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Antioxidant-enriched autologous biogel promoted diabetic wound healing by remodeling inherent posttraumatic inflammatory patterning and restoring compromised microenvironment homeostasis

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Regenerative Biomaterials 2022年第1期9卷 202-218页

作者： Yixi Yang Le Wang Yonglin Zhou Yijun He shaozhang lin Yuwei Zeng Yunhe Zhou Wei Li Zaopeng He Qi Zhao Lihao Chen Zijie Li Wenhao Wang Zhi-Yong Zhang Translational Research Centre of Regenerative Medicine and 3D Printing of Guangzhou Medical University Guangdong Province Engineering Research Center for Biomedical EngineeringState Key Laboratory of Respiratory DiseaseThe Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510150P.R.China Department of Orthopaedic Surgery The Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510150P.R.China Medical Technology and Related Equipment Laboratory The Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510150P.R.China Hand and Foot Surgery&Plastic Surgery Affiliated Shunde Hospital of Guangzhou Medical UniversityShunde DistrictFoshanP.R.China

Successful wound healing depends on the reconstruction of proper tissue homeostasis,particularly in the posttraumatic inflammatory tissue *** jeopardizes tissues’immune homeostasis in cutaneous wounds,causing persistent chronic inflammation and cytokine ***,we developed an autologous regeneration factor(ARF)technology to extract the cytokine composite from autologous tissue to restore immune homeostasis and promote wound ***,treatment efficacy was significantly compromised in diabetic ***,we proposed that a combination of melatonin and ARF,which is beneficial for proper immune homeostasis reconstruction,could be an effective treatment for diabetic *** research showed that the utilization of melatonin-mediated ARF biogel(AM gel)promoted diabetic wound regeneration at a more rapid healing ***-Seq analysis showed that AM gel treatment could restore more favorable immune tissue homeostasis with unique inflammatory patterning as a result of the diminished intensity of acute and chronic ***,AM gel could be a novel and promising therapeutic strategy for diabetic wounds in clinical practice through favorable immune homeostatic reconstructions in the tissue microenvironment and proper posttraumatic inflammation patterning.

关键词： autologous regeneration factors wound healing homeostasis tissue microenvironment inflammation patterning

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Magnesium cationic cue enriched interfacial tissue microenvironment nurtures the osseointegration of gamma-irradiated allograft bone

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Bioactive Materials 2022年第4期7卷 32-47页

作者： Wenhao Wang Jie Shen Yuan Meng Miaoman Ye shaozhang lin Qi Zhao Le Wang Kenneth M.C.Cheung Shuilin Wu Yufeng Zheng Xuanyong Liu Paul K.Chu Kelvin W.K.Yeung Zhi-Yong Zhang Translational Research Centre of Regenerative Medicine and 3D Printing of Guangzhou Medical University Guangdong Province Engineering Research Center for Biomedical EngineeringState Key Laboratory of Respiratory DiseaseThe Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhou510150PR China Department of Orthopaedics and Traumatology The University of Hong KongHong Kong999077PR China Shenzhen Key Laboratory for Innovative Technology in Orthopaedic Trauma The University of Hong Kong Shenzhen HospitalShenzhen518053PR China Department of Orthopaedic Surgery The Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhou510150PR China Shenzhen Key Laboratory of Spine Surgery Department of Spine SurgeryPeking University Shenzhen HospitalShenzhen518036PR China Ministry of Education Key Laboratory for the Green Preparation and Application of Functional Materials Hubei Key Laboratory of Polymer MaterialsSchool of Materials&EngineeringHubei UniversityWuhan430062PR China Ministry of Education Key Laboratory for Advanced Ceramics and Machining Technology School of Materials Science&EngineeringTianjin UniversityTianjin300352PR China State Key Laboratory for Turbulence and Complex System Department of Materials Science and EngineeringCollage of EngineeringPeking UniversityBeijing100871PR China State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai200050PR China Department of Materials Science and Engineering City University of Hong KongHong Kong999077PR China

