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Exosomes originating from neural stem cells undergoing necroptosis participate in cellular communication by inducing TSC2 upregulation of recipient cells following spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3273-3286页

作者： Shiming Li Jianfeng Li Guoliang Chen Tao Lin Penghui Zhang Kuileung Tong Ningning Chen shaoyu liu Shenzhen Key Laboratory of Bone Tissue Repair and Translational Research Department of Orthopedic SurgeryThe Seventh Affiliated HospitalSun Yat-sen UniversityShenzhenGuangdong ProvinceChina Department of Orthopedic Surgery The First Affiliated Hospital of Jinan UniversityGuangzhouGuangdong ProvinceChina Department of Orthopedics and Traumatology Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina Department of Orthopedic Surgery The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Department of Orthopedic Surgery The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

We previously demonstrated that inhibiting neural stem cells necroptosis enhances functional recovery after spinal cord *** exosomes are recognized as playing a pivotal role in neural stem cells exocrine function,their precise function in spinal cord injury remains *** investigate the role of exosomes generated following neural stem cells necroptosis after spinal cord injury,we conducted singlecell RNA sequencing and validated that neural stem cells originate from ependymal cells and undergo necroptosis in response to spinal cord ***,we established an in vitro necroptosis model using neural stem cells isolated from embryonic mice aged 16-17 days and extracted *** results showed that necroptosis did not significantly impact the fundamental characteristics or number of *** sequencing of exosomes in necroptosis group identified 108 differentially expressed messenger RNAs,104 long non-coding RNAs,720 circular RNAs,and 14 microRNAs compared with the control *** of a competing endogenous RNA network identified the following hub genes:tuberous sclerosis 2(Tsc2),solute carrier family 16 member 3(Slc16a3),and forkhead box protein P1(Foxp1).Notably,a significant elevation in TSC2 expression was observed in spinal cord tissues following spinal cord ***2-positive cells were localized around SRY-box transcription factor 2-positive cells within the injury ***,in vitro analysis revealed increased TSC2 expression in exosomal receptor cells compared with other *** assessment of cellular communication following spinal cord injury showed that Tsc2 was involved in ependymal cellular communication at 1 and 3 days post-injury through the epidermal growth factor and midkine signaling *** addition,Slc16a3 participated in cellular communication in ependymal cells at 7 days post-injury via the vascular endothelial growth factor and macrophage migration inhibitory factor signaling

关键词： cellular communication competing endogenous RNA exosomes Foxp1 necroptosis neural stem cells Slc16a3 spinal cord injury transcriptome sequencing Tsc2

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Monitoring the delicate operations of surgical robots via ultra-sensitive ionic electronic skin

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National Science Review 2022年第12期9卷 163-176页

作者： Danyang Wei Jiajie Guo Yuqi Qiu shaoyu liu Jiangyan Mao Yutian liu Zhenbing Chen Hao Wu Zhouping Yin State Key Laboratory of Digital Manufacturing Equipment and Technology School of Mechanical Science and EngineeringHuazhong University of Science and Technology Department of Hand Surgery Union Hospital Tongji Medical CollegeHuazhong University of Science and Technology

The arrival of surgical robots in high-end medical equipment is a landmark,and the realization of tactile sensation a major challenge in this important cutting-edge research *** to address this issue,we present ultra-sensitive ionic electronic skin in the form of flexible capacitive pressure sensors,which incorporate multistage bionic microstructures in ion gels for the purpose of monitoring the delicate operations of surgical ***,the ionic skin exhibits an ultra-high sensitivity of 9484.3 kPa-1(<15 kPa),and the sensitivity remains higher than 235 kPa-1in the wide range of 15-155 *** device has also achieved a detection limit as low as 0.12 Pa or,equivalently,0.31 mg,fast response within 24 ms,and high robustness(loading/unloading for 5000 cycles without fatigue).The sensor facilitates the challenging task of tele-operated robotic threading,which exceeds the human tactile perception limit when threading a *** have also confirmed that ionic skin can be used in robot-assisted invasive surgery,such as incision/resection of tissues and suturing of wounds,providing tactile information to surgeons to improve operation success *** flexible ionic skin is capable of conforming to the various shapes of robotic manipulators,thus has great promise for applications in robotic dexterous manipulation,prosthetics and human-machine interfaces.

