phenomenologicalΛN andΛNN *** also perform calculations using FGNNand NSC97ΛN potentials,and demonstrate the effect of the exchange part of the two-bodyΛN interaction and three-bodyΛNN interaction on the binding energy ofΛΛ*** the stability of _(ΛΛ)^(4)H remains an open question and this hypernuclear system has to be explored more theoretically.

关键词： interaction calculations stability