Regardless of the advancement of synthetic bone substitutes,allograft-derived bone substitutes still dominate in the orthopaedic circle in the treatments of bone ***,the stringent devitalization process jeopardizes their osseointegration with host bone and therefore prone to long-term ***,improving osseointegration and transplantation efficiency remains *** alteration of bone tissue microenvironment(TME)to facilitate osseointegration has been generally ***,the concept of exerting metal ionic cue in bone TME without compromising the mechanical properties of bone allograft is *** address this concern,an interfacial tissue microenvironment with magnesium cationc cue was tailored onto the gamma-irradiated allograft bone using a customized magnesium-plasma surface *** formation of the Mg cationic cue enriched interfacial tissue microenvironment on allograft bone was verified by the scanning ion-selective electrode *** cellular activities of human TERT-immortalized mesenchymal stem cells on the Mg-enriched grafts were notably *** the animal test,superior osseointegration between Mg-enriched graft and host bone was found,whereas poor integration was observed in the gamma-irradiated controls at 28 days ***,the bony in-growth appeared on magnesium-enriched allograft bone was significant *** mechanism possibly correlates to the up-regulation of integrin receptors in mesenchymal stem cells under modified bone TME that directly orchestrate the initial cell attachment and osteogenic differentiation of mesenchymal stem ***,our findings demonstrate the significance of magnesium cation modified bone allograft that can potentially translate to various orthopaedic procedures requiring bone augmentation.

关键词： Osseointegration Allograft bone Bone tissue microenvironment Bone-implant interface Magnesium

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Fabrication of a bio-instructive scaffold conferred with a favorable microenvironment allowing for superior implant osseointegration and accelerated in situ vascularized bone regeneration via type H vessel formation

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Bioactive Materials 2022年第3期7卷 491-507页

作者： Yijun He Wenhao Wang shaozhang lin Yixi Yang Lizhi Song Yihan Jing Lihao Chen Zaopeng He Wei Li Ao Xiong Kelvin W.K.Yeung Qi Zhao Yuan Jiang Zijie Li Guoxian Pei Zhi-Yong Zhang Translational Research Centre of Regenerative Medicine and 3D Printing of Guangzhou Medical University Guangdong Province Engineering Research Center for Biomedical EngineeringState Key Laboratory of Respiratory DiseaseThe Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhou510150PR China Hand and Foot Surgery&Plastic Surgery Affiliated Shunde Hospital of Guangzhou Medical UniversityFoshan528315PR China Department of Bone&Joint Surgery Peking University Shenzhen HospitalShenzhen518036PR China National&Local Joint Engineering Research Center of Orthopaedic Biomaterials Peking University Shenzhen HospitalShenzhen518036PR China Department of Orthopaedics and Traumatology The University of Hong KongPokfulamHong Kong999077PR China Shenzhen Key Laboratory for Innovative Technology in Orthopaedic Trauma The University of Hong Kong Shenzhen HospitalShenzhen518053PR China The Third Affiliated Hospital of Southern University of Science and Technology Southern University of Science and TechnologyShenzhen518055PR China Department of Orthopaedic Surgery The Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhou510150PR China Medical Technology and Related Equipment Research for Spinal Injury Treatment City Key LaboratoryThe Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhou510150PR China