关键词： surgical robots delicate operations ultra-sensitive ionic electronic skin tactile sensing

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Effect of cyclic mechanical loading on immunoinflammatory microenvironment in biofabricating hydroxyapatite scaffold for bone regeneration

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Bioactive Materials 2021年第10期6卷 3097-3108页

作者： Penghui Zhang Xizhe liu Peng Guo Xianlong Li Zhongyuan He Zhen Li Martin J.Stoddart Sibylle Grad Wei Tian Dafu Chen Xuenong Zou Zhiyu Zhou shaoyu liu Innovation Platform of Regeneration and Repair of Spinal Cord and Nerve Injury Department of Orthopaedic SurgeryThe Seventh Affiliated HospitalSun Yat-sen UniversityShenzhen518107China Guangdong Provincial Key Laboratory of Orthopedics and Traumatology Orthopaedic Research Institute/Department of Spinal SurgeryThe First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou510080China AO Research Institute Davos Clavadelerstrasse 8Davos7270Switzerland Laboratory of Bone Tissue Engineering Beijing Laboratory of Biomedical MaterialsBeijing Research Institute of Orthopaedics and TraumatologyBeijing JiShuiTan HospitalBeijing100035China

It has been proven that the mechanical microenvironment can impact the differentiation of mesenchymal stem cells(MSCs).However,the effect of mechanical stimuli in biofabricating hydroxyapatite scaffolds on the inflammatory response of MSCs remains *** study aimed to investigate the effect of mechanical loading on the inflammatory response of MSCs seeded on *** mechanical loading was applied to biofabricate the cell-scaffold composite for 15 min/day over 7,14,or 21 *** the predetermined time points,culture supernatant was collected for inflammatory mediator detection,and gene expression was analyzed by *** results showed that the expression of inflammatory mediators(IL1B and IL8)was downregulated(p<0.05)and the expression of ALP(p<0.01)and COL1A1(p<0.05)was upregulated under mechanical *** cell-scaffold composites biofabricated with or without mechanical loading were freeze-dried to prepare extracellular matrix-based scaffolds(ECM-based scaffolds).Murine macrophages were seeded on the ECM-based scaffolds to evaluate their *** ECM-based scaffolds that were biofabricated with mechanical loading before freeze-drying enhanced the expression of M2 polarization-related biomarkers(Arginase 1 and Mrc1,p<0.05)of macrophages in vitro and increased bone volume/total volume ratio in ***,these findings demonstrated that mechanical loading could dually modulate the inflammatory responses and osteogenic differentiation of ***,the ECM-based scaffolds that were biofabricated with mechanical loading before freeze-drying facilitated the M2 polarization of macrophages in vitro and bone regeneration in *** loading may be a promising biofabrication strategy for bone biomaterials.

关键词： Bioreactor Biofabrication Inflammatory microenvironment Bone biomaterials Macrophage polarization

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对川东基底性质、结构的探讨

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天然气工业 1989年第2期9卷 15-20页

作者：刘绍裕四川石油管理局地质调查处

本文利用川东过去的重、磁力资料,采用计算机重新处理,作出了该区剩余重力异常、剩余磁力异常及滋力垂直一次导数异常等图件,并结合地震、地质及钻井资料,对川东基底的性质、结构作了详细的解释,为深部气藏的勘探、研究提供了重要的资料。

关键词：油气勘探基底构造地质解释

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冲洪积扇含水层地下水可开采量数值模拟——以文峪河冲洪积扇为例

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水文地质工程地质 1998年第1期25卷 38-41页

作者：刘少玉地矿部水文地质工程地质研究所

依据钻孔岩性、水文地质资料，将文峪河冲洪积扇平面分为上游单一潜水区和中下游承压水区。中下游垂向划分为上部弱潜水含水层和下部较强承压水含水层。对上游潜水和中下游承压水用二维侧向流数学模型，对中下游弱潜水用一维垂向流数学... 详细信息

