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Tale of Two Alopecias: Alopecia Areata and central centrifugal cicatricial Alopecia Occurring in the Same Patient

International Journal of Dermatology and Venereology 2022年第1期5卷 45-49页

作者： sharlene helene c.see Timothy L.Tan Oyinade Aderibigbe Pedram Yazdan Department of Pathology Northwestern University Feinberg School of MedicineChicagoIL 60611USA consolidated Pathology consultants LibertyvilleIL 60048USA Department of Dermatology Division of DermatopathologyNorthwestern University Feinberg School of MedicineChicagoIL 60611USA

Introduction:Scarring and non-scarring alopecias have rarely been described to occur together in the same *** these two different types of alopecia is important as treatment and prognosis can be *** presentation:Here,we report the first case of simultaneous alopecia areata(AA)and central centrifugal cicatricial alopecia(cccA)in a 35-year-old *** alopecic patches were noted on her frontal and vertex *** of the frontal scalp revealed miniaturized hair follicles and dense lymphocytic infiltrate surrounding the hair bulbs,consistent with AA;while biopsy of the vertex scalp revealed decreased hair follicles,perifollicular fibroplasia with eccentric atrophy of the follicular epithelium,and premature desquamation of the inner root sheath at the level of the lower isthmus,consistent with ***:Proposed mechanisms of these two alopecia types occurring together include loss of immune privilege,genetic predisposition,as well as unknown external factors that trigger an autoimmune lymphocytic *** recently,the peptidylarginine deiminase type III gene has been implicated in both *** treatment options can overlap between thetwo diseases,treatment response can differ and cccA tendsto have a worse ***:Awareness of this concomitant presentation of two alopecic types is important for appropriate treatment and prognostication.

关键词： alopecia areata central centrifugal cicatricial alopecia non-scarring alopecia scarring alopecia peptidylarginine deiminase type III gene

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