The potential translation of bio-inert polymer scaffolds as bone substitutes is limited by the lack of neovascularization upon implantation and subsequently diminished ingrowth of host bone,most likely resulted from the inability to replicate appropriate endogenous crosstalk between *** umbilical vein endothelial cell-derived decellularized extracellular matrix(HdECM),which contains a collection of angiocrine biomolecules,has recently been demonstrated to mediate endothelial cells(ECs)-osteoprogenitors(OPs)*** employed the HdECM to create a PCL(polycaprolactone)/fibrin/HdECM(PFE)hybrid *** hypothesized PFE scaffold could reconstitute a bio-instructive microenvironment that reintroduces the crosstalk,resulting in vascularized bone *** implantation in a rat femoral bone defect,the PFE scaffold demonstrated early vascular infiltration and enhanced bone regeneration by microangiography(μ-AG)and micro-computational tomography(μ-CT).Based on the immunofluorescence studies,PFE mediated the endogenous angiogenesis and osteogenesis with a substantial number of type H vessels and *** addition,superior osseointegration was observed by a direct host bone-PCL interface,which was likely attributed to the formation of type H *** bio-instructive microenvironment created by our innovative PFE scaffold made possible superior osseointegration and type H vessel-related bone *** could become an alternative solution of improving the osseointegration of bone substitutes with the help of induced type H vessels,which could compensate for the inherent biological inertness of synthetic polymers.

关键词： Cell-derived decellularized extracellular matrix Microenvironment Vascularized bone regeneration Type H vessels Osseointegration

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Corrigendum to“Magnesium cationic cue enriched interfacial tissue microenvironment nurtures the osseointegration of gamma-irradiated allograft bone”[***.10C(April 2022)32-47]

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Bioactive Materials 2023年第2期20卷 165-165页

作者： Wenhao Wang Jie Shen Yuan Meng Miaoman Ye shaozhang lin Qi Zhao Le Wang Kenneth M.C.Cheung Shuilin Wu Yufeng Zheng Xuanyong Liu Paul K.Chu Kelvin W.K.Yeung Zhi-Yong Zhang Translational Research Centre of Regenerative Medicine and 3D Printing of Guangzhou Medical University Guangdong Province Engineering Research Center for Biomedical EngineeringState Key Laboratory of Respiratory DiseaseThe Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhou510150PR China Department of Orthopaedics and Traumatology The University of Hong Kong999077Hong KongChina Shenzhen Key Laboratory for Innovative Technology in Orthopaedic Trauma The University of Hong Kong Shenzhen HospitalShenzhen518053PR China Department of Orthopaedic Surgery The Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhou510150PR China Shenzhen Key Laboratory of Spine Surgery Department of Spine SurgeryPeking University Shenzhen HospitalShenzhen518036PR China Ministry of Education Key Laboratory for the Green Preparation and Application of Functional Materials Hubei Key Laboratory of Polymer MaterialsSchool of Materials&EngineeringHubei UniversityWuhan430062PR China Ministry of Education Key Laboratory for Advanced Ceramics and Machining Technology School of Materials Science&EngineeringTianjin UniversityTianjin300352PR China State Key Laboratory for Turbulence and Complex System Department of Materials Science and EngineeringCollage of EngineeringPeking UniversityBeijing100871PR China State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai200050PR China Department of Materials Science and Engineering City University of Hong Kong999077Hong KongChina

The authors regret a mistake of funding numbers in the Acknowledgment Section failed to be corrected during proof *** is the corrected funding statement in Acknowledgment SECTION This work was supported by the National Natural Science Foundation of China(NSFC)(Nos.81902189,81772354,82002303,31570980),Clinical Innovation Research Program of Guangzhou Regenerative Medicine and Health Guangdong Laboratory(2018GZR0201002),National Key Research and Development Plan(2018YFC1105103).

关键词： NSFC statement enriched

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Corrigendum to‘Fabrication of a bio-instructive scaffold conferred with a favorable microenvironment allowing for superior implant osseointegration and accelerated in situ vascularized bone regeneration via type H vessel formation’[Bioactive Materials,Volume 9(March 2022)Page 491-507]

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Bioactive Materials 2023年第2期20卷 164-164页