依据钻孔岩性、水文地质资料，将文峪河冲洪积扇平面分为上游单一潜水区和中下游承压水区。中下游垂向划分为上部弱潜水含水层和下部较强承压水含水层。对上游潜水和中下游承压水用二维侧向流数学模型，对中下游弱潜水用一维垂向流数学模型。在计算了现状开采条件下的水资源基础上，进一步计算出，在扇上游集中采水时，按工业开采和农业开采，以地下水多年总补排均衡、水位长期稳定为约束条件的地下水可开采量。

关键词：冲洪积扇数值模拟地下水可开采量含水层

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中医药文化传承创新发展的逻辑、困境及路径

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东南学术 2024年第6期 235-244页

作者：刘少渝福建中医药大学

中医药文化底蕴深厚,现代价值凸显,作为中华传统文化的瑰宝,蕴含着独特而丰富的健康理念与医学实践。推动中医药文化传承创新发展,有利于提升文化自信、构建中华文明标识体系,助力国家治理现代化与全球健康治理。中医药文化传承创新发... 详细信息

中医药文化底蕴深厚,现代价值凸显,作为中华传统文化的瑰宝,蕴含着独特而丰富的健康理念与医学实践。推动中医药文化传承创新发展,有利于提升文化自信、构建中华文明标识体系,助力国家治理现代化与全球健康治理。中医药文化传承创新发展有着历史、现实和价值三重逻辑,当前又面临着创新滞后、传播瓶颈与教育不足等挑战。对此,应深挖中医药文化价值意涵、加强中医药文化的国际交流、创新中医药文化传播的话语体系、强化中医药文化人才队伍建设,从而为全球健康治理贡献东方智慧,支撑中医药文化复兴与健康中国建设。

关键词：中医药文化文化自信健康中国

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A single-cell transcriptome of mesenchymal stromal cells to fabricate bioactive hydroxyapatite materials for bone regeneration

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Bioactive Materials 2022年第3期7卷 281-298页

作者： Peng Guo Xizhe liu Penghui Zhang Zhongyuan He Zhen Li Mauro Alini RGeoff Richards Sibylle Grad Martin J.Stoddart Guangqian Zhou Xuenong Zou Danny Chan Wei Tian Dafu Chen Manman Gao Zhiyu Zhou shaoyu liu Innovation Platform of Regeneration and Repair of Spinal Cord and Nerve Injury Department of Orthopaedic SurgeryThe Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhenChina Guangdong Provincial Key Laboratory of Orthopaedics and Traumatology The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina AO Research Institute Davos DavosSwitzerland Shenzhen Key Laboratory of Anti-aging and Regenerative Medicine Department of Medical Cell Biology and GeneticsHealth Sciences CenterShenzhen UniversityShenzhenChina School of Biomedical Sciences LKS Faculty of MedicineThe University of Hong KongHong Kong SARChina Laboratory of Bone Tissue Engineering Beijing Laboratory of Biomedical MaterialsBeijing Research Institute of Orthopaedics and TraumatologyBeijing JiShuiTan HospitalBeijingChina Department of Sport Medicine Inst Translat MedThe First Affiliated Hospital of Shenzhen UniversityShenzhen Second People’s HospitalShenzhenChina

The osteogenic microenvironment of bone-repairing materials plays a key role in accelerating bone regeneration but remains incompletely defined,which significantly limits the application of such bioactive ***,the transcriptional landscapes of different osteogenic microenvironments,including three-dimensional(3D)hydroxyapatite(HA)scaffolds and osteogenic medium(OM),for mesenchymal stromal cells(MSCs)in vitro were mapped at single-cell *** findings suggested that an osteogenic process reminiscent of endochondral ossification occurred in HA scaffolds through sequential activation of osteogenic-related signaling pathways,along with inflammation and angiogenesis,but inhibition of adipogenesis and ***,we revealed the mechanism during OM-mediated osteogenesis involves the ZBTB16 and WNT signaling *** of MSCs was also *** vitro ossification of LRRC75A+MSCs was shown to have better utilization of WNT-related ossification process,and PCDH10+MSCs with superiority in hydroxyapatite-related osteogenic *** findings provided further understanding of the cellular activity modulated by OM conditions and HA scaffolds,providing new insights for the improvement of osteogenic *** atlas provides a blueprint for research on MSC heterogeneity and the osteogenic microenvironment of HA scaffolds and a database reference for the application of bioactive materials for bone regeneration.