作者： Yijun He Wenhao Wang shaozhang lin Yixi Yang Lizhi Song Yihan Jing Lihao Chen Zaopeng He Wei Li Ao Xiong Kelvin W.K.Yeung Qi Zhao Yuan Jiang Zijie Li Guoxian Pei Zhi-Yong Zhang Translational Research Centre of Regenerative Medicine and 3D Printing of Guangzhou Medical University Guangdong Province Engineering Research Center for Biomedical EngineeringState Key Laboratory of Respiratory DiseaseThe Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhou510150PR China Hand and Foot Surgery&Plastic Surgery Affiliated Shunde Hospital of Guangzhou Medical UniversityFoshan528315PR China Department of Bone&Joint Surgery Peking University Shenzhen HospitalShenzhen518036PR China National&Local Joint Engineering Research Center of Orthopaedic Biomaterials Peking University Shenzhen HospitalShenzhen518036PR China Department of Orthopaedics and Traumatology The University of Hong KongPokfulamHong Kong999077PR China Shenzhen Key Laboratory for Innovative Technology in Orthopaedic Traum1 The University of Hong Kong Shenzhen HospitalShenzhen518053PR China The Third Affiliated Hospital of Southern University of Science and Technology Southern University of Science and TechnologyShenzhen518055PR China Department of Orthopaedic Surgery The Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhou510150PR China Medical Technology and Related Equipment Research for Spinal Injury Treatment City Key LaboratoryThe Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhou510150PR China

The authors regret a mistake of funding numbers in the Acknowledgment Section failed to be corrected during *** is the corrected funding statement in ACKNOWLEDGMENT SECTION:This work was supported by the National Natural Science Foundation of China(NSFC)(Nos.82072415,81772354,81902189),Clinical Innovation Research Program of Guangzhou Regenerative Medicine and Health Guangdong Laboratory(2018GZR0201002),Science Technology Project of Guangzhou City(2019ZD15).

关键词： NSFC instru statement

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双眼视乳头小凹伴黄斑部脱离1例

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陆军军医大学学报 1999年第1期21卷 34-34页

作者：刘少章谢琳袁容娣第三军医大学附属大坪医院眼科

１临床资料患者男，２７岁。因双眼视力逐渐下降一月于１９９７年１月１０日就诊。眼部检查：视力右０．５／、右０．６／。双角膜透明、ＫＰ（－）、前房（－）、虹膜瞳孔未见异常。三面镜检查：右视乳头颞上方可见一１／６ＤＤ大小黄... 详细信息

１临床资料患者男，２７岁。因双眼视力逐渐下降一月于１９９７年１月１０日就诊。眼部检查：视力右０．５／、右０．６／。双角膜透明、ＫＰ（－）、前房（－）、虹膜瞳孔未见异常。三面镜检查：右视乳头颞上方可见一１／６ＤＤ大小黄白色小凹深约４Ｄ。左眼视乳头颞上方...

关键词：视乳头小凹黄斑脱离

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乙肝病毒相关肝细胞肝癌中性激素受体的表达及其意义

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中外医疗 2021年第36期40卷 1-4页

作者：李媛郭琳张松侯绍章宁夏医科大学护理学院宁夏银川750004 宁夏医科大学总医院宁夏银川750004 宁夏医科大学基础医学院宁夏银川750004

目的探讨性激素受体[雄激素受体(AR)、雌激素受体(ER)]在乙肝病毒(HBV)相关肝细胞肝癌(HCC)及癌旁组织的表达情况,以期在HBV相关HCC患者的诊断、治疗、预后等方面提供新的思路。方法回顾性选取2016年6月—2020年12月间宁夏某医院病理科... 详细信息

目的探讨性激素受体[雄激素受体(AR)、雌激素受体(ER)]在乙肝病毒(HBV)相关肝细胞肝癌(HCC)及癌旁组织的表达情况,以期在HBV相关HCC患者的诊断、治疗、预后等方面提供新的思路。方法回顾性选取2016年6月—2020年12月间宁夏某医院病理科确诊为肝细胞肝癌患者的相关临床及病理资料,分别从获得的HBV相关HCC病例中的52例女性和188例男性进行简单随机抽样,抽取癌及癌旁组织石蜡标本54例(女25例,男29例),用IHC S-P法检测上述标本中ER和AR的表达情况。结果①AR在HBV相关HCC癌细胞中的表达主要见于细胞核,在癌旁肝细胞中主要在细胞核、浆中同时阳性表达,AR与HepPar-1等HCC特异性IHC标记物一致性检验结果较差,而AR在癌细胞核的表达与HBV DNA复制活跃有显著正相关关系(P<0.001);②ER主要在癌旁肝细胞胞核中表达,未见在癌细胞中表达的病例。结论AR更适合作为HBV相关HCC患者的一项预后指标,为预测HBV相关HCC患者预后、术后抗病毒治疗提供一定理论依据。ER或可成为鉴别高分化癌细胞与癌旁增生的标记物。

关键词：乙肝病毒肝细胞肝癌性激素受体临床病理意义

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犬后肢高速枪弹伤后眼组织结构的改变

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中华创伤杂志 1999年第5期15卷 348-350页

作者：谢琳刘少章王建民第三军医大学附属大坪医院野战外科研究所眼科重庆400042

目的　观察犬后肢高速枪弹伤后眼组织的病理改变 ,并对其致伤机制进行初步探讨 ,为临床诊治提供依据。方法　采用第三军医大学野战外科研究所创伤弹道模型 ,致犬后肢高速枪弹伤。在致伤后 2 4小时 ,观察眼组织的病理结构改变。结果　 (... 详细信息

目的　观察犬后肢高速枪弹伤后眼组织的病理改变 ,并对其致伤机制进行初步探讨 ,为临床诊治提供依据。方法　采用第三军医大学野战外科研究所创伤弹道模型 ,致犬后肢高速枪弹伤。在致伤后 2 4小时 ,观察眼组织的病理结构改变。结果　 ( 1)大体观察发现除犬伤道有不同程度损伤外 ,外眼、内眼均有损伤。 ( 2 )病理发现 ,角膜水肿 ,葡萄膜和视网膜血管扩张充血 ,甚至出现视网膜脱离。电镜下观察 ,视细胞线粒体空泡变性 ,葡萄膜血管管壁部分疏松肿胀。结论　高速投射物在对生物组织局部产生严重损伤的同时 ,远隔部位眼组织也有不同程度的损伤。

关键词：创伤四肢枪伤眼组织结构病理学枪弹伤

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实验性糖尿病肾小球的超微结构及其病变分级

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解剖学杂志 2011年第1期34卷 31-34页

作者：张建中侯绍章景丽葛新红赵琳郭风英秦憬宁夏医科大学病理学系银川750004 宁夏医科大学附属医院银川750004

目的：探讨糖尿病肾病的形态学特点及其变化规律.方法：采用链脲佐菌素制备糖尿病大鼠模型.采用透射电子显微镜,对比观察14、30、60d肾病变.结果：糖尿病模型组在14d时,肾小球等结构未见明显异常变化;在30d时,可见少数肾小球有系膜基... 详细信息

目的：探讨糖尿病肾病的形态学特点及其变化规律.方法：采用链脲佐菌素制备糖尿病大鼠模型.采用透射电子显微镜,对比观察14、30、60d肾病变.结果：糖尿病模型组在14d时,肾小球等结构未见明显异常变化;在30d时,可见少数肾小球有系膜基质灶性增多;在60d时,少部分肾小球有系膜细胞增生,系膜基质灶性增多.透射电镜观察可见,糖尿病模型组在14d时,肾小球毛细血管基底膜不均匀,个别足突相互融合;在30d时,肾小球毛细血管基底膜节段性增厚,足突细胞部分足突融合,系膜区出现灶性电子致密物沉积.在60d时,肾小球毛细血管基底膜节段性增厚,部分基底膜的3层结构变得不清晰,部分系膜区增宽,可见灶性电子致密物沉积.结论：链脲佐菌素诱导的糖尿病大鼠模型可出现肾病变,随着病程进展,可将糖尿病肾病变分为5级（DN0～DN4）.

关键词：糖尿病肾病分级肾小球超微结构大鼠

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