关键词： inflammation bioactive finding

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巨磁电阻直流电子式电流互感器的研制

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电力系统自动化 2008年第13期32卷 71-75页

作者：钱政任雪蕊刘少宇北京航空航天大学仪器科学与光电工程学院北京市100083 华北电科院有限责任公司北京市100045

随着直流输电线路逐渐广泛应用,直流电流准确测量的需求日益迫切。文中提出一种新的基于巨磁电阻效应的直流电流测量方法,研究了巨磁电阻传感器静态磁场下的外特性及温度变化对巨磁电阻传感器性能的影响,在此基础上设计了直流电子式电... 详细信息

随着直流输电线路逐渐广泛应用,直流电流准确测量的需求日益迫切。文中提出一种新的基于巨磁电阻效应的直流电流测量方法,研究了巨磁电阻传感器静态磁场下的外特性及温度变化对巨磁电阻传感器性能的影响,在此基础上设计了直流电子式电流互感器的整体结构。分析了实际应用中巨磁电阻传感器所表现出的非线性,提出了相应的非线性补偿方法。实际测试结果验证了该方法的有效性。

关键词：巨磁电阻效应电子式电流互感器直流非线性补偿

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ChatGPT模型融入数字政府建设研究:风险、基础与路径

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企业经济 2023年第10期42卷 95-104页

作者：刘绍宇中国社会科学院法学研究所北京100088

ChatGPT模型在数字政府建设中具有场景之应用,能引入公平、秩序等价值因素,重塑数字政府与民众之间的交互,对高效协同的数字政务、数字政府建设具有重要意义。然而,应注意ChatGPT模型对数字政府具有多重风险性影响:在安全方面,要注意数... 详细信息

ChatGPT模型在数字政府建设中具有场景之应用,能引入公平、秩序等价值因素,重塑数字政府与民众之间的交互,对高效协同的数字政务、数字政府建设具有重要意义。然而,应注意ChatGPT模型对数字政府具有多重风险性影响:在安全方面,要注意数据安全和国家安全的维护;在社会方面,要防止资本异化、资本同化及侵蚀社会文化;在信息方面,要预防其对生活秩序可能的破坏。因此,应从以下四个层面重构ChatGPT模型融入数字政府的基础:在技术上研发和推广拥有自主知识产权的ChatGPT模型;在制度上将数据分级作为ChatGPT模型的基准和规制路径;在权利上借助法治手段搭建ChatGPT模型的责任分配链条和溯因机制;在应用上借助伦理规范构筑ChatGPT模型应用服务的原则体系。

关键词：数字政府 ChatGPT模型数据分级数据安全风险社会

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超大互联网平台中个人信息保护独立监督机构的元规制论

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重庆理工大学学报（社会科学） 2023年第5期37卷 127-140页

作者：刘绍宇中国社会科学院法学研究所北京100732

我国《个人信息保护法》第58条在世界范围内首次引入了超大互联网平台中负责监督个人信息保护情况的独立机构,是真正意义上的中国创新。从法律定位来说,其本质上是行政法上的元规制机构,是互联网时代私人参与公共任务的一种新形式。尽... 详细信息

我国《个人信息保护法》第58条在世界范围内首次引入了超大互联网平台中负责监督个人信息保护情况的独立机构,是真正意义上的中国创新。从法律定位来说,其本质上是行政法上的元规制机构,是互联网时代私人参与公共任务的一种新形式。尽管监督个人信息保护情况的公共任务交给了私人的独立监督机构,但并不意味着其可以摆脱公法的约束。具体来说,独立监督机构应受到民主原则、正当程序原则、合作原则、基本权利保护原则、辅助性原则和效能原则等公法原则的约束,这在未来制度的进一步细化中均应体现。除此之外,政府强制平台承担公法义务构成对平台企业营业自由、平等权和公平竞争权之限制,也应受到公法规范。该制度在优化平台治理生态方面具有巨大的潜力,应用范围可扩大到信息管理、信用治理、交易监管和科技伦理审查等诸多平台监管领域。

关键词：超级互联网平台独立监督机构个人信息保护元规制

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